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CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONA CHE499 TRANSPORT MODELING Spring 2008 Prerequisites: MAT 216, a course in thermodynamics, and a course in fluid mechanics or heat transfer. Instructor: Thuan K. Nguyen Office Hours MTW 1:00-2:30 PM, Th 7:15-8:00 AM Room: 17-2108 Phone: 869-2631 TEXT: Basic Transport Phenomena in Biomedical Engineering by Fournier REFERENCES: (1) Introduction to Bioengineering by Berger, Goldsmith, and Lewis (2) Transport Phenomena in Biological Systems by Truskey, Yuan, and Katz, Prentice Hall, 2004 (3) Cellular Biophysics by Thomas Weiss by Bailey and Ollis (4) Transport Phenomena by Bird, Stewart, and Lightfoot GRADE: No late homework. No make-up quizzes or tests Homework (best 8 of 9 assignments) 15% Best 4 of 5 biweekly quizzes 45%, closed books and closed notes Final 40 Case Study (Optional) 5% A : 93-100%, A- : 90-93% , B+ : 87-90% , B : 83-87% , B- : 80-83% C+ : 77-80% , C : 73-77% , C- : 70-73% D+ : 67-70% , D : 60-67% , F : 0-60% April 4 April 11 April 18 April 25 May 2 May 9 May 16 May 23 May 30 June 6 Final Exam: Assignment #1 due Assignment #2 due. Quiz #1 Assignment #3 due. Assignment #4 due. Quiz #2 Assignment #5 due. Quiz #3 Assignment #6 due. Assignment #7 due. Quiz #4 Case Study and Assignment #8 due. Assignment #9 due. Quiz #5 Wednesday June 11, 9:10 AM-11:10 AM Standard Format for Chemical & Materials Engineering Problems An engineer's work should be neat, well organized, and easy to follow. You are expected to follow this standard format for completing chemical & materials engineering problems. Points may be deducted for work that does not adhere to this format. 1. Use 8.5x11 paper for engineering problems. 2. The problem statement is needed before the solution ; a drawing is usually required. 3. No credit will be given for final answers that do not show work involved. 4. Draw a box around your answers. Be sure to include units. 5. The top of each page should contain the following information from left to right: Course & Section # | Assignment # | Your last name, 1st name | Page #/Total pages 6. Staple all pages of an assignment together in the upper left corner. CHE499 CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONA TRANSPORT MODELING Spring 2004 COURSE DESCRIPTIONS This course provides an introduction to the modeling of mass- and momentum-transport processes in biomedical engineering. It discusses examples of transport processes relevant to the development of artificial organs, bioartificial organs, controlled drug delivery systems, and tissue engineering. This course stresses the fundamental principles underlying transport phenomena in various areas of biomedical engineering. Mathematical models are developed using the “shell balance” or compartmental approaches. Some analytical and numerical methods will be introduced to solve the transport equations. COURSE OUTLINE WEEK TOPICS READING ASSIGNMENTS 1 Physical Properties of The Body Fluids The Thermodynamics of Osmosis Capillary Filtration Rate Chap. 1 2 Solute Transport in Biological Systems The Irreversible Thermodynamics of Membrane Transport. Chap. 2 3 Transport of a Solute Between a Capillary and the Surrounding Tissue Space Solute Transport in a Vascular Bed Chap. 2 4 Hemodialysis. Design of an Artificial Kidney Utilizing Urea in Polymeric Beads. 5 The Physical and Flow Properties of Blood Rheology. The Hagan-Poiseuille Equations 6 7 8 9 Chap. 3 Velocity Profile for Tube Flow of a Casson Fluid Rheology of Blood. Marginal Zone Theory Generalized Mechanical Energy Balance Equation Oxygen Transport in Biological Systems The Hill Equation. Tissue Oxygenation Chap. 4 Oxygen Transport in a Bioartificial Organ and in the Krogh Tissue Cylinder. Approximate Solution Pharmacokinetic Analysis First-Order Drug Absorption and Elimination. Two-Compartment Models Chap. 5 10 Extracorporeal Devices Blood Oxygenators. Oxygen and Carbon Dioxide Transfer Chap. 6