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CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONA
CHE499
TRANSPORT MODELING
Spring 2008
Prerequisites: MAT 216, a course in thermodynamics, and a course in fluid mechanics or heat
transfer.
Instructor:
Thuan K. Nguyen
Office Hours
MTW 1:00-2:30 PM, Th 7:15-8:00 AM
Room:
17-2108 Phone: 869-2631
TEXT: Basic Transport Phenomena in Biomedical Engineering by Fournier
REFERENCES:
(1) Introduction to Bioengineering by Berger, Goldsmith, and Lewis
(2) Transport Phenomena in Biological Systems by Truskey, Yuan, and Katz, Prentice Hall,
2004
(3) Cellular Biophysics by Thomas Weiss by Bailey and Ollis
(4) Transport Phenomena by Bird, Stewart, and Lightfoot
GRADE:
No late homework. No make-up quizzes or tests
Homework (best 8 of 9 assignments)
15%
Best 4 of 5 biweekly quizzes
45%, closed books and closed notes
Final
40
Case Study (Optional)
5%
A : 93-100%, A- : 90-93% , B+ : 87-90% , B : 83-87% , B- : 80-83%
C+ : 77-80% , C : 73-77% , C- : 70-73%
D+ : 67-70% , D : 60-67% , F : 0-60%
April 4
April 11
April 18
April 25
May 2
May 9
May 16
May 23
May 30
June 6
Final Exam:
Assignment #1 due
Assignment #2 due. Quiz #1
Assignment #3 due.
Assignment #4 due. Quiz #2
Assignment #5 due.
Quiz #3
Assignment #6 due.
Assignment #7 due. Quiz #4
Case Study and Assignment #8 due.
Assignment #9 due. Quiz #5
Wednesday June 11, 9:10 AM-11:10 AM
Standard Format for Chemical & Materials Engineering Problems
An engineer's work should be neat, well organized, and easy to follow. You are expected to
follow this standard format for completing chemical & materials engineering problems. Points
may be deducted for work that does not adhere to this format.
1. Use 8.5x11 paper for engineering problems.
2. The problem statement is needed before the solution ; a drawing is usually required.
3. No credit will be given for final answers that do not show work involved.
4. Draw a box around your answers. Be sure to include units.
5. The top of each page should contain the following information from left to right:
Course & Section # | Assignment # | Your last name, 1st name | Page #/Total pages
6. Staple all pages of an assignment together in the upper left corner.
CHE499
CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONA
TRANSPORT MODELING
Spring 2004
COURSE DESCRIPTIONS
This course provides an introduction to the modeling of mass- and momentum-transport
processes in biomedical engineering. It discusses examples of transport processes relevant to the
development of artificial organs, bioartificial organs, controlled drug delivery systems, and
tissue engineering. This course stresses the fundamental principles underlying transport
phenomena in various areas of biomedical engineering. Mathematical models are developed
using the “shell balance” or compartmental approaches. Some analytical and numerical methods
will be introduced to solve the transport equations.
COURSE OUTLINE
WEEK
TOPICS
READING ASSIGNMENTS
1
Physical Properties of The Body Fluids
The Thermodynamics of Osmosis
Capillary Filtration Rate
Chap. 1
2
Solute Transport in Biological Systems
The Irreversible Thermodynamics of Membrane
Transport.
Chap. 2
3
Transport of a Solute Between a Capillary
and the Surrounding Tissue Space
Solute Transport in a Vascular Bed
Chap. 2
4
Hemodialysis.
Design of an Artificial Kidney Utilizing
Urea in Polymeric Beads.
5
The Physical and Flow Properties of Blood
Rheology. The Hagan-Poiseuille Equations
6
7
8
9
Chap. 3
Velocity Profile for Tube Flow of a Casson Fluid
Rheology of Blood. Marginal Zone Theory
Generalized Mechanical Energy Balance Equation
Oxygen Transport in Biological Systems
The Hill Equation. Tissue Oxygenation
Chap. 4
Oxygen Transport in a Bioartificial Organ and in the
Krogh Tissue Cylinder. Approximate Solution
Pharmacokinetic Analysis
First-Order Drug Absorption and Elimination.
Two-Compartment Models
Chap. 5
10
Extracorporeal Devices
Blood Oxygenators.
Oxygen and Carbon Dioxide Transfer
Chap. 6