Download Supplementary Table 6

Supplemental Table 6: Canonical pathways
differentially expressed in human DKD
glomeruli and tubuli. Statistical significance
is scored using Fischer’s Exact Test (pvalue<0.05).
Differentially Expressed Canonical
Pathways in DKD Glomeruli
Ingenuity Canonical Pathways p-value
Integrin Signaling
4.77E-06
Complement System
1.96E-05
Leukocyte Extravasation Signaling
8.13E-05
Hepatic Fibrosis / Hepatic Stellate Cell
Activation
4.08E-04
Macropinocytosis Signaling
1.21E-03
VDR/RXR Activation
1.32E-03
Glioma Invasiveness Signaling 2.46E-03
ILK Signaling
4.53E-03
Germ Cell-Sertoli Cell Junction Signaling
6.67E-03
Virus Entry via Endocytic Pathways
8.56E-03
RhoA Signaling
1.04E-02
Inhibition of Angiogenesis by TSP1
1.13E-02
Cdc42 Signaling
1.20E-02
PTEN Signaling
1.23E-02
VEGF Signaling
1.45E-02
Actin Cytoskeleton Signaling 1.47E-02
Role of Tissue Factor in Cancer 1.51E-02
Semaphorin Signaling in Neurons
1.76E-02
Clathrin-mediated Endocytosis Signaling
1.82E-02
Caveolar-mediated Endocytosis Signaling
1.88E-02
Lipid Antigen Presentation by CD1
2.39E-02
Natural Killer Cell Signaling
2.58E-02
FcγRIIB Signaling in B Lymphocytes
3.83E-02
Systemic Lupus Erythematosus Signaling
4.11E-02
Tight Junction Signaling
4.36E-02
Primary Immunodeficiency Signaling
4.41E-02
DAVID Term
P-Value
hsa04510:Focal adhesion
4.50E-07
hsa04520:Adherens junction
1.40E-05
hsa04512:ECM-receptor interaction
2.60E-05
hsa04810:Regulation of actin cytoskeleton
6.70E-05
hsa04610:Complement and coagulation
cascades
4.20E-04
hsa05322:Systemic lupus erythematosus
4.80E-04
hsa04670:Leukocyte transendothelial
migration
9.20E-04
hsa04666:Fc gamma R-mediated
phagocytosis
1.10E-03
hsa05412:Arrhythmogenic right ventricular
cardiomyopathy (ARVC)
1.50E-03
hsa04514:Cell adhesion molecules (CAMs)
4.20E-03
hsa05416:Viral myocarditis
7.20E-03
hsa05414:Dilated cardiomyopathy
1.10E-02
hsa05410:Hypertrophic cardiomyopathy
(HCM)
1.20E-02
hsa04640:Hematopoietic cell lineage
1.40E-02
hsa04664:Fc epsilon RI signaling pathway
4.20E-02
Differentially Expressed Canonical
Pathways in DKD Tubuli
Ingenuity Canonical Pathways p-value
Antigen Presentation Pathway 7.94E-11
Cytotoxic T Lymphocyte-mediated
Apoptosis of Target Cells
1.20E-10
Type I Diabetes Mellitus Signaling
1.10E-09
Cdc42 Signaling
3.80E-09
Role of Macrophages, Fibroblasts and
Endothelial Cells in Rheumatoid Arthritis
1.00E-08
Dendritic Cell Maturation
1.20E-08
OX40 Signaling Pathway
1.45E-08
Allograft Rejection Signaling 3.63E-08
Autoimmune Thyroid Disease Signaling
3.31E-07
Graft-versus-Host Disease Signaling
1.41E-06
Communication between Innate and
Adaptive Immune Cells
1.48E-06
Systemic Lupus Erythematosus Signaling
4.37E-06
Crosstalk between Dendritic Cells and
Natural Killer Cells
9.55E-06
Caveolar-mediated Endocytosis Signaling
1.51E-05
B Cell Development
1.51E-05
Virus Entry via Endocytic Pathways
4.68E-05
MSP-RON Signaling Pathway 6.61E-05
Role of Osteoblasts, Osteoclasts and
Chondrocytes in Rheumatoid Arthritis
7.24E-05
Interferon Signaling
8.51E-05
CTLA4 Signaling in Cytotoxic T
Lymphocytes
8.71E-05
Nur77 Signaling in T Lymphocytes
9.12E-05
CD28 Signaling in T Helper Cells
9.55E-05
Integrin Signaling
1.23E-04
Acute Phase Response Signaling 2.57E-04
Agrin Interactions at Neuromuscular
Junction
3.24E-04
Axonal Guidance Signaling
3.24E-04
Actin Cytoskeleton Signaling 3.72E-04
Tumoricidal Function of Hepatic Natural
Killer Cells
4.47E-04
Role of Pattern Recognition Receptors in
Recognition of Bacteria and Viruses
9.12E-04
Role of NFAT in Regulation of the Immune
Response
1.07E-03
Rac Signaling
1.10E-03
Toll-like Receptor Signaling
1.15E-03
Complement System
1.15E-03
Colorectal Cancer Metastasis Signaling
1.32E-03
LXR/RXR Activation
1.32E-03
IL-10 Signaling
1.38E-03
Macropinocytosis Signaling
1.38E-03
Primary Immunodeficiency Signaling
1.41E-03
Regulation of Actin-based Motility by Rho
1.48E-03
Reelin Signaling in Neurons
1.48E-03
Lipid Antigen Presentation by CD1
1.48E-03
Phospholipase C Signaling
1.66E-03
Ephrin Receptor Signaling
1.70E-03
Death Receptor Signaling
1.78E-03
Aryl Hydrocarbon Receptor Signaling
2.00E-03
Inhibition of Angiogenesis by TSP1
2.09E-03
Leukocyte Extravasation Signaling
2.34E-03
NF-κB Signaling
2.40E-03
iCOS-iCOSL Signaling in T Helper Cells
3.16E-03
Role of PKR in Interferon Induction and
Antiviral Response
3.55E-03
Fcγ Receptor-mediated Phagocytosis in
Macrophages and Monocytes
4.07E-03
CXCR4 Signaling
4.17E-03
Hepatic Fibrosis / Hepatic Stellate Cell
Activation
4.17E-03
IL-8 Signaling
4.47E-03
PKCθ Signaling in T Lymphocytes
4.90E-03
TNFR1 Signaling
5.37E-03
PDGF Signaling
6.76E-03
RhoA Signaling
6.92E-03
O-Glycan Biosynthesis
7.24E-03
Germ Cell-Sertoli Cell Junction Signaling
7.59E-03
Atherosclerosis Signaling
7.76E-03
TREM1 Signaling
7.94E-03
Mitotic Roles of Polo-Like Kinase
7.94E-03
Altered T Cell and B Cell Signaling in
Rheumatoid Arthritis
7.94E-03
Wnt/β-catenin Signaling
8.51E-03
Molecular Mechanisms of Cancer
9.33E-03
T Helper Cell Differentiation
9.55E-03
LPS/IL-1 Mediated Inhibition of RXR
Function
9.55E-03
Sphingosine-1-phosphate Signaling
1.00E-02
Neuroprotective Role of THOP1 in
Alzheimer's Disease
1.05E-02
PAK Signaling
1.26E-02
Lymphotoxin β Receptor Signaling
1.32E-02
Role of JAK2 in Hormone-like Cytokine
Signaling
1.38E-02
Role of IL-17A in Arthritis
1.55E-02
Endoplasmic Reticulum Stress Pathway
1.62E-02
Production of Nitric Oxide and Reactive
Oxygen Species in Macrophages 1.70E-02
Antiproliferative Role of Somatostatin
Receptor 2
1.70E-02
Glioblastoma Multiforme Signaling
1.95E-02
Ovarian Cancer Signaling
2.04E-02
TWEAK Signaling
2.09E-02
IL-4 Signaling
2.45E-02
Neuropathic Pain Signaling In Dorsal Horn
Neurons
2.45E-02
Role of NFAT in Cardiac Hypertrophy
2.57E-02
Calcium-induced T Lymphocyte Apoptosis
2.69E-02
G Protein Signaling Mediated by Tubby
2.69E-02
FcγRIIB Signaling in B Lymphocytes
2.82E-02
Small Cell Lung Cancer Signaling
2.82E-02
ILK Signaling
3.02E-02
SAPK/JNK Signaling
3.09E-02
Thrombin Signaling
3.39E-02
Natural Killer Cell Signaling
3.39E-02
Gα12/13 Signaling
3.39E-02
HMGB1 Signaling
3.47E-02
FAK Signaling
3.47E-02
Induction of Apoptosis by HIV1 3.55E-02
GM-CSF Signaling
3.55E-02
fMLP Signaling in Neutrophils 3.63E-02
PI3K Signaling in B Lymphocytes
3.72E-02
Human Embryonic Stem Cell Pluripotency
4.07E-02
Docosahexaenoic Acid (DHA) Signaling
4.27E-02
Factors Promoting Cardiogenesis in
Vertebrates
4.27E-02
p38 MAPK Signaling
4.57E-02
IL-6 Signaling
4.57E-02
DAVIDTerm
P-Value
hsa04512:ECM-receptor interaction
6.50E-08
hsa04510:Focal adhesion
7.10E-08
hsa05416:Viral myocarditis
5.90E-06
hsa04940:Type I diabetes mellitus
8.50E-06
hsa05332:Graft-versus-host disease
1.20E-05
hsa05330:Allograft rejection
1.60E-05
hsa04612:Antigen processing and
presentation
4.70E-05
hsa05222:Small cell lung cancer 6.50E-05
hsa04514:Cell adhesion molecules (CAMs)
8.30E-05
hsa05320:Autoimmune thyroid disease
1.50E-04
hsa05322:Systemic lupus erythematosus
1.70E-04
hsa04810:Regulation of actin cytoskeleton
2.40E-04
hsa04670:Leukocyte transendothelial
migration
8.00E-04
hsa04640:Hematopoietic cell lineage
1.20E-03
hsa05310:Asthma
2.80E-03
hsa04666:Fc gamma R-mediated
phagocytosis
3.20E-03
hsa04610:Complement and coagulation
cascades
4.90E-03
hsa05200:Pathways in cancer
5.10E-03
hsa05130:Pathogenic Escherichia coli
infection
5.90E-03
hsa04672:Intestinal immune network for
IgA production
6.80E-03
hsa00512:O-Glycan biosynthesis 1.30E-02
hsa04650:Natural killer cell mediated
cytotoxicity
1.40E-02
hsa04540:Gap junction
2.90E-02
hsa04310:Wnt signaling pathway 3.80E-02
hsa04916:Melanogenesis
4.40E-02
hsa04621:NOD-like receptor signaling
pathway
4.90E-02