Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
The Journal of Neurological Science re: Methyl B-12 in Combating Degenerative Diseases of Joints and Nerves New findings on the connection between homocysteine and vascular disease, and the failure of drugs to reduce the number of heart attacks and strokes, have brought attention to B12 and other homocysteine-lowering vitamins. Heart Disease Homocysteine, a chemical found in the blood, has emerged as a strong and independent risk factor for heart disease and stroke. New findings on the connection between homocysteine and vascular disease, and the failure of drugs to reduce the number of heart attacks and strokes, have brought attention to B12 and other homocysteine-lowering vitamins. New research indicates that sublingual (under the tongue) B12 supplements are as effective as injections. Clinical human studies show that a supplementation of 2,000 micrograms of sublingual B12 can reduce homocysteine levels from 113.4 micromoles per litre (a safe level is under six micromoles per litre) to 8.2 micromoles per litre, over four months. Pernicious Anaemia Pernicious anaemia occurs when the body does not have enough vitamin B12. It can lead to serious health problems such as congestive heart failure, neurological problems, increased incidences of infection, and impotence in males. Those with coronary artery or pulmonary disease are especially vulnerable to the oxygen deprivation sometimes caused by anaemia. Symptoms of B12 and folic acid deficiencies also include depression, anorexia, alcohol addiction, memory loss, dementia and insanity. Neurological Diseases and Nerve Regeneration In April 1994, The Journal of Neurological Science reported that “Methyl-B12 may be of clinical benefit to patients with peripheral neuropathies. Ultra-high doses of methylcobalamin even promote nerve regeneration in experiments.” Further research shows that methylcobalamin, the active form of B12, has the unique ability to provoke the regeneration of nerves without adverse side effects. This is because B12 facilitates methylation, the process that creates and maintains nerves and brain chemicals. Research shows that a lack of methylcobalamin causes degeneration of the brain, spinal cord, and nerves. This process, known as demyelination, occurs in other neurological diseases such as multiple sclerosis, Lou Gehrig’s disease and chronic inflammatory demyelinating polyneuropathy. A double-blind, controlled study found that methylcobalamin improved muscle response after only one month of treatment. Sleep and Insomnia If you can’t get to sleep at night, you may need methyl B12. Studies show that B12 causes an earlier release of melatonin at night, which resets the sleep-wake cycle. B12 acts directly on the pineal gland, provoking a faster release of melatonin, which is often called the sleep hormone. At the end of the sleep interval, B12 causes melatonin production to drop off faster. B12 also increases sensitivity to morning light, which may help you wake up earlier if you leave a curtain open to the sun. In all, B12 helps you to fall asleep faster and wake earlier. Very serious sleep-wake disorders have been successfully treated with vitamin B12 in the methylcobalamin form. Age-related B12 Deficiency Research shows that the presence of vitamin B12 decreases every year with age. Agerelated deficiency is associated with hearing loss, memory impairment, psychiatric disorders, heart disease, and stroke. Patients with Alzheimer’s disease have less B12 in their spinal fluid than people without the disease. They also have less SAMe, the substance required to convert methylate cobalamin (B12) to its active form, methylcobalamin. Basic B12 supplementation (in cyanocobalamin form) may fail to improve the condition of Alzeimer’s patients in studies because of an inability to activate this form of B12 in the brain. The methylcobalamin form of B12 may be more successful because it is already activated and in its most useable form. B12 Deficiency Diseases Diet, age, and drugs are the prime culprits behind B12 deficiency. Meat is the primary source of vitamin B12. Elderly people can sometimes eat high quantities of meat but still be B12 deficient because of insufficient hydrochloric acid in the stomach, which is a factor necessary for B12 absorption. Meat-eaters who take certain drugs for stomach ulcers, heartburn, or to inhibit gastric secretion are also at risk for B12 deficiency. Other risk factors include stomach surgery, thyroid disease, diabetes mellitus, osteoporosis, and bone fractures. Elevated Homocysteine, Arthritis and Diabetes Elevated homocysteine is found in many chronic diseases, including arthritis, diabetes and renal failure. Researchers in Japan have discovered that non-insulin dependent diabetes patients with blood vessel problems have elevated homocysteine. When treated with 1,000 micrograms of vitamin B12 (methylcobalamin) daily for three weeks, homocysteine levels dropped significantly. Taking Methyl B12 B12 has many benefits, including the reduction of homocysteine, restoration of normal sleep patterns, and improved moods. B12 deficiency is a fairly common deficiency in elderly people who frequently have disrupted digestion. It can cause symptoms identical to Alzheimer’s disease. It is also crucial for the retention of folic acid in cells. Researchers report that the dose of Methyl B12 for sleep disorders is 3,000 micrograms a day, while 2,000 micrograms a day is useful for lowering homocysteine and correcting B12 deficiency. In published studies, it took four weeks for the sleep effect, and four months for the homocysteine-lowering effect. The dosage for patients with degenerative diseases, including Alzheimer’s, is very high, in the range of 3,000 to 4,000 milligrams a day. Purchasing Methyl B12 Your liver only converts about one percent of ingested cyanocobalamin into methylcobalamin. For optimum benefit, it is important that you purchase B12 in the active methylcobalamin form, not cyanocobalamin. For complete and immediate absorption, choose methylcobalamin sublingual tablets NOTE FROM FELICIA: The best sublingual methylcobalamin in 1 mg tablets, 800 mcgs of B6 is made by NO SHOT. I take injections each week, but this can approximate injections, although B12 is harder for older people to absorb. B6 is easily accessible sublingually. I have witnessed patients taking even 1 mg injections feeling pain free and, as one self-made millionaire put it, “I am no longer a Type A personality, I am completely out of pain and feel relaxed.” VINPOCETINE, by Jarrow. Research has shown this increases cerebral synthesis of ATP, the basis of "energy," and also enhances brain metabolism by improving utilization of oxygen. Vinpocetine also increases synthesis of several neurotransmitters that affect critical brain functions such as memory recall, focus, and mood. My own doctor, my patients, and myself feel this is an important supplement. TMG (Trimethyglyceine) is a naturally-occuring amino acid which I began taking due to research showing this supports increased energy. What has captivated me is not only my own and my patients; energy levels improving radically, but that our short-term memories did as well. Trimethylglycine (TMG) (also known as Betaine) and Dimethylglycine (DMG) are methyl donors that help in the production of several brain chemicals and hence improve mood, energy, general sense of well-being, alertness, concentration and visual clarity. A methyl donor is any substance that can transfer a methyl group to another substance. Many important biochemical processes rely on methylation, including the metabolism of lipids and DNA. Scientists suspect that adequate methylation of DNA can prevent the expression of harmful genes such as cancer genes. It is thought that as we age, the body's ability to methylate declines. This may potentially contribute to the aging process. Other research found that TMG supports healthy homocysteine metabolism and optimal liver function and health. TMG helps maintain healthy fat metabolism and maintains SAMe metabolism, an important cofactor for healthy liver function. TMG helps maintain homocysteine levels within normal ranges. TMG, Folic Acid and Vitamin B12 donate methyl groups for methylation reactions that convert homocysteine to the essential amino acid methionine. HOMOCYSTEINE DEFENSE, by Source Naturals includes B12 and folate necessary for TMG to create SAMe, which has been shown to have even more effect than just the B12 by itself and has been used successfully in Europe for decades instead of antidepressants. Additional B12 and folate is still encouraged for serious neurological needs. GABA CALMS, by Source Naturals is an amazing product to be sold in the market place. It is made up of the four major inhibitory substances, i.e., it allows your body to release contraction, to relax. This is so effective that I have used it to help patients get off morphine and other pain killers. I chew up two tablets into pieces, and let them melt under my tongue after I am already in bed and ready to sleep.