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CURRICULUM VITAE
1.
Date:
April 30, 2007
PERSONAL
2.
Name:
Nanette Hahr Bishopric, M.D., F.A.C.C., F.A.H.A.
3.
Home Phone:
Private
4.
Office Phone:
305-243-6775
5.
Home Address:
Private
6.
Academic Rank:
Professor, June 1, 2004
Tenured, June 1, 2002
7.
Primary Department:
Molecular and Cellular Pharmacology
8.
Secondary Departments:
Medicine and Pediatrics
Member, Sylvester Cancer Center
Faculty, John T. Macdonald Center for Medical Genetics
9.
Citizenship:
U.S.
10.
Visa Type:
N/A
HIGHER EDUCATION
11.
Institutional:
1969-1973
B.A., Magna Cum Laude, Music (Performance)
Duke University, Durham, North Carolina
1974-1975
Cell Biology, Massachusetts
Institute of Technology, Cambridge, Massachusetts
1975-1979
M.D., Duke University School of Medicine
Durham, North Carolina
12.
Non-Institutional:
A.
Clinical Training
1979-1980
University of Florida, Gainesville, FL
Intern, Dept. of Medicine (Dr. James E. McGuigan, Chairman)
1980-1981
Duke University, Durham, North Carolina
Fellow in Hematology/Oncology (Dr. Wendell Rosse, Chief)
1981-1983
University of Florida, Gainesville, Florida
Assistant Resident, Dept. of Medicine (Dr. James E. McGuigan,
Chairman)
Nanette H. Bishopric, M.D.
Curriculum Vitae
1983-1985
13.
University of California at San Francisco
Clinical Fellow in Cardiology (Dr. William Parmley, Chief)
Certification
1983
American Board of Internal Medicine
1985
American Board of Internal Medicine (Cardiology)
1992
National Board Examination Part III re-certification
Medical Licensure (active): State of California #G50082; State of Florida #37475
EXPERIENCE
14.
Academic
15.
1988-1989
Instructor in Medicine, University of California at San Francisco
1989-1996
Assistant Professor of Medicine, University of California at San Francisco
1992-1996
Clinical Assistant Professor of Medicine, Stanford University
1996-2004
Associate Professor of Pharmacology and Medicine, University of Miami,
Miami, Florida
1998-present
Director, UM-MHRI Cardiovascular Genetics Program
2002-2007
Associate Professor of Pediatrics, University of Miami, Miami, Florida
2004-present
Professor of Molecular and Cellular Pharmacology, University of Miami,
Miami, Florida
2004-present
Professor of Medicine, Division of Cardiology, University of Miami, Miami,
Florida
2004-present
Professor of Pediatrics, University of Miami, Miami, Florida
Non-Academic
Hospital Appointments:
2005-present
Cedars Medical Center, Staff Physician
1999-present
Jackson Memorial Hospital, Staff Physician UMMG; Teaching
1989-1991
Consulting Molecular Biologist, SRI International, Menlo Park, California
1992-1996
Senior Molecular Biologist, Life Sciences Division
1992-1997
Consultant in Health Sciences, Business and Policy Group
SRI International, Menlo Park, California
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Nanette H. Bishopric, M.D.
Curriculum Vitae
Representative Consulting Projects:
Consultant, modeling the market diffusion of a new antithrombotic agent in the U.K. (1996)
Consultant, identification of novel technologies for licensing and acquisition (for major U.S.
pharmaceutical client, 1997-1998)
Consultant, assessment of biological targets for lead development compounds (for major
U.K. pharmaceutical client, 1996-1997)
Expert witness for the defense, major US pharmaceutical company, drug outcomes litigation
(2004-2007)
Expert witness for the defense, US generic drug manufacturer, drug outcomes litigation
(2006)
Expert witness for the defense, major US pharmaceutical company, drug outcomes litigation
(2005-present)
Expert witness, tobacco-related diseases litigation (2007-)
16.
Military
N/A
PUBLICATIONS
17.
Books, reviews and monographs:
1. Webster KA and Bishopric NH. Cardiomyocyte apoptosis. In: The Heart in Biology and Disease, ed.
E. Bittar, Vol. 16 (2007, in preparation).
2. Jain S, Rodrigues CO, Webster KA, Bishopric NH (2007). New therapeutic targets to prevent
cardiomyocyte apoptosis. J. Pharmacol Exp Therap, in press.
3. Bishopric NH, Andreka P and Webster KA. Apoptosis and risk with the use of calcium
antagonists. In: Calcium Channel Antagonists in Clinical Medicine, 3rd edition, ed. M. Epstein.
Hanley and Belfus, Philadelphia, 2002.
4. Webster KA, Prentice H, Bishopric NH. Redox regulation of zinc finger transcription factors. In:
Antioxidants and Redox Signaling, 3: 535-548, 2001.
5. Webster KA, Discher DJ, Hernandez O, Yamashita K, and Bishopric NH. A glycolytic pathway to
apoptosis of hypoxic cardiac myocytes: molecular pathways of increased acid production. In:
Oxygen Sensing: Molecules to Man, S. Lahiri & N. Prabhakar, eds., Kluwer. Academic Press,
London, UK, 2000.
6. Webster KA and Bishopric NH. Molecular aspects and gene therapy prospects for diastolic failure.
In: Cardiology Clinics, SJ Kovacs, ed., W.B. Saunders & Co. volume 18(3): 621-635, 2000.
7. Webster KA, Discher DJ and Bishopric NH. Induction of proto-oncogenes and lipid second
messengers in hypoxic cardiac myocytes. In: Hypoxia and Molecular Medicine, J. R. Sutton, C. S.
Houston and G. Coates, eds. Queen City Printers, Inc., Burlington VT, pp 98-111, 1993
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Nanette H. Bishopric, M.D.
Curriculum Vitae
8. Bishopric NH, Wade R, Gahlmann R and Kedes LH. Gene expression during skeletal and cardiac
muscle development. In: The Heart and Cardiovascular System, second edition, H.A. Fozzard et
al., eds. Raven Press, Ltd., New York, pp 1587-1598, 1992
9. Bishopric NH, Long CS, Waspe LE, Simpson PC and Ordahl CP (1989). The molecular biology of
cardiac myocyte hypertrophy. Studies using a cell culture model. In: Cellular and Molecular
Biology of Muscle Development, UCLA Symposia Vol. 93 (New Series), L. H. Kedes and F. E.
Stockdale, eds., Alan R. Liss, Inc., New York, pp 399-412, 1989
10. Simpson PC, Bishopric NH, Coughlin SR, Karliner J, Ordahl CP, Starksen N, Tsao T, White N and
Williams LT: Dual trophic effects of the ß1-adrenergic receptor in cultured neonatal rat heart
muscle cells. J Mol Cell Cardiol 18 (Suppl 5): 45, 1986
11. Bishopric NH, Mehta J and Mehta P. Platelet activation and platelet-suppressive drugs. In:
Platelets and Prostaglandins in Cardiovascular Disease, Mehta J and Mehta P, eds., Futura
Publishing Co., Mt. Kisco, NY: 1981.
18.
Juried or refereed journal articles or exhibitions:
(in preparation or submitted)
1. Shehadeh L, Sharma S., Pessanha M, Wei JQ, Webster KA, and Bishopric NH (2007). Cardiac
myocyte p300 levels regulate angiogenesis during myocardial hypertrophy through Sox4. In
preparation.
2. Bishopric NH, Hilfiker D, Drexler H, Dzau V, Sugden P (2007). Facts about factors: paracrine
signalling by stem cells in cardiac repair. In preparation.
3. Rodrigues CO, Wei JQ, Li J, Llanos A, Webster KA, Bishopric NH (2007). Accelerated aging in a
mouse model of p300 histone acetylase deficiency. In preparation.
4. Papapetropoulos S et al. Gene expression of MT1 & MT2 receptors in Parkinson’s disease human
post mortem brain (2007). J Pineal Res, submitted.
5. Wei JQ, Mitrani J, Pessanha M, Shehadeh L, Slepak TI, Webster KA and Bishopric NH (2007).
Stoichiometric regulation of cardiac hypertrophy by acetyltransferase p300. Genes Devel,
submitted.
6. Wilson A, Shehadeh LA, Gosink M, Tsinoremas NF, Bishopric NH and Webster KA (2007). Age
and maturity confer distinctive gene expression profiles in murine bone marrow mesenchymal stem
cells. Stem Cell, submitted.
(in press or published)
7. Ley JJ, Prado R, Wei JQ, Bishopric NH, Ginsberg MD (2007). Neuroprotective antioxidant STAZN
protects against myocardial ischemia/reperfusion injury. Biochem. Pharmacol, in press.
8. Graham R, Thompson JW, Wei JQ, Bishopric NH and Webster KA (2007). Regulation of Bnip3
death pathways by calcium, phosphorylation and hypoxia-reoxygenation. Antiox Redox Signal,
9(9):1309-16
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Nanette H. Bishopric, M.D.
Curriculum Vitae
9. Tran TH, Andreka P, Rodrigues CO, Webster KA and Bishopric NH (2007). Jun kinase delays
caspase-9 activation by interaction with the apoptosome. J Biol Chem, 282(28):20340-50. Epub
2007 May 4.
10. Rodrigues CO, Shehadeh L, Webster KA and Bishopric NH (2007). Myocyte deficiency as a target
in the treatment of cardiomyopathy. Progress in Pediatric Cardiology, in press.
11. Shehadeh LA, Bishopric NH, Wilson A, Gosink M, Tsinoremas N, and Webster KA (2007).
Immune remodeling of mesenchymal stem cells during osteoblastic differentiation. Nature
Biotechnology Short Reports, in press.
12. Papapetropoulos S, Adi N, Shehadeh L, Mash D, Bishopric NH. (2007). Expression of -synuclein
mRNA in Parkinson’s Disease. Movement Disorders, 22(7):1057-9.
13. Frazier DP, Wilson A, Dougherty C, Li, H, Bishopric NH, Webster KA (2007). PKC-delta and
TAK-1 are intermediates in the activation of c-Jun N-terminal kinase (JNK) by hypoxiareoxygenation. Am J Physiol Heart Circ Physiol. 292(4):H1675-84. Epub 2007 Jan 5.
14. Miller TE, You L, Myerburg RJ, Benke PJ, Bishopric NH (2007). Whole blood RNA offers a rapid,
comprehensive approach to genetic diagnosis of cardiovascular diseases. Genetics in Medicine
9(1): 23-33.
15. Webster KA, Graham RM, Thompson JW, Spiga MG, Frazier DP, Wilson A, Bishopric NH (2006).
Redox stress and the contributions of BH3-only proteins to infarction. (2006) Antioxid Redox
Signal 8(9-10):1667-1676.
16. Frazier DP, Wilson A, Graham RM, Thompson JW, Bishopric NH, Webster KA (2006). Acidosis
regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3. Antioxid Redox
Signal. 8(9-10):1625-1634.
17. Rodrigues CO, White EL, King ML, Nerlick S, Bishopric N, and Cleveland JL (2006). A MYCtwist-slug regulatory circuit directing neural crest determination affects angiogenesis. Nature
Biotechnology Short Reports, 17:78
18. Spiga M-G, Layman H, Wilson AD, Jia Y, Bishopric NH, Andreopoulos FM, and Webster KA
(2006). Delivery of VEGF165 with hypoxia-regulated adeno-associated virus (AAV) serotype 9
produces stable conduction vessels in mouse ischemic limbs. Nature Biotechnology Short Reports,
17:85.
19. Pessanha M, Wei JQ, Shehadeh L, Faysal J, Webster KA, and Bishopric NH (2006). Cardiac
myocyte p300 levels regulate myocardial angiogenesis. Nature Biotechnology Short Reports, 17:87.
20. Bishopric, NH (2005). Evolution of the heart from bacteria to man. Annals of the New York
Academy of Sciences 1047:13-29.
21. Webster KA, Graham RM, Bishopric NH (2005). BNip3 and signal-specific programmed death in
the heart. J Mol Cell Cardiol 38(1):35-45.
22. Turner MS, Haywood GA, Andreka P, You L, Martin PE, Evans WH, Webster KA, Bishopric NH
(2004). Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to
cellular ATP levels. Circ Res 95(7):726-733.
23. Graham RM, Frazier DP, Thompson JW, Haliko S, Li H, Wasserlauf BJ, Spiga MG, Bishopric NH
and Webster KA (2004). A unique pathway of cardiac myocyte death cased by hypoxia-acidosis. J
Exp Biol 207(18):3189-3200.
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Nanette H. Bishopric, M.D.
Curriculum Vitae
24. Andreka P, Tran T, Webster KA, Bishopric NH (2004). Nitric oxide and promotion of cardiac
myocyte apoptosis. Molecular and Cellular Biochemistry 263:35-53.
25. Andreka P, Nadhazi Z, Muzes G, Szantho G, Vandor L, Konya L, Turner MS, Tulassay Z and
Bishopric NH (2004). Possible therapeutic targets in cardiac myocyte apoptosis. Current
Pharmaceutical Design 10(20):2445-2461.
26. Miller TE, Estrella E, Myerburg RJ, Garcia de Viera J, Moreno N, Rusconi P, Ahearn ME,
Baumbach L, Kurlansky P, Wolff G and Bishopric NH (2004). Recurrent third trimester fetal loss
and maternal mosaicism for long-QT syndrome. Circulation 109(24):3029-3034.
27. Webster KA, Bishopric NH (2003). Apoptosis inhibitors for heart disease. Circulation
108(24):2954-6.
28. Myerburg RJ and Bishopric NH (2003). Transplantation of stem cells to the heart: are there risks
counterbalancing anticipated benefits? J Cardiovasc Electrophysiol 14(8):849-50.
29. Kubasiak L, Hernandez L, Bishopric NH and Webster KA (2002). Hypoxia and acidosis activate
cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci USA 99:1282512930.
30. Bishopric NH and Webster KA (2002). Preventing apoptosis with thioredoxin: ASK me how. Circ
Res 90(12):1237-1239.
31. Graham R, Bishopric NH and Webster KA. (2002) Gene and cell-based therapy for heart disease.
IUBMB Life 54(2):59-66.
32. Bishopric NH. A Thousand Times NO. (2002) J Mol Cell Cardiol 34; 601-606.
33. Andreka P, Aiyar N, Olson LC, Wei JQ, Turner MS, Webster KA, Ohlstein EH, and Bishopric NH.
(2002) Bucindolol displays intrinsic sympathomimetic activity in human myocardium. Circulation
105:2429-2434.
34. Dougherty C, Kubasiak LA, Prentice H, Andreka P, Bishopric NH and Webster KA. (2002)
Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress.
Biochem J 362:561-571.
35. Bishopric NH (2002). Angiotensin signaling and apoptosis in the neonatal heart: necessary evils?
Pediatric Res 52(3):322-4.
36. Bishopric NH, Andreka P, Slepak T, and Webster KA (2001). Molecular mechanisms of apoptosis
in the cardiac myocyte. Curr Opinion in Pharmacology 2: 141-150.
37. Andreka P, Nadhazi Z, Muzes G, Bishopric NH (2001). Molecular regulation of myocardial
apoptosis. (Review in Hungarian) Orv Hetil 142:1717-1724.
38. Andreka P, Zang J, Dougherty C, Slepak T, Webster KA, and Bishopric NH (2001) Cytoprotection
by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ Res 88: 305-312.
39. Yamashita Y, Discher DJ, Hu J, Bishopric NH, and Webster KA (2001). Molecular regulation of
the endothelin-1 gene promoter by hypoxia: contributions of HIF-1, AP-1, GATA-2, and
CBP/p300. J Biol Chem 276:12645-12653.
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Nanette H. Bishopric, M.D.
Curriculum Vitae
40. Yamashita Y, Kajstura J, Discher DJ, Wasserlauf BJ, Bishopric NH, Anversa P and Webster KA
(2001). Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing IGF-1. Circ Res 88: 609-614.
41. Webster KA, Prentice H, Bishopric NH (2001). Oxidation of zinc finger transcription factors:
physiological consequences. Antioxid Redox Signal 3:535-548.
42. Slepak T, Webster KA, Prentice H, O’Dowd A, Hicks M and Bishopric NH (2001). Control of
cardiac-specific transcription by p300/CBP through myocyte enhancer factor-2D. J Biol Chem 276:
7575-7585.
43. Leri A, Fiordaliso F, Setoguchi M, Limana F, Bishopric NH, Kajstura J, Webster KA and Anversa
P (2000). Inhibition of p53 function prevents renin-angiotensin system activation and stretchmediated myocyte apoptosis. Am J Pathology 157:843-857.
44. Hernandez O, Discher DJ, Bishopric NH and Webster KA (2000). Rapid Activation of neutral
sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes Circ Res 86:198-204.
45. Webster KA, Discher DJ, Kaiser S, Hernandez O, Sato B and Bishopric NH (1999). Hypoxiaactivated apoptosis of cardiac myocytes requires a pH shift and is independent of p53. J Clinical
Invest 104: 239-252.
46. Discher DJ, Bishopric NH and Webster KA (1999). High Frequency Rearrangement of a Multiple
Copy Enhancer in Plasmid Vectors: Practical Considerations. Biotechniques 26:1026-1030.
47. Webster KA, Discher DJ, Kaiser S, Sato B, Zang J, Hernandez O and Bishopric NH (1999).
Induction of apoptosis by hypoxia requires reoxygenation or acidosis and is independent of p53. J
Clin Invest 104: 239-252.
48. Ing D, Zang J, Dzau V, Webster KA and Bishopric NH (1999). Modulation of cytokine-induced
cardiac myocyte apoptosis by nitric oxide, Bak and Bcl-x. Circ Res 84: 21-33.
49. Webster KA and Bishopric NH (1998). Adaptaciones de miocitos cardiacos prematuros a la
hipoxia, isquemia, y reoxígenación Revista Chilena de Cardiología Vol. 14.
50. Discher DJ, Bishopric NH, Wu XS, Petersen C and Webster KA (1998). Hypoxia regulates enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC
element. J Biol Chem 273: 26087-26093.
51. Gullestad L, Haywood G, Aass H, Ross H, Yee G, Geiran O, Kjekshus J, Simonsen S, Bishopric
NH and Fowler M (1998). Expression of angiotensin II receptor subtypes in heart transplant
recipients. Cardiovasc Res 38: 340-347.
52. Prentice H, Bishopric NH, Hicks MN, Discher DJ, Wu XS, Wylie AA and Webster KA (1997).
Regulated expression of a foreign gene targeted to the ischaemic myocardium. Cardiovasc Res
35(3): 567-574.
53. Webster KA, Discher DJ and Bishopric NH (1997). Models of Heart Disease: Early and late gene
responses to hypoxia, ischemia, and reoxygenation. Acta Andina 6:89-107.
54. Wu CF, Bishopric NH, and Pratt RE (1997). A sensitive nonradioactive method for the
determination of internucleosomal cleavage associated with apoptosis. Biotechniques 23(5): 839843.
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Nanette H. Bishopric, M.D.
Curriculum Vitae
55. Wu C-F, Bishopric NH and Pratt RE (1997). ANP induces apoptosis in rat cardiac myocytes. J Biol
Chem 272: 14860-14866.
56. Eschenhagen T, Remmers U, Scholz H, Wattchow J, Weil J, Zimmerman W, Schäfer H, Bishopric
NH, Wakatsuki T and Elson EL (1997). Three dimensional reconstitution of embryonic
cardiomyocytes in a collagen matrix: a new heart muscle model system. FASEB J 11:683-694.
57. Bishopric NH, Zeng GQ, Sato B and Webster KA (1997). Adenovirus E1A inhibits cardiac
myocyte-specific gene expression through its amino terminus. J Biol Chem 272: 20584-20594.
58. Ellison K, Bishopric N, Webster K, Morishita R, Gibbons GH, Kaneda Y, Sato B and Dzau V
(1996). Enhanced effectiveness of HVJ mediated gene transfer into cultured rat neonatal cardiac
myocytes. J Mol Cell Cardiol 28: 1385-1399.
59. Haywood GA, Tsao PS, von der Leyen HE, Mann MJ, Keeling PJ, Trindade PT, Lewis NP, Byrne
CD, Rickenbacker PR, Bishopric NH, Cooke JP, McKenna WJ and Fowler MB (1996). Expression
of inducible nitric oxide synthase in human heart failure. Circulation 93: 1087-1094.
60. Wu XS, Bishopric NH, Discher DJ, Murphy BJ and Webster KA (1996). Physical and functional
sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol 16(3): 1035-1046.
61. Webster KA, Bodí I, Wu X, Discher D, and Bishopric NH (1995). Regulation of the endothelin-1
gene by hypoxia is endothelial cell-specific and requires tyrosine kinase. Cardiovasc Res 30: 975984.
62. Webster KA, Discher D and Bishopric NH (1995). Cardioprotection in an in vitro model of
hypoxic preconditioning. J Mol Cell Cardiol 27: 453-458.
63. Webster KA, Discher DJ and Bishopric NH (1994). Regulation of Fos and Jun immediate-early
genes by redox or metabolic stress in cardiac myocytes. Circ Res 74: 679-686.
64. Webster KA, Discher DJ and Bishopric NH (1993). Induction and nuclear accumulation of Fos and
Jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem 268: 16852-16859.
65. Webster KA, Bodi I, Discher D, McNamara JP, Tracy M and Bishopric NH (1993). Negative
lusitropy and abnormal calcium handling in hypoxic cardiac myocytes exposed to the calcium
sensitizer EMD53998. J Mol Cell Cardiol 25: 747-751.
66. Bishopric NH, Jayasena V, and Webster KA (1992). Positive regulation of the skeletal -actin
gene by Fos and Jun. J Biol Chem 267: 25535-25540.
67. Bishopric NH, Sato B and Webster KA (1992). -adrenergic regulation of a myocardial actin gene
via a cyclic AMP-independent pathway. J Biol Chem 267: 20932-20936.
68. Webster KA and Bishopric NH (1992). Molecular regulation of cardiac myocyte adaptations to
chronic hypoxia. J Mol Cell Cardiol 24: 741-752.
69. Sartorelli V, Hong NA, Bishopric NH and Kedes LH (1992). Myocardial activation of the human
cardiac -actin promoter by helix-loop-helix proteins. Proc Natl Acad Sci 89: 4047-4051.
70. Bishopric NH and Kedes LH (1992). Adrenergic regulation of the skeletal -actin gene promoter
during myocardial cell hypertrophy. Proc Natl Acad Sci 88: 2132-2136.
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Nanette H. Bishopric, M.D.
Curriculum Vitae
71. Bishopric NH, Simpson PC and Ordahl CP (1987). Induction of the skeletal -actin gene in 1adrenoceptor mediated hypertrophy of rat cardiac myocytes. J Clin Invest 80: 1194-1199.
72. Starksen NF, Simpson PC, Bishopric NH, Coughlin SR, Lee WMF, Escobedo JA and Williams LT
(1986). Cardiac myocyte hypertrophy is associated with c-myc proto-oncogene expression. Proc
Natl Acad Sci 83: 8348-8350.
73. Bishopric NH, Cohen HJ and Lefkowitz RJ (1980). -adrenergic receptors in lymphocyte
subpopulations. J Allergy Clin Immunol 65: 29-33.
74. Newman, KD, Williams LT, Bishopric NH and Lefkowitz RJ (1978). Identification of the platelet
1-adrenergic receptor by direct binding of (3H)-dihydroergocryptine. J Clin Invest 61: 395-402.
19.
Other works, publications and abstracts:
Abstracts (selected).
1. Rodrigues CO, Shehadeh LA, Calero K, Bishopric NH (2007). Transcriptional variability in
cardiac stem cell clones. 4th Annual Symposium of the American Heart Association Council on
Basic Cardiovascular Sciences, July 30 - August 2, 2007, Keystone Conference Center, Keystone,
Colorado.
2. Ali MAM, Sung MM, Tran T, Crawford B, Rosenfelt CS, Sawicki G, Bishopric NH, Schulz R
(2007). Inhibitors of matrix metalloproteinases prevent H2O2-mediated cardiac myocyte membrane
permeabilization and death. Western Pharmacological Society, Banff, Alberta, Canada, March
2007.
3. Wei JQ, Llanos A, Rodrigues C, Steen D, Webster KA and Bishopric NH (2006). Cardioprotection
by p300 during myocardial ischemia-reperfusion and infarction in vivo. Circulation 114 (18): II-98.
4. Thompson JW, Graham RM, Bishopric NH and Webster KA (2006). Programmed death by
hypoxia-acidosis involves BNip3- and ERK-dependent activation of histone acetyltransferase
(HAT) and genomic reprogramming. Circulation 114 (18): II-296.
5. Wierenga KJ, Miller TE, Bishopric NH, Benke PJ (2006). A novel splice site mutation associated
with Barth syndrome. Presented at American College of Medical Genetics 2006 Annual Meeting.
Online at http://submissions.miracd.com/ACMG/ContentInfo.aspx?conID=245
6. Webster KA, Spiga M-G, Wilson AA, Bishopric NH, Eton D, Jia Y, Cesar L, Haliko S, Yu H,
Lieber BB, Laymen H, Andreopoulos FM, Wei J, Yeasky T. Combination cell and gene therapy for
peripheral ischemia using myoblasts and stem cells engineered with conditionally sliced genes.
Miami-Nature Biotechnology Winter Symposia on Angiogenesis in Cancer and Vascular Disease,
Feb. 4-8, 2006. Nature Biotechnology Short Reports, Vol 17.
7. Tran T, Andreka P Webster KA and Bishopric NH (2005). Cytoprotection by Jun kinase is
mediated through direct inhibition of the apoptosome. American Heart Association National
Meeting, November 2005; Circulation,
8. Thompson JW, Graham RM, Bishopric NH and Webster KA (2005). BNip3 promotes nuclear
translocation of mitochondrial and lysosomal DNAses: protection from genomic fragmentation by a
HH-4 peptide or calpain inhibitors. Circulation 112 (17): II-285.
9
Nanette H. Bishopric, M.D.
Curriculum Vitae
9. Baumbach L, Miller T, Cocilova S, Travers H, Elliott S, Mont E, Myerburg R, Bishopric N (2005).
Genetic Complexities of Molecular Diagnosis for Ventricular Arrhythmias. American Society of
Human Genetics 55th Annual Meeting Abstracts (Salt Lake City, Utah), October 25-29, 2005, in
press.
10. Shehadeh L, Wei JQ, Liebovitch L, Jirsa V, Fallahi M, Tsinoremas N, Prentice H, Bishopric N.
Transcription Factor Networks in Cardiac Hypertrophy. BioFlorida Annual Conference, “Building
the Vision,” Delray Beach, FL presented October 24-25, 2005.
11. Miller TE, You L, Benke PJ, Bishopric N (2005). Rapid Screening of Complex Genetic Disorders
Associated with Heart Disease Using Direct Whole Blood RT-PCR. J Am Coll Cardiol 45(3) Suppl
A: 323A, #1142-245. (ACC 3/8/2005)
12. Wei JQ, Mitrani J, Llanos A, Webster KA, Bishopric (2005). Role of the Chromatin Remodelling
Enzyme p300 In Heart Failure Progression and Survival. J Am Coll Cardiol 45(3) Suppl A: 174A,
#1160-147. (ACC 3/8/2005)
13. TE Miller, TV Pham, MJ Smets, L You, A Bassett, P Kurlansky, LL Baumbach-Reardon, RJ
Myerburg, NH Bishopric (2004). Novel Mutations (S338F and F339S) in Cardiac KvLQT1 S6
Domain Hinder KvLQT1 – KCNE1 Co-Assembly. Circulation 110(17): III-16 #67. (AHA
11/2004)
14. Webster KA, Gounis MJ, Spiga M.-G., Graham RM, Haliko S, Wilson A, Lieber BB, Bishopric
NH and Wakhloo NH (2004). Optimized therapeutic angiogenesis for peripheral ischemia using
stem cells transduced with an ischemia-regulated conditionally silenced AAV. Late-Breaking
Developments in Stem Cell Biology and Cardiac Growth Regulation, America Heart Association
National Meeting, New Orleans, LA 11/8/04.
15. Li HF, Bishopric NH, Webster KA (2004). C-Jun N-terminal Kinase (JNK) promotes apoptosis at
reperfusion under energy-limiting conditions by phosphorylating IRS-1 and blocking insulin
signaling to Akt/PKB. Circulation 110(17): III-58 #268. (AHA 11/2004)
16. L Baumbach, T Miller, H Travers, L You, ME Ahearn, W Lanier, E Estrella, S Elliott, R Myerburg,
N Bishopric (2004. Complexities of molecular diagnosis for ventricular arrhythmias. American
Society of Human Genetics 54th Annual Meeting Abstracts (Toronto, Canada), October 26-30, 2004,
p. 390, #2141.
17. Wei JQ, Slepak T, Pessanha M, Faysal J, Andreka P, Webster KA and Bishopric NH. (2003)
Transcription coactivator p300 is a critical regulator of cardiac hypertrophy. Miami Nature
Biotechnology Short Reports, 14:51.
18. Miller T, Estrella E, You LJ, Lanier W, Young ML, Baumbach L, Myerburg RJ, Bishopric NH
(2003). Compound heterozygous mutation of both alpha and beta subunits of IKs is associated with
Romano-Ward Syndrome. Circulation 108: IV-182.
19. Miller T, Estrella E, You LJ, Lanier W, Young ML, Baumbach L, Myerburg RJ, Bishopric NH
(2003). Compound heterozygous mutation of both alpha and beta subunits of IKs is associated with
Romano-Ward Syndrome. American J for Human Genetics (Suppl) 73(5): 552, #2251 (ASHG
11/03).
20. Wei JQ, Slepak T, Pessanha M, Webster KA, Bishopric NH (2003). Adenovirus target protein
p300 mediates cardiac hypertrophy and heart failure. Nature Biotechnology Short Reports 14: 22.
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Nanette H. Bishopric, M.D.
Curriculum Vitae
21. Tran TH, Andreka P, Dougherty C, Webster KA and Bishopric NH. (2003) C-Jun N-terminal
kinase protects cardiomyocytes against stress-induced apoptosis by direct interaction with APAF-1.
Miami Nature Biotechnology Short Reports 14:64.
22. Miller T, Moreno N, Estrella E, Ahearn ME, Garcia J, Rusconi P, Wolff G, Kurlansky P, Myerburg
R, Baumbach L, and Bishopric NH (2002). Recurrent pregnancies associated with fetal sudden
death in a mother mosaic for an SCN5A mutation. Circulation 106, II-700. (Oral presentation at
the 75th Annual Scientific Sessions meeting of the American Heart Association, Chicago IL,
11/2002)
23. Dougherty C, Graham RM, Prentice H, Bishopric NH, Webster KA (2002). C-Jun N-terminal
kinase functions as a bioenergetic sensor that determines cardiac myocyte fate during hypoxiareoxygenation. Circulation 106 (19) (Suppl II):II-130.
24. Wei JQ, Pessanha M, Faysal J, Webster KA, Bishopric NH (2002). Adenovirus target protein p300
mediates cardiomyopathy and heart failure. Circulation 106: II-231-232.
25. II-231-232.Turner MS, Haywood GA, Dougherty C, Andreka P, Evans WH, Webster KA,
Bishopric NH. Regulation of connexin 43 phosphorylation by ATP during hypoxia/reoxygenation
and metabolic inhibition in cardiac myocytes. Circulation 106: II-313
26. Miller T, Moreno N, Estrella E, Ahearn ME, Rusconi P, Wolff G, Kurlansky P, Myerburg R,
Baumbach L and Bishopric NH (2002). Repeated pregnancies associated with late term fetal loss
and sudden death in a mother mosaic for a SCN5A mutation. Platform Presentation, 52nd Annual
Meeting of the American Society of Human Genetics, Baltimore, MD.
27. Baumbach L, Miller T, Estrella E, Ahearn ME, Kurlansky P, Myerburg R and Bishopric NH (2002).
A cardiac ion channel (KVLQT1) mutation predisposes to drug-induced arrhythmia: direct evidence
of genetic susceptibility to an acquired disorder. Platform presentation, American Society of
Medical Genetics Annual Meeting, San Diego, CA.
28. Baumbach L, Miller T, Estrella E, Ahearn ME, Kurlansky P, Myerburg R, Bishopric NH (2002). A
cardiac ion channel (KVLQT1) mutation predisposes to drug-induced arrhythmia: direct evidence
of genetic susceptibility to an acquired disorder. Asia Pacific Scientific Forum: The Genomic
Revolution: Bench to Bedside to Community and the 42nd Annual Conference on Cardiovascular
Disease Epidemiology and Prevention. Abs #100523 (Platform presentation).
29. Baumbach L, Basterrechea H, Estrella E, Myerburg R, Wolff G, Bishopric NH (2001). Am J
Human Genetics (Suppl) 69:544, # 2126.
30. Turner MS, Discher DJ, Webster KA, Bishopric NH (2001). Different regulation of Connexin 43
in cardiac myocytes by hypoxia and ischemia. Circulation 104: Supp 17:206.
31. Dougherty CJ, Kubasiak LA, Discher DJ, Prentice H, Bishopric NH, Webster KA (2001). Coupled
electron flow through mitochondrial complex II initiates a survival pathway through c-Jun NTerminal kinase in reoxygenated cardiac myocytes. Circulation 104: Supp 17:445.
32. Andreka P, Dougherty CJ, Slepak TI, Webster KA, Bishopric NH (2001). The apoptosome is a
target of Jun kinase in nitric oxide-induced cardiac myocyte apoptosis. Circulation 104: Supp 17:
681.
33. Kubasiak LA, Discher DJ, Bishopric NH and Webster KA (2001). Hypoxia-acidosis activated
apoptosis of cardiac myocytes is mediated by MPTP opening and BNIP3 activation. Circulation
Suppl 104: 17: 976.
11
Nanette H. Bishopric, M.D.
Curriculum Vitae
34. Bishopric NH, Basterrechea H, Myerburg RJ and Baumbach L (2001). Genotype-phenotype
correlations in long QT syndrome. Presented at the Annual Clinical Genetics Meeting, Miami, FL,
March 2, 2001.
35. Turner MS, Haywood GA, Evans WH, Webster KA and Bishopric NH (2001). Hypoxia regulates
connexin 43 content in synchronously contracting cardiac myocytes. J Am Coll Cardiol 37 (2
Suppl A): 308.
36. Dougherty C, Prentice H, Hernandez H, Andreka P, Bishopric NH and Webster KA (2000).
Activation of c-Jun N-terminal kinase through the Rac1/cdc42-TAK-1 pathway promotes survival
of reoxygenated cardiomyocytes. Hypertension J 3.
37. Andreka P, Zang J, Dougherty C, Slepak T, Webster KA, Bishopric NH (2000). The role of nitric
oxide-induced myocardial apoptosis in the development of heart failure. Circulation 102(18): II-9.
38. Slepak TI, Webster KA, Xang J, Prentice H, Hicks MN and Bishopric NH (2000). Molecular basis
of the cardiac-specific effect of p300 are mediated exclusively by MEF-2D and are independent of
GATA-4. Circulation 102(18): II-219.
39. Discher DJ, Wasserlauf B, Bishopric NH and Webster KA (2000). Conditional silencing as a
means to suppress basal expression and augment the ‘therapeutic differential’ of gene therapy
vectors targeted to ischemic tissues. Circulation 102(18): II-145.
40. Yamashita K, Discher DJ, Kajstura J, Anversa P, Bishopric NH and Webster KA (2000). IGF-1
over-expressing transgenic mice are resistant to ischemia-reperfusion-induced apoptosis through
enhanced activation of the PI-3 kinase-Akt pathway. Circulation 102(18): II-214.
41. Kubasiak L, Discher DJ, Bishopric NH, and Webster KA (2000). Over-expression of hypoxiaregulated DT-diaphorase (NADH-quinone reductase) gene protects cardiac myocytes from hypoxiareoxygenation induced apoptosis. Circulation 102(18): II-84.
42. Kubasiak L, Hernandez OM, Discher DJ, Bishopric NH, and Webster KA (2000). Role of
mitochondrial complexes II and III and the permeability transition pore respectively in hypoxiareoxygenation and hypoxia-acidosis cell death pathways of cardiac myocytes. Circulation 102(18):
II-9.
43. Dougherty C, Prentice H, Andreka P, Bishopric NH, and Webster KA (2000). Activation of c-Jun
N-terminal Kinase through the Rac1/cdc42-TAK-1 pathway promotes survival of reoxygenated
cardiac myocytes. Circulation 102(18): II-168.
44. Zang J, Slepak, T, Webster KA, and Bishopric, NH (1999). Role of mitogen activated protein
kinases ERK1/2 and JNK 1/2 in nitric oxide-induced cardiac myocyte apoptosis. Circulation 99
Suppl.
45. Yamashita K, Discher D, Bishopric NH, and Webster KA (1999). Induction of endothelin-1 by
hypoxia is mediated by cooperative physical interactions between HIF-1, AP-1, GATA-2, and
CAAT binding factors. Circulation 99 Suppl.
46. Webster KA, Discher DJ, Hernandez OH, Yamashita K, Dougherty C, and Bishopric NH (2000).
Hypoxia, Gene Expression, and Gene Therapy. J Comp Biochem Physiol (Suppl)
47. Webster KA, Discher DJ, Hernandez OH, Yamashita K, Dougherty C, and Bishopric NH (1999).
Hypoxia and Reoxygenation-Mediated Signaling Pathways to Apoptosis. In: Genomics of Oxygen
Sensing, Plenum Press.
12
Nanette H. Bishopric, M.D.
Curriculum Vitae
48. Leri A, Fiordaliso F, Manabu S., Discher D., Bishopric NH, Webster KA, and Anversa P (1999).
Inhibition of p53 function prevents stretch-mediated activation of the myocyte renin-angiotensin
system and apoptosis. Circulation 99 Suppl.
49. Hernandez O, Discher D, Bishopric NH, and Webster KA (1999). Activation of Neutral
Sphingomyelinase ceramide, and JNK precede apoptosis in hypoxia-reoxygenated cardiac
myocytes. Circulation 99 Suppl.
50. Hernandez O, Discher DJ, Bishopric NH, and Webster KA (1999). Activation of neutral
sphingomyelinase and JNK precede apoptosis following reoxygenation of cardiac myocytes. Miami
Nature Biology Short Reports 10:38-38.
51. Dougherty C, Discher D, Bishopric NH, and Webster, KA (1999). C-Jun N-Terminal kinase
protects cardiac myocytes from reoxygenation-mediated apoptosis. Circulation 99 Suppl.
52. Bishopric NH, Slepak TI, Zang J, and Webster KA (1999). Transcriptional integrator p300 and
MEF-2D activate cardiac-specific transcription of the human skeletal actin promoter. Scientific
Conference on Molecular Cellular and Integrated Approaches to the Failing Heart, Salt Lake City
UT.
53. Anderson KM, Nerurkar S, Zang J, Webster KA and Bishopric NH (1999). Induction and decline
of p300/CBP availability during cardiac hypertrophy and failure in the SHHR rat. Scientific Conf.
on Molecular Cellular and Integrated Approaches to the Failing Heart, Salt Lake City, UT.
54. Slepak T, Webster KA, Zang J, and Bishopric NH (1999). Cardiac regulation of the human skeletal
actin promoter by GATA-4 and MEF-2 involves competition for p300 at a distal tissue-specific
element. Scientific Conference on Molecular Cellular and Integrated Approaches to the Failing
Heart, Salt Lake City, UT.
55. Zang J, Ing D, Dzau VJ, Webster KA, and Bishopric NH (1998). Nitric oxide activations of
cardiomyocyte apoptosis, MAPK/ERK and Jun kinases exhibit differential dose-dependence and
cGMP sensitivity. Circulation 98 (17): I-742.
56. Hu J, Discher DJ, Hernandez O, Bishopric NH, and Webster KA (1998). Hypoxia-Inducible
Factor-1 and GATA-2 are both required for the positive endothelial cell-specific activation of the
endothelin-1 gene by hypoxia. Circulation 98: I-331.
57. Daviet L, Lehtonen JYA, Hayashida W, Grandchamp J, Bishopric NH, Horiuchi M, and Dzau VJ
(1998). Antagonistic actions of angiotensin II type 1 vs. type 2 receptors on rat cardiomyocyte
apoptosis. Circulation 96(17): I-741.
58. Discher D, Sato B, Kaiser S, Hernandez O, Murphy BJ, Bishopric NH, and Webster KA (1998).
Differential regulation of antioxidant gene expression in hypoxic cardiac myocytes. Circulation 98
(17): I-124.
59. Bishopric NH, Kaiser S, Discher D, Hernandez O, Zang J, Sato B, and Webster KA (1998). p53Independent induction of apoptosis by hypoxia-reoxygenation of isolated cardiac myocytes.
Circulation 98(17): I-743.
60. Ing D, Zang J, Webster KA, Dzau V, Bishopric NH (1998). Interleukin -1β induces cardiac
myocyte apoptosis through a cyclic GMP-dependent pathway. Circulation 98(17)
61. Webster KA, Discher DJ, and Bishopric NH (1998). Hypoxia activates the transcription of Sp1dependent genes by downregulating Sp3-mediated competitive repression. Presented at Keystone
Symposium on Molecular Biology of the Cardiovascular System, Steamboat Springs CO, 1998
13
Nanette H. Bishopric, M.D.
Curriculum Vitae
62. Bishopric NH, Kaiser S, Zang J, Discher D, Sato B, and Webster KA (1998). p53 is dispensable
for redox-stress-induced cardiac myocyte apoptosis. Presented at Keystone Symposium on
Molecular Biology of the Cardiovascular System, Steamboat Springs CO.
63. Bishopric NH, Discher DJ, and Webster KA (1997). Activation of SAPK/JNK in cardiac myocytes
treated with a calcium sensitizing agent, EMD53998. Circulation 96: I-361.
64. Bishopric NH, Zang J, Zeng GQ, Webster KA (1997). p300 transactivates the human skeletal actin
promoter in cardiac myocytes via a distal promoter region. Circulation 96: I-674.
65. Wu XS, Fowler MB, Gullestad L, Webster KA, Bishopric NH (1997). Induction of c-jun
expression in human dilated cardiomyopathy. Circulation 96.
66. Wu XS, Discher DJ, Bishopric NH, and Webster KA (1996). Developmental regulation of redoxsensitive Sp1 isoforms in the heart. Circulation 94: I-483.
67. Wu C-F, Pratt RE, and Bishopric NH (1996). Cyclic AMP and cyclic GMP exert opposing effects
on cardiac myocyte apoptosis. Circulation 94: I-282.
68. Wu C-F, Bishopric NH, and Pratt RE (1996). Atrial natriuretic peptide induces apoptosis in
neonatal rat cardiac myocytes. J Am Coll Cardiol 27: 384A.
69. Zeng GQ, Webster KA, Sato B, Bishopric NH (1996). E1A induces both p53-dependent and independent apoptosis in cardiac myocytes. Circulation 94: I-158.
70. Gullestad L, Haywood G, Aass H, Ross H, Yee G, Geiran O, Kjekshus J, Simonsen S, Fowler M,
and Bishopric NH (1996). Expression of angiotensin II receptor subtypes in heart transplant
recipients. Presented at European Society of Cardiology, Birmingham, U.K. August 1996.
71. McDonald P, Hicks MN, Webster KA, Wylie A, Cobbe SM, Bishopric NH, and Prentice H (1995).
Regulation of foreign gene expression in models of myocardial gene therapy. Presented at the
Cellular Engineering Conference, San Diego, CA, August 1995.
72. McDonald P, Hicks MN, Webster KA, Wylie A, Cobbe SM, Bishopric NH, and Prentice H (1995).
Induced activity of the skeletal α-actin promoter in ischemic/reperfused myocardium. J Mol Cell
Cardiol 27:A255.
73. Webster KA, Bódi I, Sato B, Discher DJ, and Bishopric NH (1995). Induction of stress response
and hypertrophy-related genes by the positive inotropic, calcium-sensitizing agent EMD53998.
Circulation 92(8):I-43.
20.
Other works accepted for publication:
Patent application #08/880, 342, continuation.
PROFESSIONAL
21.
Funded Research Performed (as P.I. unless otherwise noted)
A.
Extramural support (prior years)
1988-1992
Research Associate of the Veterans Administration
14
Nanette H. Bishopric, M.D.
Curriculum Vitae
1988-1991 and
1991-1994
Veterans Administration Merit Review Award
1990-1993 and
1993-1996
American Heart Association (Calif. Affil.) Grants-in-Aid
1990-1993 and
1993-1996
University of California Tobacco-Related Diseases Research
Program Grant Co-P.I
1993-1999
Grant R-01-HL37475, “Beta-Adrenergic regulation of a myocardial
actin gene” Direct $780,000/5 years, 40% effort.
2000-2001
GlaxoSmithKline research fund, $37,000 total direct costs
1998-2002
American Heart Association Established Investigator Award
$272,727 total direct costs
2001-2003
American Heart Association Grant-In-Aid (Florida-PR Affiliate)
$100,000 total costs
15
Nanette H. Bishopric, M.D.
Curriculum Vitae
B. Current, Pending and Recent Extramural Support
Grant Title
Grant # R-01HL71094,“Transcription
programming in cardiac growth”
Trans-Atlantic Network of Excellence
Grant, “Adaptation and Maladaptation
in Cardiac Hypertrophy, Failure and
Regeneration”
Trans-Atlantic Network of Excellence
Grant, “Preventing Sudden Cardiac
Death”
R. Myerburg, M.D.
NRSA Postdoctoral Fellowship
“Transcription Factor Networks in
Cardiac Hypertrophy”
Lina Shehadeh, Ph.D.
Grant # R-01-HL44578, "Pathways of
apoptosis in hypoxic cardiac
myocytes"
Keith A. Webster, Ph.D.
Team Sciences Award
Keith A. Webster, Ph.D.
Scientist Development Grant,
“Mechanisms of cardiac stem cell
survival”
C. Rodrigues, Ph.D.
NRSA Predoctoral Fellowship
“Body Burden of PAHs and
Cardiovascular Disease in the United
States”
John D. Clark, III
NIH R-01 “Epigenetics of Aging and
Cell Renewal”
Recently Completed:
Genotype-Phenotype Correlations in
Long QT Syndrome (renewed)
Grant #R-01-HL69812-01,
“Regulated therapeutic angiogenesis
to treat ischemic disease”
Cardiovascular Genetics Center
Grant;
"Sudden Death and Cardiomyopathy”
(renewed 2x)
Project
Role
P.I.
(40%)
Amount
(direct)
Year 1
250,000
(total)
1,000,000
Core
Member
(30%)
Year 2
138,000
(total)
720,000
Year 2
140,000
(total)
1,000,000
Year 2
60,000
Affiliate
Member
(6%)
Sponsor
Co-I.
(5%)
Co-I
(5%)
Sponsor
Year 5
171,158
(total)
951,232
Year 1
(yr 1)
65,000
(total)
$260,000
Co-sponsor Year 1
$34,032
Period
Funding Agency
07/01/03NIH/NHLBI
06/30/08
percentile
20.7,
resubmitted
7/1/07
10/1/05Leducq Foundation,
9/30/10
Paris, France
10/1/059/30/10
Leducq Foundation,
Paris, France
12/1/0511/1/08
N.I.H.
09/01/9608/30/08
N.I.H./N.H.L.B.I.
7/01/076/30/09
06/01/0705/31/11
Florida Biomedical
Research Council
American Heart
Association (National)
06/01/0705/31/10
N.I.H./N.H.L.B.I.
P.I.
(40%)
(yr 1)
250,000
(direct)
1,250,000
In
preparation
for October
2007
N.I.H./N.H.L.B.I./N.I.
A.
Co-I.
(10%)
(yr 4) 55,000
(total)
110,000
(yr. 3)
$250,000
annually
(yr 1)
136,000
(total)
2,064,528
7/1/0112/30/05
American Heart
Association (FL-PR
affil.)
N.I.H./N.H.L.B.I.
Co-I.
(5%)
P.I.
16
04/01/0303/31/07
4/01/993/31/07
Florida Heart
Research
Institute, Miami, FL
Nanette H. Bishopric, M.D.
22.
Curriculum Vitae
Editorial Responsibilities:
Editorial Board, Circulation Research (2000-present)
Editorial Board, Circulation (2003, 2005-present)
Editorial Board, Journal of the American College of Cardiology (2005-present)
Editorial Board, Journal of Molecular and Cellular Cardiology (2001-present)
Reviewer for:
American Journal of Physiology
Basic Research in Cardiology
Biochemistry
Biochemical Pharmacology
Cardiovascular Research
Circulation Research
Circulation
Comparative Physiology and Biophysics
Journal of Applied Physiology
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of the American College of Cardiology
Journal of Molecular and Cellular Cardiology
Molecular and Cellular Biology
Pediatric Research
Physica A
23.
Professional and Honorary Organizations (current)
Founding Fellow, American Heart Association, 2001
American Heart Association Councils for Basic Science and Clinical Cardiology
Fellow, American College of Cardiology
American Federation for Clinical Research
American Association for the Advancement of Science
International Academy of Cardiovascular Science – American Section, Council Member
European Society of Cardiology
24.
25.
Honors and Awards:
1969
National Merit Scholarship Finalist
1973
Phi Beta Kappa
1985
Merck/American College of Cardiology Fellowship Award
American Heart Association Postdoctoral Fellowship
National Institutes of Health NRSA (#HL07475)
1987
American Heart Association Post-doctoral Fellowship
1993
SRI International Technical Excellence Award
1999
First Prize, UM/Sylvester Cancer Center Research Competition
2005
Researcher of the Year, Florida Chapter, American College of Cardiology
Post-Doctoral Fellowships
17
Nanette H. Bishopric, M.D.
Curriculum Vitae
1978-1979
Research assistant in the laboratory of Dr. Robert J. Lefkowitz, Duke University, Durham,
North Carolina. Research topics: - and -adrenoceptor identification by radioligand
binding to platelets and lymphocytes and correlation with adenyl cyclase activity;
histamine receptor analysis by radiolabelled antagonist binding; production and analysis of
a putative anti-ß-adrenoceptor antibody.
1985-1988
Postdoctoral fellow in the laboratory of Dr. Charles P. Ordahl, University of California,
San Francisco. Research interests: Molecular biology of cardiac muscle gene expression,
regulation of gene expression by norepinephrine.
1988-1989
Visiting Scientist in the laboratory of Dr. Laurence H. Kedes, Stanford University, Palo
Alto, California. Research interests: Expression of human skeletal actin and rat myosin
heavy chain genes in transfected cardiac myocytes; regulation of bioenergetic genes by
oxygen availability in cardiomyocytes; effects of E1A and MyoD1 proteins on cardiac
myocyte gene expression.
26.
Other Professional Activities
2007
Member, American Heart Association (National) Peer Review Group, Basic
Sciences
2007
Member, American Heart Association National Committee on Women and
Minorities (nominated)
2006
Session moderator, AHA Annual Scientific Sessions, “Molecular Biology of
Cardiac Development,” Chicago, IL, McCormick Place, Nov. 14, 2006
2006
Chair of session: “Interventional Cardiology: cell and gene therapy,” 8th
International Dead Sea Symposium & 17th Rappaport Symposium Joint
Mtg., Tel Aviv, Israel, Hilton Convention Center, October 17, 2006.
2006
Representative of ACC to Johns Hopkins University Genetics and Public
Policy Center meeting on development of practice guidelines for genetic
testing, Bethesda, MD, February 1, Hyatt Regency Bethesda.
2005-2008
Regular Member, NIH CSR, Myocardial Ischemia and Metabolism Study
Section
2004-2006
Member and Vice Chair, Research Committee, American Heart Association
Florida-Puerto Rico Affiliate
2004-2005
Ad Hoc Member, NIH Center for Scientific Review. Cardiovascular
Sciences IRG, SRA, Myocardial Ischemia and Metabolism Study Section,
July and September 2004; February 2005.
2002-2005
Member, the Katz Young Investigator Prize Selection Committee, AHA
Council on Basic Cardiovascular Sciences
2004
26th Annual Meeting of the ISHR (International Society for Heart Research):
Bench to Bedside and Back: Exploring New Paradigms - A Multinational
Perspective of Cardiovascular Research in North America, Cancun, Mexico,
May 2-5, 2004
18
Nanette H. Bishopric, M.D.
Curriculum Vitae
2003
Symposium Moderator, “Regulating Myocardial Growth: Survival and
Function”. Heart Failure Society of America, Las Vegas, NV. September 22,
2003
2003
Peer Review Committee Member, American Heart Association (National)
2002
Invited Session Moderator, “Transcriptional Regulation in Cardiac
Hypertrophy,” American Heart Association Scientific Sessions, November
18, 2002 Chicago, IL
2001-2002
Faculty Member and Abstract Judge, AstraZeneca Cardiovascular Young
Investigator’s Forum
1999-2002
Member, American Heart Association Southeastern-Ohio Affiliate Peer
Review Committee
1996-present Session Moderator (various), American Heart Association National Meetings
1998-Present Member, University of Miami Medical Group
2001
Platform Speaker, Heart Failure Society of America, Washington DC,
September 9-12
2001
Session Moderator, “Oxidant Signaling in Cardiac Pathophysiology”,
American Heart Association National Meeting, Anaheim, CA
2001
Chairman, AHA Student Scholars Program Review Committee
1999-2001
Member, American College of Cardiology Career Development Awards
Program (National) Review Committee- Student Scholars in Cardiovascular
Disease and Stroke
1998-2000
Abstract Grader, American Heart Association Annual Scientific Session
Program Committee
Member, American Heart Association (National) Peer Review Committee
1997
Session Moderator, American College of Cardiology National Meeting
1997-2000
Invited Lecturer, Dept. of Molecular Physiology, Stanford University
1996-1998
Member, NIH Program Project Review Committee
1995-1998
Member, Research Program Review Committee, Dept. of Veterans Affairs
Invited Lectures (since 1997):
19
Nanette H. Bishopric, M.D.
Curriculum Vitae
“Molecular correlates of the growth/death decision in cardiac myocytes”. Presented at the 2nd
International Workshop on Cardiac Cells in Culture: Molecular Mechanisms of Hypertrophy,
Monte Veritá, Ascona, Switzerland, March 5, 1997
“Myocardial stress”. Presented at Eidgenossen Technische Hochschule- Zurich, Switzerland
August 13, 1997
“Molecular insights on cardiac remodelling”. Presented at Workshop on Cardiovascular Genetics,
SmithKline Beecham Pharmaceuticals, November 17, 1997
“Modulation of apoptosis by survival factors in the cardiac myocyte”. Presented at the Third
Annual International Conference on Heart Failure, sponsored by International Business
Communications, Philadelphia, PA. December 10, 1997
“Programmed cell death in cardiovascular disease”. Presented at Medical Grand Rounds,
Department of Medicine, University of Miami, December 17, 1997
“Role of nitric oxide in the modulation of cardiac myocyte apoptosis.” Presented at Eli Lilly
Pharmaceuticals, January 28, 1998
“Modulation of apoptosis by cardiac growth factors.” Presented at Conference on Vascular and
Myocardial Aspects of Ischemic Heart Disease, sponsored by American Heart Association,
Incline Village, Nevada, February 23, 1998
“Hypertrophic cardiomyopathy. Clinical and molecular aspects.” Presented at Department of
Molecular and Cellular Physiology, Stanford University School of Medicine, February 27,
1998
“The role of apoptosis in the cardiovascular system.” Presented at The Maryland Club, Baltimore,
MD, April 15, 1998
“Aging, apoptosis and the heart.” Keynote address, CardioPulmonary Seminar 1998, Sarasota
Memorial Hospital, Sarasota FL, July 17, 1998
“Adenovirus E1A and the cardiac myocyte phenotype.” International Society for Heart Failure
Research, Ann Arbor MI, August 10, 1998
Chair of session, “Subcellular Abnormalities in Heart Failure,” Second Annual Meeting of the
Heart Failure Society of America, Boca Raton FL, September 16, 1998
"Regulation of apoptosis by hypoxia and reoxygenation." Presented at the Second International
Meeting on Pathophysiology of Stunning, Hibernation and Preconditioning, sponsored by
European Society of Cardiology, Taormina, Sicily, Italy, October 16, 1998
"Gene regulation of the cardiac myocytes." Symposium on New Frontiers in Heart Failure
Research, NYU School of Medicine, Key Biscayne FL, October 31, 1998
20
Nanette H. Bishopric, M.D.
Curriculum Vitae
“Hypertrophic cardiomyopathy. Clinical and molecular aspects.” Presented at Department of
Molecular and Cellular Physiology, Stanford University School of Medicine, February 22,
1999
“NO, free radicals and cardiac myocyte apoptosis.” Presented at Mini Symposium on Metabolic
Regulation of Cardiac Gene Expression, University of Texas at Houston, March 5, 1999
“Signal transduction in ischemic cell death.” Presented at the Scientific Conference on Molecular,
Cellular and Integrated Physiological Approaches to the Failing Heart, Salt Lake City, UT,
August 21, 1999
“Redox stress and Apoptosis." American Heart Association Scientific Conference on Molecular,
Cellular, and Integrated Physiological Approaches to the Failing Heart. Salt Lake City, Utah.
August 1999
“Nitric Oxide and Cardiac Signal Transduction.” Texas A & M University, Department of
Physiology. September 1999
“Molecular and Clinical Aspects of Hypertrophic Cardiomyopathy." Stanford University,
Department of Molecular and Cellular Physiology. February 2000
“p300 and Cardiac Transcriptional Control." Albert Einstein College of Medicine, Division of
Cardiology, March 2000
“Cardiac Remodelling at the Molecular Level.” Heart Failure Summit, 2000. Invited Speaker.
University of Toronto, Canada, June 7, 2000
“Redox stress and mechanisms of myocardial apoptosis." International Society for Heart Research,
22nd Meeting, Louisville, Kentucky, July 2000
“Apoptosis and Redox Stress,” Sylvester Comprehensive Cancer Center, Tumor Biology Seminar
Series, October 2000
“Mechanisms of Angiogenesis.” Surgical Oncology Seminar Series, University of Miami, February
8, 2001
Expert Panelist, C.A.R.E. Foundation Symposium, Ft. Lauderdale, FL. “Everything you always
wanted to know about Long QT…but didn’t know whom to ask,” March 16, 2001
“Hypertrophic Cardiomyopathy and Familial Sudden Death.” C.A.R.E. Foundation Symposium,
Ft. Myers, Florida, March 17, 2001
“Molecular Mechanisms of Cardiac Growth and Death," University of Miami Dept. of Molecular
and Cellular Pharmacology Seminar Series, April 19, 2001
“Nitric Oxide and Myocyte Cell Fate.” American Heart Association Research Symposium, Dallas,
Texas, May 5, 2001
21
Nanette H. Bishopric, M.D.
Curriculum Vitae
“Redox Stress and Heart Failure: Role of stress-activated protein kinases.” Heart Failure Society of
America National Meeting, Washington DC, September 2001
“Role of HIF-1 in Ischemia.” Platform speaker, American Heart Association Scientific Sessions
2001, Anaheim, California, November 11-14, 2001
“Transcription factor-opathy: a genetic model for the transition from hypertrophy to heart failure,”
Florida Atlantic University, January 2002
"Nitric Oxide-Mediated Cardiac Myocyte Apoptosis," Symposium on Advances in Cardiovascular
Research – Clinical & Basic Sciences and Workshop – Genome Based Resources for
Identification of Cardiovascular Genes, University of the West Indies, St. Augustine, Trinidad,
March 5, 2002
"Viral Oncogenes and Dilated Cardiomyopathy," Symposium on Advances in Cardiovascular
Research – Clinical & Basic Sciences and Workshop – Genome Based Resources for
Identification of Cardiovascular Genes, University of the West Indies, St. Augustine, Trinidad,
March 6, 2002
"Genetics and Genetic Models of Dilated Cardiomyopathy," University of Miami School of
Medicine, Department of Medicine Medical Grand Rounds, March 13, 2002
“The Genetic Diagnosis of Sudden Death Risk,” BioFlorida, Miami, Florida, June 5, 2002
“Stress and Death in the Ischemic Heart,” American Heart Association symposium, Snowbird,
Utah, August 24, 2002
"Oxidative Stress as a Trigger for Cardiac Myocyte Apoptosis," Heart Failure Society of America,
September 2002
"Chromatin Remodelling and Heart Failure,” Winters Center for Heart Failure Research, Baylor
College of Medicine, Houston, TX, January 7, 2003.
"Adenovirus target protein p300 mediates cardiac hypertrophy and heart failure." Miami Nature
Biotechnology Winter Symposium, February 3, 2003.
“Atherosclerosis as an autoimmune disorder,” Genetics Journal Club, Department of Pediatrics,
University of Miami, March 6, 2003.
“Transcription programming in a genetic model of heart failure,” University of Winnipeg, Canada,
March 10, 2003
“Transcription Coactivator p300 is Critical Regulator of Cardiac Hypertrophy,” Pediatrics/Genetics
weekly conference series, University of Miami School of Medicine, April 8, 2003
“The impact of diabetes on vascular disease,” Jackson Memorial Hospital in-service lecture, May
23, 2003.
22
Nanette H. Bishopric, M.D.
Curriculum Vitae
“Cytoskeletal signal transduction and cardiomyopathy,” Cardiomyopathy in Muscular Dystrophy
Workshop, Muscular Dystrophy Association, Tucson, AZ. September 2003.
“Signalling cell death by hypoxia and oxidative stress in cardiac myocytes,” European Society of
Hematology/MD Anderson 4th Annual Conference on Mechanisms of Cell Death and Disease,
Cancun, Mexico, November 2003.
"Transcription factor p300: a chromosome-modifying regulator of heart growth and failure,"
Department of Medicine, University of Miami School of Medicine, April 6, 2004.
ACC News Release (2004). Commentary on “Genes Linked to Heart Attacks More Common
Among African Americans,” posted online on July 7, 2004 at the URL address:
http://www.acc.org/media/releases/highlights/2004/july04/genes.htm
“p300 Chromatin Remodeling and Growth Control in Normal Tissue,” Braman Family Breast
Cancer Institute, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL,
July 30, 2004.
Session entitled “Regulators of Cell Death, Survival and Function,” (1) Chair: Bishopric NH. Heart
Failure Society of America Annual Meeting, Toronto, Canada, September 14, 2004.
Session 3 “Failure and Intervention” (1) Chair: Bishopric NH / Holtz J, Heart-Failure in the
Elderly: Cellular Mechanisms and Therapy (2nd Annual Halle Meeting on the Ageing Heart),
Martin-Luther University of Halle-Wittenberg, Nov. 20, 2004
“ROS and other molecular mediators of apoptotic signalling in the failing human heart,” Session 2 Oxidative stress and ageing, Heart-Failure in the Elderly: Cellular Mechanisms and Therapy (2.
Halle Meeting on the Ageing Heart), Martin-Luther University of Halle-Wittenberg, Nov. 20,
2004
"p300- a cardiac transcription super-factor“, presented at Medizinische Hochschule Hannover, Abt.
Kardiologie und Angiologie, Hannover, Germany, Nov. 17, 2004
“Connexins between sudden death and heart failure,” Department of Molecular and Cellular
Pharmacology Seminar, University of Miami School of Medicine, December 2, 2004.
“Evolution of the heart from bacteria to man,” in session on Cardiac Cell Development, 3rd Larry &
Horti Fairberg Workshop – The Communicative Cardiac Cell, Sintra, Portugal, January 15-19,
2005.
“Jun kinase interacts with APAF1 and inhibits Caspase-9 activation induced by oxidative stress,”
Miami-Nature Biotechnology Winter Symposia on Signal Transduction in Cancer, poster
presentation, February 5-9, 2005.
“Complexities of molecular diagnosis for ventricular arrhythmias,” Masters of Pediatrics Poster
Session, Division of Medical Genetics/John T. Macdonald Fdn. Center for Medical Genetics,
Miller School of Medicine at the University of Miami
“Novel mutations (S338F & F339S) in cardiac KvLQT1 S6 domain hinder KvLQT1-KCNE1
coassembly,” Masters of Pediatrics Poster Session, Division of Medical Genetics/John T.
23
Nanette H. Bishopric, M.D.
Curriculum Vitae
Macdonald Fdn. Center for Medical Genetics, Miller School of Medicine, University of
Miami, Bal Harbor, FL, January 27, 2005
Attendee, ESH-UT MD Anderson Cancer Center International Conference On Mechanisms Of Cell
Death And Disease: Advances In Therapeutic Intervention And Drug Development, Cascais,
Portugal, October 22-25, 2004
“The Role of the BNip 3 Pathway in Apoptosis”, Heart Failure Society of America Annual
Scientific Meeting, Boca Raton, FL, September 20, 2005
“Molecular connections in aging and heart failure”, Cardiovascular Ageing: from molecular biology
to clinical perspectives (2nd Annual Halle Meeting on the Ageing Heart), Martin-Luther
University of Halle-Wittenberg, Germany, September 24, 2005
Co-Chair of Session: “Tissue Protection During Ageing,” Cardiovascular Ageing: from molecular
biology to clinical perspectives (2nd Annual Halle Meeting on the Ageing Heart), MartinLuther University of Halle-Wittenberg, Germany, September 24, 2005
“Genetic Complexities of Molecular Diagnosis for Ventricular Arrhythmias” presented poster for
Research Update, Dr. John T. Macdonald Foundation Center for Medical Genetics and Miami
GeneCure Diagnostic Laboratories of the University of Miami Miller School of Medicine,
Country Club of Coral Gables, Coral Gables, FL, November 8, 2005
Poster Judge for AHA 2005 Scientific Sessions, “Stem/Progenitor Cells in Cardiac Repair II,”
Dallas, TX, November 13, 2005
Co-Moderator for AHA 2005 Scientific Sessions AOP.38.2a, “Molecular and Cellular Mechanisms
of Myocardial Apoptosis,” Dallas, TX, November 15, 2005
“Apoptosis in Congestive Heart Failure,” Invited Speaker, AHA Scientific Sessions, Dallas, TX,
November 15, 2005
“Reciprocal control of growth and aging by the adenovirus target protein 300.” Distinguished
Cardiovascular Lectureship Series, University of California at Los Angeles, December 5, 2005
“Cardiac myocyte p300 levels regulate myocardial angiogenesis,” short report, Miami-Nature
Biotechnology Winter Symposia on Angiogenesis in Cancer and Vascular Disease, February 48, 2006.
“p300 prevents aging: a role in stem cell maintenance?” Cardiovascular Research Seminar series,
New York Medical College, New York, NY, February 15, 2006.
“The apoptosome as a target for Jun Kinase during cardiac myocyte apoptosis”. Visiting Speaker,
Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre,
University of Manitoba, Winnipeg, Canada, February 21-22, 2006
“p300 in Cardiac Growth and Regeneration,” Fondation Leducq Annual Network Meeting
Hannover Germany, May 6, 2006
“The Sudden Death Database: Needs and Obstacles,” Fondation Leducq Semi-Annual Network
Meeting, Opio, France, June 18, 2006
24
Nanette H. Bishopric, M.D.
Curriculum Vitae
“Mechanisms and targets in cardiac myocyte apoptosis”, 8th International Dead Sea Symposium &
17th Rappaport Symposium Joint Mtg., Tel Aviv, Israel, Hilton Convention Center, October
15 through 18, 2006.
“The Reference Population Project”. University of Miami McDonald Center for Genetics, October
25, 2006
“Cell- and gene-based mechanisms in the pathogenesis and treatment of cardiomyopathy”,
presented at Idiopathic and Primary Cardiomyopathy in Children: Research, Directions and
Strategies Conference, Bethesda, MD, January 25, 2007.
“Evolution of the heart”, University of South Florida College of Engineering, Department of
Bioengineering, February 9, 2007
“Cardiac signaling and apoptosis”, Heart Failure Association of the European Society of
Cardiology, Hamburg, Germany, June 11, 2007
“Modulation of apoptosis and heart failure risk” XIX World Congress of the ISHR, Bologna, Italy,
June 22-26, 2007.
27.
Teaching Awards Received
none
28.
Teaching Specialization
Molecular and Cellular Pharmacology (Cardiovascular diseases)
General Cardiology (Outpatient Cardiology clinic and inpatient Cardiology consult service, Jackson
Memorial Hospital).
Medical Genetics
a., b.
Courses Taught and Scheduled (May, 2005 - June, 2006):
“Angiogenesis” Lecture, MDB 665, Tumor Biology Course and Small Group Discussion
class (approximately 4 hours preparation and 4 hours class time) University of Miami
School of Medicine, October, 2006
Cardiology, Consult Attending, June (1/2 month) 2006, approximately 30 hours of
cardiology fellow oversight and teaching
Cardiology, Consult Attending, May 2006, approximately 60 hours of cardiology fellow
oversight and teaching
Molecular and Cellular Pharmacology, Spring 2006 MCP 632, Cardiovascular
Pharmacology (3 credit, 15 week course)
2005-2006 Curriculum, Cardiovascular System (CVS) MODULE, May 10, 2006, Graduate
course for medical students, 1 hr lecture, Drugs for Heart Failure.
2005-2006 Curriculum, Cardiovascular System (CVS) MODULE, May 9, 2006, Graduate
course for medical students, 1 hr lecture, Hypertrophic Cardiomyopathy.
25
Nanette H. Bishopric, M.D.
Curriculum Vitae
2006-2006 Curriculum, Cardiovascular System (CVS) MODULE, May 2, 2006, Graduate
course for medical students, 1 hr lecture, Drug Treatment of Angina Pectoris.
2005-2006 Curriculum, Cardiovascular System (CVS) MODULE, April 18, 2006, Graduate
course for medical students, 1 hr lecture, Cardiac Hypertrophy.
2005-2006 Curriculum, Cardiovascular System (CVS) MODULE, April 12, 2006, Graduate
course for medical students, 1 hr lecture, Positive Inotropic Drugs.
Cardiology, Consult Attending, March 2006, approximately 60 hours of cardiology fellow
oversight and teaching
Cardiology, Consult Attending, December (1/2 month) 2005, approximately 30 hours of
cardiology fellow oversight and teaching
“Angiogenesis” Lecture, MDB 665, Tumor Biology Course and Small Group Discussion
class (approximately 4 hours preparation and 4 hours class time) University of Miami
School of Medicine, November, 2005
Molecular and Cellular Pharmacology Core Course 2005, Small Group Discussion class,
(approximately 1 hour preparation and 2 hours class time) University of Miami Miller
School of Medicine, October 5, 2005
Cardiovascular Pharmacology course director, 2002-present; 30 hours of Graduate student
lectures and teaching annually.
Cardiovascular Journal Club director, 2001-2005. 12 hours of graduate and postdoctoral
fellow teaching and contact time annually.
UM-JMH Cardiology Outpatient Clinic, Co-director, 75 contact/teaching hours with
cardiology fellow annually.
29.
Trainees:
Name
Dates of Training
Degree, Institution/Current Position
Kristin Ellison, M.D. 1993-1995
M.D., Tufts University, M.D.
Assistant Professor and Staff Electrophysiologist,
Brown University Medical School
Project: “Fusigenic liposome-mediated transfection into cardiac myocytes”
Douglas J. Ing, M.D.
1995-1996
M.D., McGill School of Medicine
Clinical Studies Resource Centre Member
Division of Clinical Investigation & Human
Physiology
Toronto General Research Institute
Project: “Nitric oxide as an apoptosis effector in cardiac myocytes”
Can-Fang Wu, Ph.D. 1995-1996
Ph.D., U.C.L.A.
Research Assistant Professor, Stanford University
Project: “Atrial natriuretic peptide as an apoptosis effector in cardiac myocytes”
26
Nanette H. Bishopric, M.D.
Xiao-Su Wu, Ph.D.
Curriculum Vitae
1995-1996
Ph.D., Beijing, China
Staff Scientist, Roche Palo Alto, Palo Alto, California
Project: “Upregulation of proto-oncogenes in human heart failure”
Guy Haywood, M.D. 1994-1995
Consulting Cardiologist, Southwest Cardiothoracic
Centre, Plymouth, UK.
Project: “Induction of iNOS in dilated cardiomyopathy”
Guo-Qing Zeng, Ph.D. 1994-1996
Ph.D., Paris, France, Assistant Professor,
University of North Carolina School of Medicine
Project: “Regulation of cardiac myocyte differentiation and mitosis by adenoviral oncoprotein
E1A”
Lars Gullestad, M.D., Ph.D. 1995-1997
M.D., Ph.D., University of Oslo, Senior Cardiologist,
Rikshospitalet, University Hospital, Oslo, Norway
Project: “Regulation of iNOS and Angiotensin receptor subtypes in heart failure”
Jie Zang, M.D.
1996- 1999
M.D., China
Research Associate, University of Miami
Project: “Mechanisms and effectors of nitric oxide-mediated apoptosis”
Sandrine Hardouin, Ph.D. 1997-1998
Ph.D., Institute Pasteur, Paris, France
Postdoctoral Fellow, Department of Pharmacology,
University of Washington, Seattle
Project: “Oxidative stress and Beta adrenoceptor-mediated apoptosis”
Peter Andreka, M.D.
1998-2002
M.D., Semmelweis University School of Medicine
Chief, Hungarian Institute of Cardiology, Budapest,
Hungary
Project: “Jun kinase and the mitochondrial pathway for cardiac myocyte death”
Monica Pessanha, PhD 2002-2003
Ph.D., Federal University Fluminense
On leave from University of Miami
Project: “Cellular hypertrophy in p300-mediated cardiac growth”
Mark Turner, M.D.
M.D., Plymouth, UK
Consultant, Bristol Royal Infirmary
Project: “Connexin43 phosphorylation and regulation by ischemia”
Jian Qin Wei, M.D.
2002-2004
2000-present
M.D., Medical College of Shanghai, TieDao Univ.
Postdoctoral Research Associate, NIH R-01 supported
Project: “Genetic and molecular physiology of transcription coactivator p300”
27
Nanette H. Bishopric, M.D.
Todd Miller, Ph.D.
Curriculum Vitae
Ph.D., University of Miami,
Senior Scientist, Specialty Laboratories, Inc.,
Valencia, CA
Project: “Genotype-Phenotype Correlations in Long QT Syndrome”
Alex Llanos, M.D.
2001-present
2004- 2006
MD and Resident in Medicine, University of Miami
Cardiology Fellow, Emery University
Project: “Induction of p300 expression in human heart failure and myocardial ischemia”
Claudia Rodrigues PhD.
2005-
Ph.D., Federal University of Rio de Janeiro
Postdoctoral Fellow, NIH Training Grant in
Cardiovascular Signalling
Project: “A novel model of aging caused by haploinsufficiency of transcription coactivator p300”
Lina Shehadeh, Ph.D. 2005-
Ph.D., Florida Atlantic University
NIH Kirchstein NRSA Award
Project: “Novel algorithms for microarray data analysis applied to cardiac hypertrophy”
Dylan Steen, MD
2006-present
Instructor in Medicine, UM Housestaff R3
Project: “Growth and oxidant susceptibility of cardiac stem cells”
Pre-doctoral Trainees:
Tatiana I. Slepak, B.S. 1997-2001
B.S., Moscow, Russia
Research Scientist, John T. Macdonald Center for
Genetics, University of Miami
Project: “Cardiac transcriptional activation partners for p300”
Mark Turner, M.D.
1998-2004
M.D., University of Wales; earned Ph.D. from my
laboratory, granted at University of Wales.
Consultant in congenital heart diseases, University
Hospital, London, UK
Project: “Connexin43 regulation during myocardial hypoxia and reoxygenation”
Thanh Tranh, Ph.D.
2000-2006
Ana G. Cristancho
2003-2004
B.S., Tufts University; PhD, Univ of Miami
Graduate Student, NIH Cardiovascular Training Grant,
AHA Predoctoral Fellowship
Postdoctoral Fellow, Novartis Institute for Biomedical
Research, Cambridge, MA
Project: “Mechanisms of Jun kinase-mediated cardiac myocyte cytoprotection”
Project: “A novel model of aging in mice”
Earned B.S. from University of Miami while in lab
M.D.-Ph.D. degree program, University of
Pennsylvania
28
Nanette H. Bishopric, M.D.
Curriculum Vitae
Mauricio Montezuma, 2002-2003
MD, Universidad del Valle, Cali, Columbia
Postdoctoral fellow, Universidad del Valle, Cali,
Columbia
Project: “Candidate genes in right ventricular dysplasia”
Brian Weber
2000-2002
Coral Gables High School Student
Intel High School Student Scholar
Project: “Genetic testing in Long QT syndrome”
James Mitrani
2001-2004
Hillel School
Intel High School Student Scholar
Project: “p300 levels as a determinant of hypertrophy in the cardiac myocyte”
Dane Thomas
2002-2003
Sophomore, University of Florida, Gainesville, FL
Project: “Models of cardiac hypertrophy and pressure overload”
Raul Blanco
2002 Summer
Cardiovascular Grant Predoctoral Fellow
Project: “Genetic testing for mutations in the sodium channel SCN5A”
Niberto Moreno, B.S. 2001-2002
B.S., University of Miami
Medical student year 4, University of Miami
Project: “Manifestations of Long QT syndrome in the preterm infant”
Hooshang Bolooki, Jr. November 2002
Medical Student year 4, UMSM
Project: “Human Mutations in Cardiac Troponin T”
Maria Gallego
Oct-Dec 2002
Project: “A novel Long QT mutation”
Medical Student year 4, UMSM
Leon McCaskill
September 2002
Medical Student year 4, UMSM
Project: “The LQT1 Y1102 polymorphism and frequency in African Americans”
Katherine Lee
2004 Summer
Senior at Stanford Univ., Stanford, CA
Project: “Validating blood cell RNA as a source for genetic testing material”
Arieh Fox
2004 -2005
Medical Student year 1, UMSM
Project: “Screening for dilated cardiomyopathy mutations using blood RNA”
Yehuda Deutsch
2004-2005
Medical Student year 1, UMSM.
Project: “Cardiac myosin binding protein-C expression and genotyping in peripheral blood”
Kerline Ductan
2005-Summer
Medical Student, 2nd year, University of Miami
Project: “Screening for Long QT1 Mutations”
29
Nanette H. Bishopric, M.D.
Curriculum Vitae
Sam Weiss
2005-Summer
Undergraduate Student, University of Miami
Project: “Screening for Mutations in the SCN5A Sodium Channel”
Tara Chang
2005-Summer
Medical Student, 2nd year, University of Virginia
Project: “Apoptosis in a Mouse Genetic Model of Calcium Overload”
Harley Gould
2005-Summer
Undergraduate Student, 1st year, Duke University
Project: “Bioinformatic applications in cardiovascular genetics”
Noam Koenigsberg 2005-2006
Medical Student, 1st year, UM Miller SM
Project: “Novel genetic screen for laminopathies”
Jason Au
Summer 2005
B.S., 2005, UM Medical Student, 1st year
Project: “Regulation of the p300 promoter in cardiac myocytes”
Erik Bernstein
2005-2006
Medical Student, 4th year, University of Miami
Project: “Genetics of Acquired Long QT Syndrome”
Melanie Adamsky
Summer 2006
Undergraduate student, 2nd year, Cornell University
Project: “Genetic screening for sudden death genes”
Lindsay Mitrani
2006-present
Hillel School, Intel Scholar competitor
Project: “Immunohistological characterization of cardiac stem cells”
Anisha Gupta
2006-present
Undergraduate student, 1st year, U. Miami
Project: “Expression of p300 target genes”
Sasha Sitahal
2006-present
Undergraduate student, 2nd year, U. Miami
Project: “Expression profiling in cardiac hypertrophy”
Yousuf Ali
Fall 2006
Rotation IBS graduate student, U. Miami
Project: “Sizing the apoptosome by chromatography”
Emily Heenan
Fall 2006
Rotation Pharmacology graduate student, UM
Project: “Effects of siRNA inactivation of p300 in normal and transformed cells”
Ines Chopra
Winter 2006
Rotation Pharmacology graduate student, UM
Project: “Differentiation potential of cardiac stem cells”
Sumit Jain
Winter 2006
Rotation IBS graduate student, UM
Project: “Purification of an Apaf-1-Jun kinase complex”
Salil Sharma
Spring 2007
Rotation Pharmacology graduate student, UM
Project: “Lentiviral modification of cardiac stem cells”
Sanjeev Sirpal
Spring 2007
Rotation MD-PhD student
Project: “Neural cell adhesion molecule as a modulator of hypertrophy”
Karel Calero
2007MSIV Elective in Pharmacology Research, UM
Project: “Cardiogenic potential of an adult ventricular stem cell clone”
30
Nanette H. Bishopric, M.D.
Curriculum Vitae
Dylan Steen
2006Medical Resident III, research elective
Project: “Ischemic and Cell cycle regulation of p300”
John D. Clark, III
2007-
M.D.-PhD candidate
------Dissertation Committee for Physiolopogy and Biophysics Student Gayathri Venkatraman
(completed)
Dissertation Committee for Physiology & Biophysics Student Yuhui Wen, (June 30, 2006 –
present)
Dissertation Committee for Molecular and Cellular Pharmacology Student David Dweck (October
16, 2006 – present)
SERVICE
30.
University committee and administrative responsibilities:
Scientific Advisory Committee (1999-2001)
Pharmacology Faculty Advisory Committee (1998-2000)
Sylvester Cancer Center Intramural Grant Review Committee (1999-present)
School of Medicine New Curriculum Subcommittee (Cardiovascular) (1999-2001)
Search Committee, Dept. of Genetics John T. Macdonald Foundation Center Director (2000-02)
Medical School Faculty Council (June 2001-present)
Subcommittee on Research Priorities (2001 – 2002)
Subcommittee on Parental Leave Policy (2003)
Subcommittee on UMMG Part Time Status and Work Relief (2003)
Council Representative to Library Committee (October 2005 – present)
Member, Search Committee for Head of Library Services (2006-present)
Member, Chair Search Committee, Department of Pediatrics, (2001-2002)
Chair, Faculty Search Committee, Dept. of Molecular and Cellular Pharmacology, (2004-2005)
MD-Ph.D. Committee, Member (2004 – 2007)
Facilities and Planning Committee, Member (2005)
Faculty Council Promotion and Tenure Subcommittee (2007)
Appointment, Promotion and Tenure Committee, Member (June 1, 2006 – May 31, 2009)
31
Nanette H. Bishopric, M.D.
Curriculum Vitae
Member, Dean’s Research Cabinet (2006-present)
Medical Library Director Search Committee (2006-2007)
Faculty Senate Hearing Panel, (2004-present)
31.
Community Activities:
Soprano I, University of Miami Frost Collegium Musicum,
Donald Oglesby, director (2000-present)
Representative Performances (last 5 years):
G.F. Handel, Coronation Anthems Nos.1-4 and Chandos Anthem No. 8, Nov. 2002
J.S. Bach, The Passion According to St. John, March 2003
J.S. Bach, Cantata 147, “Herz und Mund und Tat und Leben” October 2003.
Marc-Antoine Charpentier, Messe de Minuit pour Noël, and Noël variations by LaLande,
Balbastre, and other French baroque composers, Miami, FL, Nov. 2004
J.S. Bach, Mass in B Minor, April 2005
Ranked in Miami Herald Top 10 Musical Performances of 2005
(http://www.miami.com/mld/miamiherald/entertainment/music/11490443.htm)
Franz Schubert, Mass #4 in C Major, November 2005
Tomas Luis de Victoria, Lamentations of Jeremiah and Tenebrae Responsories, April 2006
Evensong Service in celebration of the 110th anniversary of Trinity Episcopal Cathedral,
Miami, FL- works by Palestrina, Weelks, Tchaikovsky, Stanford, and others.
Tomas Luis de Victoria and others, Good Friday Tenebrae service, Trinity Episcopal
Cathedral, April 2007
G.F. Handel, “Saul” oratorio, April 2007, Temple Israel, Miami, FL
Founding member, Grove Consort
Debut performance June 25, 2006 at Books & Books, Coral Gables, FL. Works by
Monteverde, Wilbye, Telemann, and Handel.
Soprano I, St. Stephen's Episcopal Church Adult Choir, Coconut Grove, FL (1997-2001, 2005-)
Soprano I, Plymouth Congregational Church, Coconut Grove, FL (2001- present)
Coral Gables High School Band Boosters, 2000-2004
32
Nanette H. Bishopric, M.D.
Curriculum Vitae
CBS, Channel 4 Panel, Ask the Experts - Feb. Heart Month Call-in (3 hours), Florida Heart
Research Institute, February 5, 2004.
Lighthouse Point Yacht and Racquet Club, invited speaker, along with Dr. Steven E. Lipshultz, on
“Adult Aspects of Cardiology,” (~ 3½ hours) January 12, 2006.
33