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ONLINE SUPPLEMENT
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TITLE PAGE
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Original Article
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dsRNA-induced changes in gene expression profiles of primary
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nasal and bronchial epithelial cells from patients with asthma,
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rhinitis and controls
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Ariane H Wagener, MD,a Aeilko H Zwinderman, PhD,b Silvia Luiten,c Wytske J Fokkens,
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MD, PhD,c Elisabeth H Bel, MD, PhD,a Peter J Sterk, MD, PhD,a and Cornelis M van Drunen,
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PhD,c
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a
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The Netherlands
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b
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Center, University of Amsterdam, The Netherlands
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c
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The Netherlands
Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam,
Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical
Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam,
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Corresponding author
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Ariane H. Wagener, MD
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Department of Respiratory Medicine, F5-260
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Academic Medical Center (AMC)
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University of Amsterdam
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Meibergdreef 9
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1105 AZ Amsterdam
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The Netherlands
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Telephone: +31 (0)20 5661660
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E-mail: [email protected]
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METHODS
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Primary epithelial cell culture
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Epithelal cell cultures were done as previously described [1]. Primary cells were obtained by
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first digesting the biopsies and brushes with collagenase 4 (Worthington Biochemical Corp.,
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Lakewood, NJ, USA) for 1 hour in Hanks’ balanced salt solution (Sigma-Aldrich,
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Zwijndrecht, The Netherlands). Subsequently cells were washed with Hanks’ balanced salt
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solution (HBSS) and resuspended in BEGM (Invitrogen, Breda, The Netherlands) and seeded
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in one well of a 6 wells plate. Cells were grown in fully humidified air containing 5% CO2 at
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37°C, and culture medium was replaced every other day. Cells were cultured to 80%
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confluence and were pre-incubated with BEBM for 24 hours prior to exposure to BEBM
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containing 20µg/ml poly(I:C) or with BEBM alone (control condition) for 24 hours before
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removal of supernatant and RNA extraction. For bronchial epithelial cells it took 14 days on
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average, and for nasal epithelial cells it took 24 days on average to grow to 80% confluence.
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There was no difference in time of culture between the three subject groups.
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RNA extraction
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Total RNA from each sample was extracted using Trizol (Life Technologies Inc., Gaitersburg,
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MD, USA) using manufacturer’s protocol, followed by purification by nucleospin RNA II
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(Machery-Nagel, Düren, Germany). RNA concentration of all samples was measured on the
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nanodrop ND-1000 (NanoDrop Technologies Inc., Wilmington, DE, USA). The quality of the
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RNA was checked by using Agilent 2100 bio-analyser (Agilent Technologies, Palo Alto, CA,
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USA). All RIN scores were ≥9.5.
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Microarray Affymetrix U133+ PM
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Microarray analysis was done by previously published method [1]. Human Genome U133+
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PM Genechip Array (Affymetrix inc., Santa Clara, CA, USA) representing more than 47,000
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transcripts and variants, including over 33,000 well-characterized genes, was used in the
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analysis of the genes. The MicroArray Department (MAD) of the University of Amsterdam, a
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fully licensed microarray technologies centre for Affymetrix Genechip® platforms,
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performed the technical handling and the quality control of the microarray experiments. The
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quality of the images was checked by visual inspection and all raw data passed quality
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criteria based on borderplots, pseudocolor slide images, RNA degradation plots, box and
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density plots, RI plots (against a pseudoreference), correlation and PCA plots.
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Real-time polymerase chain reaction and analysis
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Quantitative real-time PCR was used to validate the differential expression of selected genes.
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A random selection of 9 genes was used that showed a variance of responses to Poly(I:C).
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PCR was performed on Bio-Rad CFX96 real-time PCR detection system (Bio-Rad,
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Veenendaal, The Netherlands). SYBR® Green primer sequences for IL13-Rα2, EREG,
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PDE4D, IL1-β, IP-10, TIMP2, IL8, β –actin and GAPDH were obtained from Sigma-Aldrich
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(Sigma-Aldrich, Zwijndrecht, The Netherlands). The following primers were used: IL13-Rα2;
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sense: TGC-TCA-GAT-GAC-GGA-ATT-TGG, antisense: TGG-TAG-CCA-GAA-ACG-
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TAG-CAA-AG, EREG; sense: ATC-CTG-GCA-TGT-GCT-AGG-GT, antisense: GTG-CTC-
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CAG-AGG-TCA-GCC-AT,
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antisense: ACC-AGA-CAA-CTC-TGC-TAT-TCT, IL1-β; sense: GGA-TAT-GGA-GCA-
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ACA-AGT-GG, antisense: ATG-TAC-CAG-TTG-GGG-AAC-TG, IP-10; sense: TGA-AAT-
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TAT-TCC-TGC-AAG-CCA-AT, antisense: CAG-ACA-TCT-CTT-CTC-ACC-CTT-CTT-T,
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TIMP2; sense: ATA-AGC-AGG-CCT-CCA-ACG-C, antisense: GAG-CTG-GAC-CAG-
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TCG-AAA-CC,
IL8;
PDE4D;
sense:
sense:
GGC-CTC-CAA-CAA-GTT-TAA-AA,
CCA-CAC-TGC-GCC-AAC-ACA-GAA-ATT-ATT-G,
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antisense: GCC-CTC-TTC-AAA-AAC-TTC-TCC-ACA-ACC-C, β –actin; sense: TGA-GCG-
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CGG-CTA-CAG-CTT, antisense: TCC-TTA-ATG-TCA-CGC-ACG-ATT-T, GAPDH; sense:
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GAA-GGT-GAA-GGT-CGG-AGT-C, antisense:
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For ATF3 and DUSP1 we used TaqMan® gene expression assays from Applied Biosystems
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(Nieuwerkerk a/d IJssel, The Netherlands) with the following assay IDs: ATF3;
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HS00231069_M1, DUSP1; HS006102757_G1.
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Correlations between fold changes (FC) within the microarray data and the real-time PCR
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data were determined using Pearson’s correlation.
GAA-GAT-GGT-GAT-GGG-ATT-TC.
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RESULTS
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Validation of microarray data
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The results of this microarray experiment were validated by independent real time PCR on the
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same starting material used for the microarray analysis. We first determined the expression of
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the housekeeping genes (ACTB and GAPDH) which were not statistically significantly
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induced by poly(I:C). Table S1 shows the fold changes (FC) calculated from the microarray
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data and the real-time PCR-derived expression. Statistical analysis revealed a high level of
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correspondence (R=0.929, P<0.0001) between the microarray data and the real-time PCR
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(Figure
S1).
FCs
were
logtranformed
because
of
such
large
variances.
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REFERENCES
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1.
Wagener AH, Zwinderman AH, Luiten S, Fokkens WJ, Bel EH, Sterk PJ, van Drunen
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CM. The impact of allergic rhinitis and asthma on human nasal and bronchial
101
epithelial gene expression. PLoS One, in press.
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Table S1. Validatory PCR of housekeeping genes and significantly different genes.
Bronchial epithelial cells
Healthy
Allergic rhinitis
Allergic rhinitis & asthma
PCR FC
Microarray
FC
PCR FC
Microarray
FC
PCR FC
Microarray
FC
ACTB
1.16
-1.03
1.52
1.04
1.38
-1.11
GAPDH
ATF3
-1.83
-1.00
-1.82
-1.03
-1.49
-1.03
1.43
2.37
-1.78
1.21
-2.10
1.51
CXCL10
DUSP1
EREG
568.10
263.55
214.38
121.34
170.31
88.92
5.78
6.71
4.01
2.35
4.96
4.16
1.37
2.07
-3.59
-1.83
-1.26
1.17
IL13RA2
10.59
14.62
7.32
8.66
7.41
13.44
IL1B
IL8
2.83
3.52
1.30
1.75
2.43
3.11
32.48
13.98
44.45
23.40
26.06
16.60
PDE4D
-3.63
-1.33
-6.19
-1.15
-3.81
-1.33
TIMP2
1.50
2.67
1.29
2.39
1.52
2.56
103
Nasal epithelial cells
Healthy
PCR FC
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Allergic rhinitis & asthma
Microarray
FC
PCR FC
Microarray
FC
PCR FC
Microarray
FC
ACTB
-1.43
-1.04
1.04
-1.05
-1.03
-1.06
GAPDH
ATF3
CXCL10
DUSP1
EREG
-1.92
-1.04
-2.45
-1.06
-1.77
-1.02
9.61
5.02
4.35
3.97
1.69
2.75
465.72
74.79
587.32
175.30
161.27
72.35
11.45
17.60
7.48
15.22
5.98
7.17
3.90
3.13
1.67
3.24
1.03
1.35
IL13RA2
22.16
12.13
17.20
14.39
6.15
5.83
5.25
3.33
3.02
4.04
4.14
3.75
IL1B
IL8
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Allergic rhinitis
178.73
73.41
122.11
64.77
63.85
23.72
PDE4D
-1.09
-1.03
-7.87
-1.29
-1.86
-1.04
TIMP2
3.02
4.25
1.77
5.73
1.31
2.97
PCR expression is given as fold change (FC).
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Table S2. dsRNA-induced genes in upper and lower airways
Probesets
P<0.05
Probesets
P<0.05
&FC>4
Genes
P<0.05
Genes
P<0.05 &
FC>4
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Healthy
Nose
Healthy
Bronchus
Rhinitis
Nose
Rhinitis
Bronchus
Asthma
Nose
Asthma
Bronchus
17402
13424
15538
7517
6996
8560
1255
550
1439
517
517
427
10163
↑4636
↓5527
8342
↑3638
↓4704
9353
↑4204
↓5149
5190
↑2294
↓2896
4919
↑2293
↓2626
5810
↑2621
↓3189
894
↑528
↓366
401
↑274
↓127
1037
↑586
↓451
391
↑244
↓147
383
↑275
↓108
319
↑227
↓92
FC=fold change; P=p-value adjusted for multiple testing
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Table S3A. Genes assigned to GO-cluster response to virus induced in the upper airways
Gene symbol
C7orf25 /// PSMA2
CFL1
LILRB1
PIM2
POLR3F
ACTA2
BANF1
BECN1
BNIP3L
CCL22
CREBZF
CYP1A1
DNAJC3
EEF1G /// TUT1
ENO1
FOSL1
HBXIP
IFNAR1
IL12A
IL28B
LYST
MAVS
POLR3A
POLR3H
POLR3K
TBK1
ABCE1
ACE2
AP1S1
APOBEC3F
APOBEC3G
BCL2
BCL3
BNIP3
BST2
C19orf2
CCDC130
CCL4
CCL5
CCT5
DDX58
DUOX2
EIF2AK2
GPAM
GTF2F1
HERC5
HNRNPUL1
HSPB1
IFI16
IFI35
IFI44
IFIH1
IFITM1
IFITM2
IFITM3
IFNAR2
IFNB1
IFNE
Venn diagram
A
A
A
A
A
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
B
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
FC Healthy
1.30
-1.17
1.21
-1.32
-1.22
-1.27
-1.56
-1.25
1.53
1.42
-1.57
-2.60
1.95
-1.77
-1.33
3.39
-1.23
1.53
2.64
4.53
1.99
-2.00
1.53
-2.61
-2.95
1.83
-3.91
15.24
-1.73
2.78
11.38
-1.24
3.08
2.05
45.73
-1.60
1.40
255.13
517.58
-3.44
25.21
3.01
4.09
-4.25
1.31
46.50
-1.35
-1.99
1.70
38.88
64.88
18.03
8.15
2.92
2.27
3.40
3.17
-1.88
FC Rhinitis
FC Asthma
-1.34
-1.59
-1.25
1.76
1.33
-1.53
-1.73
1.81
-1.85
-1.38
3.90
-1.32
1.39
2.96
7.30
1.73
-1.69
1.65
-2.44
-2.52
1.49
-4.42
12.25
-1.63
2.80
10.82
-1.40
3.17
2.05
79.99
-1.90
1.41
243.83
717.90
-3.23
38.03
3.86
6.12
-4.77
1.55
72.10
-1.37
-2.25
1.59
67.89
164.77
22.18
10.90
2.99
2.25
3.13
2.77
-2.68
-2.48
7.55
-1.40
2.29
5.06
-1.46
2.43
1.66
27.17
-1.43
1.27
39.32
148.81
-2.21
14.32
2.03
3.56
-2.70
1.33
26.64
-1.27
-1.80
1.74
27.76
42.51
10.42
6.25
2.45
1.93
2.38
1.77
-2.45
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IFNGR1
IFNGR2
IFNK
IL23A
IL28A
IL29
IL6
IRF3
IRF7
IRF9
ISG15
ISG20
ITCH
IVNS1ABP
MST1R
MX1
MX2
MYD88
NLRC5
ODC1
PCBP2
PLSCR1
POLR3B
POLR3C
POLR3D
POLR3E
POLR3G
PRKRA
PVR
RELA
RPS15A
RSAD2
SAMHD1
SIVA1
STAT1
STAT2
STMN1
TICAM1
TLR3
TNF
TRIM11
TRIM22
TRIM25
TRIM5
UNC13D
UNC93B1
XPO1
XPR1
ZC3HAV1
ZNF175
ABCC9
CLU
DMBT1
MICA /// MICB
PSMA2
PTPRC
IRAK3
CDK6
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
E
E
E
E
E
E
F
G
1.82
2.45
3.23
20.52
13.29
25.01
20.34
1.57
28.26
2.87
23.50
32.65
2.67
-5.44
2.95
30.17
115.45
2.60
38.61
-2.23
-1.49
6.38
-1.44
1.42
1.70
-2.14
-1.87
-1.90
1.93
2.38
-8.15
260.58
16.36
-2.16
13.66
3.50
-5.68
3.14
11.82
8.16
1.73
4.90
6.43
3.81
1.60
2.40
-1.51
-1.76
16.13
1.67
1.48
2.36
4.05
24.06
15.78
20.48
11.13
1.56
40.73
3.41
46.89
41.94
3.02
-6.14
3.39
92.06
287.26
2.98
38.77
-1.78
-1.56
8.28
-1.63
1.30
1.91
-2.32
-2.15
-2.11
1.81
2.45
-9.98
638.34
31.76
-2.48
17.43
4.78
-4.89
3.12
10.00
6.72
1.78
5.16
8.67
3.90
1.76
3.27
-1.63
-2.49
18.83
1.80
1.23
-1.26
1.44
1.21
-1.27
1.24
-1.82
1.68
1.99
3.67
6.43
4.49
7.40
10.02
1.40
16.88
2.94
15.63
14.82
2.43
-2.57
2.04
21.00
72.32
2.37
12.56
-2.04
-1.38
5.22
-1.45
1.27
1.55
-1.67
-1.36
-1.61
1.54
1.98
-4.19
98.63
12.09
-1.57
10.47
3.40
-2.96
2.38
6.68
4.38
1.59
4.61
4.13
2.94
1.53
2.33
-1.41
-1.23
9.78
1.32
1.38
-1.41
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Venn diagram: A=healthy specific; B=overlap healthy–rhinitis; C=overlap all groups;
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D=overlap healthy–asthma; E=rhinitis specific; F=overlap rhinitis–asthma; G=asthma
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specific. FC = fold change.
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Table S3B. Genes assigned to GO-cluster response to virus induced in the lower airways
Gene symbol
BANF1
BECN1
BNIP3L
CXCL12
ENO1
IRF3
MAVS
MST1R
POLR3D
POLR3G
PSMA2
RNASEL
SIVA1
XPR1
BNIP3
IFNAR1
IFNB1
IFNGR1
IL28B
LYST
POLR3E
POLR3K
ZNF175
ABCE1
APOBEC3F
APOBEC3G
BCL3
BST2
C19orf2
CCL4
CCL5
CCT5
CDK6
CREBZF
CYP1A1
DDX58
DNAJC3
DUOX2
EEF1G /// TUT1
EIF2AK2
GPAM
HERC5
HNRNPUL1
HSPB1
IFI35
IFI44
IFIH1
IFITM1
IFITM2
IFITM3
IFNAR2
IFNGR2
IL23A
IL28A
IL29
IL6
IRF7
IRF9
Venn diagram
A
A
A
A
A
A
A
A
A
A
A
A
A
A
B
B
B
B
B
B
B
B
B
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
FC Healthy
-1.36
-1.23
1.30
-1.20
-1.21
1.31
-1.47
1.37
1.40
-1.62
-1.30
-1.35
-1.73
-1.45
1.55
1.23
1.60
1.64
2.40
1.73
-1.62
-2.11
1.54
-2.06
1.90
6.62
2.44
24.79
-1.42
83.19
736.54
-2.10
-1.46
-1.29
-1.91
28.49
1.48
9.56
-1.53
4.63
-2.90
35.87
-1.26
-1.53
48.10
236.92
18.21
14.95
3.33
2.97
2.43
2.25
9.34
4.21
6.80
8.80
26.30
4.44
FC Rhinitis
FC Asthma
1.69
1.42
1.47
1.50
2.16
1.68
-1.93
-2.00
1.88
-2.49
1.76
5.28
2.45
48.02
-1.56
20.90
322.77
-1.80
-1.30
-1.36
-2.85
23.14
1.36
4.80
-1.57
5.40
-2.26
25.29
-1.27
-1.74
39.73
70.93
6.27
10.61
3.65
3.53
2.54
1.87
12.37
4.48
3.95
4.92
19.88
3.44
-1.89
2.11
8.11
1.98
13.00
-1.43
35.57
231.87
-1.85
-1.52
-1.38
-2.10
18.03
1.40
7.87
-1.38
3.60
-2.44
27.95
-1.25
-1.61
31.80
104.82
12.76
11.08
3.48
2.73
2.36
2.01
7.90
4.99
4.96
7.60
20.32
3.67
14
113
ISG15
ISG20
ITCH
IVNS1ABP
MX1
MX2
MYD88
NLRC5
ODC1
PCBP2
PLSCR1
POLR3A
PRKRA
RELA
RPS15A
RSAD2
SAMHD1
STAT1
STAT2
TBK1
TICAM1
TLR3
TNF
TRIM22
TRIM25
TRIM5
UNC13D
UNC93B1
ZC3HAV1
ACE2
ACTA2
AP1S1
BCL2
CCDC130
FOSL1
GTF2F1
IFI16
IRAK3
NLRP3
POLR3H
PVR
STMN1
TRIM11
XPO1
IFNE
CLU
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
C
D
D
D
D
D
D
D
D
D
D
D
D
D
D
D
E
G
49.88
10.51
1.93
-2.43
140.44
201.46
2.17
17.88
-2.02
-1.29
7.77
1.49
-1.59
1.91
-4.45
363.02
17.56
16.34
3.40
1.44
2.30
6.70
4.81
6.91
3.96
2.60
1.50
2.52
12.00
6.49
-1.36
-1.46
-1.43
1.26
2.40
1.25
1.50
1.40
1.77
-1.74
1.65
-2.24
1.59
-1.25
64.58
7.46
1.75
-2.16
175.11
163.72
2.32
12.59
-2.87
-1.29
7.54
1.61
-1.41
1.62
-4.65
304.55
3.38
6.17
2.97
1.42
2.15
3.71
3.95
9.76
3.13
2.55
1.43
1.82
15.83
32.63
8.46
1.86
-2.07
67.81
96.81
2.19
11.61
-2.11
-1.31
5.70
1.29
-1.57
1.69
-3.17
167.47
13.59
11.13
2.59
1.30
2.31
5.54
4.35
4.63
3.72
2.51
1.45
2.21
8.50
5.12
-1.38
-1.34
-1.42
1.23
1.89
1.29
1.62
1.56
1.46
-1.45
1.60
-1.93
1.54
-1.31
-2.22
-1.35
Venn diagram: A=healthy specific; B=overlap healthy–rhinitis; C=overlap all groups;
114
D=overlap healthy–asthma; E=rhinitis specific; F=overlap rhinitis–asthma; G=asthma
115
specific. FC = fold change.
15
116
Table S4. Genes induced in the upper airways of healthy controls and allergic rhinitis
117
patients, assigned to GO cluster Mitochondrion.
Gene alias
Gene name/description
AARS2
ABCA12
ABCF2
ACACB
ACAD8
ACAD9
ACADM
ACADVL
ACN9
ACO2
ACOT13
ACP6
ACSF2
ACSL1
ACSS1
ADCK4
ADH5
ADO
AIFM1
AK2
AK3
AKAP10
AKT2
ALDH1B1
ALDH1L1
ALDH1L2
ALDH2
ALDH5A1
ALKBH1
ALKBH7
AP2M1
APOA1BP
ARG2
ARMC10
ATIC
ATP5B
ATP5C1
ATP5D
ATP5G1
ATP5G2
ATP5G3
ATP5H
ATP5I
ATP5J
ATP5J2
ATP5L
ATP5S
ATP5SL
ATPAF1
BAX
BBOX1
alanyl-tRNA synthetase 2, mitochondrial (putative)
ATP-binding cassette, sub-family A (ABC1), member 12
ATP-binding cassette, sub-family F (GCN20), member 2
acetyl-CoA carboxylase beta
acyl-CoA dehydrogenase family, member 8
acyl-CoA dehydrogenase family, member 9
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
acyl-CoA dehydrogenase, very long chain
ACN9 homolog (S. cerevisiae)
aconitase 2, mitochondrial
acyl-CoA thioesterase 13
acid phosphatase 6, lysophosphatidic
acyl-CoA synthetase family member 2
acyl-CoA synthetase long-chain family member 1
acyl-CoA synthetase short-chain family member 1
aarF domain containing kinase 4
alcohol dehydrogenase 5 (class III), chi polypeptide
2-aminoethanethiol (cysteamine) dioxygenase
apoptosis-inducing factor, mitochondrion-associated, 1
adenylate kinase 2
adenylate kinase 3
A kinase (PRKA) anchor protein 10
v-akt murine thymoma viral oncogene homolog 2
aldehyde dehydrogenase 1 family, member B1
aldehyde dehydrogenase 1 family, member L1
aldehyde dehydrogenase 1 family, member L2
aldehyde dehydrogenase 2 family (mitochondrial)
aldehyde dehydrogenase 5 family, member A1
alkB, alkylation repair homolog 1 (E. coli)
alkB, alkylation repair homolog 7 (E. coli)
adaptor-related protein complex 2, mu 1 subunit
apolipoprotein A-I binding protein
arginase, type II
armadillo repeat containing 10
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
ATP5S-like
ATP synthase mitochondrial F1 complex assembly factor 1
BCL2-associated X protein
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
16
BCL2L1
BCS1L
BDH2
BNIP3L
BOLA1
BPHL
BRP44
C10orf2
C10orf58
C12orf10
C12orf62
C14orf156
C14orf159
C15orf62
C17orf61
C17orf90
C18orf19
C19orf70
C1orf151
C20orf24
C21orf33
C2orf47
C2orf64
C3orf1
C3orf31
C4orf46 /// TOMM7
C5orf54
C6orf57
C7orf55
C7orf55 /// LUC7L2
C9orf46
CA5B
CA5BP
CAV1
CBARA1
CCBL2
CCDC123
CCDC58
CCT7
CDS2 /// LOC149832
CECR5
CHCHD1
CHCHD2
CHCHD7
CISD2
CISD3
CKMT1A /// CKMT1B
CLN3
COL4A3BP
COMTD1
COQ10A
COQ3
COQ5
COQ6
COQ9
COX10
COX15
COX4I1
COX4NB
BCL2-like 1
BCS1-like (yeast)
3-hydroxybutyrate dehydrogenase, type 2
BCL2/adenovirus E1B 19kDa interacting protein 3-like
bolA homolog 1 (E. coli)
biphenyl hydrolase-like (serine hydrolase)
brain protein 44
chromosome 10 open reading frame 2
chromosome 10 open reading frame 58
chromosome 12 open reading frame 10
chromosome 12 open reading frame 62
chromosome 14 open reading frame 156
chromosome 14 open reading frame 159
chromosome 15 open reading frame 62
chromosome 17 open reading frame 61
chromosome 17 open reading frame 90
chromosome 18 open reading frame 19
chromosome 19 open reading frame 70
chromosome 1 open reading frame 151
chromosome 20 open reading frame 24
chromosome 21 open reading frame 33
chromosome 2 open reading frame 47
chromosome 2 open reading frame 64
chromosome 3 open reading frame 1
Chromosome 3 open reading frame 31
chromosome 4 open reading frame 46 /// translocase of outer mitochondrial membrane 7 homolog (yeast)
chromosome 5 open reading frame 54
chromosome 6 open reading frame 57
chromosome 7 open reading frame 55
chromosome 7 open reading frame 55 /// LUC7-like 2 (S. cerevisiae)
chromosome 9 open reading frame 46
carbonic anhydrase VB, mitochondrial
Carbonic anhydrase VB pseudogene
caveolin 1, caveolae protein, 22kDa
calcium binding atopy-related autoantigen 1
cysteine conjugate-beta lyase 2
coiled-coil domain containing 123
coiled-coil domain containing 58
chaperonin containing TCP1, subunit 7 (eta)
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
cat eye syndrome chromosome region, candidate 5
coiled-coil-helix-coiled-coil-helix domain containing 1
coiled-coil-helix-coiled-coil-helix domain containing 2
coiled-coil-helix-coiled-coil-helix domain containing 7
CDGSH iron sulfur domain 2
CDGSH iron sulfur domain 3
creatine kinase, mitochondrial 1A /// creatine kinase, mitochondrial 1B
ceroid-lipofuscinosis, neuronal 3
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
catechol-O-methyltransferase domain containing 1
coenzyme Q10 homolog A (S. cerevisiae)
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
coenzyme Q6 homolog, monooxygenase (S. cerevisiae)
coenzyme Q9 homolog (S. cerevisiae)
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
COX15 homolog, cytochrome c oxidase assembly protein (yeast)
cytochrome c oxidase subunit IV isoform 1
COX4 neighbor
17
COX5B
COX6B1
COX6C
COX7A2L
COX7B
COX7C
CPOX
CPS1
CPT2
CRAT
CS
CYB5B
CYC1
CYP1A1
CYP24A1
DAB1 /// OMA1
DARS2
DBI
DECR1
DHODH
DHRS4 /// DHRS4L2
DLD
DLST
DNAJA3
DNAJC19
DNLZ
DNM3
DRG2
DYNLL1
EARS2
ECH1
EHHADH
ELAC2
ENDOG
ENO1
ETFA
ETFB
FAHD1
FAM110B
FAM136A
FAM175A
FAM82B
FANCG
FARS2
FASTK
FDPS
FDX1
FECH
FEZ1
FIBP
FIS1
FUNDC2
FXC1
FXN
GABBR1 /// UBD
GAD1
GADD45GIP1
GAS8
cytochrome c oxidase subunit Vb
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
cytochrome c oxidase subunit VIc
cytochrome c oxidase subunit VIIa polypeptide 2 like
cytochrome c oxidase subunit VIIb
cytochrome c oxidase subunit VIIc
coproporphyrinogen oxidase
carbamoyl-phosphate synthase 1, mitochondrial
carnitine palmitoyltransferase 2
carnitine O-acetyltransferase
citrate synthase
cytochrome b5 type B (outer mitochondrial membrane)
cytochrome c-1
cytochrome P450, family 1, subfamily A, polypeptide 1
cytochrome P450, family 24, subfamily A, polypeptide 1
disabled homolog 1 (Drosophila) /// OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
aspartyl-tRNA synthetase 2, mitochondrial
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
2,4-dienoyl CoA reductase 1, mitochondrial
dihydroorotate dehydrogenase
dehydrogenase/reductase (SDR family) member 4 /// dehydrogenase/reductase (SDR family) member 4 like 2
dihydrolipoamide dehydrogenase
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DnaJ (Hsp40) homolog, subfamily A, member 3
DnaJ (Hsp40) homolog, subfamily C, member 19
DNL-type zinc finger
dynamin 3
developmentally regulated GTP binding protein 2
dynein, light chain, LC8-type 1
glutamyl-tRNA synthetase 2, mitochondrial (putative)
enoyl CoA hydratase 1, peroxisomal
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
elaC homolog 2 (E. coli)
endonuclease G
enolase 1, (alpha)
electron-transfer-flavoprotein, alpha polypeptide
electron-transfer-flavoprotein, beta polypeptide
fumarylacetoacetate hydrolase domain containing 1
family with sequence similarity 110, member B
family with sequence similarity 136, member A
family with sequence similarity 175, member A
Family with sequence similarity 82, member B
Fanconi anemia, complementation group G
Phenylalanyl-tRNA synthetase 2, mitochondrial
Fas-activated serine/threonine kinase
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase,
geranyltranstransferase)
ferredoxin 1
ferrochelatase
fasciculation and elongation protein zeta 1 (zygin I)
fibroblast growth factor (acidic) intracellular binding protein
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FUN14 domain containing 2
fracture callus 1 homolog (rat)
frataxin
gamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D
glutamate decarboxylase 1 (brain, 67kDa)
growth arrest and DNA-damage-inducible, gamma interacting protein 1
growth arrest-specific 8
18
GBAS
GCDH
GHITM
GJA1
GK
GK /// GK3P
GK3P
GLOD4
GLS2
GLT8D1
GLYCTK
GM2A
GNPAT
GPX4
GRAMD4
GRN
GTF2H4
GTPBP3
HCCS
HDDC2
HEBP1
HEBP2
HEMK1
HIBADH
HINT2
HK1
HK2
HLCS
HRSP12
HSD17B10
HSD17B8
HSP90AB1
HSPE1
ICT1
IDH1
IDH2
IDH3A
IDH3B
IMMP2L
ISCA1
ISOC2
KARS
KIAA0141
KMO
KRT5
L2HGDH
LARS2
LETM1
LETMD1
LGALS3
LIMK2
LIPT1
LONP1
LRP5
LYRM1
LYRM2
LYRM4
LYRM5
MARS2
glioblastoma amplified sequence
glutaryl-CoA dehydrogenase
growth hormone inducible transmembrane protein
gap junction protein, alpha 1, 43kDa
glycerol kinase
glycerol kinase /// glycerol kinase 3 pseudogene
glycerol kinase 3 pseudogene
glyoxalase domain containing 4
glutaminase 2 (liver, mitochondrial)
Glycosyltransferase 8 domain containing 1
glycerate kinase
GM2 ganglioside activator
glyceronephosphate O-acyltransferase
glutathione peroxidase 4 (phospholipid hydroperoxidase)
GRAM domain containing 4
granulin
general transcription factor IIH, polypeptide 4, 52kDa
GTP binding protein 3 (mitochondrial)
holocytochrome c synthase
HD domain containing 2
heme binding protein 1
heme binding protein 2
HemK methyltransferase family member 1
3-hydroxyisobutyrate dehydrogenase
histidine triad nucleotide binding protein 2
hexokinase 1
hexokinase 2
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Heat-responsive protein 12
hydroxysteroid (17-beta) dehydrogenase 10
hydroxysteroid (17-beta) dehydrogenase 8
heat shock protein 90kDa alpha (cytosolic), class B member 1
heat shock 10kDa protein 1 (chaperonin 10)
immature colon carcinoma transcript 1
Isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase 3 (NAD+) alpha
isocitrate dehydrogenase 3 (NAD+) beta
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
isochorismatase domain containing 2
lysyl-tRNA synthetase
KIAA0141
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
keratin 5
L-2-hydroxyglutarate dehydrogenase
leucyl-tRNA synthetase 2, mitochondrial
leucine zipper-EF-hand containing transmembrane protein 1
LETM1 domain containing 1
Lectin, galactoside-binding, soluble, 3
LIM domain kinase 2
lipoyltransferase 1
lon peptidase 1, mitochondrial
Low density lipoprotein receptor-related protein 5
LYR motif containing 1
LYR motif containing 2
LYR motif containing 4
LYR motif containing 5
methionyl-tRNA synthetase 2, mitochondrial
19
MAT2B
MAVS
MCAT
MCEE
MCL1
ME3
MECR
MFF
MIPEP
MLXIP
MMACHC
MOSC1
MPST
MPV17
MPV17L2
MRPL1
MRPL11
MRPL12
MRPL13
MRPL16
MRPL18
MRPL19
MRPL2
MRPL20
MRPL21
MRPL22
MRPL23
MRPL30
MRPL32
MRPL35
MRPL4
MRPL40
MRPL41
MRPL42
MRPL45
MRPL48
MRPL49
MRPL50
MRPL51 /// SPTLC1
MRPL55
MRPL9
MRPS12
MRPS14
MRPS17 /// ZNF713
MRPS18A
MRPS2
MRPS21
MRPS23
MRPS25
MRPS27
MRPS28
MRPS31
MRPS33
MRPS34
MRPS7
MRPS9
MSRB2
MSTO1
MTERFD1
Methionine adenosyltransferase II, beta
mitochondrial antiviral signaling protein
malonyl CoA:ACP acyltransferase (mitochondrial)
methylmalonyl CoA epimerase
myeloid cell leukemia sequence 1 (BCL2-related)
malic enzyme 3, NADP(+)-dependent, mitochondrial
mitochondrial trans-2-enoyl-CoA reductase
mitochondrial fission factor
mitochondrial intermediate peptidase
MLX interacting protein
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCO sulphurase C-terminal domain containing 1
mercaptopyruvate sulfurtransferase
MpV17 mitochondrial inner membrane protein
MPV17 mitochondrial membrane protein-like 2
mitochondrial ribosomal protein L1
mitochondrial ribosomal protein L11
Mitochondrial ribosomal protein L12
mitochondrial ribosomal protein L13
mitochondrial ribosomal protein L16
mitochondrial ribosomal protein L18
mitochondrial ribosomal protein L19
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L20
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L23
mitochondrial ribosomal protein L30
mitochondrial ribosomal protein L32
mitochondrial ribosomal protein L35
mitochondrial ribosomal protein L4
mitochondrial ribosomal protein L40
mitochondrial ribosomal protein L41
mitochondrial ribosomal protein L42
mitochondrial ribosomal protein L45
mitochondrial ribosomal protein L48
mitochondrial ribosomal protein L49
mitochondrial ribosomal protein L50
mitochondrial ribosomal protein L51 /// serine palmitoyltransferase, long chain base subunit 1
mitochondrial ribosomal protein L55
mitochondrial ribosomal protein L9
mitochondrial ribosomal protein S12
mitochondrial ribosomal protein S14
mitochondrial ribosomal protein S17 /// zinc finger protein 713
mitochondrial ribosomal protein S18A
mitochondrial ribosomal protein S2
mitochondrial ribosomal protein S21
mitochondrial ribosomal protein S23
mitochondrial ribosomal protein S25
mitochondrial ribosomal protein S27
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S31
mitochondrial ribosomal protein S33
mitochondrial ribosomal protein S34
mitochondrial ribosomal protein S7
mitochondrial ribosomal protein S9
methionine sulfoxide reductase B2
misato homolog 1 (Drosophila)
MTERF domain containing 1
20
MTERFD3
MTG1
MTHFD1L
MTIF2
MTOR
MTUS1
MUT
MUTYH
NCRNA00219
NDUFA1
NDUFA10
NDUFA11
NDUFA12
NDUFA13
NDUFA2
NDUFA3
NDUFA4
NDUFA6
NDUFA7
NDUFA8
NDUFA9
NDUFAB1
NDUFAF2
NDUFB3
NDUFB5
NDUFB7
NDUFB8
NDUFB9
NDUFC2
NDUFS5 /// RPL10
NDUFS7
NDUFV1
NDUFV3
NEFH
NFS1
NFU1
NIT2
NLRX1
NOP14
NR3C1
NRAS
NRD1
NT5DC3
NUDT13
NUDT19
NUDT6
NUDT9
OAT
OCIAD1
OGDH
OGG1
OMA1
OXA1L
OXR1
OXSM
P4HA1
PACS2
PARG
PARK7
MTERF domain containing 3
mitochondrial GTPase 1 homolog (S. cerevisiae)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
mitochondrial translational initiation factor 2
mechanistic target of rapamycin (serine/threonine kinase)
Microtubule associated tumor suppressor 1
methylmalonyl CoA mutase
mutY homolog (E. coli)
non-protein coding RNA 219
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NADH dehydrogenase (ubiquinone) Fe-S protein 5, (NADH-coenzyme Q reductase) /// ribosomal protein L10
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
neurofilament, heavy polypeptide
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
nitrilase family, member 2
NLR family member X1
NOP14 nucleolar protein homolog (yeast)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
neuroblastoma RAS viral (v-ras) oncogene homolog
nardilysin (N-arginine dibasic convertase)
5'-nucleotidase domain containing 3
nudix (nucleoside diphosphate linked moiety X)-type motif 13
nudix (nucleoside diphosphate linked moiety X)-type motif 19
nudix (nucleoside diphosphate linked moiety X)-type motif 6
nudix (nucleoside diphosphate linked moiety X)-type motif 9
ornithine aminotransferase
OCIA domain containing 1
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
8-oxoguanine DNA glycosylase
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
oxidase (cytochrome c) assembly 1-like
oxidation resistance 1
3-oxoacyl-ACP synthase, mitochondrial
prolyl 4-hydroxylase, alpha polypeptide I
phosphofurin acidic cluster sorting protein 2
poly (ADP-ribose) glycohydrolase
Parkinson disease (autosomal recessive, early onset) 7
21
PARL
PARS2
PCCB
PCK2
PDK1
PDSS2
PECI
PEMT
PERP
PET112L
PGAM5
PHYH
PHYHIPL
PICK1
PIGY
PINK1
PITRM1
PMPCA
PNKD
POLDIP2
POLG
POLG2
POLRMT
PON2
PPIF
PPOX
PPP1CA
PPP2CA
PPP3CB
PRDX1
PRDX2
PRDX5
PRKACA
PTGR2
PTRF
PTRH1
PTRH2
PTS
PUS1
PYCR1
QTRT1
QTRTD1
RAF1
RAI14
RARS2
RBFA
RDBP
RDH13
RG9MTD1
RNF5
RPL9
RPP21 /// TRIM39 ///
TRIM39R
RPS6KB1
RPUSD4
SAMM50
SARS
SCCPDH
SDHA
presenilin associated, rhomboid-like
prolyl-tRNA synthetase 2, mitochondrial (putative)
propionyl CoA carboxylase, beta polypeptide
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
pyruvate dehydrogenase kinase, isozyme 1
prenyl (decaprenyl) diphosphate synthase, subunit 2
peroxisomal D3,D2-enoyl-CoA isomerase
phosphatidylethanolamine N-methyltransferase
PERP, TP53 apoptosis effector
PET112-like (yeast)
phosphoglycerate mutase family member 5
phytanoyl-CoA 2-hydroxylase
phytanoyl-CoA 2-hydroxylase interacting protein-like
protein interacting with PRKCA 1
phosphatidylinositol glycan anchor biosynthesis, class Y
PTEN induced putative kinase 1
pitrilysin metallopeptidase 1
peptidase (mitochondrial processing) alpha
paroxysmal nonkinesigenic dyskinesia
polymerase (DNA-directed), delta interacting protein 2
polymerase (DNA directed), gamma
polymerase (DNA directed), gamma 2, accessory subunit
polymerase (RNA) mitochondrial (DNA directed)
paraoxonase 2
peptidylprolyl isomerase F
protoporphyrinogen oxidase
protein phosphatase 1, catalytic subunit, alpha isozyme
protein phosphatase 2, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, beta isozyme
peroxiredoxin 1
peroxiredoxin 2
peroxiredoxin 5
protein kinase, cAMP-dependent, catalytic, alpha
prostaglandin reductase 2
polymerase I and transcript release factor
Peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
peptidyl-tRNA hydrolase 2
6-pyruvoyltetrahydropterin synthase
pseudouridylate synthase 1
pyrroline-5-carboxylate reductase 1
queuine tRNA-ribosyltransferase 1
queuine tRNA-ribosyltransferase domain containing 1
v-raf-1 murine leukemia viral oncogene homolog 1
retinoic acid induced 14
arginyl-tRNA synthetase 2, mitochondrial
ribosome binding factor A
RD RNA binding protein
Retinol dehydrogenase 13 (all-trans/9-cis)
RNA (guanine-9-) methyltransferase domain containing 1
ring finger protein 5
ribosomal protein L9
ribonuclease P/MRP 21kDa subunit /// tripartite motif-containing 39 /// TRIM39-like protein
ribosomal protein S6 kinase, 70kDa, polypeptide 1
RNA pseudouridylate synthase domain containing 4
sorting and assembly machinery component 50 homolog (S. cerevisiae)
Seryl-tRNA synthetase
saccharopine dehydrogenase (putative)
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
22
SDHA /// SDHAP1 ///
SDHAP2
SDHAF1
SDHC
SDHD
SFXN1
SFXN2
SHC1
SIRT5
SLC1A3
SLC25A12
SLC25A14
SLC25A25
SLC25A26
SLC25A29
SLC25A3
SLC25A32
SLC25A36
SLC25A38
SLC25A39
SLC25A44
SLC25A6
SLC27A3
SLIT3
SLMO2
SNN
SOD1
STAR
STOML2
SUCLG1
SURF1
TATDN3
TBC1D15
TBRG4
THG1L
TIMM13
TIMM17A
TIMM22
TIMM23 /// TIMM23B
TIMM8A
TMEM126A
TMEM14B ///
TMEM14C
TMEM14C
TMEM160
TMEM223
TMTC1
TOMM22
TOMM34
TOMM70A
TP53
TRAP1
TRIT1
TRNT1
TXNDC12
TXNRD1
UQCC
UQCR10
UQCR11
succinate dehydrogenase complex, subunit A, flavoprotein (Fp) /// succinate dehydrogenase complex, subunit A,
flavoprotein pseudogene 1 /// succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
succinate dehydrogenase complex assembly factor 1
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit D, integral membrane protein
sideroflexin 1
sideroflexin 2
SHC (Src homology 2 domain containing) transforming protein 1
sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
solute carrier family 1 (glial high affinity glutamate transporter), member 3
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
solute carrier family 25 (mitochondrial carrier, brain), member 14
solute carrier family 25, member 25
solute carrier family 25, member 26
solute carrier family 25, member 29
solute carrier family 25, member 3
solute carrier family 25, member 32
Solute carrier family 25, member 36
solute carrier family 25, member 38
solute carrier family 25, member 39
solute carrier family 25, member 44
solute carrier family 25, member 6
solute carrier family 27 (fatty acid transporter), member 3
slit homolog 3 (Drosophila)
slowmo homolog 2 (Drosophila)
stannin
superoxide dismutase 1, soluble
steroidogenic acute regulatory protein
stomatin (EPB72)-like 2
succinate-CoA ligase, alpha subunit
surfeit 1
TatD DNase domain containing 3
TBC1 domain family, member 15
transforming growth factor beta regulator 4
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
translocase of inner mitochondrial membrane 13 homolog (yeast)
translocase of inner mitochondrial membrane 17 homolog A (yeast)
Translocase of inner mitochondrial membrane 22 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog (yeast) /// translocase of inner mitochondrial
membrane 23 homolog B (yeast)
translocase of inner mitochondrial membrane 8 homolog A (yeast)
transmembrane protein 126A
transmembrane protein 14B /// transmembrane protein 14C
transmembrane protein 14C
transmembrane protein 160
transmembrane protein 223
transmembrane and tetratricopeptide repeat containing 1
translocase of outer mitochondrial membrane 22 homolog (yeast)
translocase of outer mitochondrial membrane 34
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
tumor protein p53
TNF receptor-associated protein 1
tRNA isopentenyltransferase 1
tRNA nucleotidyl transferase, CCA-adding, 1
thioredoxin domain containing 12 (endoplasmic reticulum)
thioredoxin reductase 1
ubiquinol-cytochrome c reductase complex chaperone
ubiquinol-cytochrome c reductase, complex III subunit X
ubiquinol-cytochrome c reductase, complex III subunit XI
23
UQCRB
UQCRH
UQCRQ
USP30
VARS2
VHL
WARS2
WASF1
YME1L1
YWHAE
YWHAZ
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase hinge protein
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
ubiquitin specific peptidase 30
valyl-tRNA synthetase 2, mitochondrial (putative)
von Hippel-Lindau tumor suppressor
tryptophanyl tRNA synthetase 2, mitochondrial
WAS protein family, member 1
YME1-like 1 (S. cerevisiae)
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
24
118
119
Table S5. Genes induced in the lower airways of healthy controls, assigned to GO cluster
Mitochondrion.
Gene alias
Gene name/description
ABCB6
ACADVL
ACP6
ADH5
ADO
AIFM1
AK1
AKT2
ALDH18A1
ALKBH7
ARAF
ARSB
ASS1
ATP5C1
ATP5G3
ATP5H
ATP5I
ATP5J2
ATP5SL
ATP6V1A
AURKAIP1
BCL2L10
BCL2L2
BLOC1S1
BNIP3L
C10orf58
C12orf10
C12orf62
C14orf159
C15orf62
C17orf61
C18orf19
C1orf31
C22orf32
C2orf56
C9orf46
CA5B
CCDC142 /// MRPL53
CCDC58
CDS2 /// LOC149832
CHAF1B
CHCHD1
CHCHD2
CHCHD4
CIDEA
CISD3
CLPX
CLTC
COL4A3BP
COMTD1
COQ5
ATP-binding cassette, sub-family B (MDR/TAP), member 6
acyl-CoA dehydrogenase, very long chain
acid phosphatase 6, lysophosphatidic
alcohol dehydrogenase 5 (class III), chi polypeptide
2-aminoethanethiol (cysteamine) dioxygenase
apoptosis-inducing factor, mitochondrion-associated, 1
adenylate kinase 1
v-akt murine thymoma viral oncogene homolog 2
aldehyde dehydrogenase 18 family, member A1
AlkB, alkylation repair homolog 7 (E. coli)
v-raf murine sarcoma 3611 viral oncogene homolog
arylsulfatase B
argininosuccinate synthase 1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
ATP5S-like
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
aurora kinase A interacting protein 1
BCL2-like 10 (apoptosis facilitator)
BCL2-like 2
biogenesis of lysosomal organelles complex-1, subunit 1
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chromosome 10 open reading frame 58
chromosome 12 open reading frame 10
chromosome 12 open reading frame 62
chromosome 14 open reading frame 159
chromosome 15 open reading frame 62
chromosome 17 open reading frame 61
chromosome 18 open reading frame 19
chromosome 1 open reading frame 31
chromosome 22 open reading frame 32
chromosome 2 open reading frame 56
chromosome 9 open reading frame 46
carbonic anhydrase VB, mitochondrial
coiled-coil domain containing 142 /// mitochondrial ribosomal protein L53
coiled-coil domain containing 58
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chromatin assembly factor 1, subunit B (p60)
coiled-coil-helix-coiled-coil-helix domain containing 1
coiled-coil-helix-coiled-coil-helix domain containing 2
coiled-coil-helix-coiled-coil-helix domain containing 4
cell death-inducing DFFA-like effector a
CDGSH iron sulfur domain 3
ClpX caseinolytic peptidase X homolog (E. coli)
Clathrin, heavy chain (Hc)
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
catechol-O-methyltransferase domain containing 1
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
25
COQ9
COX10
COX15
COX16
COX4NB
COX5B
COX6B1
COX7C
CRAT
CROT
CXorf23
CYB5R1
CYB5R3
DDX28
DHODH
DHX29
DHX30
DLST
DNAJC15
DNAJC4
DPYSL2
DRG2
DYNLL1
EHHADH
ELAC2
ENDOG
ENO1
FAHD1
FASTK
FOXRED1
FTSJ2
FUNDC2
FXC1
FXN
GADD45GIP1
GATC
GATM
GHITM
GK /// GK3P
GK3P
GLUL
GLYCTK
GNPAT
GOT2
GRN
GRPEL1
GRPEL2
GSTZ1
GTF2H4
GTPBP5
GTPBP8
HEBP2
HEMK1
HK2
HSCB
HTRA2
ICT1
IDH1
IDH3B
coenzyme Q9 homolog (S. cerevisiae)
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
COX15 homolog, cytochrome c oxidase assembly protein (yeast)
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX4 neighbor
Cytochrome c oxidase subunit Vb
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
cytochrome c oxidase subunit VIIc
carnitine O-acetyltransferase
carnitine O-octanoyltransferase
chromosome X open reading frame 23
cytochrome b5 reductase 1
cytochrome b5 reductase 3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
dihydroorotate dehydrogenase
DEAH (Asp-Glu-Ala-His) box polypeptide 29
DEAH (Asp-Glu-Ala-His) box polypeptide 30
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DnaJ (Hsp40) homolog, subfamily C, member 15
DnaJ (Hsp40) homolog, subfamily C, member 4
dihydropyrimidinase-like 2
developmentally regulated GTP binding protein 2
dynein, light chain, LC8-type 1
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
elaC homolog 2 (E. coli)
endonuclease G
enolase 1, (alpha)
fumarylacetoacetate hydrolase domain containing 1
Fas-activated serine/threonine kinase
FAD-dependent oxidoreductase domain containing 1
FtsJ homolog 2 (E. coli)
FUN14 domain containing 2
fracture callus 1 homolog (rat)
frataxin
Growth arrest and DNA-damage-inducible, gamma interacting protein 1
Glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
Glycine amidinotransferase (L-arginine:glycine amidinotransferase)
growth hormone inducible transmembrane protein
glycerol kinase /// glycerol kinase 3 pseudogene
glycerol kinase 3 pseudogene
glutamate-ammonia ligase
glycerate kinase
glyceronephosphate O-acyltransferase
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
granulin
GrpE-like 1, mitochondrial (E. coli)
GrpE-like 2, mitochondrial (E. coli)
glutathione transferase zeta 1
general transcription factor IIH, polypeptide 4, 52kDa
GTP binding protein 5 (putative)
GTP-binding protein 8 (putative)
heme binding protein 2
HemK methyltransferase family member 1
hexokinase 2
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
HtrA serine peptidase 2
immature colon carcinoma transcript 1
Isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 3 (NAD+) beta
26
ISCA1
ISCA2
IVD
JMJD7
KIAA0141
KIF1B
KMO
LARS2
LETM1
LETMD1
LGALS3
LIMK2
LOC100510009 /// WBSCR16
LYRM2
MAVS
MCAT
MCL1
MECR
MMACHC
MRPL11
MRPL13
MRPL16
MRPL17
MRPL18
MRPL20
MRPL22
MRPL32
MRPL33
MRPL36
MRPL4
MRPL41
MRPL43
MRPL45
MRPL50
MRPL55
MRPL9
MRPS12
MRPS14
MRPS15
MRPS17 /// ZNF713
MRPS2
MRPS24
MRPS26
MRPS28
MRPS9
MSTO1 /// MSTO2P
MTFMT
MTG1
MTOR
MUT
NAGS
NDUFA1
NDUFA11
NDUFA12
NDUFA13
NDUFA3
NDUFA4
NDUFA8
NDUFAB1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
isovaleryl-CoA dehydrogenase
jumonji domain containing 7
KIAA0141
kinesin family member 1B
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
leucyl-tRNA synthetase 2, mitochondrial
leucine zipper-EF-hand containing transmembrane protein 1
LETM1 domain containing 1
lectin, galactoside-binding, soluble, 3
LIM domain kinase 2
Williams-Beuren syndrome chromosome region 16
LYR motif containing 2
mitochondrial antiviral signaling protein
malonyl CoA:ACP acyltransferase (mitochondrial)
myeloid cell leukemia sequence 1 (BCL2-related)
mitochondrial trans-2-enoyl-CoA reductase
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
mitochondrial ribosomal protein L11
mitochondrial ribosomal protein L13
mitochondrial ribosomal protein L16
mitochondrial ribosomal protein L17
mitochondrial ribosomal protein L18
mitochondrial ribosomal protein L20
mitochondrial ribosomal protein L22
mitochondrial ribosomal protein L32
mitochondrial ribosomal protein L33
mitochondrial ribosomal protein L36
mitochondrial ribosomal protein L4
mitochondrial ribosomal protein L41
mitochondrial ribosomal protein L43
mitochondrial ribosomal protein L45
mitochondrial ribosomal protein L50
Mitochondrial ribosomal protein L55
mitochondrial ribosomal protein L9
Mitochondrial ribosomal protein S12
mitochondrial ribosomal protein S14
mitochondrial ribosomal protein S15
mitochondrial ribosomal protein S17 /// zinc finger protein 713
mitochondrial ribosomal protein S2
mitochondrial ribosomal protein S24
mitochondrial ribosomal protein S26
mitochondrial ribosomal protein S28
mitochondrial ribosomal protein S9
misato homolog 1 (Drosophila) /// misato homolog 2 pseudogene
mitochondrial methionyl-tRNA formyltransferase
mitochondrial GTPase 1 homolog (S. cerevisiae)
Mechanistic target of rapamycin (serine/threonine kinase)
methylmalonyl CoA mutase
N-acetylglutamate synthase
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
27
NDUFB1
NDUFB3
NDUFB5
NDUFB7
NDUFB9
NDUFS5 /// RPL10
NDUFS6
NFS1
NLRX1
NR3C1
NRAS
NRD1
NT5C
OAT
OCIAD1
OXSM
P4HA1
PAM16
PANK2
PARG
PARL
PARS2
PCCA
PDK1
PDSS2
PECR
PET112L
PIN4
PMPCA
POLDIP2
PPP1CA
PPP1CC
PPP3CA
PROSC
PTRH1
PTRH2
PUS1
RAB11A
RAB3D
RAI14
RARS2
RBFA
RDBP
RDH13
RNASEL
RNF5
RPP21 /// TRIM39 ///
TRIM39R
SACS
SARDH
SARS2
SEC61A1
SFXN5
SH3BP5
SIVA1
SLC1A3
SLC25A13
SLC25A14
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) /// ribosomal
protein L10
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
NLR family member X1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
neuroblastoma RAS viral (v-ras) oncogene homolog
nardilysin (N-arginine dibasic convertase)
5', 3'-nucleotidase, cytosolic
ornithine aminotransferase
OCIA domain containing 1
3-oxoacyl-ACP synthase, mitochondrial
prolyl 4-hydroxylase, alpha polypeptide I
presequence translocase-associated motor 16 homolog
Pantothenate kinase 2
poly (ADP-ribose) glycohydrolase
presenilin associated, rhomboid-like
prolyl-tRNA synthetase 2, mitochondrial (putative)
Propionyl Coenzyme A carboxylase, alpha polypeptide
pyruvate dehydrogenase kinase, isozyme 1
prenyl (decaprenyl) diphosphate synthase, subunit 2
peroxisomal trans-2-enoyl-CoA reductase
PET112-like (yeast)
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
peptidase (mitochondrial processing) alpha
polymerase (DNA-directed), delta interacting protein 2
protein phosphatase 1, catalytic subunit, alpha isozyme
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
Proline synthetase co-transcribed homolog (bacterial)
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
peptidyl-tRNA hydrolase 2
pseudouridylate synthase 1
RAB11A, member RAS oncogene family
RAB3D, member RAS oncogene family
retinoic acid induced 14
arginyl-tRNA synthetase 2, mitochondrial
ribosome binding factor A
RD RNA binding protein
Retinol dehydrogenase 13 (all-trans/9-cis)
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
ring finger protein 5
ribonuclease P/MRP 21kDa subunit /// tripartite motif-containing 39 /// TRIM39-like protein
spastic ataxia of Charlevoix-Saguenay (sacsin)
Sarcosine dehydrogenase
seryl-tRNA synthetase 2, mitochondrial
Sec61 alpha 1 subunit (S. cerevisiae)
sideroflexin 5
SH3-domain binding protein 5 (BTK-associated)
SIVA1, apoptosis-inducing factor
solute carrier family 1 (glial high affinity glutamate transporter), member 3
Solute carrier family 25, member 13 (citrin)
solute carrier family 25 (mitochondrial carrier, brain), member 14
28
SLC25A25
SLC25A26
SLC25A29
SLC25A30
SLC25A32
SLC25A38
SLC25A44
SLC25A45
SLC27A1
SLC27A3
SLMO2
SND1
SOD1
SRGAP2
SSSCA1
STAR
SURF1
SYNJ2BP
TAOK3
TATDN3
TBC1D15
TBRG4
TDRKH
TIMM17A
TIMM23
TMEM126A
TMEM14B /// TMEM14C
TMEM14C
TMEM186
TMEM223
TOMM40
TXNIP
UQCR11
UQCRC2
UQCRFS1
WARS2
ZFHX3
solute carrier family 25, member 25
solute carrier family 25, member 26
Solute carrier family 25, member 29
solute carrier family 25, member 30
solute carrier family 25, member 32
solute carrier family 25, member 38
solute carrier family 25, member 44
solute carrier family 25, member 45
solute carrier family 27 (fatty acid transporter), member 1
solute carrier family 27 (fatty acid transporter), member 3
slowmo homolog 2 (Drosophila)
staphylococcal nuclease and tudor domain containing 1
superoxide dismutase 1, soluble
SLIT-ROBO Rho GTPase activating protein 2
Sjogren syndrome/scleroderma autoantigen 1
steroidogenic acute regulatory protein
surfeit 1
synaptojanin 2 binding protein
TAO kinase 3
TatD DNase domain containing 3
TBC1 domain family, member 15
transforming growth factor beta regulator 4
tudor and KH domain containing
translocase of inner mitochondrial membrane 17 homolog A (yeast)
translocase of inner mitochondrial membrane 23 homolog (yeast)
transmembrane protein 126A
transmembrane protein 14B /// transmembrane protein 14C
transmembrane protein 14C
transmembrane protein 186
transmembrane protein 223
translocase of outer mitochondrial membrane 40 homolog (yeast)
thioredoxin interacting protein
ubiquinol-cytochrome c reductase, complex III subunit XI
ubiquinol-cytochrome c reductase core protein II
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
tryptophanyl tRNA synthetase 2, mitochondrial
Zinc finger homeobox 3
29
120
121
Table S6. Genes induced in the lower airways of healthy controls and allergic rhinitis
patients, assigned to GO cluster Mitochondrion.
Gene alias
Gene name/description
AASS
ADCK2
AK3
AK4
ATP5J
ATP5L
BBOX1
BCAT1
BNIP3
C10orf2
C14orf156
C19orf70
C2orf47
C3orf1
C3orf78
C4orf14
C6orf203
C7orf55 /// LUC7L2
CCBL2
CCT7
CKB
CKMT1A /// CKMT1B
COX11
COX3
COX7A2L
CPS1
CS
CYCS
DARS2
DHRS1
DLAT
EFHD1
FIS1
GCAT
GCDH
GLRX2
HERC2
KARS
KRT4
LONP1
LYRM4
MARS2
MCCC2
METT11D1
METTL12
MMAA
MPST
MRPL12
MRPL2
MRPL21
MRPL35
aminoadipate-semialdehyde synthase
aarF domain containing kinase 2
adenylate kinase 3
adenylate kinase 4
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
branched chain amino-acid transaminase 1, cytosolic
BCL2/adenovirus E1B 19kDa interacting protein 3
chromosome 10 open reading frame 2
chromosome 14 open reading frame 156
chromosome 19 open reading frame 70
chromosome 2 open reading frame 47
chromosome 3 open reading frame 1
small integral membrane protein 4
chromosome 4 open reading frame 14
chromosome 6 open reading frame 203
chromosome 7 open reading frame 55 /// LUC7-like 2 (S. cerevisiae)
cysteine conjugate-beta lyase 2
chaperonin containing TCP1, subunit 7 (eta)
creatine kinase, brain
creatine kinase, mitochondrial 1A /// creatine kinase, mitochondrial 1B
COX11 cytochrome c oxidase assembly homolog (yeast)
mitochondrially encoded cytochrome c oxidase III
cytochrome c oxidase subunit VIIa polypeptide 2 like
carbamoyl-phosphate synthase 1, mitochondrial
citrate synthase
cytochrome c, somatic
aspartyl-tRNA synthetase 2, mitochondrial
dehydrogenase/reductase (SDR family) member 1
dihydrolipoamide S-acetyltransferase
EF-hand domain family, member D1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
glycine C-acetyltransferase
glutaryl-CoA dehydrogenase
glutaredoxin 2
hect domain and RLD 2
lysyl-tRNA synthetase
keratin 4
lon peptidase 1, mitochondrial
LYR motif containing 4
methionyl-tRNA synthetase 2, mitochondrial
Methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
methyltransferase like 17
methyltransferase like 12
methylmalonic aciduria (cobalamin deficiency) cblA type
mercaptopyruvate sulfurtransferase
mitochondrial ribosomal protein L12
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L35
30
MRPL42
MRPS16
MRPS23
MRPS25
MRPS33
MRPS34
MRPS35
MRPS7
MSTO1
MTERFD1
MTHFD2
MTPAP
NAPG
NDUFA9
NDUFB8
NDUFC1
NDUFS7
NDUFV3
NIPSNAP1
NIT2
NOP14
NR1D1 /// THRA
NUDT19
NUDT9
PITRM1
POLG2
PPOX
PRDX1
QTRTD1
RARS
REXO2
SFXN4
SLC22A4
SLC25A15
SLC25A19
SMCR7L
SUPV3L1
TFB1M
TFB2M
TIMM44
TK2
TMEM160
TMLHE
TOMM70A
TXNDC12
UQCRB
UQCRQ
VARS
YME1L1
YWHAE
mitochondrial ribosomal protein L42
mitochondrial ribosomal protein S16
mitochondrial ribosomal protein S23
mitochondrial ribosomal protein S25
mitochondrial ribosomal protein S33
mitochondrial ribosomal protein S34
mitochondrial ribosomal protein S35
mitochondrial ribosomal protein S7
misato homolog 1 (Drosophila)
MTERF domain containing 1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
mitochondrial poly(A) polymerase
N-ethylmaleimide-sensitive factor attachment protein, gamma
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
nipsnap homolog 1 (C. elegans)
nitrilase family, member 2
NOP14 nucleolar protein homolog (yeast)
nuclear receptor subfamily 1, group D, member 1 /// thyroid hormone receptor, alpha (erythroblastic
leukemia viral (v-erb-a) oncogene homolog, avian)
nudix (nucleoside diphosphate linked moiety X)-type motif 19
nudix (nucleoside diphosphate linked moiety X)-type motif 9
pitrilysin metallopeptidase 1
polymerase (DNA directed), gamma 2, accessory subunit
protoporphyrinogen oxidase
peroxiredoxin 1
queuine tRNA-ribosyltransferase domain containing 1
arginyl-tRNA synthetase
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
Sideroflexin 4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
solute carrier family 25 (mitochondrial carrier; ornithine transporter), member 15
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Smith-Magenis syndrome chromosome region, candidate 7-like
suppressor of var1, 3-like 1 (S. cerevisiae)
transcription factor B1, mitochondrial
transcription factor B2, mitochondrial
translocase of inner mitochondrial membrane 44 homolog (yeast)
thymidine kinase 2, mitochondrial
transmembrane protein 160
trimethyllysine hydroxylase, epsilon
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
thioredoxin domain containing 12 (endoplasmic reticulum)
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
valyl-tRNA synthetase
YME1-like 1 (S. cerevisiae)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
31
122
Figure legends
123
Figure S1. Correlation plot of real-time PCR data and microarray results. FCs were
124
logtranformed.