Download Supplementary table 5. Functions of genes connected to lncRNA

Supplementary table 5. Functions of genes connected to lncRNA-HEIH in
subnetwork
Gene
Description
References
symbol
CDC27
Component of the anaphase promoting complex/cyclosome
(APC/C), a cell cycle-regulated E3 ubiquitin ligase that
1
controls progression through mitosis and the G1 phase of
the cell cycle.
EDG3
Receptor for the lysosphingolipid sphingosine 1-phosphate.
When expressed in rat HTC4 hepatoma cells, is capable of
2
mediating S1P-induced cell proliferation and suppression of
apoptosis.
HAX1
Promotes cell survival
MVP
MVP tyrosyl phosphorylation by SHP-2 may play an
3
4
important role in cell survival signaling.
PSMC5
PSMC5 positively regulates p53-mediated transcription at
5
p21waf1 promoter.
RBM10
X-chromosome RBM genes play a formerly unknown role
in the regulation of programmed cell death (apoptosis) in
6
breast cancer
TBPL1
TBP (TATA-binding protein)-like protein (TLP) contributes
7
to the regulation of stress-mediated cell cycle checkpoint
and apoptotic pathways
UBE2E3
UBE2E3 is a major enzyme in modulating the balance
8
between cell proliferation and differentiation
DENR
Plays a role in the modulation of the translational profile of
a subset of cancer-related mRNAs when recruited to the
9
translational initiation complex by the oncogene MCTS1.
1.
Topper, L.M., et al. The dephosphorylated form of the anaphase-promoting
complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome
arms in mitosis. Cell Cycle 1, 282-292 (2002).
2.
An, S., Zheng, Y. & Bleu, T. Sphingosine 1-phosphate-induced cell
proliferation, survival, and related signaling events mediated by G
protein-coupled receptors Edg3 and Edg5. J Biol Chem 275, 288-296 (2000).
3.
Kang, Y.J., et al. Molecular interaction between HAX-1 and XIAP inhibits
apoptosis. Biochem Biophys Res Commun 393, 794-799 (2010).
4.
Kolli, S., Zito, C.I., Mossink, M.H., Wiemer, E.A. & Bennett, A.M. The major
vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and
scaffold protein in epidermal growth factor signaling. J Biol Chem 279,
29374-29385 (2004).
5.
Zhu, Q., et al. The ubiquitin-proteasome system regulates p53-mediated
transcription at p21waf1 promoter. Oncogene 26, 4199-4208 (2007).
6.
Martinez-Arribas, F., et al. Positive correlation between the expression of
X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic
Bax gene in human breast cancer. J Cell Biochem 97, 1275-1282 (2006).
7.
Suenaga, Y., et al. TATA-binding Protein (TBP)-like Protein Is Engaged in
Etoposide-induced Apoptosis through Transcriptional Activation of Human
TAp63 Gene. J Biol Chem 284, 35433-35440 (2009).
8.
Plafker, K.S., Farjo, K.M., Wiechmann, A.F. & Plafker, S.M. The human
ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal
pigment epithelial cells. Invest Ophthalmol Vis Sci 49, 5611-5618 (2008).
9.
Reinert, L.S., et al. MCT-1 protein interacts with the cap complex and
modulates messenger RNA translational profiles. Cancer Res 66, 8994-9001
(2006).