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Supplemental Digital Content 1: Classification of Low, Standard, and High Dose
Prescribing
Low Daily
Dose
Drug
Standard Daily
Dose
High Daily
Dose
ESTRADIOL
≤1.5mg
>1.5mg to ≤3mg
>3mg
ESTRADIOL ACETATE (0.45mg is
equivalent to 0.39 of estradiol)
≤1.5mg (as
estradiol)
>3mg (as
estradiol)
CONJUGATED ESTROGEN
≤0.45mg
ESTERIFIED ESTROGEN
≤0.45mg
>1.5mg to ≤3mg
(as estradiol)
>0.45mg to
≤0.9mg
>0.45mg to
≤0.9mg
ESTROPIPATE (0.75mg is
equivalent to 0.625mg of estrone
sulfate)
≤0.45mg (as
estrone
sulfate)
>0.45mg to
≤0.9mg (as
estrone sulfate)
>0.9mg (as
estrone
sulfate)
ETHINYL ESTRADIOL
≤3.75mcg
>3.75mcg to
≤22.5mcg
>22.5mcg
>0.9mg
>0.9mg
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