Download Resting heart rate does not provide significant prognostic

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Supplementary Table 2: Baseline characteristics of the study population (n=5388)
Characteristics
Value (*)
Age, mean (SD), years
Female, n
55.8 (13.8)
3,353 (62.2%)
Arterial Hypertension, n
1,848 (34.3%)
Systolic blood pressure, mean (SD), mmHg
Diastolic blood pressure, mean (SD), mmHg
Antihypertensive treatment, n
ACE inhibitor/AT receptor antagonist, n
Beta-blocker, n
Calcium channel blocker, n
Diuretics, n
131.5 (18.1)
80.1 (9.8)
1,621 (31.7%)
841 (16.4%)
1,039 (20.3%)
515 (10.1%)
641 (12.5%)
Diabetes mellitus, n
Fasting plasma glucose, mean (SD), mg/dl
Insulin treatment, n
Hyperlipidemia, n
Statins, n
other lipid lowering drugs, n
total cholesterol, mean (SD), mg/dl
HDL cholesterol, mean (SD), mg/dl
LDL cholesterol, mean (SD), mg/dl
Current smoker, n
Ex-smoker, n
Family history of CAD, n
662 (12.3%)
99.5 (33.0)
181 (3.5%)
1,498 (27.8%)
547 (10.7%)
149 (2.9%)
225.5 (42.0)
55.7 (18.5)
129.3 (33.2)
1,052 (21.2%)
1,209 (24.3%)
770 (14.8%)
Hip to waist ratio, mean (SD)
Body mass index, mean (SD), kg/m²
1.13 (0.13)
26.9 (4.9)
eGFR (ml/min/1,73 m2)
57.8 (10.9)
Biomarkers
Sensitive Troponin I (cTnI) ng/l
hsCRP, mean (SD), mg/l
NT-pro-BNP, mean (SD), ng/l
10 (330)
4.3 (7.0)
122.3 (307.5)
(*) = All percentages refer to number of subjects with existing data
Abbreviations: n = number; SD = standard deviation; CAD = coronary artery disease; hsCRP =
highsensitive C-reactive protein; NT-pro-BNP = N-terminal pro brain natriuretic peptide; cTnI =
sensitive Troponin I ; eGFR = estimated glomerular filtration rate (Cockroft/Gault; Nephron
1976;16(1):31-41)
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Supplementary Table 3 : Independent predictors of cTnI levels in the third tertile by multivariate regression model
univariate
Age ; mean (SD)
Male gender
Framingham – score predicted risk; %; mean
Arterial Hypertension
Systolic blood pressure; mmHg; mean
Diastolic blood pressure; mmHg; mean
Diabetes mellitus
Insulin dependent diabetes mellitus
HbA1c; % ; mean
Hyperlipidemia
LDL cholesterol; mg/dl; mean (SD)
Triglyceride; mg/dl; mean (SD)
Body mass index; kg/m2 ; mean (SD)
Current smoker
eGFR ; (ml/min/1,73 m2); mean (SD)
hsCRP, mean (SD), mg/l
NT-pro-BNP, mean (SD), ng/l
multivariate
OR (*)
95 % CI
p value
OR (*)
95 % CI
p value
2.96
2.31
1.88
3.52
1.68
1.16
3.03
2.64
1.46
1.65
1.07
1.14
1.30
0.71
0.69
1.09
2.72
2.54 - 3.46
1.84 - 2.89
1.68 - 2.10
2.80 - 4.42
1.51 - 1.87
1.04 - 1.28
2.31 - 3.96
1.62 - 4.33
1.35 - 1.59
1.31 - 2.09
0.95 - 1.19
1.05 - 1.25
1.18 - 1.43
0.52 - 0.97
0.60 , 0.79
0.99 , 1.20
2.06 , 3.59
<0.001
<0.001
<0.001
<0.001
<0.001
0.006
<0.001
<0.001
<0.001
<0.001
0.258
0.003
<0.001
0.030
<0.001
0.095
<0.001
1.59
2.93
1.21
1.72
0.98
0.88
0.98
1.22
1.14
1.02
0.98
1.02
1.20
1.16
0.78
1.02
1.75
1.15 , 2.22
1.87 , 4.61
0.91 , 1.60
1.18 , 2.52
0.77 , 1.24
0.73 , 1.07
0.56 , 1.75
0.55 , 2.71
0.97 , 1.33
0.72 , 1.46
0.82 , 1.17
0.90 , 1.16
1.02 , 1.41
0.74 , 1.81
0.64 , 0.95
0.87 , 1.18
1.38 , 2.22
0.006
<0.001
0.195
0.005
0.857
0.193
0.959
0.617
0.108
0.908
0.839
0.750
0.025
0.512
0.013
0.837
<0.001
Abbreviations: CI = Confidence interval; OR = Odds-Ratio; SD standard deviation ; cTnI = sensitive Troponin I ; eGFR = estimated glomerular filtration rate
(Cockroft/Gault; Nephron 1976;16(1):31-41); hsCRP = highsensitive C-reactive protein; NT-pro-BNP = N-terminal pro brain natriuretic peptide; (*) = reference group is
the group of participiants with cTnI concentrations under the detection level ; OR for increase of 1SD for metric cardiovascular risk factors
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Supplementary Table 4: Hazard Ratios for death by all causes and for major adverse cardiovascular events (MACE) according to cTnI
levels using study specific detection limit
Death by all causes
MACE
HR (95% CI)
p value
HR (95% CI)
p value
4.82 (3.45 - 6.74)
5.38 (3.69 , 7.86)
<0.001
<0.001
4.59 (3.16 , 6.66)
7.84 (5.02 , 12.25)
<0.001
<0.001
2.09 (1.46 , 2.98)
2.41 (1.59 , 3.64)
<0.001
<0.001
1.92 (1.23 , 2.98)
3.74 (2.29 , 6.10)
0.004
<0.001
3.50 (2.49 , 4.94)
3.77 (2.56 , 5.54)
<0.001
<0.001
3.22 (2.19 , 4.73)
4.86 (3.00 , 7.87)
<0.001
<0.001
1.94 (1.35 , 2.79)
2.22 (1.46 , 3.36)
<0.001
<0.001
1.78 (1.15 , 2.75)
3.38 (2.03 , 5.63)
0.009
<0.001
0.006
0.002
1.48 (0.96 , 2.29)
2.61 (1.56 , 4.36)
0.075
<0.001
crude
cTnI detecable (+)
cTnI > optimal cut-off value (*)
adjusted for age, gender and eGFR
cTnI detecable (+)
cTnI > optimal cut-off value (*)
adjusted for hs CRP and NT-pro-BNP (*)
cTnI detecable (+)
cTnI > optimal cut-off value (*)
adjusted for age,gender, eGFR and risk factors (**)
cTnI detecable (+)
cTnI > optimal cut-off value (*)
adjusted for age, gender,eGFR, hs CRP, NT-pro-BNP (*) and risk factors (**)
cTnI detecable (+)
cTnI > optimal cut-off value (*)
1.68 (1.16 , 2.43)
1.96 (1.29 , 2.99)
Abbreviations: CI = Confidence interval; HR = Hazard-Ratio; MACE = major adverse cardiovascular event; cTnI = sensitive Troponin I; hs CRP = high sensitive C-reactive protein; NT-pro-BNP = N-terminal probrain natriuretic peptide; ; eGFR = estimated glomerular filtration rate (Cockroft/Gault; Nephron 1976;16(1):31-41)
(+) cTnI over assay specific detection limit (> 6 ng/l)
(*) Over optimal DETECT-discriminatory cutoff value (=study-specific optimal cut-off derived from ROC analysis) : NT-pro-BNP: All-cause-death (> 85.85 ng/l); Major adverse cardiovascular event (> 121.9 ng/l); hs
CRP: All-cause-death (> 1.43 mg/l); Major adverse cardiovascular event (> 1.4 mg/l); cTnI : All-cause-death (> 11 ng/l); Major adverse cardiovascular event (> 17 ng/l)
(**) = Data were adjusted for the following variables: hypertension (binary); hyperlipidemia (binary); diabetes (binary), familial predisposition (binary); smoking status (binary) and body mass index (continuous)
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