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HUGO Gene Symbol SI SI p-value 2 28469173 0.038004 FOS-like antigen 2 Myosin, light chain 6, alkali, smooth muscle and non-muscle Associated GO Terms (biological End process) Bone mineralization Cellular component movement Cyclooxygenase pathway Negative regulation of cell proliferation Positive regulation of smooth muscle 184916179 contraction Cell death Positive regulation of fibroblast 28493683 proliferation 12 54838367 54841633 0.015369 Heat shock 27kDa protein 1 7 75769859 75771548 0.048248 BCL2-associated athanogene 0.034563 Aldehyde dehydrogenase 3 family, memberA1 MiDAS p-value PTGS2 1.576622545 2.50E-005 0.039326 FOSL2 1.238757143 8.35E-005 0.037087 MYL6 1.3451185 0.000185557 HSPB1 2.71975125 2.32E-006 BAG1 ALDH3A1 1.1834204 1.1590225 0.000587895 8.26E-005 Description Prostaglandinendoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Chromosome Start 1 184907592 9 17 33242469 19581889 33254744 19592338 Muscle contraction Anti-apoptosis Response to unfolded protein Response to heat Regulation of translational initiation Cellular component movement Anti-apoptosis Cell surface receptor linked signaling pathway Neuron differentiation Cellular aldehyde metabolic process Oxidation Associated GO Terms (biological function) Associated GO Terms (Cellular component) Oxidoreductase activity Metal Ion binding Transcription factor activity Nucleolus Calcium ion binding Protein binding Myosin complex Protein binding Intracellular Protein binding Receptor signaling protein activity Aldehyde dehydrogenase [NAD(P)+] activity Cytoplasm reduction DDX5 1.3968224 6.13E-005 0.03296 ODC1 3.004757333 8.16E-005 0.032597 SDC1 1.744767222 0.000264622 0.036034 1.1896005 0.000224683 0.040638 SLC2A1 CDKN1A ID1 1.0431505 1.309727667 2.99E-005 2.26E-005 DEAD (Asp-Glu-AlaAsp) box polypeptide 5 Ornithine decarboxylase 1 Syndecan 1 Solute carrier family 2 (facilitated glucose transporter), member 1 0.027685 Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.02344 Inhibitor of DNA binding 1, dominant negative helix-loophelix protein 17 59926202 59932869 2 10497992 10506053 2 20264041 20288675 1 20 36754465 36763086 29656753 29657974 Cell growth RNA splicing Positive regulation of cell proliferation Polyamine biosynthetic process Myoblast development Odontogenesis Response to cAMP Response to hydrogen peroxide Response to glucocorticoid stimulus Wound healing Carbohydrate transport Xenobiotic transport DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Positive regulation of anti-apoptosis Angiogenesis BMP signaling pathway Negative regulation of transcription factor activity ATP-dependent helicase activity Transcription cofactor activity RNA binding Nucleolus Protein binding Ornithine decarboxylase activity Cytoplasm Cytoskeletal protein binding Membrane Focal adhesion Membrane Protein kinase inhibitor activity D-glucose transmembrane transporter activity Kinase binding Protein binding Nucleus SAT1 1.301496 3.23E-006 0.022075 LDLR 1.718375923 1.14E-006 0.018594 H3F3B 1.230592 8.80E-005 0.036417 TPT1 1.817552 1.771112 0.000188175 0.000281651 0.033659 0.042088 Spermidine/spermine N1-acetyltransferase 1 Low density lipoprotein receptor (familial hypercholesterolemia) H3 histone, family 3B (H3.3B) Tumor protein, translationallycontrolled 1 -- RRAS2 BHLHB2/BHLHE40 1.540893 0.000683235 X 23711211 23714244 19 11061132 11105490 13 13 44809008 44809008 44813347 44813347 0.040374 Related RAS viral (rras) oncogene homolog 2 11 14256889 14337289 Basic helix-loop-helix domain containing, class B, 2//Class E basic helix-loophelix protein 40 3 4996208 5001861 9 74956495 74975129 1 180618292 180627573 1.1488258 4.97E-007 0.017024 ANXA1 2.802423357 0.000279926 0.033871 GLUL 1.099733667 0.000197287 0.043578 Annexin A1 Glutamate-ammonia ligase (glutamine synthetase) diamine Nacetyltransferase activity Protein binding Cytoplasm Calcium ion binding Cholesterol Protein binding transport VLDL receptor Endocytosis activity Nucleosome assembly DNA binding Anti-apoptosis Cellular calcium Tubulin complex ion homeostasis Protein binding -Ras protein signal transduction Positive regulation of GTP binding Protein binding cell migration Entrainment of circadian clock Negative regulation of transcription, DNAdependent Regulation of neuronal Transcription synaptic repressor activity plasticity Protein binding Anti-apoptosis Arachidonic acid secretion Cell surface receptor linked signaling pathway Inflammatory response Keratinocyte Calcium ion binding differentiation Protein binding Plasma menbrane Nucleus Cytoplasm Endoplasmic reticulum Nucleus Cytoplasm CTSL2 1.094167143 0.000440578 0.04337 JDP2 1.533066333 0.00041938 0.046136 MUC4 -2.381124 0.000230893 0.035633 1.38088175 0.000519414 0.047848 KIAA1754/ITPRIP RPS27A/UBC 2.516878 2.377699 9.01E-007 1.90E-007 0.01407 0.011957 Cathepsin L2 Jun dimerization protein 2 Mucin 4, cell surface associated Inositol 1,4,5triphosphate receptorinteracting protein Ubiquitin C Ubiquitin C 9 98834760 74968590 75006908 3 196959307 Cell-matrix 197023545 adhesion 10 106061884 106088152 12 12 123962147 123962147 1.477233333 4.37E-005 0.030974 NUAK family, SNF1like kinase, 2 1 203537816 WEE1 1.23448875 0.000218466 0.045119 WEE1 homolog (S. pombe) 11 9550916 SERTAD3 1.46086375 3.36E-005 0.030601 SERTA domain containing 3 19 45638591 0.014372 Methionine adenosyltransferase II, alpha 1.30806775 9.77E-007 Proteolysis Negative regulation of transcription from RNA polymerase II promoter Regulation of transcription, DNA-dependent 14 NUAK2 MAT2A 98841413 2 85619799 Anti-apoptosis Positive regulation of transcription Protein 123965360 ubiquitination 123965360 -Regulation of apoptosis Actin cytoskeleton 203557506 organization Cell cycle Protein amino acid 9567874 phosphorylation Negative regulation of cell 45642122 growth Circadian rhythm one-carbon metabolic process Response to 85625912 light stimulus Peptidase activity Cysteine-type endopeptidase activity Protein binding Lysosome Protein heterodimerization activity Transcription repressor activity Extracellular matrix constituent Lubricant activity Protein binding ErbB-2 class receptor binding Nucleus Proteinaceous extracellular matrix Integral to plasma membrane Plasma membrane Transcription regulator activity Protein binding Nucleoplasm ATP-binding Protein serine/threonine kinase activity ATP-binding Protein serine/threonine kinase activity Nucleoplasm Transcription activator activity Nucleus ATP-binding Methionine adenosyltransferase activity EFNA1 1.3046575 4.66E-006 0.023577 Ephrin-A1 1 153366560 OVOL1 1.1783914 3.77E-005 0.03375 Ovo-like 1(Drosophila) 11 65311105 ACTG1 TACSTD2 1.80342575 0.000218673 0.040402 Actin, gamma 1 Tumor-associated calcium signal transducer 2 1 58813683 Insulin induced gene 1 7 154720476 Prothymosin, alpha 2 232281480 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1 205561488 1.48619 7.17E-005 0.03347 INSIG1 1.3886544 7.39E-005 PTMA 1.412009 4.21E-005 0.03263 3.20E002 CD55 2.563824875 2.02E-005 0.018917 17 77091594 Activation of MAPK activity Angiogenesis Regulation of 153373956 axonogenesis Epidermis development Regulation of 65321259 transcription Cellular component movement Response to 77094422 calcium ion Cell proliferation Cell surface receptor linked signaling 58816033 pathway Cell proliferation Cholesterol metabolic process Visual 154732877 perception 232286492 Transcription Complement activation, classical pathway Innate immune 205600934 response Receptor binding Ephrin receptor binding Anchored to membrane Extracellular region DNA binding Zinc ion binding Nucleus ATP-binding Structural constituent of cytoskeleton Actin cytoskeleton Receptor activity Integral to plasma membrane Protein binding Integral to membrane Nucleus Membrane raft