Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Table S1
Document related concepts
no text concepts found
Transcript
Supplemental Table S1. Reaction Stoichiometry of Model Adipocyte Network NO. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 PATHWAY Glycolysis Glycolysis Glycolysis Glycolysis Glycolysis STOICHIOMETRY Glucose + ATP = Glucose 6-P + ADP Glucose 6-P = Fructose 6-P Fructose 6-P + ATP = Glyceraldehyde 3-P + Glycerone-P + ADP Glycerone-P = Glyceraldehyde 3-P Glyceraldehyde 3-P + NAD+ + ADP + Pi = P-Enolpyruvate + ATP + H2O P-Enolpyruvate + ADP + H+ = Pyruvate + ATP Pyruvate + NADH + H+ = Lactate + NAD+ Glucose 6-P + 2 NADP+ + H2O = Ribulose 5-P + CO2 + 2 NADPH + 2 H+ 3 Ribulose 5-P = 2 Fructose 6-P + Glyceraldehyde 3-P Glycolysis Glycolysis Pentose phosphate pathway Pentose phosphate pathway TCA cycle (mitochondria) Pyruvate + Oxaloacetate + NAD+ + H2O = Citrate + CO2 + NADH + H+ TCA cycle (mitochondria) Pyruvate + HCO3- + ATP = Oxaloacetate + ADP + Pi TCA cycle (mitochondria) Citrate + NAD+ = 2-Oxoglutarate + CO2 + NADH + H+ TCA cycle (mitochondria) 2-Oxoglutarate + NAD+ + CoA = Succinyl-CoA + CO2 + NADH TCA cycle (mitochondria) Succinyl-CoA + FAD + Pi + ADP = Fumarate + FADH2 + ATP + CoA TCA cycle (mitochondria) Fumarate + H2O = Malate TCA cycle (mitochondria) Malate + NAD+ = Oxaloacetate + NADH + H+ TCA cycle Citrate + CoA + ATP = Acetyl-CoA + Oxaloacetate + ADP + Pi TCA cycle Oxaloacetate + NADH + H+ = Malate + NAD+ TCA cycle Malate + NADP+ = Pyruvate + CO2 + NADPH TCA cycle Citrate + NADP+ = 2-Oxoglutarate + CO2 + NADPH + H+ TCA cycle Oxaloacetate + ATP = P-Enolpyruvate + CO2 + ADP Oxidative phosphorylation NADH + 0.5 O2 + 3 ADP + 3 Pi + 4 H+ = NAD+ + 3 ATP + 4 H2O Oxidative phosphorylation FADH2 + 0.5 O2 + 2 ADP + 2 Pi + 3 H+ = FAD + 2 ATP + 3 H2O Palmitate biosynthesis 8 Acetyl-CoA + 14 NADPH + 7 ATP + 7 HCO3- + 14 H+ = Palmitate + 14 NADP+ + 8 CoA + 7 ADP + 7 Pi + 7 CO2 + 6 H2O Tripalmitoylglycerol Tripalmitoylglycerol = Tripalmitoylglycerol accumulation Tripalmitoylglycerol Glycerone-P + 3 Palmitate + NADH + 3 ATP + H2O + H+ = biosynthesis Tripalmitoylglycerol + NAD+ + Pi + 3 AMP + 3 PPi Tripalmitoylglycerol Tripalmitoylglycerol + 3 H2O = Glycerol + 3 Palmitate biosynthesis Metabolism of ketone 2 Acetyl-CoA = Acetoacetate + 2 CoA bodies Metabolism of ketone Acetoacetyl-CoA = Acetoacetate + CoA bodies Metabolism of ketone Acetoacetate + NADH = 3-Hydroxybutyrate bodies Amino acid metabolism Pyruvate + NH4+ + NADPH = Alanine Amino acid metabolism Aspartate + NH4+ = Asparagine Amino acid metabolism Aspartate = Oxaloacetate + NH4+ + NADH Amino acid metabolism Cysteine = Pyruvate + NH4+ + NADH Amino acid metabolism Glutamate = 2-Oxoglutarate + NH4+ + NADH Amino acid metabolism Glutamate + NH4+ + ATP = Glutamine Amino acid metabolism Serine + THF = Glycine Amino acid metabolism Histidine + THF = Glutamate + NH4+ Amino acid metabolism Isoleucine + 2 CoA = Succinyl-CoA + Acetyl-CoA + NH4+ + FADH2 NO. PATHWAY 40 Amino acid metabolism 41 42 43 Amino acid metabolism Amino acid metabolism Amino acid metabolism 44 45 46 47 48 Amino acid metabolism Amino acid metabolism Amino acid metabolism Amino acid metabolism Amino acid metabolism 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 Amino acid metabolism Amino acid metabolism Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Plasma exchange Mitochondrial exchange Mitochondrial exchange Mitochondrial exchange Mitochondrial exchange STOICHIOMETRY + 2 NADH Leucine + CoA + CO2 + ATP = Acetoacetate + Acetyl-CoA + NH4+ + FADH2 + 2 NADH Lysine = 2-Oxoadipate + 2 NH4+ + 3 NADH 2-Oxoadipate + CoA = Acetoacetyl-CoA + 2 CO2 + FADH2 + 2 NADH Methionine + Serine + ATP + CoA + THF = Succinyl-CoA + Cysteine + NH4+ + NADH Phenylalanine + O2 + NADH = Tyrosine Glutamate + ATP + 2 NADPH = Proline Serine = Pyruvate + NH4+ Threonine + CoA = Glycine + Acetyl-CoA + NADH Tryptophan + 3 O2 + NADPH = 2-Oxoadipate + Alanine + CO2 + NH4+ Tyrosine + 2 O2 = Acetoacetate + Fumarate + CO2 + NH4+ + NADH Valine + CoA = Succinyl-CoA + CO2 + 4 NADH + FADH2 + NH4+ Palmitate = Palmitate Acetoacetate = Acetoacetate Alanine = Alanine Aspartate = Aspartate Cysteine = Cysteine Glutamate = Glutamate Glycine = Glycine Serine = Serine Tyrosine = Tyrosine O2 = O2 CO2 = CO2 NH4+ = NH4+ Pyruvate = Pyruvate Citrate + Malate = Citrate + Malate 2-Oxoglutarate + Malate = 2-Oxoglutarate + Malate Malate + Pi = Malate + Pi
Related documents