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Unit 10: Evolution
Section 4: Genes and Variation
How Common is Genetic Variation?
Many genes have at least two forms, or alleles. All organisms have genetic variation
that is “invisible” because it involves small differences in biochemical processes. An
individual organism is heterozygous for many genes.
Darwin recognized that such variation among individuals as the raw material of
evolution.
Variation and Gene Pools
Genetic variation is studied in populations. A population is a group of individuals of
the same species that interbreed.
A gene pool consists of all genes, including all the different alleles, that are present in
a population.
Relative Frequency
The relative frequency of an allele is the number of times the allele occurs in a gene
pool, compared with the number of times other alleles for the same gene occur.
Relative frequency is often expressed as a percentage.
The Hardy-Weinburg Principle
The Hardy-Weinburg principle states that allele frequencies in a population will
remain constant unless one or more factors cause those frequencies to change.
The situation in which allele frequencies remain the same is called genetic
equilibrium. However, if allele frequencies do not change, evolution will not occur.
Five conditions are required to maintain genetic equilibrium:
1. Random mating
2. Population must be very large
3. No immigration or emigration (moving in or out)
4. No mutations
5. No natural selection
Based on these requirements, it is clear that genetic equilibrium is very rare.
How is Evolution Defined in Genetic Terms?
In genetic terms, evolution is any change in the relative frequency of alleles in a
population. The two main sources of genetic variation are mutations and the genetic
shuffling that results from sexual reproduction.
Unit 10, Section 4, Page 15
Mutations
A mutation is any change in a sequence of DNA.
 Mutations occur because of mistakes in DNA replication or as a result of
radiation or chemicals in the environment.
 Mutations do not always affect an organism’s phenotype.
Genetic Shuffling
Most heritable differences are due to gene shuffling.
 Crossing-over increases the number of genotypes that can appear in offspring.
 Sexual reproduction produces different phenotypes, but it does not change the
relative frequency of alleles in a population.
What determines the numbers of phenotypes for a given trait?
The number of phenotypes produced for a given trait depends on how many genes
control the trait.
Single-gene Trait
A single-gene trait is controlled by one gene that
has two alleles. Variation in this gene leads to
only two possible phenotypes.
Example: The allele for a widow’s peak is
dominant over the allele for a hairline with no
peak. However, the presence of a widow’s peak
may be less common in a population.
In real populations, phenotypic ratios are determined by the frequency of alleles as
well as by whether the alleles are dominant or recessive.
Natural Selection
Natural selection affects which individuals survive and reproduce and which do not.
 If an individual dies without reproducing, it does not contribute its alleles to
the population’s gene pool.
 If an individual produces many offspring, its alleles stay in the gene pool and
may increase in frequency.
Evolution is a change over time in the relative frequencies of alleles in a population.
Populations, not individual organisms, can evolve over time.
Unit 10, Section 4, Page 16
How does natural selection affect single-gene traits?
Natural selection on single-gene traits can lead to changes in allele frequencies and
thus to evolution.
Organisms of one color may produce fewer offspring than organisms of other colors.
A lizard population is normally brown, but has mutations that produce red and black
forms.
 Red lizards are more visible to predators, so they will be less likely to survive
and reproduce, Therefore, the allele for red color will become rare.
 Black lizards may warm up faster on cold days. This may give them energy to
avoid predators. In turn, they may produce more offspring. The allele for black
color will increase in relative frequency.
Polygenic Trait
Many traits are controlled by two or more genes and are
called polygenic traits. One polygenic trait can have
many possible genotypes and phenotypes.
Height in humans is a polygenic trait.
A bell-shaped curve is typical of polygenic traits. A bellshaped curve is also called normal distribution.
Section 4 Vocabulary
Gene Pool
Relative Frequency
Unit 10, Section 4, Page 17
Genetic Equilibrium
Hardy-Weinburg Principle