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Simpsons Genetic Probability Worksheet There are six Punnett square problems featured below. You will be graded on both filling in the Punnett square as well as filling in the correct answer next to the multiple choice questions after each problem. Problem One: Typical Punnett Square Problem Milhouse is extremely worried that because his dad is bald he will also be bald. To relieve his fear, he has asked you to use your Punnett square skills to determine what the probability of him being bald will be. Milhouse is aware that his dad is heterozygous for baldness (Bb) while his mom does not carry the baldness gene and so she is homozygous for no baldness (bb). Remember baldness is dominant (B) while no baldness is recessive (b). ___________ 1. What is the probability that Milhouse will be bald? a. 0% b. 25% c. 50% d. 75% Problem Two: Incomplete Dominance Homer has decided he wants to go into the dog breeding business and wants to use Santa’s Little Helper. Santa’s Little Helper is heterozygous light brown (BB’), a combination of dark brown (B) and white (B’). Homer wants to get puppies that are dark brown, light brown and white and has two choices of dogs he can mate with Santa’s Little Helper: Penelope, who is also light brown (BB’) or Samantha, who is white (B’B’). Create Punnett Squares for each dog to help Homer figure out the answer. Penelope 2. Samantha Which dog would be best to mate with Santa’s Little Helper to get the most different colored puppies? a. Penelope b. Samantha c. Neither one d. Either one (same odds) Problem Three: Codominance Itchy and Scratchy created two brand new breeds of flowers: one lime green (GG) and one bright orange (OO). Green is codominant with orange. Itchy and Scratchy know that because of codominance, if they cross these two plants, the flowers should be both green and orange. If they cross these two plants, how many will be both green and orange if they grow ten plants? Itchy & Scratchy __________3. How many out of 10 will be orange and green? a. 0 b. 5 c. 7 d. 10 Problem Four: Multiple Alleles Mr. Burns is in desperate need of a blood transfusion but unfortunately has the rare blood type OO and needs a donor that is also OO. He offers a reward to anyone who could help him (enter Homer). Homer knows unfortunately that his blood type is heterozygous type A (AO) and that Marge is heterozygous type B (BO). What is the probability that one of the Simpson’s children will have the blood type to match Mr. Burns? __________ 4. What is the likelihood that one of the Simpson children has the OO blood type? a. 0 % b. 25 % c. 50% d. 75% Problem Five: Sex-linked Traits Dr. Hibbert is treating a young Springfield couple who are having a child. The parents are worried that since the mom is a carrier for the disorder of color blindness (XXc ), which is linked only to the female sex chromosome Xc , that the child will have color blindness as well. The father does not have color blindness (XY) which is the dominant gene. What are the odds that the child will NOT have color blindness? X = no color blindness (dominant) Xc = color blindness (recessive) _____________5. What are the odds that their child will not be color blind? a. 0% b. 25 % c. 50% d. 75% Problem Six: Dihybrid Cross Chief Wiggum and his wife are talking about having another child, giving Ralph another brother or sister. What are the chances that Ralph’s sibling will have blue hair like their parents as well as straight hair like Ralph? The following are the genotypes of the parents B=Blue, b=black, C=Curly, c=straight. Chief Wiggum: Heterozygous curly = Cc Ralph’s mom: Heterozygous curly = Cc Heterozygous Blue Hair = Bb Heterozygous Blue Hair = Bb The cross would be ________________ X ____________________ The Punnett square and the offspring would be: _______________ 6. How many out of 16 will have blue hair and straight hair? a. 3 b. 6 c. 9 d. 16 B Simpson’s Genetic Probability—Answer Key Problem One: Typical Punnett Square, Milhouse 1. What is the probability that Milhouse will be bald? Answer: C. 50 % a. 0% b. 25 c. 50% d. 75% b b Bb bb b Bb bb Problem Two: Incomplete Dominance 1. Which dog would be best to mate with Santa’s Little Helper to get the most different colored puppies? a. Penelope b. Samantha c. Neither one d. Either one Answer: a. Penelope B’ B’ B B’ Penelope Samantha 1 dark brown B B BB’ BB’ BB BB’ 2 light brown 2 light brown 2 white 1 white B’ B’ B’B’ B’B’ BB’ B’B’ Problem Three: Codominance 2. How many of 10 flowers will be orange and green? Answer: d. 10 a. 0 b. 5 c. 7 d. 10 (All are GO or green and orange) G G O GO GO O GO GO Problem Four: Multiple Alleles A B O O AB BO AO OO 4. What is the likelihood that one of the Simpson children has a OO blood type? a. 0% b. 25% c. 50% d. 75% Answer: B. 25 % is the likelihood that one child will have type OO blood X Problem Five: Sex-linked Traits What are the odds that the Springfield couple will have a child that will not be colorblind? a. 0 b.25% c. 50% d. 75% Answer: D. 75% Problem Six: Dihybrid Cross The Punnett square and the cross would be: CcBb x CcBb CB Cb C= Curly cB CCBB CCBb CcBB Curly Blue Curly Blue Curly Blue CCBb CCbb CcBb Cb Curly Blue Curly black Curly Blue CcBB CcBb ccBB cB Curly Blue Curly Blue straight Blue CcBb Ccbb ccBb cb Curly Blue Curly black straight Blue How many out of 16 will have blue, straight hair? a. 3 b. 6 c. 9 CB X Y c= straight Xc XX XcX XY Xc Y B= Blue b= black cb CcBb Curly Blue Ccbb Curly black ccBb straight Blue ccbb straight black d. 16 Answer: a. 3