Download Chapter 12 - M. de Jesus

BIOL V04 Lec: Cell Cycle & Cell Division (Ch 12)
© copyright 2015 Marta D. de Jesus
I. Overview: Cells are born, age, reproduce and die
A. cell cycle
B. cell division
C. functions of cell division
II. Prokaryotic cell reproduction
binary fission
III. Eukaryotic chromosome structure
A. chromatin
B. relaxed
C. single copy
D. double copies
E. condensation
F. How many chromosomes do cells have?
IV. Eukaryotic cell cycle
A. Interphase
1. G1
2. S
3. G2
V. Eukaryotic cell division
A. 2 processes:
1. mitosis
2. cytokinesis
B. Mitosis:
1. requires a spindle apparatus
a. centrosome
centrioles
b. 3 kinds of microtubules
1) aster fibrils
2) kinetochore microtubules
3) nonkinetochore or polar microtubules
2. occurs in 4 phases
start in Interphase
b. Prophase
c. Metaphase
d. Anaphase
e. Telophase
f. end result
C. Cytokinesis
actual mechanism
a. in animal cells
b. in land plant cells & certain green algae
VI. Control of cell cycle and cell division
A. signals from inside the cell
1. cyclin-dependent kinases
2. cyclins
3. How does it work (human example)?
4. other examples
a. G1 checkpoint
b. M checkpoint
C. signals from outside the cell
1. growth factors, eg: platelet-derived growth factor (PDGF)
2. density-dependent inhibition
3. anchorage dependence
D. Cancer
1. benign vs. malignant
metastasis