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Biochem 423 SI with Curtis
Study Guide Week 1
These questions are not “exam” level questions. My goal with them is to encourage
active reading of the Lecture Notes (e-book). Read the lecture notes and answer these as
you go along or use them for review. They can serve as your notes on the text. Use them
as you like but understand they were made to help you focus on the reading outside of SI
and should be done alongside the lecture questions and formative exams.
Water
1. What is a colligative property and what does it depend on?
2. Describe isotonic, hypotonic, and hypertonic. When does osmosis come into
play?
3. Does water have a relatively high or low heat capacity? Why is this important for
life?
4. Draw the structure of water (or ice)
Noncovalent Interactions
1. Why are NI important? (hint: think of enzyme function)
2. Describe electrostatic interactions. What happens in water?
3. Describe van der Waals forces. What is created?
4. Describe hydrophobic interactions. How does water “freeze?” What promotes
them?
5. What are amphipathic molecules?
Determining pH and other Problems
Important Equations
 pH+ pOH = 14
 pH = pka + log([A-]/[HA])
 [HA] + [A-] = Molarity
1. Find the pH of 20 mM of H2SO4. What is the pOH?
2. What is the hydrogen ion concentration that corresponds to a pH of 2.52?
3. What is the hydrogen ion concentration in a solution with pOH of 12.3?
4. The pH of a 2x10-2 M acetic acid (pKa=4.7) solution is 3.19. What is the
concentration of the acetate anion in that solution?
Buffers
1. What is the buffer in blood?
Titration activity to be performed in session.
Bio Molecules
1. Draw the formation of peptide and glycoside bonds.
2. Name and draw an important reaction of hydroxyl groups?
3. Draw an important reaction cystein groups?
4. Define amphoteric and zwitterions.
5. Define aldose and ketose and epimer.
6. What is the fancy name for the glucose ring formation?
7. What are 3 major functions of carbs?
8. Draw a base, nucleoside, and nucleotide.
9. Name the 3 purines and pyrimidines. Which have larger rings?
10. What are the 2 main types of lipids?
11. Draw a fatty acid, triglyceride, phospholipids, and cholesterol.
15. What are the 3 major functions of lipids?
16. How many carbons are in an ecosinoid?
17. Name two commonalities between sphingolipids and P-lipids?
18. List 3 other functions of Nucleic acids other than DNA and RNA roles.
Notes from SI Session