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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA. ANNEXURE II PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION 1 Name of the Candidate and Address SMRUTI SANGAMNERKAR SRINIVAS COLLEGE OF PHYSIOTHERAPY, PANDESHWARA, MANGALORE-575001 2 Name of the Institute SRINIVAS COLLEGE OF PHYSIOTHERAPY, MANGALORE. 3 Course of Study and Subject MASTER OF PHYSIOTHERAPY (MPT) 2 YEARS DEGREE COURSE. “NEUROLOGICAL AND PSYCHOSOMATIC DISORDERS”. 4 Date of Admission 25/5/2011. To Course 5 Title of the Topic “EFFECT OF COORDINATION EXERCISES AND STRENGTH TRAINING IN IMPROVING COGNITION IN ELDERLY POPULATION- A RANDOMIZED CONTROL TRIAL.” 1 6 Brief resume of the intended work: 6.1 Need for the study: Aging involves gradual progressive and spontaneous deterioration of most physiological functions.1Many studies on the process of aging have revealed decline in numerous sensory and motor functions in elderly1.The aging process is accompanied by deterioration of cognitive functions such as memory,attention, reaction time, and speed of informationprocessing.2 Exercise has multiple positive effects in older adults.3 Physical exercise is associated with decreased risk of dementia and Alzheimer disease.4 Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons. 5 Regular exercise that focuses on functional fitness, such as walking, has been associated with significant reductions in the levels of dependence and disability in older adults. 6,7 The relationship among physical fitness levels, specifically aerobic fitness, cognition, and physical health in older adults, is well established.8,9 Physical improve, or exercise atleast and resistance maintain health, training may physical and psychological well-being and cognitive functioning in elderly people. The benefits consistently shown improvement of for of physical objective cardiorespiratory 2 exercise health have measures fitness, been e.g. favourable physiological changes such as lower serum cholesterol concentrations and increase in bone density.10 Cognition refers to all mental process, by which the sensory inputs are transformed, reduced, elaborated, stored, recovered and used, and this covers memory, attention, reasoning, creativity and problem solving.11 Poor cognitive function is a predictor of mortality at all ages and as such can be seen as a marker of general health status.12 Subjective complaints about cognitive capacity increase with age and an objective decline in cognitive performance accelerates around the age of 50.13 There is also empirical support for exercise improving physical fitness,behavior,cognition,14,15 communication, and functioning in older people with cognitive impairments.16 The benefits for older people who regularly participate in endurance, balance and resistance training programmes are vast. Such health benefits include improved muscle mass, arterial compliance, energy metabolism, cardiovascular fitness, muscle strength, overall functional capacity, and the maintenance or even enhancement of cognitive function.17 Coordination or coordinated movement is the ability to execute smooth, accurate, controlled motor response.18 Coordinated movements are characterized by appropriate speed, distance, direction, timing and muscular tension.In addition, they involve appropriate synergistic influences, easy reversal between opposing muscle groups, and proximal fixation to allow distal motion or maintanance of posture.19 Exercise has been shown to possitively affect cognitive 3 performance. Henning Budde, Claudia Voelcker- Rehage did a study to know the effect of coordination exercises on cognition, in which 115 healthy adolescents were included in the study. The results of the study revealed that Coordination exercises improve cognition which could be because of enhanced neuronal connection between the cerebellum and the frontal cortex.20 No study has been done to measure the effectiveness of coordination exercises and strength training in cognition improvement. This study is an attempt to know whether Coordination exercises and Strength training will improve the cognition of elderly individuals who have impaired cognition. 6.2 Review of literature : 1.T Seng CN, Gau BS (2011) did a study on the effectiveness on improving cognitive function in older people and concluded that an exercise regimen of 6 weeks and at least 3 times per week for 60 minutes had a positive effect on cognition24. 2.Timothy CY, Kwok (2011) did a prospective study on the effectiveness of coordination exercises in improving cognition in older adults.The findings demonstrate that low physical level exercise is beneficial for cognitive function and helps maintain the physical mobility of the elderly21. 3.Claudia VR, Ben G(2011) did a study on how 4 Cardiovascular and Coordination Training Differentially Improve Cognitive Performance and Neural Processing in Older Adults which quotes that besides cardiovascular training also other types of physical activity improve cognition of older adults25. 4.Anderson H C, Nimon JP (2010) did a study on Cognitive health benefits of strengthening exercise for communitydwelling older adults.They concluded that there are possitive effects of strength training on cognition26. 5.Patricia H, Beatriz C.A(2004) did a study on the effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis, from which he concluded that exercise training increases fitness, physical function, cognitive function, and possitive behavior in people with dementia and related cognitive impairments27. 6.Pasquauna PC, Walter J, Perrig(1998) conducted the study on the effects of resistance training on well-being and memory in elderly volunteers concluding that resistance training lessens the anxiety and self-attentivenes and improves muscle strength and they found possitive corelation between cognition and physical fitness10. 7.Molloy DW, Beerschoten (1988) did a study on acute effects of exercise on neuropsychological function in elderly subjects. He concluded that elderly patients who have taken 5 part in exercise programs have shown improvement in mental function14. 8.John WJ (1977) BioPsychoSocial Assessment Tools for the Elderly - Assessment Summary Sheet. In Cognitive Capacity Screening Exam, the Pearson correlation was 0.92 (kappa 0.62). Had a sensitivity of 84% and a specificity of 94% using a cutting-point of 19 or 2023. 9.Marshal M, Molloy(1975) reported inter-rater reliability of 0.69 and 0.78. In a sample of 15 neurological inpatients, inter-rater reliability gave a Pearson correlation of 0.95 and a Kendall coefficient of 0.63. The concurrent validity of 0.78 with the WAIS Verbal IQ scale and 0.66 with the WAIS Performance scale22. 6.3 Objectives of the study To know the effect of co-ordination exercises in improving cognition in elderly population. To know the effect of strength training in improving cognition in elderly population. To compare the effectiveness of strength training and co-ordination exercises in improving cognition in elderly population. 6 6.4 Hypothesis: ExperimentalHypothesis: 1.coordination exercises will be effective in improving cognition. 2.Strength training will be effective in improving cognition. 3.There will be significant difference beween effect of strength training and co-ordination exercises on cognition improvement. Null Hypothesis: 1.Co-ordination exercises will not be effective in improving cognition. 2.Strength training will not be effective in improving cognition. 3.There will be no significant difference beween effect of strength training and co-ordination exercises on cognition improvement. 7 Materials and Method: 7.1 Source of data: The participants who are willing to participate in the study and meeting the selection criteria will be included from the society and old age homes in karnataka. 7 7.2 Method of collection of data: Sample size: 15 patients will be included in each group. Study duration : The study would be conducted for 8 weeks. The intervention will be given on 2nd, 4th, 6th and 8th week. The treatment session would last for 40 minutes, twice a week. Sampling: Purposive sampling. Procedure: The participants who meet the inclusion criteria will be randomly allocated to following groups to receive intervention. There would be three groups, i.e, one experimental group which would receive coordination exercises, the second experimental group would receive strength training. And the control group would receive the combination of coordination exercises and strength training. Outcome measures : Mini Mental State Examination (MMSE)22 Mini mental state examination designed to give a practical clinical assessment of change in cognitive status in geriatric inpatients .It covers the person's orientation to time and place, recall ability, short-term memory, and arithmetic ability.It may 8 be used as a screening test for cognitive loss or as a brief bedside cognitive assessment.It includes components like orientation, registration, attention and calculation, recall and language. The scoring is done according to performance. For each correct answer 1 mark and for wrong answer 0 mark will be given. The maximum score of MMSE is 30. Interpretation: Higher score shows good cognition of subjects. The cutoff score for MMSE is 23. Time: Time to complete the test will be 10-15 minutes. Cognitive capacity screening exam23 It includes components like, judgment, mental speed, and sustained effort. The scoring is done according to the performance. For every correct answer score the question as 1. The maximum score will be 30. If the score is less than 20, diminished cognitive capacity is suspected. Materials to be used: MMSE- Pen, pencil, watch, recording sheet. CCSE- pen, pencil, recording sheet. Inclusion Criteria Sixty years and above elderly people who can ambulate with and without walking aids. 9 Both males and females will be included. Participants should able to understand the commands properly.MMSE- less than 24. Exclusion Criteria Neurological disorder leading to balance impairment. Musculoskeletal disorders. Uncontrolled hypertension. Severe ankle edema. Limb length discrepancy. Statistical analysis: Study design: A RANDOMIZED CONTROL TRIAL. The participants who meet the inclusion criteria will be randomly allocated to 3 groups to receive intervention. 1.experimental group-strengh training 2.experimental group-coordination exercises 3.control group- coordination exercises and strength training. TEST: 1. Repeated measures ANOVA- will be used to find out signifanct difference among three treatment group.in which participants will be randomly allocated. 7.3 Does the study require 10 any investigations or interventions to be conducted on patients or other humans or animals? If so please describe briefly. YES. This study will assess cognition by using MMSE and CCSE in elderly population. 7.4 Has ethical clearance been obtained from your institution in case of 7.3? YES. Consent has been taken from the Institute’s ethical committee. 8 List of references: 1.Anne Shumway Cook, Marjorie H Woollacott. Normal postural control. Anne Shumway Cook. Motor Control Theory and Practical Applications. 2nd edition. Pennsylvania, Lippincott Williams and Wilkins, 2001;164-6. 2.Van boxtel Mental Health and Physical Activity 2008; 62–68. 3.Kleyman P.Toward healthy aging 2010: meeting the national agenda. Aging Today 2002;23(5):7-10. 4.Yonas E. Geda, Rosebud O. Roberts. Physical Exercise, Aging, and Mild Cognitive Impairment A Population-Based Study. Arch Neurol. 2010;67(1):80-6. 5. Laurin D. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58(3):49804. 6.Singh MA. Exercise comes 11 of age: rationale and recommendations for a geriatric exercise prescription. J Gerontol A Biol Med Sci. 2002;57:262-82. 7.Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women:women who walk. Arch Intern Med. 2001;161:1703-8 8.Powell RR. Effects of exercise on mental functioning. J Sports Med. 1975;15:125-31 9.Spirduso W. Physical dimensions of aging. Champaign: HumanKinetics.1995. 10.Pasquauna perrig-chiello, walter j, Perrig. The effect of resistance training on well being and memory in elderly volunteers.1998; 27: 469-75. 11.Neisser, Uric. Cognitive Psychology. Grolier Multimedia Encylopedia. 2009. 12.Archana Singh-Manoux, PhD, Melvyn Hillsdon Effects of Physical Activity on Cognitive Functioningin Middle Age: Evidence From the Whitehall II Prospective Cohort Study 2005;95:2252-8. 13.Angevaren M, Aufdemkampe G, Verhaar HJJ Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment 2008:(2). 14.Molloy DW, Richardson LD, Crilly RG. The effects of a threemonth exercise program on neuropsychological function in elderly institutionalized women: a randomized controlled trial. Age Ageing 1988;17:303-10. 15.McMurdo ME, Rennie L. A controlled trial of exercise by residents of old people’s home. Age Ageing 1993;22:11-5. 12 16.Brill PA, Probst JC, Greenhouse DL, Schell B, Macera CA.Clinical feasibility of free-weight strength training program for older adults. J Am Board Fam Pract 1998;11:445-51. 17.Colcombe. Fitness effects on the cognitive function of older adults: a meta-analytic study. 2003;14(2):125-30. 18.Susan O Sullivan. Physical rehabilitation. Thomas J. Schmitz. Coordination assessment. (4):157. 19.Ghez C , Gordon J .voluntary movement. In Kandel ER. Essentials of neuroscience and behaviour.Appleton and Lange. Norwalk CT.1995;529. 20.Henning Budde, Claudia Voelcker-Rehage, Acute coordinative exercise improves attentional performance in adolescents 2008;441: 219-23. 21.Timothy CY, Kwok.Effectiveness of coordination exercise in improving cognitive function in older adults: a prospective study 2011;6:261–67. 22.Mini Mental State Examination http://lifemanagement.com/nextsteps/Mini_Mental_Status_E xam.pdf. 23.Cognitive capacity screening exam file:///H:/CCSE.html 24.T Seng CN, Gau BS Lou MF. The effectiveness of exercise on improving cognitive function in older people: a systematic review. J Nurs Res 2011; 19(2):119-31. 25. Claudia Staudinger. Voelcker-Rehage, Ben Cardiovascular and Godde and Coordination Ursula Training Differentially Improve Cognitive Performance and Neural Processing in Older Adults. Front Hum Neurosci. 2011; 5: 26. 26. Anderson-Hanley C, Nimon JP, Westen SC 2010. Cognitive 13 health benefits of strengthening exercise for community dwelling older adult. j Clin Exp Neuropsychol. 2010 Nov;32(9):996-1001. 27. Patricia Heyn, Beatriz C. Abreu, Kenneth J. Ottenbacher. The Effects of Exercise Training on Elderly Persons With Cognitive Impairment and Dementia: A Meta-Analysis. Arch Phys Med Rehabil. 2004;85. 14 9 Signature of the Candidate 10 Remarks of the Guide 11 Name & Designation of: 11.1 Guide DR. S.BALASUBRAMANIAM Associate Professor in Physiotherapy. 11.2 Signature 11.3 Co-Guide (If Any) DR. SAHANA S Assisstant professor Physiotherapy. in 11.4 Signature DR. T.JOSELEY SUNDERRAJ PANDIAN Associate Professor in Physiotherapy and P.G. Coordinator. 11.5 Head of the Department 11.6 Signature 12 12.1 Remarks of Chairman and Principal 12.2 Signature 15 DR. RAMPRASAD M. Principal and Professor in Physiotherapy. Accepted by scientific and ethical committee reviewers.