MADIT-I and MADIT-II
... ICD. This study was reviewed by the Food and Drug Administration (FDA) in 1996, and the ICD was quickly approved for a MADIT-I indication. Because of the small sample size of the study and the limited number on mortality events, only a few secondary substudies were possible. One important secondary ...
... ICD. This study was reviewed by the Food and Drug Administration (FDA) in 1996, and the ICD was quickly approved for a MADIT-I indication. Because of the small sample size of the study and the limited number on mortality events, only a few secondary substudies were possible. One important secondary ...
Janus face of thrombospondin-4 - American Journal of Physiology
... pressure (2, 3, 5, 19). The authors went on to speculate that induction of endoplasmic reticulum (ER) stress via activation of transcription facto 6␣ (Atf6␣) by intracellular actions of TSP-4 could potentially impair the endothelium-dependent vasodilation. Although the authors previously observed in ...
... pressure (2, 3, 5, 19). The authors went on to speculate that induction of endoplasmic reticulum (ER) stress via activation of transcription facto 6␣ (Atf6␣) by intracellular actions of TSP-4 could potentially impair the endothelium-dependent vasodilation. Although the authors previously observed in ...
Preventing cardiovascular disease among Canadians: Is the
... cardiovascular risk factors among Canadians. Moreover, it provides reasonable estimates of baseline blood pressure and lipid measures among Canadians before treatment. The data for men and women between 40 and 74 years of age visiting the clinic were analyzed. Survey participants who reported having ...
... cardiovascular risk factors among Canadians. Moreover, it provides reasonable estimates of baseline blood pressure and lipid measures among Canadians before treatment. The data for men and women between 40 and 74 years of age visiting the clinic were analyzed. Survey participants who reported having ...
Myocardial tissue engineering - Oxford Academic
... have been explored, including bone marrow,4 skeletal muscle5 and embryonic stem cells (ESCs).6 Table 1 summarizes the cell sources explored for cell transplantation, which have been extensively reviewed elsewhere.7 – 9 In general, all cell sources explored have had mixed results. No candidate cell h ...
... have been explored, including bone marrow,4 skeletal muscle5 and embryonic stem cells (ESCs).6 Table 1 summarizes the cell sources explored for cell transplantation, which have been extensively reviewed elsewhere.7 – 9 In general, all cell sources explored have had mixed results. No candidate cell h ...
Cardiac patients undergoing non
... In patients with one or more cardiac risk factors a preoperative baseline ECG is recommended to monitor changes during the perioperative period. Statin therapy and a titrated low dose beta-blocker regimen are recommended prior to surgery. In patients with systolic LV dysfunction ACE-inhibitors are r ...
... In patients with one or more cardiac risk factors a preoperative baseline ECG is recommended to monitor changes during the perioperative period. Statin therapy and a titrated low dose beta-blocker regimen are recommended prior to surgery. In patients with systolic LV dysfunction ACE-inhibitors are r ...
Indications and Technique for Permanent Cardiac Pacemaker
... ventricular rate of 30 to 40 beats/min is controlled by a slow, relatively unstable idioventricular pacemaker that may be affected by electrolyte changes, hypoxia, or acidosis. 8 . 9 ...
... ventricular rate of 30 to 40 beats/min is controlled by a slow, relatively unstable idioventricular pacemaker that may be affected by electrolyte changes, hypoxia, or acidosis. 8 . 9 ...
VT IN NORMAL AND ABNORMAL HEARTS
... • VT incorporating both bundle branches into the reentry circuit • usually in an acquired heart disease and significant conduction system impairment • Reentry within HPS in humans was first documented by Akhtar et al 1974 • sustained bundle branch reentry can not be induced in patients with normal ...
... • VT incorporating both bundle branches into the reentry circuit • usually in an acquired heart disease and significant conduction system impairment • Reentry within HPS in humans was first documented by Akhtar et al 1974 • sustained bundle branch reentry can not be induced in patients with normal ...
FOCUS ON: ATRIAL FIBRILLATION
... atrial fibrillation “Atrial fibrillation is the most common arrhythmia in clinical practice, accounting for approximately one-third of hospitalizations for cardiac rhythm disturbances.”1 As with other chronic conditions, atrial fibrillation and other arrhythmias must be assessed, documented and accu ...
... atrial fibrillation “Atrial fibrillation is the most common arrhythmia in clinical practice, accounting for approximately one-third of hospitalizations for cardiac rhythm disturbances.”1 As with other chronic conditions, atrial fibrillation and other arrhythmias must be assessed, documented and accu ...
Valvular Heart Disease(HVD)
... disorders of CT diseases Marfan syndrome (fibrillin-1 mutation), where there is intrinsic defect of CT either in its Synthesis or Remodeling. ...
... disorders of CT diseases Marfan syndrome (fibrillin-1 mutation), where there is intrinsic defect of CT either in its Synthesis or Remodeling. ...
Cardiovascular System
... An ischemic stroke is occasionally treated in a hospital with thrombolysis (also known as a "clot buster"), and some hemorrhagic strokes benefit from neurosurgery. Treatment to recover any lost function is termed stroke rehabilitation, ideally in a stroke unit and involving health professions such a ...
... An ischemic stroke is occasionally treated in a hospital with thrombolysis (also known as a "clot buster"), and some hemorrhagic strokes benefit from neurosurgery. Treatment to recover any lost function is termed stroke rehabilitation, ideally in a stroke unit and involving health professions such a ...
Cardiohepatic Syndrome: Liver Injury in Decompensated Heart Failure
... Heart failure (HF) is a major healthcare concern [1, 2]. Indeed, 2 % of the population in Western countries are affected by HF, and this prevalence increases from 1 % at 40 years of age to 10 % among the population over 70 years [3]. The burden of prevalent HF will increase due to an aging society, ...
... Heart failure (HF) is a major healthcare concern [1, 2]. Indeed, 2 % of the population in Western countries are affected by HF, and this prevalence increases from 1 % at 40 years of age to 10 % among the population over 70 years [3]. The burden of prevalent HF will increase due to an aging society, ...
The thick left ventricular wall of the giraffe heart normalises wall
... system. The experimental site was located at approximately 1200 m above sea level, and therefore we corrected for the actual barometric pressure. The rebreathing technique provides a reliable measure of effective pulmonary blood flow (Gabrielsen et al., 2002), but could underestimate systemic cardia ...
... system. The experimental site was located at approximately 1200 m above sea level, and therefore we corrected for the actual barometric pressure. The rebreathing technique provides a reliable measure of effective pulmonary blood flow (Gabrielsen et al., 2002), but could underestimate systemic cardia ...
Understanding Peripheral Arterial Disease and the Drug
... called plaque, inside your arteries. Another name for this condition is atherosclerosis, or hardening of the arteries. The plaque deposits can cause your arteries to stiffen and become narrowed or blocked, limiting the supply of oxygen-rich blood throughout your body (see Figure 2). This can cause d ...
... called plaque, inside your arteries. Another name for this condition is atherosclerosis, or hardening of the arteries. The plaque deposits can cause your arteries to stiffen and become narrowed or blocked, limiting the supply of oxygen-rich blood throughout your body (see Figure 2). This can cause d ...
ACC/AHA Guideline
... 1. ACE inhibitor in patients with CAD* or other vascular disease. (Level of Evidence: B) *Significant CAD by angiography or previous myocardial infarction. The results of the Heart Outcomes Prevention Evaluation (HOPE) trial now confirm that use of the ACE inhibitor ramipril (10 mg/d) reduced the in ...
... 1. ACE inhibitor in patients with CAD* or other vascular disease. (Level of Evidence: B) *Significant CAD by angiography or previous myocardial infarction. The results of the Heart Outcomes Prevention Evaluation (HOPE) trial now confirm that use of the ACE inhibitor ramipril (10 mg/d) reduced the in ...
Atrial fibrillation - Heart Rhythm Alliance
... will still beat irregularly and possibly rapidly. This may contribute to symptoms of palpitations, shortness of breath, chest discomfort, light headedness, fainting or fatigue. The goal of treatment in AF is to restore the heart’s normal rhythm and if this is not possible then to slow the irregular ...
... will still beat irregularly and possibly rapidly. This may contribute to symptoms of palpitations, shortness of breath, chest discomfort, light headedness, fainting or fatigue. The goal of treatment in AF is to restore the heart’s normal rhythm and if this is not possible then to slow the irregular ...
Periodic Paralysis and Oxygen
... Some people who have Periodic Paralysis may need oxygen therapy. I am one of them. I first noticed a breathing problem during total paralytic episodes. I was unable to move in any way, speak, or open my eyes. I had tachycardia and palpitations of my heart and I was having difficulty breathing. It wo ...
... Some people who have Periodic Paralysis may need oxygen therapy. I am one of them. I first noticed a breathing problem during total paralytic episodes. I was unable to move in any way, speak, or open my eyes. I had tachycardia and palpitations of my heart and I was having difficulty breathing. It wo ...
Figure Legends for Movies
... retinoic acid. Real-time recording shows how the tube has still not undergone normal heart looping where the ventricle is shifted to the right side of the embryo. The heart tube is shown from a frontal view of the embryo. Movie 16: Wide Atrium with heart looping at 3 days post-fertilization in an em ...
... retinoic acid. Real-time recording shows how the tube has still not undergone normal heart looping where the ventricle is shifted to the right side of the embryo. The heart tube is shown from a frontal view of the embryo. Movie 16: Wide Atrium with heart looping at 3 days post-fertilization in an em ...
Left Ventricular Assist Device as a Bridge to Recovery
... With this in mind, overall recovery rates remain low in the majority of large scale studies which have investigated LVAD use over the past 15 years. This impresses upon us the importance of patient selection to maximize the odds of recovery. Several studies have found a few unifying factors associat ...
... With this in mind, overall recovery rates remain low in the majority of large scale studies which have investigated LVAD use over the past 15 years. This impresses upon us the importance of patient selection to maximize the odds of recovery. Several studies have found a few unifying factors associat ...
Situs inversus totalis with congenitally corrected transposition of the
... Echocardiography (Echo) showed a situs inversus totalis with meso- or dextrocardia of the heart. There was a side-by-side position of the great thoracic vessels with suspected atrio-ventricular discordance and ventriculararterial discordance. We detected an L-transposition or congenitally corrected ...
... Echocardiography (Echo) showed a situs inversus totalis with meso- or dextrocardia of the heart. There was a side-by-side position of the great thoracic vessels with suspected atrio-ventricular discordance and ventriculararterial discordance. We detected an L-transposition or congenitally corrected ...
Normal Fetal Circulation and Cardiovascular Adaptations at Birth
... – Wall thickness and mass increases ...
... – Wall thickness and mass increases ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.