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PEEP and cardiac output
PEEP and cardiac output

... However, as first suggested by Scharf et al. [29] and later demonstrated in experimental studies [30, 31], PEEP also increases MCP, thus preserving the gradient for venous return. Recently, Jellinek et al. [32], were able to confirm that positive airway pressure increased RAP and MCP equally in pati ...
Different Immersion Temperatures` Impact Upon Blood Pressure of
Different Immersion Temperatures` Impact Upon Blood Pressure of

... In our study, older women had a significantly different SBP response from baseline to cool water than the YF and YM. It may be the responsiveness of the aging heart to temperature changes makes it more difficult to regulate heart rate, heart muscle contraction, and blood flow to the skin and viscera ...
LIVING WELL WITH HEART FAILURE
LIVING WELL WITH HEART FAILURE

... control the direction of blood flow through the heart. When valves are damaged they may not open or close properly. Valves may become stiff (stenotic) or they may fail to close completely (insufficient) which can cause a back flow of blood (regurgitation). Either way, blood flow through the heart is ...
Impact of Longitudinal Myocardial Deformation on the Prognosis of
Impact of Longitudinal Myocardial Deformation on the Prognosis of

... of strain over strain rate may also be related to a les allowing an easier e assessment of peak value. The use of longitudinal global strain er straa by speckle tracking in assessing LV contractility should be encouraged in clinical practicee for its good s sing reproducibility and ability to strati ...
Evolution of Paroxysmal Atrial Fibrillation to Persistent or Permanent
Evolution of Paroxysmal Atrial Fibrillation to Persistent or Permanent

... variables and were considered as present when echocardiographic findings reported moderate to severe dysfunction (Grade 2 and grade 3 of diastolic dysfunction and moderate to severe mitral and aortic valve disease). Cardiomyopathy was defined as present if any patient had a documented diagnosis of i ...
Cardiotoxicity in cancer patients treated with 5
Cardiotoxicity in cancer patients treated with 5

... mitomycin, etoposide, interferon, paclitaxel, methotrexate, vincristine, peptichemio (a peptide complex of m-L-phenylalanine mustard), gemcitabine and irinotecan. Various dosing regimens for both 5-FU and co-administered drugs were used. Capecitabine was administered in doses of 1000–2500 mg/m2/day ...
SYMPOSIUM ON CONGESTIVE HEART FAILURE
SYMPOSIUM ON CONGESTIVE HEART FAILURE

... in cases of congestive heart failure. In general, right (aand indirectly determiiied left) ventricular diastolic pressure falls (reducing coligYestioii) while eardiae o-utput rises and the heart rate (inconstantly) slows. There is, however, no tinaiiiinity amoiig the various observers about the orde ...
Delayed Presentation of Ventricular Septal Rupture – A Case Report Case Reports
Delayed Presentation of Ventricular Septal Rupture – A Case Report Case Reports

... occlusion of the infarct- related artery.3,6,11 In our patient it was total occlusion of the RCA and LAD & LCX were normal. In the GUSTO-I study, total occlusion of the infarct-related artery was documented in 57 percent of patients with ventricular septal rupture, as compared with 18 percent of tho ...
Left main bronchus compression due to main pulmonary artery
Left main bronchus compression due to main pulmonary artery

... sion 11 years earlier. On diagnosis, she had a pulmonary arterial systolic pressure of 98 mmHg, diastolic pressure of 40 mmHg, mean pulmonary artery pressure of 67 mmHg, pulmonary capillary wedge pressure of 8 mmHg, mean right atrial pressure of 10 mmHg, cardiac index of 1.92 L/min/m2, and pulmonary ...
Case Report Contained Left Ventricular Free Wall Rupture
Case Report Contained Left Ventricular Free Wall Rupture

... (MI) and accounts for approximately 20% of mortality of these patients [1, 2]. Premortem diagnosis of rupture is made in approximately 15% of in-hospital deaths from acute MI in a coronary care unit [3]. However, one series of autopsies claims that up to 31% of MI fatalities had cardiac rupture. Hen ...
Torsade de pointes: the clinical considerations
Torsade de pointes: the clinical considerations

... min. In the out-of-hospital setting, treatment of torsade de pointes with percutaneous overdrive pacing has been found as an effective bridge before the definitive therapy is available [46]. Isoproterenol and atropine have been used to increase the sinus rate and decrease the QT interval, and both o ...
Screening for Cardiovascular Disease and Risk Factors
Screening for Cardiovascular Disease and Risk Factors

... reduction therapy to the level of risk ...
Pulmonary circulation
Pulmonary circulation

... pressure and diastolic pressure? ANSWER: Systolic pressure is the result of the contraction of the ventricles increasing the pressure in the arteries. Diastolic pressure is the result of the relaxation of the ventricles lowering the pressure in the ...
Numerical simulation of blood flow in venous networks
Numerical simulation of blood flow in venous networks

... The three layers of the vascular wall, from the lumen outward, are the tunica intima, tunica media and tunica adventitia. The intima is the innermost coat. It consists of three elements: a single layer of squamous epithelial cells, the endothelium; the basal lamina of the endothelial cells; the sube ...
Cardiovascular β-adrenergic signaling Maturation and programming effects of hypoxia in a
Cardiovascular β-adrenergic signaling Maturation and programming effects of hypoxia in a

... desensitization/downregulation mechanisms. Hypoxia quite commonly occurs in utero and it is well known that prenatal insults, like malnutrition or hypoxia, are coupled to an increased risk of developing adult cardiovascular disease. This is referred to as developmental programming and constitutes an ...
Infectious Endocarditis: Diagnosis and Treatment
Infectious Endocarditis: Diagnosis and Treatment

... Infectious endocarditis results from bacterial or fungal infection of the endocardial surface of the heart and is associated with significant morbidity and mortality. Risk factors include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a re ...
Management of atrial fibrillation in patients with heart failure
Management of atrial fibrillation in patients with heart failure

... largely be explained by an increased risk for progressive heart failure death. In the VALIANT trial, both current and prior AF were associated with an increased risk of death and major cardiovascular events during 3 years following an acute myocardial infarction [plus left ventricular (LV) systolic ...
Calibrated integrated backscatter and
Calibrated integrated backscatter and

... (table 4), log soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and log soluble RAGE (sRAGE) were associated with increased cIB (figure 2), but not with capillary length density (data not shown). None of the plasma angiogenesis-related biomarkers evaluated (table 4) were correlated wi ...
Drug induced QT prolongation: the measurement and assessment of
Drug induced QT prolongation: the measurement and assessment of

... diurnal variation in the QT interval which makes it important to consider time of day in the assessment of the QT interval [15]. The most common pathological conditions associated with QT prolongation are electrolyte disturbance, including hypocalcaemia [19, 20], hypokalaemia [20–23] and hypomagnesa ...
Thermal Therapy Improves Left Ventricular Diastolic Function in
Thermal Therapy Improves Left Ventricular Diastolic Function in

... 8.1±3.9 before sauna, suggesting that LV filling pressure was not elevated in our patients before sauna. E/E’decreased significantly 30 min after sauna compared to before sauna, suggesting that LV filling pressure decreased significantly 30 min after sauna. Mitral flow peak velocity before sauna was ...
effects of norepinephrine on human pulmonary - Heart
effects of norepinephrine on human pulmonary - Heart

... animals (Carlill and Duke, 1956; Borst et al., 1956; Piiper, 1957) and has also been confirmed in man by observations of the reverse phenomenon, i.e. an increase in pulmonary vascular resistance following the fall of left atrial pressure, immediately after surgical splitting of a stenotic mitral val ...
Ch26_Disorders of Cardiac Fxn - University of Perpetual Help
Ch26_Disorders of Cardiac Fxn - University of Perpetual Help

... ST-segment elevations and PR-segment depression, but unlike myocardial infarction, the T waves are not inverted.5 Treatment depends on the cause. When infection is present, antibiotics specific for the causative agent usually are prescribed. Antiinflammatory drugs such as aspirin and nonsteroidal anti ...
Diagnosis of Acute Myocardial Infarction
Diagnosis of Acute Myocardial Infarction

... ejection fraction; and any associated abnormality (Table 2). Echo also helps in ruling out other causes of chest pain like aortic dissection, pericarditis and acute cor pulmonale associated with pulmonary embolism. Patients with hypertrophic cardiomyopathy and aortic stenosis can also present with c ...
Acquired Heart Diseases - Akademija nauka i umjetnosti Bosne i
Acquired Heart Diseases - Akademija nauka i umjetnosti Bosne i

... - Digoxin – not in acute phase, and only in stable patients. First 20-30 mcg/kg divided into three doses, then 8-10 mcg/kg divided into two doses. Some centres no longer use digoxin as an inotropic drug in children; - Diuretics (furosemide 1-2mg/kg/dose, spironolactone 1-3mg/kg/day); - Control of ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Acute myocardial infarction is one of the most common diagnosis in hospitalized patients in the industrialized countries, which is a serious complication of atherosclerotic coronary heart disease. In most patients (80-95%) it results from thrombotic occlusion of the related vessel resulting in infar ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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