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Heart Failure with Mid-Range Ejection Fraction – a New Category of
Heart Failure with Mid-Range Ejection Fraction – a New Category of

... Patients with HF and a LVEF of 40-55% had increased LV diastolic stiffness, similar to those with LVEF ≥55%, but had significant abnormalities of ventricular size and function that were more similar to patients with LVEF <40%. Despite a mildly reduced LVEF, the ventricles of these patients were mark ...
The Pathology of Acute Myocardial Infarction
The Pathology of Acute Myocardial Infarction

... strategy for AMI • In the short and long term the pattern of cardiac pathology is very different to ...
Cardiovascular Dynamics
Cardiovascular Dynamics

... flow. Note that the effect of radius (r) on blood flow is especially strong (fluid flow varies with radius to the fourth degree). The main method of controlling blood flow is via contraction or relaxation of the smooth muscle found in the tunica media of an artery. When contracted, the radius of the ...
J. Hypertension 252185-2192 (2007).doc
J. Hypertension 252185-2192 (2007).doc

... supported by two facts: (1) subjects with essential hypertension are at increased risk for a particular form of chronic kidney disease (e.g. nephroangiosclerosis) [77], and (2) the kidney ...
Needs to Know - Preventive Cardiovascular Nurses Association
Needs to Know - Preventive Cardiovascular Nurses Association

... Heart Disease, A textbook of Cardiovascular Medicine. 6th ed. 2001. W.B. Saunders, Co. ...
Heart Failure with Preserved Ejection Fraction
Heart Failure with Preserved Ejection Fraction

... correspond with the pressure changes. If, small volume variations, cause significant changes in diastolic pressure for longer period, there is a tendency for the patients to develop venous congestion and diastolic heart failure [12]. When the left ventricular function has been disturbed, the heart “ ...
Aortic stenosis and CT calcium scoring: is it for - Heart
Aortic stenosis and CT calcium scoring: is it for - Heart

... with bicuspid valves cause a pressure drop in excess of the reduction in effective orifice area. While each is plausible, why these factors would affect younger patients with bicuspid valve disease but not older subjects remains unclear. The alternative explanation is that this phenomenon instead sim ...
myocardial infarction - THRUTH ALWAYS SATISFY U ( Adeeb ul
myocardial infarction - THRUTH ALWAYS SATISFY U ( Adeeb ul

... that there are remaining normal myocardial fibers at the top. Below these fibers are many macrophages along with numerous capillaries and little collagenization ...
Outcome of non-cardiac, non-obstetric surgery in patients with
Outcome of non-cardiac, non-obstetric surgery in patients with

... perioperative management from all patients but it appears that modern anaesthesiology is capable  of preventing hemodynamic deterioration in most cases. Although there is consensus amongst  anaesthesiologists that regional anaesthesia is preferred over general anaesthesia in patients with PH  [19, 2 ...
The SAMe-TT2R2 score and quality of anticoagulation in AF: Can
The SAMe-TT2R2 score and quality of anticoagulation in AF: Can

... clinical practices? The quality of anticoagulation is the result of a dynamic process with potential for rapid and long-term variation within the single patient in relation to compliance, health status or intercurrent disease. An inherent problem of the SAMe-TT2R2 score is the assumption that a fixe ...
Cardiac Defects: Patent Ductus Arteriosus
Cardiac Defects: Patent Ductus Arteriosus

... • electrocardiogram (ECG)—a record of the electrical activity of the heart • chest X ray. Some babies with PDA have other heart defects and will require other tests, including cardiac catheterization and cardiac MRI. ...
Observation Is Never Obsolete∗
Observation Is Never Obsolete∗

... suggests elevated right-sided heart pressures but is less specific and less sensitive than JVP for elevated left-sided filling pressures. Edema is generally absent in young patients with severely elevated filling pressures, who may instead have ascites, whereas edema often occurs in elderly patients, i ...
Aortic Stenosis and Comorbidities
Aortic Stenosis and Comorbidities

... - TAVI should only be proposed in patients with severe symptoms that can definitely be attributed to valve disease because of pending questions on safety and valve durability. - TAVI is not recommended for patients who simply refuse surgery on the basis of personal preference. -TAVI is seldom consid ...
Cardiac magnetic resonance imaging in pulmonary arterial
Cardiac magnetic resonance imaging in pulmonary arterial

... methodology and to reduce the time taken and the cost associated with CMRI. Validation of the CMRI variables in PAH will also enhance its use in clinical practice. CMRI is also likely to play a key role in determining the potential efficacy of new treatments in PAH. As morbidity and mortality end-po ...
B Carotid Intima-media Thickness And Vascular Look
B Carotid Intima-media Thickness And Vascular Look

... two or more risk factors for CHD, the Framingham risk algorithm should be used to determine 10-year risk of heart attack or cardiac death more precisely. To do so, a certain number of points are assigned for every risk factor the patient has including their age, total cholesterol level, whether or n ...
Resolution of left ventricular postinfarction thrombi in patients
Resolution of left ventricular postinfarction thrombi in patients

... in fatal and intracranial bleeding without clinical benefit.28 In ATLAS ACS 2, low-dose rivaroxaban (2.5–5 mg two times per day) was administered with aspirin and clopidogrel in 92% of patients. This was associated with a 16% reduction in the composite efficacy end point (cardiovascular death, myocard ...
Slide 1
Slide 1

... associated with pulmonary and hepatic disease; and again, the fatty degeneration. It is remarkable, that although the beneficial action of mercury in the affection is known to may practical physicians, but little practical information can be found on the subject…it is impossible to speak too highly ...
vsd closure following pulmonary artery banding in congenital vsd
vsd closure following pulmonary artery banding in congenital vsd

... This trend has evolved because many centers have demonstrated improved outcome with primary corrective surgery as an initial intervention in the neonates with congenital heart defects. Although the use of PA-banding has recently significantly decreased, it continues to maintain a therapeutic role in ...
Unit 2 06
Unit 2 06

... resting level of 68 bpm to 191 bpm. The subject fainted. Most likely, A. reflexogenic activation of vascular a adrenergic receptors induced a passive decrease in total peripheral resistance. B. arterial pressure increased markedly because of sympathetic withdrawal. C. cerebral vascular hyperemia exc ...
Cardiac Remodeling in Patients With Primary and Secondary
Cardiac Remodeling in Patients With Primary and Secondary

... rimary aldosteronism (PA) is a common curable cause of high blood pressure (BP) characterized by undetectable renin and angiotensin II, and an excess rate of metabolic syndrome,1 cardiovascular damage,2,3 and events.4,5 Secondary aldosteronism (SA) is a common feature of conditions characterized by ...
Abstract
Abstract

... Introduction: Parental hypertension (HTN) is known to predict HTN in offspring. However, the relative impact of objectively diagnosed early- vs. late-onset parental HTN on risk of HTN in the community is unknown. Hypothesis: We hypothesized that parental early- vs. late-onset HTN is associated with ...
The Heart
The Heart

... Structural Differences in Arteries, Veins, Capillaries  Arteries have a thicker tunica media than veins to withstand changes in pressure  Veins have a thinner tunica media than arteries and operate under low pressure  Veins also have valves to prevent backflow of blood  Lumen of veins is larger ...
Coupled systolic-ventricular and vascular stiffening with age
Coupled systolic-ventricular and vascular stiffening with age

... Nonetheless, the data supported the hypothesis that patients with greater vascular stiffening were more likely to have increased ventricular stiffness. As demonstrated by univariate regression and supported by prior data (32), aging raised Ea principally by its effects on pulsatile loading, with an ...
Heart failure outcomes with empagliflozin in patients with type 2
Heart failure outcomes with empagliflozin in patients with type 2

... Definitions of the major clinical outcomes in the EMPA-REG OUTCOMEw trial have been published.19 All cardiovascular outcome events and deaths were prospectively adjudicated by two Clinical Events Committees (for cardiac and neurological events).19 Outcomes assessed included hospitalization for heart ...
Vital Capacity and Congestive Heart Failure
Vital Capacity and Congestive Heart Failure

... of function can be present in the absence of any or all of these morbid phenomena.2 It would seem reasonable to attempt to detect impaired left ventricular function while some myocardial reserve still exists and there are compensatory mechanisms on which the heart can call. Assistance by judiciously ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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