"Technical, Economics and Legal Obstacles to the Development of Faccines and other Therapeutics for Potential Bioterrorism Agents"
... – Government is deeply involved in the immunization enterprise, a role that reflects the public-good and spillover characteristics of vaccines. – Government policy toward vaccine R&D is inconsistent: it both promotes and discourages the development of new vaccines. – While states continue to take pr ...
... – Government is deeply involved in the immunization enterprise, a role that reflects the public-good and spillover characteristics of vaccines. – Government policy toward vaccine R&D is inconsistent: it both promotes and discourages the development of new vaccines. – While states continue to take pr ...
The prevention and eradication of smallpox
... Sir Hans Sloane’s account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called ‘variolation’) involved the introduction of small amounts of infectious material from smallpox vesicle ...
... Sir Hans Sloane’s account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called ‘variolation’) involved the introduction of small amounts of infectious material from smallpox vesicle ...
Smallpox as a Biological Weapon
... cases are clinically characteristic and readily diagnosed in endemic areas, 2 other forms of smallpox are difficult to recognize—hemorrhagic and malignant. Hemorrhagic cases are uniformly fatal and occur among all ages and in both sexes, but pregnant women appear to be unusually susceptible. Illness ...
... cases are clinically characteristic and readily diagnosed in endemic areas, 2 other forms of smallpox are difficult to recognize—hemorrhagic and malignant. Hemorrhagic cases are uniformly fatal and occur among all ages and in both sexes, but pregnant women appear to be unusually susceptible. Illness ...
05. The concept of disease, controlled by the International Health
... onset of fever – Next priority – non face-to-face contacts exposed in a medical care facility or in home – Last priority – people in same facility after onset of fever (other than home or hospital) but without face-to-face contact ...
... onset of fever – Next priority – non face-to-face contacts exposed in a medical care facility or in home – Last priority – people in same facility after onset of fever (other than home or hospital) but without face-to-face contact ...
Vaccines - Quest Garden
... understood, an interesting thing was observed: if people recovered from a disease, rather than succumbing to it, they appeared to be immune from a second bout with the same illness. Perhaps it was these types of observations that led the Chinese to try to prevent smallpox--a deadly disease character ...
... understood, an interesting thing was observed: if people recovered from a disease, rather than succumbing to it, they appeared to be immune from a second bout with the same illness. Perhaps it was these types of observations that led the Chinese to try to prevent smallpox--a deadly disease character ...
smallpox
... characterized by a short incubation period, prostrating prodromal illness, severe systemic toxicity, and high mortality (96%). The rash begins as a dusky erythema, followed by extensive petechiae, mucosal hemorrhage, and intense toxemia. Thrombocytopenia and coagulopathy may be present. These patien ...
... characterized by a short incubation period, prostrating prodromal illness, severe systemic toxicity, and high mortality (96%). The rash begins as a dusky erythema, followed by extensive petechiae, mucosal hemorrhage, and intense toxemia. Thrombocytopenia and coagulopathy may be present. These patien ...
Exanthems05.pps
... Congenital Rubella Syndrome deafness, eye lesions, heart malformations & mr 24 cases 1997-1999, mostly immigrant 25-50,000 cases Mexico 1998 Higher suspicion cases in patients immigrating from countries with higher rates Vaccination contraindicated ...
... Congenital Rubella Syndrome deafness, eye lesions, heart malformations & mr 24 cases 1997-1999, mostly immigrant 25-50,000 cases Mexico 1998 Higher suspicion cases in patients immigrating from countries with higher rates Vaccination contraindicated ...
Pox virus
... variola major = 20-40% variola minor = 1% Potential for significant ongoing transmission due to secondary spread Ease of large-scale virus production Existence of clandestine smallpox virus stockpiles Worldwide supplies of smallpox vaccine are limited ...
... variola major = 20-40% variola minor = 1% Potential for significant ongoing transmission due to secondary spread Ease of large-scale virus production Existence of clandestine smallpox virus stockpiles Worldwide supplies of smallpox vaccine are limited ...
December 2008 - NWMOinfo.org
... smallpox. Although what Pasteur actually produced was a rabies antitoxin that functioned as a post infection antidote only because of the long incubation period of the rabies germ, he expanded the term beyond its Latin association with cows and cowpox to include all inoculating agents. Thus, we larg ...
... smallpox. Although what Pasteur actually produced was a rabies antitoxin that functioned as a post infection antidote only because of the long incubation period of the rabies germ, he expanded the term beyond its Latin association with cows and cowpox to include all inoculating agents. Thus, we larg ...
Smallpox Vaccine - Northwest Center for Public Health Practice
... Immunocompromised persons and pregnant women at risk Shortened incubation period, severe prodrome Extensive viral multiplication, coagulopathy Dusky erythema followed by petechiae and hemorrhages into skin and mucous membranes Almost uniformly fatal within 7 days ...
... Immunocompromised persons and pregnant women at risk Shortened incubation period, severe prodrome Extensive viral multiplication, coagulopathy Dusky erythema followed by petechiae and hemorrhages into skin and mucous membranes Almost uniformly fatal within 7 days ...
Human-Human interaction: epidemiology
... overall health status of a given population. In most countries of the world, publichealth authorities regularly gather epidemiological data on specific diseases and mortality rates in their populaces2. Main field of their studies focus on noninteracting systems. Most of knowledge came from analytic ...
... overall health status of a given population. In most countries of the world, publichealth authorities regularly gather epidemiological data on specific diseases and mortality rates in their populaces2. Main field of their studies focus on noninteracting systems. Most of knowledge came from analytic ...
#1 - School of Public Health
... • High fever, malaise, headache, backache • Rash (about 15 days after exposure): – maculopapules, day 1-2 of rash – vesicles, day 4-5 of rash – pustules - round, firm, embedded in dermis, day 7 ...
... • High fever, malaise, headache, backache • Rash (about 15 days after exposure): – maculopapules, day 1-2 of rash – vesicles, day 4-5 of rash – pustules - round, firm, embedded in dermis, day 7 ...
Overview of Category A Bioterrorism Agents
... • High fever, malaise, headache, backache • Rash (about 15 days after exposure): – maculopapules, day 1-2 of rash – vesicles, day 4-5 of rash – pustules - round, firm, embedded in dermis, day 7 ...
... • High fever, malaise, headache, backache • Rash (about 15 days after exposure): – maculopapules, day 1-2 of rash – vesicles, day 4-5 of rash – pustules - round, firm, embedded in dermis, day 7 ...
PowerPoint
... • Cremate, if possible: – If not, bury, but no embalming – Put in ground, not “on surface.” – If you can’t bury in ground, move remains ...
... • Cremate, if possible: – If not, bury, but no embalming – Put in ground, not “on surface.” – If you can’t bury in ground, move remains ...
Isolation and Quarantine Measures in Response
... • Cremate, if possible: – If not, bury, but no embalming – Put in ground, not “on surface.” – If you can’t bury in ground, move remains ...
... • Cremate, if possible: – If not, bury, but no embalming – Put in ground, not “on surface.” – If you can’t bury in ground, move remains ...
History and eradication of smallpox in Turkey
... the same ancestor. Babkin and Babkina7 suggested that the taterapox, camelpox and variola viruses originated from the same ancestor around the Horn of Africa and spread to East Africa through camel movements dating back 3500 years. Manifesting itself with fever and flaky skin, the disease has four di ...
... the same ancestor. Babkin and Babkina7 suggested that the taterapox, camelpox and variola viruses originated from the same ancestor around the Horn of Africa and spread to East Africa through camel movements dating back 3500 years. Manifesting itself with fever and flaky skin, the disease has four di ...
Medmyst assigment
... refugee camp. What is the name of this fringe group? Before arriving in Prokaryon, Eureka helps you review the Germ Theory first proposed by Louis Pasteur. What is this theory? Eureka also shows you information on Joseph Lister, a surgeon who believed in the Germ Theory and therefore insisted that d ...
... refugee camp. What is the name of this fringe group? Before arriving in Prokaryon, Eureka helps you review the Germ Theory first proposed by Louis Pasteur. What is this theory? Eureka also shows you information on Joseph Lister, a surgeon who believed in the Germ Theory and therefore insisted that d ...
The General Practitioner - Western Connecticut State University
... has been estimated that the task he started has led to the saving of more human lives than the work of any other person. The last remaining specimens of the smallpox virus are now held in just two laboratories, in Siberia and the USA. The samples, used for research, are afforded higher security than ...
... has been estimated that the task he started has led to the saving of more human lives than the work of any other person. The last remaining specimens of the smallpox virus are now held in just two laboratories, in Siberia and the USA. The samples, used for research, are afforded higher security than ...
Smallpox Infection Control
... number of cases infected by a primary case is estimated at 3.5-6. In populations with little herd immunity, this transmission potential of smallpox has the capability to create a rapid rise in outbreak cases before control measures can be applied. Communicability lasts until all the lesions have sca ...
... number of cases infected by a primary case is estimated at 3.5-6. In populations with little herd immunity, this transmission potential of smallpox has the capability to create a rapid rise in outbreak cases before control measures can be applied. Communicability lasts until all the lesions have sca ...
Document
... acceptance of the Convention by virtually all countries as presenting an unusual opportunity for the Soviet Union to gain an important advantage in the Cold War. • Accordingly, an extensive expansion of its bioweapons research and production capacity began. • In 1980 the Soviet leadership embarked o ...
... acceptance of the Convention by virtually all countries as presenting an unusual opportunity for the Soviet Union to gain an important advantage in the Cold War. • Accordingly, an extensive expansion of its bioweapons research and production capacity began. • In 1980 the Soviet leadership embarked o ...
Terrorism 101
... Rarely spread by air Transmission prevented by using airborne and contact precautions in health care settings ...
... Rarely spread by air Transmission prevented by using airborne and contact precautions in health care settings ...
IOSR Journal Of Humanities And Social Science (IOSR-JHSS)
... difficult to eradicate completely. The history of vaccination can be traced back to 1802 when a Superintendent General of Vaccination was appointed in India after the discovery of its Vaccine. Great efforts were made for the vaccination under the charge of the superintendents of vaccination. Smallpo ...
... difficult to eradicate completely. The history of vaccination can be traced back to 1802 when a Superintendent General of Vaccination was appointed in India after the discovery of its Vaccine. Great efforts were made for the vaccination under the charge of the superintendents of vaccination. Smallpo ...
Eradicating a Disease: Lessons from Mathematical Epidemiology
... would dispute the magnitude of his contribution to the science. In his fifties, already established as a respected physician, professor of anatomy, physiology, botany, physics and mathematics, Bernoulli turned his attention to the problem of smallpox. Smallpox (Variola major and its less virulent co ...
... would dispute the magnitude of his contribution to the science. In his fifties, already established as a respected physician, professor of anatomy, physiology, botany, physics and mathematics, Bernoulli turned his attention to the problem of smallpox. Smallpox (Variola major and its less virulent co ...
Diseases of Bioterrorist Potential For Epidemiologists
... Large outbreaks in schools were uncommon ...
... Large outbreaks in schools were uncommon ...
Smallpox
Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, derived from varius (""spotted"") or varus (""pimple""). The disease was originally known in English as the ""pox"" or ""red plague""; the term ""smallpox"" was first used in Britain in the 15th century to distinguish variola from the ""great pox"" (syphilis). The last naturally occurring case of smallpox (Variola minor) was diagnosed on 26 October 1977.Infection with smallpox is focused in small blood vessels of the skin and in the mouth and throat before disseminating. In the skin it results in a characteristic maculopapular rash and, later, raised fluid-filled blisters. V. major produced a more serious disease and had an overall mortality rate of 30–35 percent. V. minor caused a milder form of disease (also known as alastrim, cottonpox, milkpox, whitepox, and Cuban itch) which killed about 1 percent of its victims. Long-term complications of V. major infection included characteristic scars, commonly on the face, which occur in 65–85 percent of survivors. Blindness resulting from corneal ulceration and scarring, and limb deformities due to arthritis and osteomyelitis were less common complications, seen in about 2–5 percent of cases.Smallpox is believed to have emerged in human populations about 10,000 BC. The earliest physical evidence of it is probably the pustular rash on the mummified body of Pharaoh Ramses V of Egypt. The disease killed an estimated 400,000 Europeans annually during the closing years of the 18th century (including five reigning monarchs), and was responsible for a third of all blindness. Of all those infected, 20–60 percent—and over 80 percent of infected children—died from the disease. Smallpox was responsible for an estimated 300–500 million deaths during the 20th century. As recently as 1967, the World Health Organization (WHO) estimated that 15 million people contracted the disease and that two million died in that year.After vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in 1979. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest, which was declared eradicated in 2011.