Disorders of Sex Development: Nomenclature
... • Androgen synthesis is variable and cell dependent. • Therefore the time-dependent androgenisation potential will make up the individual composition of phenotype (regardless of karyotype) also in Disorders of Sex Development ...
... • Androgen synthesis is variable and cell dependent. • Therefore the time-dependent androgenisation potential will make up the individual composition of phenotype (regardless of karyotype) also in Disorders of Sex Development ...
ambiguous genitalia -
... development(paracrine effect); doesnot occur if T is suppied by peripheral circulation. In tissues equipped with 5α-reductase (e.g., prostate, ...
... development(paracrine effect); doesnot occur if T is suppied by peripheral circulation. In tissues equipped with 5α-reductase (e.g., prostate, ...
Polycystic Ovarian Syndrome
... which results in cyclical ovarian steroid output Women with PCOS have an increased LH Androgen production by the theca cells is LH dependent ...
... which results in cyclical ovarian steroid output Women with PCOS have an increased LH Androgen production by the theca cells is LH dependent ...
The Pace of Evolution
... Researchers have discovered a genetic marker for post-traumatic stress disorder (PTSD) in women. They found that the gene’s effect relies on the hormone estrogen and therefore is not linked to the disorder in men, who have very low levels of estrogen. Led by HHMI investigator Kerry Ressler at Emory ...
... Researchers have discovered a genetic marker for post-traumatic stress disorder (PTSD) in women. They found that the gene’s effect relies on the hormone estrogen and therefore is not linked to the disorder in men, who have very low levels of estrogen. Led by HHMI investigator Kerry Ressler at Emory ...
Sexual Differentiation and Intersex
... • 46,XY karyotype and absent testes but clear evidence of testicular function during embryogenesis • "embryonic testicular regression" = loss of testicular tissue within the first trimester and is associated with ambiguity of external genitalia • "bilateral vanishing testes syndrome" refers to indiv ...
... • 46,XY karyotype and absent testes but clear evidence of testicular function during embryogenesis • "embryonic testicular regression" = loss of testicular tissue within the first trimester and is associated with ambiguity of external genitalia • "bilateral vanishing testes syndrome" refers to indiv ...
Human Sexual Anatomy & Physiology (Part 1)
... – Absence of receptors for this hormone • In an XY male, defeminization does not occur but masculanization does • Person is born with both sets of internal sex organs ...
... – Absence of receptors for this hormone • In an XY male, defeminization does not occur but masculanization does • Person is born with both sets of internal sex organs ...
307-3285-1-SP - Journal of the ASEAN Federation of
... mutation of gene participating in sex determining cascade could result in normal male sexual differentiation in absence of normal SRY gene. This would further suggest that although incomplete masculization is a result of the absence of Y DNA, however different consequences could occur. Other possibl ...
... mutation of gene participating in sex determining cascade could result in normal male sexual differentiation in absence of normal SRY gene. This would further suggest that although incomplete masculization is a result of the absence of Y DNA, however different consequences could occur. Other possibl ...
307-3259-1-SP - Journal of the ASEAN Federation of
... mutation of gene participating in sex determining cascade could result in normal male sexual differentiation in absence of normal SRY gene. This would further suggest that although incomplete masculization is a result of the absence of Y DNA, however different consequences could occur. Other possibl ...
... mutation of gene participating in sex determining cascade could result in normal male sexual differentiation in absence of normal SRY gene. This would further suggest that although incomplete masculization is a result of the absence of Y DNA, however different consequences could occur. Other possibl ...
Sexual Differentiation in Mammals (Chap 11)
... receptor gene • Androgen ineffective small testes, no male ducts, female genitalia but no female ducts. Have female identity • (supports a role for androgen receptors in some aspects of masculinization of human brain) • At puberty don’t see pubic hair or darkening of nipples (normal androgen effect ...
... receptor gene • Androgen ineffective small testes, no male ducts, female genitalia but no female ducts. Have female identity • (supports a role for androgen receptors in some aspects of masculinization of human brain) • At puberty don’t see pubic hair or darkening of nipples (normal androgen effect ...
Genotype Versus Phenotype in Families with Androgen Insensitivity
... is 1:99,000. Phenotypic variation was absent in families with CAIS, but distinct phenotypic variation was observed relatively frequent in families with partial androgen insensitivity. Molecular observations suggest that phenotypic variation had different etiologies among these families. Sex assignme ...
... is 1:99,000. Phenotypic variation was absent in families with CAIS, but distinct phenotypic variation was observed relatively frequent in families with partial androgen insensitivity. Molecular observations suggest that phenotypic variation had different etiologies among these families. Sex assignme ...
male - WordPress.com
... that genetic female (XX) fetuses are exposed to high levels of testosterone during the entire embryonic development (assume the brain was exposed to testosterone during the “sensitive period”). Predict the effect that such an experiment would have on sexual differentiation of the following structure ...
... that genetic female (XX) fetuses are exposed to high levels of testosterone during the entire embryonic development (assume the brain was exposed to testosterone during the “sensitive period”). Predict the effect that such an experiment would have on sexual differentiation of the following structure ...
Partial androgen insensitivity syndrome. Multidisciplinary approach
... recognition and constructive aggression. Major stress is discussed both from the perspective of maximum severity (individual preservation by life or health threat and species preservation by reproduction threat), and from the perspective of response to cumulative stress factors, based on the "unterg ...
... recognition and constructive aggression. Major stress is discussed both from the perspective of maximum severity (individual preservation by life or health threat and species preservation by reproduction threat), and from the perspective of response to cumulative stress factors, based on the "unterg ...
Ambiguous Genitalia Dr. Eve G. Fernandez August 17, 2010 Normal
... The diagnosis of the patient will depend upon what is absent, what is lacking, and what is in exist. From the urogenital ridge, we have the bipotential gonad. The presence of the SRY gene will develop it into testis; its absence into an ovary. The testis has the Sertoli cells secrete the anti-Muller ...
... The diagnosis of the patient will depend upon what is absent, what is lacking, and what is in exist. From the urogenital ridge, we have the bipotential gonad. The presence of the SRY gene will develop it into testis; its absence into an ovary. The testis has the Sertoli cells secrete the anti-Muller ...
Male Pseudo Hermaphrodite
... – Gonad of one sex and genitalia of other Male Pseudo Hermaphrodite: • Genetic males whose target cells lack receptors for testosterone are feminized ( testicular feminizing syndrome) • Defective testicular development • 5α reductsae deficiency ( enzyme, coverts testosteron to DHT) ...
... – Gonad of one sex and genitalia of other Male Pseudo Hermaphrodite: • Genetic males whose target cells lack receptors for testosterone are feminized ( testicular feminizing syndrome) • Defective testicular development • 5α reductsae deficiency ( enzyme, coverts testosteron to DHT) ...
Gynaecology and Perinatology
... mild androgen insensitivity syndrome are born phenotypically male, according to their XY karyotype. They have fully masculinized genitalia and their problems are mostly related to the condition of infertility (oligospermia or azoospermia), decreased secondary terminal hair, and high pitch of voice. ...
... mild androgen insensitivity syndrome are born phenotypically male, according to their XY karyotype. They have fully masculinized genitalia and their problems are mostly related to the condition of infertility (oligospermia or azoospermia), decreased secondary terminal hair, and high pitch of voice. ...
Are there specific genetic defects affecting the male reproductive tract?
... testosterone and MIS production is normal so that Mullerian regression occurs and internal Wolffian duct structures develop to varying degrees. However, the sperm carrying ducts end blindly so sperm are necessarily absent in the ejaculate and prostate development is impaired. The genetic mutation is ...
... testosterone and MIS production is normal so that Mullerian regression occurs and internal Wolffian duct structures develop to varying degrees. However, the sperm carrying ducts end blindly so sperm are necessarily absent in the ejaculate and prostate development is impaired. The genetic mutation is ...
AIS Factsheet
... If the parents’ emotional needs/anxieties are addressed first (via psychological support/counselling from professionally trained staff) it will be easier for them to provide effective support to their child. Everyone will feel better if there are no taboos about the subject. Talking, like grieving, ...
... If the parents’ emotional needs/anxieties are addressed first (via psychological support/counselling from professionally trained staff) it will be easier for them to provide effective support to their child. Everyone will feel better if there are no taboos about the subject. Talking, like grieving, ...
Steroid/nuclear receptors and human disease
... 1) Steroid/nuclear receptors and human disease: Use of molecular tools to uncover the basic mechanisms whereby androgen receptor mutations lead to male infertility, disorders of sexual differentiation and prostate cancer; how estrogen-regulate genes result in uterine fibroids. Regulation of transcri ...
... 1) Steroid/nuclear receptors and human disease: Use of molecular tools to uncover the basic mechanisms whereby androgen receptor mutations lead to male infertility, disorders of sexual differentiation and prostate cancer; how estrogen-regulate genes result in uterine fibroids. Regulation of transcri ...
Applied Female Reproductive Physiology and the anatomy of the
... • Classically a result of absent androgen receptors so all cells are unresponsive to testosterone • Have female external genitalia but absent uterus and vagina and undescended testes • Present with primary amenorrhoea but good breast development, absent pubic hair • Testes are usually surgically rem ...
... • Classically a result of absent androgen receptors so all cells are unresponsive to testosterone • Have female external genitalia but absent uterus and vagina and undescended testes • Present with primary amenorrhoea but good breast development, absent pubic hair • Testes are usually surgically rem ...
Pseudohermaphroditism - Welcome to Cherokee High School
... first. The CAH females also showed consistent patterns of psychosocial delay in dating and sexual relations as compared to the control group. Gender identity in this group appears to be mediated by body image. The resulting ambivalence may be evidence of feelings of incompetence, leading to resistan ...
... first. The CAH females also showed consistent patterns of psychosocial delay in dating and sexual relations as compared to the control group. Gender identity in this group appears to be mediated by body image. The resulting ambivalence may be evidence of feelings of incompetence, leading to resistan ...
11/14/2016 1 Human Variations in Sexual Development Also
... • Moderate increase in bisexuality or homosexuality, or continued low interest in sexual relationships • Usually score intermediate between females and males and degree is correlated with androgen level (e.g. on tests of ...
... • Moderate increase in bisexuality or homosexuality, or continued low interest in sexual relationships • Usually score intermediate between females and males and degree is correlated with androgen level (e.g. on tests of ...
Androgen insensitivity syndrome
Androgen insensitivity syndrome (AIS) is a condition that results in the partial or complete inability of the cell to respond to androgens (androgenic hormones) that stimulate or control the development and maintenance of male physiological characteristics by binding to androgen receptors. The unresponsiveness of the cell to the presence of androgenic hormones can impair, or prevent, both the masculinization of male genitalia in the developing fetus, and the development of male secondary sexual characteristics at puberty, though it does not significantly impair the development of female genital or sexual characteristics in females and males with the condition. As such, androgen insensitivity syndrome is of clinical significance only when it occurs in individuals that are genetically male (that is, persons with a Y-chromosome, or more specifically, an SRY gene).Clinical phenotypes in genetically male individuals with androgen insensitivity syndrome range from a normal external male body plus mild spermatogenic defect in post-pubertal stages, to a full female external body (although internal gonads are male testes instead of female ovaries) including post-pubertal external female characteristic development, despite the presence of a Y-chromosome. Both genetically male and genetically female individuals with AIS show reduced to no secondary terminal hair development.In genetic males with AIS, the condition is divided into three categories that are differentiated by the degree of genital masculinization: CAIS, or complete androgen insensitivity syndrome, is indicated when the external genitalia are that of a normal female; PAIS, or partial androgen insensitivity syndrome, is indicated when the external genitalia are partially, but not fully, masculinized; MAIS, or mild androgen insensitivity syndrome, is indicated when the external genitalia are that of a normal male.Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinized genitalia in intersex persons. As with other intersex conditions, androgen insensitivity syndrome is independent of both sexual orientation and gender identity. The full spectrum of human sexual orientations has been reported among genetically female and genetically male AIS individuals alike, including: androphilia (i.e. sexual attraction to males) reported by most female-identified genetically-male female-bodied CAIS individuals; gynephilia (i.e. sexual attraction to females) reported even among some female-identified genetically-male female-bodied CAIS individuals in ""lesbian"" relationships; ambiphilia (bisexuality).Similarly, although AIS individuals may report any gender identity, a female gender identity is the gender identity of most, but not all, genetically-male female-bodied individuals with CAIS. Historically, however, the gender identity of CAIS individuals who identify as female has often been the cause of negative social bias and discrimination once their condition is made public. It is a matter of contention for some whether a CAIS individual with a female gender identity and external female body but genetic male sex should be regarded as ""transgender"". Some might regard such a person as ""transgender"" for identifying as female despite their genetic sex being male (even though they have an external female body), or they can be regarded as simply identifying as female in harmony to their external female body (despite their genetic male sex). Much social debate and litigation has resulted as a consequence of both arguments.Male gender identities among a minority of individuals with complete androgen insensitivity syndrome, have also been reported. This has resulted in CAIS individuals who are genetically male with an external female body but a male gender identity (irrespective of sexual orientation). A male gender identity among this minority, however, does not eliminate social contentions among some as to whether these individuals are ""transgender"", as they might be regarded to be identifying as male despite their external female body (even though their genetic sex is male), or they can be regarded as simply identifying as male in harmony to their genetic male sex (despite their external female body). This contention can be seen even in modern medical literature, where in one case study the genetically male CAIS patient with male gender identity was said to ""qualif[y] as female-to-male transsexual"" after undergoing genital reconstruction surgery.