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Basics for Bioinformatics
Basics for Bioinformatics

... the concept of a gene as the fragments of the DNA sequence that finally produce some protein products. This is still true in many contexts today. More strictly, these DNA segments should be called protein-coding genes, as scientists have found that there are some or many other parts on the genome th ...
Gene Section CHEK2 (CHK2 checkpoint homolog (S. pombe)) in Oncology and Haematology
Gene Section CHEK2 (CHK2 checkpoint homolog (S. pombe)) in Oncology and Haematology

... Chk2 is also involved in the regulation of BRCA1. Under normal conditions the two proteins are associated; after irradiation Chk2 phosphorylates Ser988 of BRCA1. This step is required for their dissociation, and the liberated BRCA1 participates directly in DNA repair and cell cycle arrest. Finally, ...
The role of endogenous and exogenous DNA damage and
The role of endogenous and exogenous DNA damage and

Recombinant DNA Technology
Recombinant DNA Technology

...  Gene therapy raises ethical questions, such as whether human germ-line cells should be treated to correct the defect in future generations  Many gene therapies have received approval from theNational Institutes of Health for trials in human patients, including the introduction of gene constructs ...
Recombinant DNA Technology
Recombinant DNA Technology

... together (also called a polylinker). This allows many different restriction enzymes to be used. Most cloning vectors use a system for detecting the presence of a recombinant insert, usually the blue/white betagalactosidase system. ...
In birds, the male is the homogametic sex
In birds, the male is the homogametic sex

... d. __________ Two genetically distinct populations of cells in a single individual e. __________ Will result in abnormal gamete formation (more than one answer) f. __________ Involved in familial Down syndrome g. __________ Lethal if it occurs in the same region of two homologous chromosomes ...
Dangerous DNA: The truth about the `warrior gene`
Dangerous DNA: The truth about the `warrior gene`

... potential that behavioural genetics offers. Once we move beyond genetic determinism, the nature/nurture dichotomy and simplistic generalisations, the discovery of genes related to mental or behavioural disorders can only improve our knowledge of ourselves. It will also help us make better decisions. ...
Genetically Modified Organisms
Genetically Modified Organisms

... The toxin is produced by the Cry gene Found on plasmids in the bacterium The gene is added to the genomes of crop plants using a bacterium that forms root nodules in plants (Agrobacterium tumificiens) Bt crops produced from 1996 onwards: maize, potato, cotton, soybean ...
PowerPoint Presentation - Gene Linkage and Genetic Mapping
PowerPoint Presentation - Gene Linkage and Genetic Mapping

... size of a postage stamp. ...
Tumor-Suppressor Genes
Tumor-Suppressor Genes

... • The genes encoding the various globin proteins evolved from one common ancestral globin gene, which duplicated and diverged • After the duplication events, differences between the genes in the globin family arose from mutations that accumulated in the gene copies ...
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Genetics - Osteogenesis Imperfecta Foundation
Genetics - Osteogenesis Imperfecta Foundation

... Most cases of osteogenesis imperfecta involve a dominant mutation. When a gene with a dominant mutation is paired with a normal gene, the faulty gene “dominates” the normal gene. In OI, a dominant genetic defect causes one of two things to occur: 1. The dominant altered gene directs cells to make an ...
UNIVERSITI MALAYSIA PERLIS UJIAN 2 Semester Kedua Sidang
UNIVERSITI MALAYSIA PERLIS UJIAN 2 Semester Kedua Sidang

... a) Functions of plasma membrane separation of cell from its environment - It is the chief point of contact with the cell’s environment and thus is responsible for much of its relationship with the outside world. selectively permeable barrier – some molecules are allowed to pass into or out of the ce ...
Bioethics Topics BioEthics
Bioethics Topics BioEthics

... (apart from any associated process or usage) if they are sufficiently "isolated" from their naturally occurring states. Prominent historical examples of such patents include those on adrenaline, insulin, vitamin B12, and various genes. However, a landmark ruling by the U.S. Supreme Court in June 201 ...
The Effects of Plasmid on Genotype and Phenotype
The Effects of Plasmid on Genotype and Phenotype

... addition to the large circular DNA molecule of the bacterial chromosome. Plasmid DNAs replicate independently of the bacterial chromosome, and many plasmids can also be transferred naturally among their bacterial hosts. Generally, plasmid genes code for proteins that are not essential for the surviv ...
What is Ecological Genetics
What is Ecological Genetics

... designated as n. Chromosome number can vary greatly: n = 2 in some scorpions and 127 in a species of hermit crab! A typical chromosome contains several thousand genes, in humans averaging approximately 1500 genes per chromosome. The position of a gene along a chromosome is called the locus of the ge ...
Leukaemia Section t(5;14)(q35;q32) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(5;14)(q35;q32) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... Genes involved and proteins Note The consequence of the translocation is the ectopic expression of the HOX11L2, gene normally located to 5q35, and normally not expressed in ALL without 5q rearrangement. The "deregulation" of HOX11L2 expression is thought to result from abnormal control of the gene b ...
Questions - Kettering Science Academy
Questions - Kettering Science Academy

... (ii) Both parents are carriers of the CF allele. State the term used to describe an individual who is a carrier and has both a dominant and a recessive allele. ...
Gene Ontology
Gene Ontology

... well  as  the  nucleic  and   proteic  sequences. ...
CYSTIC FIBROSIS (CF)
CYSTIC FIBROSIS (CF)

... Conductance Regulator (CFTR) protein results in its destruction The cell membranes in epithelial cells of lungs, pancreas, colon and urinogenital tract lack chloride ion pores Chloride and sodium imbalance results Excessively salty sweat Mucus secretion becomes thick and viscous. It cannot easily be ...
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09_01.jpg

... E. coli phage adapted for DNA sequencing. Can clone small DNA inserts in double stranded plasmid version, and convert to single strand version for sequencing ...
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B - DHSTAKS

... B.4B – Investigate and identify cellular processes including homeostasis, permeability, energy production, transportation of molecules, disposal of wastes, function of cellular parts, and synthesis of new molecules. ...
Chapter 9, 10, and 11
Chapter 9, 10, and 11

... b. Females only mate once and lay hundreds of eggs. c. The fruit fly generation time is short, allowing rapid experiments. 6. Fruit flies have an XY sex chromosome system similar to the human system; experiments can be correlated to the human situation. a. Newly discovered mutant male fruit flies ha ...
Solid Tumour Section Liver: Hepatocellular carcinoma Atlas of Genetics and Cytogenetics
Solid Tumour Section Liver: Hepatocellular carcinoma Atlas of Genetics and Cytogenetics

... involved in HCC. Many genes are altered in hepatocarcinogenesis but the frequency of individual gene mutations is low. Genes involved in important regulatory pathways are the targets of these mutations. Four main pathways can be distinguished: the p53 pathway involved in DNA damage response and apop ...
Topic 3 MCQs revision
Topic 3 MCQs revision

... The rate of reaction decreases continuously with increase in substrate concentration. ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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