Modeling of gene regulatory networks: A review
... accelerate biotechnological projects and such predictions are quicker and cheaper than lab experiments. Creating accurate dynamic models of GRNs is gaining importance in biomedical research and development. Gene expression microarrays monitor the transcription activities of thousands of genes simult ...
... accelerate biotechnological projects and such predictions are quicker and cheaper than lab experiments. Creating accurate dynamic models of GRNs is gaining importance in biomedical research and development. Gene expression microarrays monitor the transcription activities of thousands of genes simult ...
How were introns inserted into nuclear genes?
... clearly not random. In the serine protease genes, they tend to map to variable surface loops in the proteins L~. In the TFIIIA gene, they tend to m a p to the loops between domains L2. In other genes, they tend to fall near the middles of pre-existing exons 7.s,1~. This behaviour explains the genera ...
... clearly not random. In the serine protease genes, they tend to map to variable surface loops in the proteins L~. In the TFIIIA gene, they tend to m a p to the loops between domains L2. In other genes, they tend to fall near the middles of pre-existing exons 7.s,1~. This behaviour explains the genera ...
Energetics of protein–DNA interactions
... protein–DNA interactions nor has a systematic and rigorous method been proposed to compare these models. In addition to gaining a better understanding of these important interactions, the unique features of protein–DNA interactions provide additional motivation for investigation. These unique featur ...
... protein–DNA interactions nor has a systematic and rigorous method been proposed to compare these models. In addition to gaining a better understanding of these important interactions, the unique features of protein–DNA interactions provide additional motivation for investigation. These unique featur ...
DNA, RNA and Protein Structure Prediction
... mutual information and helix plot scores. There are various options determining how the scores are computed, and if both mutual information and helix plot scores are used the relative weights given to each source can be specified. The program will display a circle plot of the pairings for the sequen ...
... mutual information and helix plot scores. There are various options determining how the scores are computed, and if both mutual information and helix plot scores are used the relative weights given to each source can be specified. The program will display a circle plot of the pairings for the sequen ...
Widespread expression of the bovine Agouti gene results from at
... promoter sequences because of the repetitive content of its 5¢UTR. However, this C promoter sequence that remains to be isolated must be localized between exon 3A and 2 or upstream A promoter. The two 5¢UTR sequences corresponding to the 2 and 1.5 kb lung mRNA transcripts are reported here. The A an ...
... promoter sequences because of the repetitive content of its 5¢UTR. However, this C promoter sequence that remains to be isolated must be localized between exon 3A and 2 or upstream A promoter. The two 5¢UTR sequences corresponding to the 2 and 1.5 kb lung mRNA transcripts are reported here. The A an ...
Textbook Chapter 2 Answer
... 5. Without meiosis, the child would have four sets of genetic information. This could make the reading of instructions for making proteins confusing or difficult. Also, space in the cell is limited. If meiosis did not occur, each new generation would obtain more and more genetic information, whic ...
... 5. Without meiosis, the child would have four sets of genetic information. This could make the reading of instructions for making proteins confusing or difficult. Also, space in the cell is limited. If meiosis did not occur, each new generation would obtain more and more genetic information, whic ...
Accelerated gene evolution through replication
... previously identified as essential, we did not detect a difference in structural variability between the two strands (Supplementary Fig. 4). The observed difference between the rates at which leading- and lagging-strand genes vary may be due to orientation-dependent encounters between replication an ...
... previously identified as essential, we did not detect a difference in structural variability between the two strands (Supplementary Fig. 4). The observed difference between the rates at which leading- and lagging-strand genes vary may be due to orientation-dependent encounters between replication an ...
S010
... microRNAs. Here, one transcript may be processed to produce multiple functional microRNA sequences. In addition, each microRNA precursor hairpin has the potential to produce two different mature microRNAs. We have investigated the evolutionary and functional relationships between the multiple produc ...
... microRNAs. Here, one transcript may be processed to produce multiple functional microRNA sequences. In addition, each microRNA precursor hairpin has the potential to produce two different mature microRNAs. We have investigated the evolutionary and functional relationships between the multiple produc ...
MICROBIAL GENETICS-III UGc - E
... phosphodiester bonds which link the 5’ carbon of the deoxyribose of one mononucleotide unit with the 3’ carbon of the deoxyribose of the next mononucleotide unit. According to Watson and Crick DNA molecule consists of two such polynucleotide chains wrapped helically around each other, with the sugar ...
... phosphodiester bonds which link the 5’ carbon of the deoxyribose of one mononucleotide unit with the 3’ carbon of the deoxyribose of the next mononucleotide unit. According to Watson and Crick DNA molecule consists of two such polynucleotide chains wrapped helically around each other, with the sugar ...
DNA Testing - Who Murdered Robert Wone
... profiles representing the contaminants. Alternatively, the blank may show no profile, consistent with, but not proving that contamination didn't occur. Unfortunately, a few forensic DNA laboratories omit their controls. A few favor the controls by using special equipment on them, or by not carrying ...
... profiles representing the contaminants. Alternatively, the blank may show no profile, consistent with, but not proving that contamination didn't occur. Unfortunately, a few forensic DNA laboratories omit their controls. A few favor the controls by using special equipment on them, or by not carrying ...
Divergent evolution of oxidosqualene cyclases in plants
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
Virus-mediated reprogramming of gene expression in plants John A
... Mechanism of PTGS The phenomena of RNAi in animals and quelling in fungi are functional equivalents of PTGS in plants. Genetic and biochemical analyses of PTGS, RNAi and quelling have demonstrated that the original PTGS model proposed by Dougherty and colleagues was remarkably accurate [16,17]. This ...
... Mechanism of PTGS The phenomena of RNAi in animals and quelling in fungi are functional equivalents of PTGS in plants. Genetic and biochemical analyses of PTGS, RNAi and quelling have demonstrated that the original PTGS model proposed by Dougherty and colleagues was remarkably accurate [16,17]. This ...
Divergent evolution of oxidosqualene cyclases in plants
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
Infectivity analysis of two variable DNA B components of Mungbean
... Mungbean yellow mosaic virus-Vigna; NES, nuclear export signal; NLS, nuclear localization signal; nt, nucleotide; oc, open circular; OD, optical density; ORF, open reading frame; Rep, replication-associated protein; RF, replicative form; sc, supercoiled; ss, single-stranded; YMD, yellow mosaic disea ...
... Mungbean yellow mosaic virus-Vigna; NES, nuclear export signal; NLS, nuclear localization signal; nt, nucleotide; oc, open circular; OD, optical density; ORF, open reading frame; Rep, replication-associated protein; RF, replicative form; sc, supercoiled; ss, single-stranded; YMD, yellow mosaic disea ...
Application of rpoB sequence similarity analysis, REP‐PCR and
... phylogenetically informative size; and (iv) sequence divergence among related species. rpoB gene could be a strong candidate as a genome similarity predictor, as this gene encodes for the b subunit of RNA polymerase and has been proposed as an alternative to 16S rRNA for phylogenetic and biodiversit ...
... phylogenetically informative size; and (iv) sequence divergence among related species. rpoB gene could be a strong candidate as a genome similarity predictor, as this gene encodes for the b subunit of RNA polymerase and has been proposed as an alternative to 16S rRNA for phylogenetic and biodiversit ...
Ion AmpliSeq™ Colon and Lung Cancer Panel
... of Ion AmpliSeq™ technology and the affordability of Ion semiconductor sequencing to develop a screening solution that meets the following goals: • Selective gene content—targets regions of a comprehensive set of genes implicated in colon and lung cancer, including known hotspot regions • Low inpu ...
... of Ion AmpliSeq™ technology and the affordability of Ion semiconductor sequencing to develop a screening solution that meets the following goals: • Selective gene content—targets regions of a comprehensive set of genes implicated in colon and lung cancer, including known hotspot regions • Low inpu ...
The vertebrate genome annotation (Vega) database
... tagged as being subject to nonsense-mediated decay (NMD) Further more, transcript variants for which a CDS cannot be assigned confidently, are classified into the following main types: (i) Transcript: does not qualify for any of the specific types below. (ii) Retained intron: relative to an appropriate ...
... tagged as being subject to nonsense-mediated decay (NMD) Further more, transcript variants for which a CDS cannot be assigned confidently, are classified into the following main types: (i) Transcript: does not qualify for any of the specific types below. (ii) Retained intron: relative to an appropriate ...
DNA crosslinking and biological activity of a
... reached the value of 75% of total DNA after 60 min treatment (Fig. 2B, chart). Longer exposures to 1-Chl resulted in DNA degradation, which manifested as a low molecular `smear' on the gels (data not shown). Sequence selectivity of DNA damage in cell-free systems. 1Chl and its parent polyamide 1 wer ...
... reached the value of 75% of total DNA after 60 min treatment (Fig. 2B, chart). Longer exposures to 1-Chl resulted in DNA degradation, which manifested as a low molecular `smear' on the gels (data not shown). Sequence selectivity of DNA damage in cell-free systems. 1Chl and its parent polyamide 1 wer ...
A DNA Polymerase ε Mutant That Specifically Causes 1
... the yeast homologue of human flap endonuclease (FEN1), is a 5⬘ → 3⬘ exo/endonuclease responsible for the maturation of Okazaki fragments during lagging strand DNA synthesis and removal of 5⬘ flaps (reviewed in Lieber 1997). Rad27 has also been proposed to function in MMR (Johnson et al. 1995). Howev ...
... the yeast homologue of human flap endonuclease (FEN1), is a 5⬘ → 3⬘ exo/endonuclease responsible for the maturation of Okazaki fragments during lagging strand DNA synthesis and removal of 5⬘ flaps (reviewed in Lieber 1997). Rad27 has also been proposed to function in MMR (Johnson et al. 1995). Howev ...
A natural chimeric yeast containing genetic material from three species
... al., 1985). The ATP9 genes in the isolates analysed were also found to be 228 bp long (Fig. 2). The amino acid sequences were identical in all cases, but several silent substitutions were observed. The A TP9 gene sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. A ...
... al., 1985). The ATP9 genes in the isolates analysed were also found to be 228 bp long (Fig. 2). The amino acid sequences were identical in all cases, but several silent substitutions were observed. The A TP9 gene sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. A ...
Replication origin plasticity, Taylor-made: inhibition vs
... with a combination of CldU and HU. In this way, replication forks that were active before replication stress (HU) are tagged with IdU, the degree of extension of those forks in the presence of HU is revealed by consecutive IdU/ CldU tracks, and any newly fired origins generate tracks labeled exclusi ...
... with a combination of CldU and HU. In this way, replication forks that were active before replication stress (HU) are tagged with IdU, the degree of extension of those forks in the presence of HU is revealed by consecutive IdU/ CldU tracks, and any newly fired origins generate tracks labeled exclusi ...
A Sex Chromosome Rearrangement in a Human XX
... the paternal Y but also a proximal portion of the pseudoautosomal region of the paternal X. In this XX male, the recombination point on the X is likely to lie within the pseudoautosomal region (Page et al., 1987a). Taken together, these studies show that in Y(+)XX males the positions of both the Yp ...
... the paternal Y but also a proximal portion of the pseudoautosomal region of the paternal X. In this XX male, the recombination point on the X is likely to lie within the pseudoautosomal region (Page et al., 1987a). Taken together, these studies show that in Y(+)XX males the positions of both the Yp ...
DNA methylation involved in proline accumulation in - Funpec-RP
... (Siripornadulsil et al., 2002; Verbruggen and Hermans, 2008). Recent findings have suggested that proline may also play a role in flowering and development both as a metabolite and a signal molecule (Mattioli et al., 2009). In any case, proline clearly plays crucial roles not only in drought toleran ...
... (Siripornadulsil et al., 2002; Verbruggen and Hermans, 2008). Recent findings have suggested that proline may also play a role in flowering and development both as a metabolite and a signal molecule (Mattioli et al., 2009). In any case, proline clearly plays crucial roles not only in drought toleran ...
We need an optimality criterion to choose a best estimate (tree
... How strongly is a phylogenetic hypothesis supported by the data? Bootstrap replicates generate new data sets by randomly sampling from the actual data, with replacement. These new data sets should contain phylogenetic signal similar to that in the original data. A high percentage of replicates (75%+ ...
... How strongly is a phylogenetic hypothesis supported by the data? Bootstrap replicates generate new data sets by randomly sampling from the actual data, with replacement. These new data sets should contain phylogenetic signal similar to that in the original data. A high percentage of replicates (75%+ ...
1b. Mendalian Genetics Definitions
... 5. An individual who has a genotype of Hh can be said to be homozygous/heterozygous/recessive for this particular trait. ...
... 5. An individual who has a genotype of Hh can be said to be homozygous/heterozygous/recessive for this particular trait. ...