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Geometrical ordering of DNA in bacteria
Geometrical ordering of DNA in bacteria

... Figure 1. Average subcellular position of genes as function of their position on the chromosome in C. crescentus and E. coli as obtained from numerical simulations of compacted DNA. (A and B) show the position of genes along the cell axis as function of their position on the chromosomal map for an a ...
Molecular mechanisms of the origin of micronuclei
Molecular mechanisms of the origin of micronuclei

... with lamina (15), it was consistent with a report that the anaphase bridge breakage produced genetically inert micronuclei (36). Another reason that determines the heterogeneity among micronuclei may be obtained from the position in the anaphase cells where the chromatin that generates micronuclei l ...
Services Experimental Design
Services Experimental Design

... reactions occur. The flow cell is composed of 2 or 8 “lanes” which are microfluidic channels. Sequencing takes place on synthetic genomic “clusters”. Image capture from a Flow Cell showing a “Cluster” Cluster represents a discrete clonal amplification of a single 400bp DNA fragment from the genome. ...
Control of reproduction by Polycomb Group complexes in animals
Control of reproduction by Polycomb Group complexes in animals

... the PRC2 complex, is also obvious in plants. Several PcG genes have been cloned in Arabidopsis thaliana. In Arabidopsis, the first PcG gene identified was CURLY LEAF (CLF ), homologous to E(Z) (Goodrich et al., 1997). E(Z) homologues in Arabidopsis constitute a family of three genes, CLF, its closes ...
Chapter 4: The Chromosome Theory of Inheritance - McGraw
Chapter 4: The Chromosome Theory of Inheritance - McGraw

... This article describes the genetic mechanism of sex-determination in Drosophila. Specifically it examines some of role of genes in determining the X:A ratio.  Marx, J. 1995. Tracing How the Sexes Develop. Science 269(5232):1822-1824. [Entrez-PubMed link] This article examines how sex-determination ...
Instructions
Instructions

... have any peptidoglycan in their cell walls and also have internal cell membranes that look a lot like the endoplasmic reticulum and nuclear envelope! Rather than dividing by binary fission, they divide by a kind of budding, similar to my favorite organism, yeast. Thus, in some ways, Planctomycetes c ...
21-Thalassemia
21-Thalassemia

... Decrease in β-chain production relative to αchain production. Common in Mediterranean, Asian & African populations (areas endemic with malaria). Trait --- asymptomatic. Clinical anemia ---- is seen in homozygous or compound heterozygous e.g. β thalassemia/Hb E. ...
Chapter 3
Chapter 3

Yeast whole-genome analysis of conserved regulatory motifs
Yeast whole-genome analysis of conserved regulatory motifs

... • Chromatin states capture chromatin dynamics – Single annotation track for each cell type – One 15-state track per cell type instead of 29 combinations ...
Heredity and Cancer DNA, genes, and chromosomes Genes and
Heredity and Cancer DNA, genes, and chromosomes Genes and

... The most common inherited syndrome that increases a person's risk for colon cancer is called hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome. People with this syndrome have a high risk of colorectal cancer. Most of these cancers occur before age 50. People with HNPCC may also h ...
Comparative Genomic Study of upstream Open Reading Frames
Comparative Genomic Study of upstream Open Reading Frames

... upstream open reading frames (uORFs) are present. A general method for detecting uORFs with a regulatory role is of great importance. The ribosome can recognise the AUG of a uORF as an initiation codon, translate the downstream sequence into protein and terminate before the main ORF is translated. A ...


... analysis is a powerful methodology to investigate not only history but also selection mechanisms and function of biological networks at all levels [1]. Phylogenetic trees based on single loci should be viewed with caution and the best approach is to examine numerous loci across the genome. Due to la ...
Molecular genetic basis of porcine histo
Molecular genetic basis of porcine histo

... for DNA transfection assays. Both A antigen expression and A transferase activity were observed with the sense construct (Table 1). Therefore, we concluded that the sequence encoded A transferase. The other amplified sequence was also homologous to the ABO genes but to a lesser degree. This sequence ...
File
File

Biochemical Pathways - NCEA Level 2 Biology
Biochemical Pathways - NCEA Level 2 Biology

... People with this disease are lightly pigmented, although there is usually enough tyrosine in their diets to allow them to make melanin.  All babies in NZ are tested for PKU at birth, and if it is present the children are put on a strict diet which can prevent the effects. ...
introduction_to_micr..
introduction_to_micr..

... Microarray analysis • Whole genome sequencing makes it possible to predict the entire gene complement • Various technologies have built on this knowledge to produce systems that will monitor the expression (usually transcription) at the whole genome level – Measurement of global transcription is ca ...
Booklet 3
Booklet 3

... The resulting protein has 40 or more additional molecules of the amino acid glutamine in its primary structure. This protein accumulates in neurones. (i) Suggest why an increase in the number of repeats leads to an earlier onset of the symptoms of Huntington’s disease. ______________________________ ...
Mcp7, a meiosis-specific coiled-coil protein of fission yeast
Mcp7, a meiosis-specific coiled-coil protein of fission yeast

... Figure 1. Mcp7 is a meiosis-specific coiled-coil protein that is conserved in a variety of species. (A) Northern blot analysis of mcp7+ and aro3+ (loading control). Total RNA was extracted from CD16-1 (h+/h) and CD16-5 (h/h) cells at the indicated times after meiosis was induced by nitrogen starv ...
Document
Document

... will be passed to the next generation of daughter cells, and so forth. The accumulation of many mutations eventually kills the cells. That is why mutagens are more effective at killing dividing cells compared to nondividing cells. It is because the number of mutations accumulates to a lethal level. ...
C1. A. G→A, which is a transition. B. T→G, which is a transversion. C
C1. A. G→A, which is a transition. B. T→G, which is a transversion. C

... will be passed to the next generation of daughter cells, and so forth. The accumulation of many mutations eventually kills the cells. That is why mutagens are more effective at killing dividing cells compared to nondividing cells. It is because the number of mutations accumulates to a lethal level. ...
Genetic Alteration Panels
Genetic Alteration Panels

... the plasma membrane, which is mediated by receptor tyrosine kinase-PI3K pathway. Activated AKT phosphorylates many key proteins such as glycogen synthase kinase 3 and the FOXOs, and regulates cell survival, proliferation and other cellular processes. Amplification of AKT1 and AKT2 has been discovere ...
Slide 1
Slide 1

... research in Australia, and internationally through:  the provision of clinically validated but de-identified patient material complete phenotypic descriptors of disease and family, or cohort structure permits genetic analyses for disease gene identification. ...
Validated preCRMs
Validated preCRMs

... likely to have GATA-1 and its binding site involved in regulation and applied our bioinformatics tools to predict CRMs. Many of the predicted CRMs had significant effects on the expression of reporter genes in transfected cells, showing the power of bioinformatic predictions based on RP scores plus ...
Lecture 5 pdf
Lecture 5 pdf

... Phenotype is result of complex, integrated pattern of reactions under control of more than one gene and the environment. 1. Epistasis (true non-allelic interaction) - expression of a single trait depends on interaction between 2 or more genes examples: comb shape in chickens ...
notes - Humble ISD
notes - Humble ISD

...  With treatment, patients can survive into adulthood.  Most common ___________ genetic disorder in the __________________________ among Caucasians. 3. Phenylketonuria or ________  Characterized by an inability to breakdown the amino acid, ________________________.  If untreated, results in sever ...
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NEDD9

Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.
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