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genstat - University of Illinois at Urbana
genstat - University of Illinois at Urbana

... A “classifier” can be trained to separate exons from non-exons, based on the three scores Closer to reality – other factors could also help to distinguish exons from non-exons ...
GAL4 enhancer trap strains with reporter gene expression during
GAL4 enhancer trap strains with reporter gene expression during

... gene throughout the pupal development in this strain. The expression at 0-h pupa is strong in the mushroom body (mb), cb, sog and in the interhemispheric junction (ij) (figure 2a). At 20 h APF, there is a decline in the level of expression in the cb and sog, where as it remains very strong in the ol ...
Prostate cancer - American Cancer Society
Prostate cancer - American Cancer Society

... without symptoms of prostate cancer who do not have a 10-year life expectancy should not be offered testing since they are not likely to benefit. Overall health status, and not age alone, is important when making decisions ...
Why Gene Duplication? ,
Why Gene Duplication? ,

... middle of the nucleolar organizer of its homologue. The result of such shifted pairing is "unequal crossing-over". Where both chromosomes had the nucleolar organizer made of 450 copies of a ribosomal gene, one would now receive only 200 copies (deletion), while the other receives 700 copies (further ...
Leukaemia Section Acute megakaryoblastic leukemia (AMegL) M7 acute non lymphocytic leukemia (M7-ANLL)
Leukaemia Section Acute megakaryoblastic leukemia (AMegL) M7 acute non lymphocytic leukemia (M7-ANLL)

... or CD7 positivity can be found on some occasions. The CD34, CD13 and CD33 markers are positive in a substantial fraction of cases, as is the case with the CD36/thrombospondin receptor. The myeloperoxidase stain is negative by light microscopy, but ultrastructural peroxidase activity with a specific ...
Edvotek 222
Edvotek 222

... organisms, such as E. coli and the nematode Caenorhabditis elegans. Scientists also identified particular amino acid substitutions in GFP N HO that altered the behavior of its ‘chromophore’, a special structure within the protein that is responsible for light production (Figure 4). Figure 4: GFP Chr ...
05_Lecture_Presentation
05_Lecture_Presentation

... billion of your cells die each day? • Is your body making any new cells right now? What kind? • Are certain types of cells replaced faster? What might be examples? • Are certain types of cells never replaced or slowly replaced? What might be examples? © 2015 Pearson Education, Inc. ...
Galactose Metabolism in Saccharomyces cerevisiae
Galactose Metabolism in Saccharomyces cerevisiae

... Mig1p also represses the transcription of the GAL genes by interacting with the general transcriptional co-repressor complex Ssn6p-Tup1p (Keleher et al. 1992; Treitel and Carlson 1995). This complex recruits the histone deacetylases Hda1p, Rpd3p, Hos1p and Hos2p (Wu et al. 2001; Davie et al. 2003; M ...
Immunogenicity of Protein Therapeutics: time to get
Immunogenicity of Protein Therapeutics: time to get

Meiosis Notes I. Each parent donates genes to their offspring via
Meiosis Notes I. Each parent donates genes to their offspring via

... 2n + 1 total chromosomes. ...
Fetal Hemoglobin Levels in Sickle Cell Disease and
Fetal Hemoglobin Levels in Sickle Cell Disease and

... the peripheral circulation of F cells compared with RBCs containing no detectable Hb F.9 In SS individuals, the variation in F-cell production as measured by the percent F reticulocytes is the major variable contributing to differences in Hb F levels. The broad distribution of Hb F levels in normal ...
Lack of Association in Caucasians and African
Lack of Association in Caucasians and African

... sians to have the ml MspI allele (16). The AA-RFLP has been In the United States, breast cancer currently afflicts 1 of 8 women associated with an increased risk of adenocarcinoma of the lung (17). by the age of 85 and the incidence continues to rise (1). The etiology Presently, only one small study ...
Misregulation of pre-mRNA splicing that causes human diseases
Misregulation of pre-mRNA splicing that causes human diseases

... in exons or as thin boxes in introns. The 5' splice-site (CAGguaagu) and 3' splice-site (y) 10 ncagG, as well as the branch point (ynyyray), are indicated (y=c or u, n=a, g, c or u). Upper-case letters refer to nucleotides that remain in the mature mRNA. Two major groups of proteins, hnRNPs (yellow) ...
aeiab Meiosis
aeiab Meiosis

... that crossing over could be used as an important tool for discerning the physical location of genes on chromosomes. They reasoned that if chiasmata can form at any point between two homologous chromosomes, then the frequency of crossing over in the region between two different genes on a chromosomes ...
Fact Sheet 61|TUBEROUS SCLEROSIS COMPLEX In summary
Fact Sheet 61|TUBEROUS SCLEROSIS COMPLEX In summary

... numbered and are known as autosomal chromosomes. The 23rd pair is made up of the sex chromosomes called X and Y. Males have an X and a Y chromosome and females have two copies of the X chromosome. Since all our chromosomes come in pairs, all our genes also come in pairs. Sometimes, a gene may have a ...
Evolution: The evolvability enigma
Evolution: The evolvability enigma

... genetic variation to a non-neutral state may facilitate the evolution of new traits” [2]. In an accompanying commentary, however, Partridge and Barton [3] endeavour to place the result in the context of established population genetics theory of mutation rates, pointing out the problems with any proc ...
Exam2004 - Stanford University
Exam2004 - Stanford University

... homology to a C. elegans protein, abc-1. Abc-1 has been previously shown to be involved in synapse function. You wish to determine if this putative mouse homolog, mabc-1, has any effect on synapses. You decide to go ahead and make the loss-of-function mouse mutant. The mouse does not exhibit gross m ...
Intestinal Mucosa a Novel Immunological Player in the Sodium
Intestinal Mucosa a Novel Immunological Player in the Sodium

... the mucosa must rapidly recognize detrimental pathogenic threats to the lumen (3). Recent studies have provided evidence that enterocytes express different TLRs that play a key role in microbial recognition and in adaptive immune response control (4). Intestinal epithelial cells (IECs)4 are sensors ...
Student Accomplishments for 2005 – 2006
Student Accomplishments for 2005 – 2006

... Genetic health status of the corn snake, Elaphe gutatta, an endangered species in New Jersey Tim Jarvela (Senior) Mentor: Dr. Amanda Norvell Development of a genetic screen in Drosophila melanogaster for identifying new genes that are required for the production of correctly formed eggs Jordan Kapla ...
Jolly Good Knowledge from the Seven Seas Monday,October 9
Jolly Good Knowledge from the Seven Seas Monday,October 9

... 1. What did Mendel experiment with to learn about genetics? Pea plants 2. A scientist who studies heredity is a geneticist. 3. Where do organisms inherit genes from?the parents 4. What are physical characteristics of an organism that are passed down from one generation to the next called? traits ...
GENETIC DETERMINANTS OF PROSTATE CANCER: A REVIEW
GENETIC DETERMINANTS OF PROSTATE CANCER: A REVIEW

... This is probably the most important locus related to prostate cancer development. It is located on chromosome 1q24–25 and a gene at position 1q25.3 is RNAseL encoding an endoribonuclease. This enzyme is important in the immune response of the organism to viral infection (degradation of single-strand ...
Hemolytic Anemias – the Hemoglobinopathies
Hemolytic Anemias – the Hemoglobinopathies

... to an aberration of hemoglobin synthesis  Abnormal hemoglobins ...
Role of virulence factors, cell components and adhesion in
Role of virulence factors, cell components and adhesion in

... the adhesion molecules AlpA and AlpB by comparison of the wild-type strain and an isogenic mutant de¢cient in alpAB loci. AlpA and AlpB are highly related outer membrane proteins that have been shown to be crucial for the adhesion to KatoIII cells and gastric tissue [10]. Their role in colonization ...
Pseudogene function: regulation of gene expression
Pseudogene function: regulation of gene expression

... another scientific paper demonstrating function for some form of junk DNA. As summarized in this article, there is also growing evidence that at least some pseudogenes are functional. It should be stressed that pseudogenes, unlike other so-called junk DNA, have long been burdened not only with the in ...
Punnett Square Practice Worksheet Part A: Vocabulary
Punnett Square Practice Worksheet Part A: Vocabulary

... 11. What do the letters on the outside of the Punnett square stand for? 12. What do the letters on the inside of the Punnett square stand for? 13. In corn plants, normal height, N, is dominant to short height, n. Complete these four Punnett squares showing different crosses. Then, circle all of the ...
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NEDD9

Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene. NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.
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