Lecture#17 Page 1 BIOLOGY 207 – Dr McDermid Lecture#17
... 1. Gene loci on the same chromosome may show linkage, not independent assortment. 2. Most linkage between gene loci is not complete because crossing over between loci can occur during meiosis. 3. The extent of linkage between gene loci is expressed as the frequency of recombinant type progeny (vs. p ...
... 1. Gene loci on the same chromosome may show linkage, not independent assortment. 2. Most linkage between gene loci is not complete because crossing over between loci can occur during meiosis. 3. The extent of linkage between gene loci is expressed as the frequency of recombinant type progeny (vs. p ...
Gabriele Marras
... identifies individual SNPs associated with traits and not directly regions of the genome or genes. Additionally, standard GWAS is prone to return a certain proportion of spurious associations. We propose alternative and complementary approaches to association studies ...
... identifies individual SNPs associated with traits and not directly regions of the genome or genes. Additionally, standard GWAS is prone to return a certain proportion of spurious associations. We propose alternative and complementary approaches to association studies ...
PPT
... Can be considered as frequency of occurence X expressive power of regulatory motif It is squared to get rid of negatives Correlate gene expression with occurence of motif Largest dot product is most significant motif ...
... Can be considered as frequency of occurence X expressive power of regulatory motif It is squared to get rid of negatives Correlate gene expression with occurence of motif Largest dot product is most significant motif ...
Exploring HLA Diversity in Brazil
... gene produces an immune tolerance protein that is active at the fetal/maternal interface. We were trying to understand the genetics of HLA-G. It is quite different from the other HLA genes because it is highly conserved. Our main focus was on the population genetics around this gene. As we learned m ...
... gene produces an immune tolerance protein that is active at the fetal/maternal interface. We were trying to understand the genetics of HLA-G. It is quite different from the other HLA genes because it is highly conserved. Our main focus was on the population genetics around this gene. As we learned m ...
Angelman Syndrome: Genotype, Phenotype and Differential
... Very few dry by night Need 24 hr supervision Many able to do simple tasks eg table laying, hoovering but need supervision • Need encouragement to “stay on task” ...
... Very few dry by night Need 24 hr supervision Many able to do simple tasks eg table laying, hoovering but need supervision • Need encouragement to “stay on task” ...
GENETICS – BIO 300
... genes close together on a chromosome do not assort independently at meiosis recombination genotypes with new combinations of parental alleles homologous chromosomes can exchange segments by crossing-over recombination results from either independent assortment or crossing-over ...
... genes close together on a chromosome do not assort independently at meiosis recombination genotypes with new combinations of parental alleles homologous chromosomes can exchange segments by crossing-over recombination results from either independent assortment or crossing-over ...
Gene sequences useful for predicting relatedness of whole
... speciation, the various forces that change genome sequence content act at discrete rates in a time-dependent manner. As a result, the ratio between sequence differences in conserved regions and overall genome sequence differences remains fairly constant, at least while the bacteria are related as cl ...
... speciation, the various forces that change genome sequence content act at discrete rates in a time-dependent manner. As a result, the ratio between sequence differences in conserved regions and overall genome sequence differences remains fairly constant, at least while the bacteria are related as cl ...
journals - the biopsychology research group
... underlying the reading of the imprint can involve many aspects of gene expression, and the silencing can be stable throughout the individual’s life [Federman, 2006]. A high proportion of the imprinted genes that have been identified are highly expressed in the central nervous system and encompass a ...
... underlying the reading of the imprint can involve many aspects of gene expression, and the silencing can be stable throughout the individual’s life [Federman, 2006]. A high proportion of the imprinted genes that have been identified are highly expressed in the central nervous system and encompass a ...
Disease Genomics Part 2 - Medical Sciences Division
... – Collect data points from one or more sources – Take a “Gold Standard” set of genes for this disease – Train a method using known true +ives (and true –ives ...
... – Collect data points from one or more sources – Take a “Gold Standard” set of genes for this disease – Train a method using known true +ives (and true –ives ...
An enlarged largest subunit or Plasmodium falciparum RNA
... sequences of clone gl5 and the cDNA clones were colinear (Fig. 1C. and ID.). Oligonucleotide probes B and C, derived from the 5' region of clone gl5, hybridized with a 12 kb genomic Xbal fragment (Fig. 2B.). Probe B and C selected a clone, XI, from a Xbal genomic DNA library. Clone XI contained the ...
... sequences of clone gl5 and the cDNA clones were colinear (Fig. 1C. and ID.). Oligonucleotide probes B and C, derived from the 5' region of clone gl5, hybridized with a 12 kb genomic Xbal fragment (Fig. 2B.). Probe B and C selected a clone, XI, from a Xbal genomic DNA library. Clone XI contained the ...
pTcGW platform guideline Gateway® cloning system: general
... plasmids. For screening of the clones, an additional step for confirmation of the clone size is recommended. This may be done by running the bacterial lysate on an agarose gel. In this confirmation, a careful inspection of the clone size is important. Colonies with single or additional band, less th ...
... plasmids. For screening of the clones, an additional step for confirmation of the clone size is recommended. This may be done by running the bacterial lysate on an agarose gel. In this confirmation, a careful inspection of the clone size is important. Colonies with single or additional band, less th ...
LECTURE 6: TETRAD ANALYSIS Reading: Ch. 5, p. 132
... ---------First we went over “interference” (see notes from last lecture)-------TETRAD ANALYSIS IN FUNGI In the diploid organisms that we’ve considered so far, each individual represents only one of four potential gametes that are produced from each parent in a single meiotic event. We don’t know whi ...
... ---------First we went over “interference” (see notes from last lecture)-------TETRAD ANALYSIS IN FUNGI In the diploid organisms that we’ve considered so far, each individual represents only one of four potential gametes that are produced from each parent in a single meiotic event. We don’t know whi ...
(Part 1) Eolution and Development
... Homeotic genes and evolution 2. Each gene has distinctive 180 bp homeobox domain • the homeobox is a DNA binding motif. 3. Perfect correlation between 3’-5’ order of genes and their embryonic expression/targets • genes at 3’ end of cluster expressed in head. • genes at 5’ end expressed in most post ...
... Homeotic genes and evolution 2. Each gene has distinctive 180 bp homeobox domain • the homeobox is a DNA binding motif. 3. Perfect correlation between 3’-5’ order of genes and their embryonic expression/targets • genes at 3’ end of cluster expressed in head. • genes at 5’ end expressed in most post ...
MAGMA manual (v0.2)
... location file, only SNPs with rs-ID present in both the data and the SNP location file can be used in the analysis. WARNING: when using your data .bim file as SNP location file, make sure that the SNP locations in the .bim file refer to the same human reference genome build version as the gene loca ...
... location file, only SNPs with rs-ID present in both the data and the SNP location file can be used in the analysis. WARNING: when using your data .bim file as SNP location file, make sure that the SNP locations in the .bim file refer to the same human reference genome build version as the gene loca ...
Duplication and Inherited Susceptibility of Chromosome 15q11
... related to compulsions and rigidity, or display more (or less) social impairment. This approach is likely to identify genetically more homogeneous groups of families; analysis of these families should reveal more significant findings for gene locus variants that specifically affect a particular phenoty ...
... related to compulsions and rigidity, or display more (or less) social impairment. This approach is likely to identify genetically more homogeneous groups of families; analysis of these families should reveal more significant findings for gene locus variants that specifically affect a particular phenoty ...
Regions of XY homology in the pig X pseudoautosomal region
... Duroc genomic DNA on a pig X-chromosome BAC tiling-path microarray. Putative XY-homologous BACs from regions of interest were subsequently FISH mapped. Results: We show that the porcine PAR is approximately 6.5-6.9 Mb at the beginning of the short arm of the X, with gene content reflective of the ar ...
... Duroc genomic DNA on a pig X-chromosome BAC tiling-path microarray. Putative XY-homologous BACs from regions of interest were subsequently FISH mapped. Results: We show that the porcine PAR is approximately 6.5-6.9 Mb at the beginning of the short arm of the X, with gene content reflective of the ar ...
Leukaemia Section t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL) in Oncology and Haematology
... 322 amino acids; contains a caspase recruitment domain; role in the apoptosis. ...
... 322 amino acids; contains a caspase recruitment domain; role in the apoptosis. ...
Gene Section HMGA2 (high mobility group AT-hook 2) in Oncology and Haematology
... In a majority of cases, there is no fusion gene: the breakpoint is located 10 kb up to 100 kb 5' to HMGIC; the recombinational repair gene RAD51B is a candidate to be the partner gene of HMGIC in t(12;14). In two cases (out of 81 primary tumors) exon 7 of RAD51B was fused in frame to either exon 2 o ...
... In a majority of cases, there is no fusion gene: the breakpoint is located 10 kb up to 100 kb 5' to HMGIC; the recombinational repair gene RAD51B is a candidate to be the partner gene of HMGIC in t(12;14). In two cases (out of 81 primary tumors) exon 7 of RAD51B was fused in frame to either exon 2 o ...
The application of molecular genetics to detection of
... level. There have been few definitive findings which hold up in more than a single model system, and any genetic or environmental factor that appears critical in one case can be excluded in another. The analysis of single gene mutations using RFLPs for linkage studies has had considerable success in ...
... level. There have been few definitive findings which hold up in more than a single model system, and any genetic or environmental factor that appears critical in one case can be excluded in another. The analysis of single gene mutations using RFLPs for linkage studies has had considerable success in ...
Transvection, nuclear structure, and chromatin proteins.
... including plants and vertebrates, also exists (reviewed by Grell, 1969). For example, Arnoldus et al. (1991) have found evidence for tissue specific somatic pairing in humans, suggesting that pairing is not only developmentally regulated but a form of regulation in itself. ...
... including plants and vertebrates, also exists (reviewed by Grell, 1969). For example, Arnoldus et al. (1991) have found evidence for tissue specific somatic pairing in humans, suggesting that pairing is not only developmentally regulated but a form of regulation in itself. ...
RNAi and RNAa - The Yin and Yang of RNAome
... Figure 1: RNAa/RNAi constitutes the Yin and Yang of the RNAome. The dual concepts of yin and yang which describe two primal opposing but complementary principles or cosmic forces said to be found in all non-static objects and processes in the universe. This paradoxical concept can potentially be app ...
... Figure 1: RNAa/RNAi constitutes the Yin and Yang of the RNAome. The dual concepts of yin and yang which describe two primal opposing but complementary principles or cosmic forces said to be found in all non-static objects and processes in the universe. This paradoxical concept can potentially be app ...
Recitation Section 16 Answer Key Recombination and Pedigrees
... People who are related to each other are more likely to have alleles in common. For rare recessive traits, sometimes the best hope of seeing a number of patients who all exhibit the trait is to observe a population or a large family where consanguineous marriages are common. These populations are li ...
... People who are related to each other are more likely to have alleles in common. For rare recessive traits, sometimes the best hope of seeing a number of patients who all exhibit the trait is to observe a population or a large family where consanguineous marriages are common. These populations are li ...