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Introduction to Angelfish Genetics
Introduction to Angelfish Genetics

... Once I saw two adult angels in a pet store tank with a spawn of wigglers. The male was black and the female was gold. I wondered, what will the babies look like? ...
The NF1 Locus Encodes a Protein Functionally
The NF1 Locus Encodes a Protein Functionally

... In particular, ifal- or ira2- strains are exquisitely sensitive to heat shock. This phenotype is suppressed by the overexpression of the yeast phosphodiesterase gene, PDEP, which also suppresses the phenotype resulting from the activated yeast RAS2va’-1g(Tanaka et al., 1989; Sass et al., 1986). fDE2 ...
Sequence and transcription analysis of the Petunia mitochondrial
Sequence and transcription analysis of the Petunia mitochondrial

... with a probe 5-end labelled at the same BamH1 site and extending out to the Xhol site. ...
AI - tcurry1977
AI - tcurry1977

... Mendelian Genetics Unit ...
Molecular basis of the adult i phenotype and the gene responsible
Molecular basis of the adult i phenotype and the gene responsible

... categorized to comprise collection 207 according to the International Society of Blood Transfusion terminology. In 1993, Bierhuizen et al18 reported the expression cloning of a cDNA encoding an I-branching ␤6GlcNAc-T. The gene, designated IGnT, is located on chromosome 6p24.19,20 Another gene, locat ...
Expression of E. coli Phosphofructokinase Gene in an Autotrophic
Expression of E. coli Phosphofructokinase Gene in an Autotrophic

... genes have been isolated by functional complementation of E. coli mutants. In addition, some genes originating from heterotrophic bacteria, including the kanamycin, streptomycin, tetracycline resistance genes, the tra gene of RP4, and the arsenic resistance gene [12, 13, 20], have been cloned and ex ...
n 1 , n 2 , n 3 - Carnegie Mellon School of Computer Science
n 1 , n 2 , n 3 - Carnegie Mellon School of Computer Science

... wish to determine whether the windows share more homologous genes than expected by chance. ...
Unequal Crossing Over Locus by KIR Cutting Edge: Expansion of the
Unequal Crossing Over Locus by KIR Cutting Edge: Expansion of the

... indicate that the mechanism by which this haplotype was derived involved unequal crossing over between two well-defined KIR haplotypes. We propose that this mechanism represents a common means by which expansion and contraction of KIR haplotypes occur, facilitating rapid evolution of the KIR gene co ...
Cloning and characterisation of a cysteine proteinase gene
Cloning and characterisation of a cysteine proteinase gene

... PCR amplification and screening of an amastigote cDNA library. Sequence analysis of the Llacys1 gene showed a high identity to sequence of Leishmania (L.) pifanoi Lpcys1, Leishmania (L.) major cpa, Leishmania (L.) mexicana LCPa, and Leishmania (L.) chagasi Ldccys2. The Llacys1 gene is present in a s ...
Prokaryotic Evolution in Light of Gene Transfer
Prokaryotic Evolution in Light of Gene Transfer

... it is often homologous recombination—not the stepwise accumulation of mutations after separation of lineages— that accounts for the lion’s share of sequence differences between isolates. Feil et al. (2001), in a study of conserved loci in bacterial pathogens, conclude for lineages within a species t ...
Slide 1
Slide 1

... • Information retrieval alone is difficult if ...
Slcyt, a Newly Identified Sex-Linked Gene, Has
Slcyt, a Newly Identified Sex-Linked Gene, Has

... are consistent with the hypothesis that, in both these X chromosomes, sexually antagonistic genes may have accumulated over time, leading to selective pressure for suppressed recombination in regions where recombination formerly occurred, to maintain associations between such genes and the sex-deter ...
Statistical analysis of DNA microarray data
Statistical analysis of DNA microarray data

... T-test relies on the parametric distribution assumption (normal distribution). Permutation tests do not depend on such an assumption. Examples include the permutation t-test and Wilcoxon rank-sum test. Perform regular t-test to obtain t-value t0. The randomly permute the N1+N2 samples and designate ...
Comparative Analysis of Parallel Gene Transfer Operators in the
Comparative Analysis of Parallel Gene Transfer Operators in the

... The second suggested gene transfer was called “gene transfer inspired by Microbial Genetic Algorithm” (pMGA, Fig. 4). The Microbial Genetic Algorithm (MGA) [8] is a simplistic GA. The MGA gave the idea of a new gene transfer because its selection and crossover can be regarded as a gene transfer. pMG ...
An archaebacterial homolog of pelota, a meiotic cell division protein
An archaebacterial homolog of pelota, a meiotic cell division protein

... units of RNA polymerase [7], translation initiation factors [8], ribosomal proteins [9], and a VCP-like two-domain ATPase that in eukaryotes is involved in cell-cycle regulation [lo]. Thus, an appropriate archaebacterial genome could be a better ‘prokaryotic model of the eukaryotic genome’ than coul ...
Linkage and Recombination
Linkage and Recombination

... Note that the genes are linked; if they weren't, we would have 8 phenotypes and 8 gamete genotypes in approximately equal numbers. Arranged in pairs of equal numbers, in order of magnitude. Which are parental genotypes? Which are double crossover genotypes? ...
Expression analysis of a chicory fructan 1‐exohydrolase gene
Expression analysis of a chicory fructan 1‐exohydrolase gene

... by heterologous expression in potato, and the identity of all three cDNA clones were con®rmed by comparison with trypsin digest and mass spectrometry of the puri®ed enzymes (Van den Ende et al., 2000, 2001). Sequence comparison of 1-FEH I to 1-FEH IIa and IIb reveals 50% sequence identity. The cDNAs ...
Both parents affected
Both parents affected

... For some conditions, being homozygous for the dominant disorder causes the individual to be more severely affected (as in achondroplasia) or for the disorder to have an earlier age of onset (eg familial hypercholesterolaemia). In other disorders, for instance Huntington disease, homozygotes appear t ...
Building a Better Mouse(trap): A New Model of Huntington`s Disease
Building a Better Mouse(trap): A New Model of Huntington`s Disease

... Fortunately, scientists all over the world are studying this problem. To help them, they use fancy genetics to recreate the genetic change from human Huntington’s disease in animals. Working with worms, fruit flies, mice, rats, and monkeys – a veritable ark of different species – scientists can then ...
Slide 1
Slide 1

... subsequent pregnancy? – The parents should be informed of the risk of disease in subsequent pregnancies, the availability of prenatal diagnosis, and the impact of the disease should it recur. ...
Cellular function prediction and biological pathway discovery in
Cellular function prediction and biological pathway discovery in

... Determination of protein function is one of the most important and challenging problems in the post-genomic era. The traditional wet laboratory experiments for this purpose are accurate, but the process is time-consuming and costly. Despite all the efforts, only 50–60% of genes have been annotated i ...
Construction of the optimal single gene ranking
Construction of the optimal single gene ranking

... Section 2: Construction of the Individual Property Network (IPN) In this work we propose that if gene function can be learned using guilt-by-association from a nonnetwork property of genes, then the effect of guilt-by-association in the original network must be discounted. In particular as we propo ...
A Case Study of Leopard Appaloosa Alpacas in one
A Case Study of Leopard Appaloosa Alpacas in one

... Ambersun herd showed them to have been sired by five separate males. If the gene is so rare, it seems beyond coincidence that five different males would be carrying the same gene. The results, therefore, would tend to support the earlier assertion based on research with horses as (Wilpedia, 2009) th ...
Human Gene Therapy : A Brief Overview of the Genetic
Human Gene Therapy : A Brief Overview of the Genetic

... such modified host cells divide later, their descendants will contain the new genes. Although retroviruses have been used in most gene therapy experiments so far, they present problems.13 One such problem is that integrase enzyme can insert genetic material of the virus into any arbitrary position i ...
this PDF file
this PDF file

... When 5A7 was first isolated, it was identified as a “brown” non-photosynthetic mutant. Spectrophotometric and HPLC results have shown that 5A7 lacks detectable Chl (Fig. 3; Table 1). Collaborative work with Dr. Bernhard Grimm of Humboldt University (Berlin, Germany), has revealed that 5A7 over-accum ...
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Gene nomenclature

Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms. An international committee published recommendations for genetic symbols and nomenclature in 1957. The need to develop formal guidelines for human gene names and symbols was recognized in the 1960s and full guidelines were issued in 1979 (Edinburgh Human Genome Meeting). Several other species-specific research communities (e.g., Drosophila, mouse) have adopted nomenclature standards, as well, and have published them on the relevant model organism websites and in scientific journals, including the Trends in Genetics Genetic Nomenclature Guide. Scientists familiar with a particular gene family may work together to revise the nomenclature for the entire set of genes when new information becomes available. For many genes and their corresponding proteins, an assortment of alternate names is in use across the scientific literature and public biological databases, posing a challenge to effective organization and exchange of biological information. Standardization of nomenclature thus tries to achieve the benefits of vocabulary control and bibliographic control, although adherence is voluntary. The advent of the information age has brought gene ontology, which in some ways is a next step of gene nomenclature, because it aims to unify the representation of gene and gene product attributes across all species.Gene nomenclature and protein nomenclature are not separate endeavors; they are aspects of the same whole. Any name or symbol used for a protein can potentially also be used for the gene that encodes it, and vice versa. But owing to the nature of how science has developed (with knowledge being uncovered bit by bit over decades), proteins and their corresponding genes have not always been discovered simultaneously (and not always physiologically understood when discovered), which is the largest reason why protein and gene names do not always match, or why scientists tend to favor one symbol or name for the protein and another for the gene. Another reason is that many of the mechanisms of life are the same or very similar across species, genera, orders, and phyla, so that a given protein may be produced in many kinds of organisms; and thus scientists naturally often use the same symbol and name for a given protein in one species (for example, mice) as in another species (for example, humans). Regarding the first duality (same symbol and name for gene or protein), the context usually makes the sense clear to scientific readers, and the nomenclatural systems also provide for some specificity by using italic for a symbol when the gene is meant and plain (roman) for when the protein is meant. Regarding the second duality (a given protein is endogenous in many kinds of organisms), the nomenclatural systems also provide for at least human-versus-nonhuman specificity by using different capitalization, although scientists often ignore this distinction, given that it is often biologically irrelevant.Also owing to the nature of how scientific knowledge has unfolded, proteins and their corresponding genes often have several names and symbols that are synonymous. Some of the earlier ones may be deprecated in favor of newer ones, although such deprecation is voluntary. Some older names and symbols live on simply because they have been widely used in the scientific literature (including before the newer ones were coined) and are well established among users.
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