Gene Section KLF5 (Kruppel-like factor 5 (intestinal)) Atlas of Genetics and Cytogenetics
... Down-regulation of KLF5 may be an early event in intestinal tumorigenesis. Expression of KLF5 in nontransformed intestinal epithelial cells enhances cell growth; however, KLF5 inhibits cell growth in colon cancer cell lines. Another group found that all-trans retinoic acid inhibits intestinal epithe ...
... Down-regulation of KLF5 may be an early event in intestinal tumorigenesis. Expression of KLF5 in nontransformed intestinal epithelial cells enhances cell growth; however, KLF5 inhibits cell growth in colon cancer cell lines. Another group found that all-trans retinoic acid inhibits intestinal epithe ...
Factors that influence gene expression
... otherwise ORF will be wrong (need to know the precise sequence of these two proteins) ...
... otherwise ORF will be wrong (need to know the precise sequence of these two proteins) ...
Fusion Detection using Archer Analysis
... is grouped together and an initial consensus sequence is constructed by concatenating the two (or more) reference sequence fragments that are spanned by the supporting reads. The original fusion candidate reads are mapped back to this initial consensus sequence to construct the final consensus seque ...
... is grouped together and an initial consensus sequence is constructed by concatenating the two (or more) reference sequence fragments that are spanned by the supporting reads. The original fusion candidate reads are mapped back to this initial consensus sequence to construct the final consensus seque ...
Promoter identification
... but housekeeping genes are not regulated that strongly. So if biologist wants to up- or down-regulate the expression and you tell him he has CpG island promoter, he is usually not happy. • non-CpG islands correspond to tissue-specific expression. And are the bottleneck in accurate promoter predictio ...
... but housekeeping genes are not regulated that strongly. So if biologist wants to up- or down-regulate the expression and you tell him he has CpG island promoter, he is usually not happy. • non-CpG islands correspond to tissue-specific expression. And are the bottleneck in accurate promoter predictio ...
More detail on linkage and Morgan
... and fertilization. • Under normal Mendelian genetic rules, we would not expect linked genes to recombine into assortments of alleles not found in the parents. – If the seed color and seed coat genes were linked, we would expect the F1 offspring to produce only two types of gametes, YR and yr when th ...
... and fertilization. • Under normal Mendelian genetic rules, we would not expect linked genes to recombine into assortments of alleles not found in the parents. – If the seed color and seed coat genes were linked, we would expect the F1 offspring to produce only two types of gametes, YR and yr when th ...
Genetics On a separate quiz fill in the blanks from the text below:
... which stated that all traits blend with each other, with the _________________ theory: 1. Inherited characters are determined by particular factors (today called _________________, which are located on DNA). 2. The particulate factors (genes) occur in _________________ (on maternal and paternal homo ...
... which stated that all traits blend with each other, with the _________________ theory: 1. Inherited characters are determined by particular factors (today called _________________, which are located on DNA). 2. The particulate factors (genes) occur in _________________ (on maternal and paternal homo ...
16.7 Screening for clinically important genes
... • It detects oncogene mutations responsible for cancer. Screening can determine the type of cancer that the patient has and hence the most effective drug or radiotherapy to use. • It can also detect tumour suppressor genes which inhibit cell division. Mutations can occur that effect these genes. Mut ...
... • It detects oncogene mutations responsible for cancer. Screening can determine the type of cancer that the patient has and hence the most effective drug or radiotherapy to use. • It can also detect tumour suppressor genes which inhibit cell division. Mutations can occur that effect these genes. Mut ...
Patterns of inheritance
... Recessive traits and alleles - the offspring will only get the trait if both parents contribute the trait. These traits can be carried in the persons genes, without appearing in the person. They are represented by a lower case letter (a, for example) – Eg, a dark-haired person may have one gene for ...
... Recessive traits and alleles - the offspring will only get the trait if both parents contribute the trait. These traits can be carried in the persons genes, without appearing in the person. They are represented by a lower case letter (a, for example) – Eg, a dark-haired person may have one gene for ...
Guo, Ming: Biological Pathways - A pathway to explore diseases mechanism
... The transcriptional regulators of a pathway can be identified with genome-wide binding analysis (also known as genome-wide location analysis). Investigators can identify the set of target genes bound in vivo by each of the transcriptional regulators that are encoded in a cell’s genome. [8] Lee etc. ...
... The transcriptional regulators of a pathway can be identified with genome-wide binding analysis (also known as genome-wide location analysis). Investigators can identify the set of target genes bound in vivo by each of the transcriptional regulators that are encoded in a cell’s genome. [8] Lee etc. ...
Chapter 8 Lecture Notes
... 7. RNA polymerase assembles the mRNA strand from free nucleotides through complimentary base pairing using the DNA template strand as a guide. 8. Transcription stops when the RNA polymerase reaches the terminator sequence, and the mRNA and the RNA polymerase are released from the DNA. 9. The process ...
... 7. RNA polymerase assembles the mRNA strand from free nucleotides through complimentary base pairing using the DNA template strand as a guide. 8. Transcription stops when the RNA polymerase reaches the terminator sequence, and the mRNA and the RNA polymerase are released from the DNA. 9. The process ...
Phenotype
... • Mechanistically predicting relationships between different data types is very difficult • Empirical mappings are important • Functions from Genome to Phenotype stands out in importance G is the most abundant data form - heritable and precise. F is of greatest interest. DNA ...
... • Mechanistically predicting relationships between different data types is very difficult • Empirical mappings are important • Functions from Genome to Phenotype stands out in importance G is the most abundant data form - heritable and precise. F is of greatest interest. DNA ...
Genetic Drift
... Nonrandom mating occurs when individuals have mating preferences rather than randomly mating with any other individual in the population. There are several ways nonrandom mating may occur: 1. Assortative mating – for example, when AA individuals preferentially mate with other AA individuals. This in ...
... Nonrandom mating occurs when individuals have mating preferences rather than randomly mating with any other individual in the population. There are several ways nonrandom mating may occur: 1. Assortative mating – for example, when AA individuals preferentially mate with other AA individuals. This in ...
College Prep: Review
... 2. DNA is double stranded, RNA is single 3. DNA has thymine, RNA has uracil 4. DNA is helical, RNA is not 5. DNA has 1 type, RNA has 3 mRNA tRNA rRNA 16. What type of macromolecule are DNA and RNA? Nucleic acid 17. List and describe the three types of RNA. 1. mRNA carries the gene’s message from DNA ...
... 2. DNA is double stranded, RNA is single 3. DNA has thymine, RNA has uracil 4. DNA is helical, RNA is not 5. DNA has 1 type, RNA has 3 mRNA tRNA rRNA 16. What type of macromolecule are DNA and RNA? Nucleic acid 17. List and describe the three types of RNA. 1. mRNA carries the gene’s message from DNA ...
Bio07_TR__U04_CH11.QXD
... Probability can be used to predict the outcome of genetic crosses because alleles segregate randomly. The gene combinations that might result from a genetic cross can be determined by drawing a Punnett square. In a Punnett square, alleles are represented by letters. A capital letter represents the d ...
... Probability can be used to predict the outcome of genetic crosses because alleles segregate randomly. The gene combinations that might result from a genetic cross can be determined by drawing a Punnett square. In a Punnett square, alleles are represented by letters. A capital letter represents the d ...
Toward forward genetic screens in malaria-causing
... in Plasmodium: (1) low transformation efficiency where by very few parasites in a population receive DNA during an individual transfection experiment, and (2) an inability to use RNA interference approaches (which is an alterna tive to traditional transformation methods) because the specific RNAi ...
... in Plasmodium: (1) low transformation efficiency where by very few parasites in a population receive DNA during an individual transfection experiment, and (2) an inability to use RNA interference approaches (which is an alterna tive to traditional transformation methods) because the specific RNAi ...
Evolutionary Systems Biology: multilevel evolution
... mutations segmental duplications/ deletions, pointmutations fitness: homestasis (evolves regulatory adaptation) evolving in varying environment ...
... mutations segmental duplications/ deletions, pointmutations fitness: homestasis (evolves regulatory adaptation) evolving in varying environment ...
Part I - OCCC.edu
... acid. When this new amino acid is at position #6 instead of the correct amino acid, the hemoglobin molecule is altered so that it becomes more hydrophobic. As a result, when the altered hemoglobin chains fold into their three-dimensional shape, they tend to stick to each other, forming long insolubl ...
... acid. When this new amino acid is at position #6 instead of the correct amino acid, the hemoglobin molecule is altered so that it becomes more hydrophobic. As a result, when the altered hemoglobin chains fold into their three-dimensional shape, they tend to stick to each other, forming long insolubl ...
The Autism Spectrum Disorders: from gene to function
... We seek a technician with experience in cell culture and/or microscopy to become involved in these studies. ...
... We seek a technician with experience in cell culture and/or microscopy to become involved in these studies. ...
How to create a personalized syndrome description
... straightforward approach to investigate a patient’s deletion. ...
... straightforward approach to investigate a patient’s deletion. ...
Educational Items Section Nomenclature for the description of mutations and
... Nomenclature for the description of mutations and other sequence variations Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France ...
... Nomenclature for the description of mutations and other sequence variations Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France ...
LETTER The Preferential Retention of Starch Synthesis Genes
... Gene duplication is a major force in evolution and can provide the genetic material necessary for the origin of new genes with novel functions (Ohno 1970). Polyploidy, which duplicates all genes in the genome, is an important source of biological innovation (Wendel 2000). In paleopolyploids, gene lo ...
... Gene duplication is a major force in evolution and can provide the genetic material necessary for the origin of new genes with novel functions (Ohno 1970). Polyploidy, which duplicates all genes in the genome, is an important source of biological innovation (Wendel 2000). In paleopolyploids, gene lo ...
Next lectures: Differential Gene expression
... • Timing and activation: LCR, enhancer • Facilitating factor access: MAR, LCR • Insulation: boundary, LCR • RNA pol II activity: promoter, enhancer • Needs chromatin: LCR, MAR, boundary** ...
... • Timing and activation: LCR, enhancer • Facilitating factor access: MAR, LCR • Insulation: boundary, LCR • RNA pol II activity: promoter, enhancer • Needs chromatin: LCR, MAR, boundary** ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.