CorrelateTalk
... • In this talk, we’ll consider the case of DNA copy number and gene expression measurements on a single set of samples. • Sparse CCA gives us a tool that can be used to answer the question: Can we identify a small set of gene expression measurements that is correlated with a region of DNA copy numbe ...
... • In this talk, we’ll consider the case of DNA copy number and gene expression measurements on a single set of samples. • Sparse CCA gives us a tool that can be used to answer the question: Can we identify a small set of gene expression measurements that is correlated with a region of DNA copy numbe ...
Model Organisms pre-class activity: Huntington disease
... The number of repeats is related to the age of onset of Huntington disease. The greater the number of repeats the earlier the onset of the disease. 3. How does an excess number of repeats affect the protein created by this gene? ...
... The number of repeats is related to the age of onset of Huntington disease. The greater the number of repeats the earlier the onset of the disease. 3. How does an excess number of repeats affect the protein created by this gene? ...
Cell Cycle, Cancer, and the Biology Student Workbench
... The letters in blue mean that the amino acids are highly conserved. In real people terms, it means they are the same. Notice the change from proline in the normal p53 gene to alanine in the Li Fraumeni p53 gene. This means that the DNA was mutated and as a result it coded for the wrong amino acid. I ...
... The letters in blue mean that the amino acids are highly conserved. In real people terms, it means they are the same. Notice the change from proline in the normal p53 gene to alanine in the Li Fraumeni p53 gene. This means that the DNA was mutated and as a result it coded for the wrong amino acid. I ...
Genomics of the evolutionary process
... the primary means by which functional elements are first identified, often preceding even the identification of their function. Although this approach capitalizes on the conservation of homologous functions, it has also been successful in identifying evolutionary novelties, including new genes and p ...
... the primary means by which functional elements are first identified, often preceding even the identification of their function. Although this approach capitalizes on the conservation of homologous functions, it has also been successful in identifying evolutionary novelties, including new genes and p ...
Mutation and Genetic Change
... iii. Inversion- When two genes on the same chromosome are in reverse order. ...
... iii. Inversion- When two genes on the same chromosome are in reverse order. ...
Macromolecule: Carbohydrates Polarity: Polar Functions: Store
... Functional groups and formation: Phosphate group Amino group Phosphodiester bond – occurs between phosphate group on one nucleotide and a hydroxyl group on the sugar of the next nucleotide in the strand (makes up the alternating sugar-phosphate backbone of DNA ...
... Functional groups and formation: Phosphate group Amino group Phosphodiester bond – occurs between phosphate group on one nucleotide and a hydroxyl group on the sugar of the next nucleotide in the strand (makes up the alternating sugar-phosphate backbone of DNA ...
Some - Laker Science
... Explain the role of promoters, enhancers, activators, and repressors in transcriptional control. Understand coordinately expressed genes in eukaryotes. Describe the roles small RNAs play on gene expression. Describe two sources o information that instruct cells to express genes at the appropriate ti ...
... Explain the role of promoters, enhancers, activators, and repressors in transcriptional control. Understand coordinately expressed genes in eukaryotes. Describe the roles small RNAs play on gene expression. Describe two sources o information that instruct cells to express genes at the appropriate ti ...
Global MicroRNA Amplification Kit
... preamplification of small RNAs for either qRT-PCR or miRNA microarray studies. There are estimated to be hundreds of distinct miRNAs in mammalian cells, not including the many other small noncoding RNAs. Because it is clear that a specific miRNA can influence the gene expression level of multiple ge ...
... preamplification of small RNAs for either qRT-PCR or miRNA microarray studies. There are estimated to be hundreds of distinct miRNAs in mammalian cells, not including the many other small noncoding RNAs. Because it is clear that a specific miRNA can influence the gene expression level of multiple ge ...
Protocells: At the Interface of Life and Non-Life
... The key point is: a functional molecule (either a protein or an RNA) typically has only one function (two occasionally and at most several in some rare cases). Therefore, given that more and more functions would emerge through evolution, more and more functional molecules would become involved in th ...
... The key point is: a functional molecule (either a protein or an RNA) typically has only one function (two occasionally and at most several in some rare cases). Therefore, given that more and more functions would emerge through evolution, more and more functional molecules would become involved in th ...
Understanding protein lists from comparative proteomics studies
... “I’ve attached a spreadsheet of our proteomics results comparing 5 Vehicle and 5 Aldosterone treated patients. We’ve included only those proteins whose summed spectral counts are >30 in one treatment group. Would it be possible to get the GO annotations for these? The Uniprot name is listed in colum ...
... “I’ve attached a spreadsheet of our proteomics results comparing 5 Vehicle and 5 Aldosterone treated patients. We’ve included only those proteins whose summed spectral counts are >30 in one treatment group. Would it be possible to get the GO annotations for these? The Uniprot name is listed in colum ...
TF binding
... changes in gene activity that are not caused by changes in the DNA sequence • The study of stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable • Functionally relevant changes to the genome that do not involve a change in the nucleotide sequence ...
... changes in gene activity that are not caused by changes in the DNA sequence • The study of stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable • Functionally relevant changes to the genome that do not involve a change in the nucleotide sequence ...
doc 3.7.1 inheritance checklist
... The use of fully labelled genetic diagrams to interpret, or predict, the results of: •• monohybrid and dihybrid crosses involving dominant, recessive and codominant alleles •• crosses involving sex-linkage, autosomal linkage, multiple alleles and epistasis. ...
... The use of fully labelled genetic diagrams to interpret, or predict, the results of: •• monohybrid and dihybrid crosses involving dominant, recessive and codominant alleles •• crosses involving sex-linkage, autosomal linkage, multiple alleles and epistasis. ...
CONTENTS DNA, RNA AND PROTEIN SYNTHESIS DNA
... DNA biosynthesis proceeds in the 5′- to 3′-direction. This makes it impossible for DNA polymerases to synthesize both strands simultaneously. A portion of the double helix must first unwind, and this is mediated by helicase enzymes. The leading strand is synthesized continuously but the opposite str ...
... DNA biosynthesis proceeds in the 5′- to 3′-direction. This makes it impossible for DNA polymerases to synthesize both strands simultaneously. A portion of the double helix must first unwind, and this is mediated by helicase enzymes. The leading strand is synthesized continuously but the opposite str ...
Brooker Chapter 4
... Gene interactions occur when two or more different genes influence the outcome of a single trait Most morphological traits (height, weight, color) are affected by multiple genes Epistasis describes situation between various alleles of two genes Quantitative loci is a term to describe those loci cont ...
... Gene interactions occur when two or more different genes influence the outcome of a single trait Most morphological traits (height, weight, color) are affected by multiple genes Epistasis describes situation between various alleles of two genes Quantitative loci is a term to describe those loci cont ...
About this Book
... A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptib ...
... A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptib ...
FoldNucleus: web server for the prediction of RNA
... The server was used to determine the folding nuclei for 21 proteins. A comparison of the calculation results with the experimental data shows that the model provides good A-value predictions for protein structures determined by X-ray analysis with consideration of hydrogen atoms and, less successful ...
... The server was used to determine the folding nuclei for 21 proteins. A comparison of the calculation results with the experimental data shows that the model provides good A-value predictions for protein structures determined by X-ray analysis with consideration of hydrogen atoms and, less successful ...
Nature vs. Nurture Article
... The hoopla with which these discoveries have been greeted-"GAY GENE!" the headlines blared--has obscured the fact that other institutions have had mixed results when trying to replicate the findings. It has also made it seem as if single genes dictate specific behaviors. The reality is more complica ...
... The hoopla with which these discoveries have been greeted-"GAY GENE!" the headlines blared--has obscured the fact that other institutions have had mixed results when trying to replicate the findings. It has also made it seem as if single genes dictate specific behaviors. The reality is more complica ...
slides - Yin Lab @ NIU
... This information is shown in “tracks,” with each track showing either the genomic sequence from a particular species or a particular kind of annotation on the gene. The tracks are aligned so that the information about a particular base in the sequence is lined up and can be viewed easily. ...
... This information is shown in “tracks,” with each track showing either the genomic sequence from a particular species or a particular kind of annotation on the gene. The tracks are aligned so that the information about a particular base in the sequence is lined up and can be viewed easily. ...
Potential Transcriptional Biomarkers in Human Transplant Renal
... biomarkers that subsequently benefit diagnosis and treatment of allograft injury. Methods: Renal biopsies from LD and CAD paired at 30 minutes and 3 months post-transplantation (n=5-6) were used for whole-genome profiling and pathway analysis. Additional 33 biopsies (n=6-13) unpaired at two time poi ...
... biomarkers that subsequently benefit diagnosis and treatment of allograft injury. Methods: Renal biopsies from LD and CAD paired at 30 minutes and 3 months post-transplantation (n=5-6) were used for whole-genome profiling and pathway analysis. Additional 33 biopsies (n=6-13) unpaired at two time poi ...
Progressive rod-cone degeneration (PRCD) in selected dog breeds
... showing conservation of synteny with human HSA17q22 (Acland et al., 1998; Acland et al., 1999). Based on clinical similarities of the diseases, as well as chromosomal location, PRCD has been proposed as a locus homologous for RP17 and the only animal model for RP17 (Acland et al., 1998). The order o ...
... showing conservation of synteny with human HSA17q22 (Acland et al., 1998; Acland et al., 1999). Based on clinical similarities of the diseases, as well as chromosomal location, PRCD has been proposed as a locus homologous for RP17 and the only animal model for RP17 (Acland et al., 1998). The order o ...
Prentice Hall Biology
... include a form of leukemia and neurofibromatosis. Also contains long stretches of repetitive DNA that are unstable sites where rearrangements can occur (breakage). ...
... include a form of leukemia and neurofibromatosis. Also contains long stretches of repetitive DNA that are unstable sites where rearrangements can occur (breakage). ...
Meiosis and Genetics
... Diploid (2n) = 2 Haploid (n) = 1 •Explain how this diagram of meiosis could relate to Mendel’s idea that two “factors” must control a trait. ...
... Diploid (2n) = 2 Haploid (n) = 1 •Explain how this diagram of meiosis could relate to Mendel’s idea that two “factors” must control a trait. ...
Gene ontology analysis of gene-gene interactions in two genome
... Despite the relatively low incidence rate compared to more prevalent diseases such as Alzheimer’s and Parkinson’s, ALS is a devastating disease with the average life expectancy of only two to five years from the time of diagnosis. Unfortunately, genomewide association studies (GWAS) across multiple ...
... Despite the relatively low incidence rate compared to more prevalent diseases such as Alzheimer’s and Parkinson’s, ALS is a devastating disease with the average life expectancy of only two to five years from the time of diagnosis. Unfortunately, genomewide association studies (GWAS) across multiple ...
11-3 Exploring Mendelian Genetics
... some of the alleles may be dominant and others may be recessive. In most sexually reproducing organisms, each adult has two copies of each gene. These genes are segregated from each other when gametes are formed. The alleles for different genes usually segregate independently of one another ...
... some of the alleles may be dominant and others may be recessive. In most sexually reproducing organisms, each adult has two copies of each gene. These genes are segregated from each other when gametes are formed. The alleles for different genes usually segregate independently of one another ...
Diapositiva 1
... population we have two alleles between 5-37 CTG repeats. In patients the length of one allele is expanded from more than 50 repeats up to even thousands of repeats. (B) Mutant transcripts form stable CUG hairpins that avoid their normal transportation to cytoplasm, with the ability of forming nuclea ...
... population we have two alleles between 5-37 CTG repeats. In patients the length of one allele is expanded from more than 50 repeats up to even thousands of repeats. (B) Mutant transcripts form stable CUG hairpins that avoid their normal transportation to cytoplasm, with the ability of forming nuclea ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.