A haploid-specific transcriptional response to
... Gamma irradiation generates various types of DNA damage, including double-strand breaks (DSBs). A single unre- 55 paired DSB is deleterious for cells, as it may lead to genetic instability and the loss of chromosome fragments. Such damage may occur anywhere in the genome and may have a major effect ...
... Gamma irradiation generates various types of DNA damage, including double-strand breaks (DSBs). A single unre- 55 paired DSB is deleterious for cells, as it may lead to genetic instability and the loss of chromosome fragments. Such damage may occur anywhere in the genome and may have a major effect ...
NSCLC with high PD-L1 expression on tumor cells or tumor
... Background: Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression ...
... Background: Programmed death-ligand 1 (PD-L1) expression on tumor cells (TC) or tumor-infiltrating immune cells (IC) is associated with OS, PFS and ORR in pts with advanced NSCLC treated with atezolizumab (anti-PDL1, MPDL3280A; Spigel et al, Spira et al, ASCO 2015), indicating that PD-L1 expression ...
Table S1: Properties of OC cell lines used in this
... 27. M. Nikrad, T. Johnson, H. Puthalalath, L. Coultas, J. AdamsA. S. Kraft, The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim, Mol Cancer Ther 4 (2005) 443-9 28. J. Han, P. SabbatiniE. White, Induction of apoptosis by hum ...
... 27. M. Nikrad, T. Johnson, H. Puthalalath, L. Coultas, J. AdamsA. S. Kraft, The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim, Mol Cancer Ther 4 (2005) 443-9 28. J. Han, P. SabbatiniE. White, Induction of apoptosis by hum ...
Genetics Guided Notes: ANSWER KEY Name
... Homozygous Dominant – when an individual has two dominant alleles for a gene Ex : AA Homozygous Recessive – when an individual has two recessive alleles for a gene Ex: aa Heterozygous – when an individual has both a dominant and a recessive allele for a gene ...
... Homozygous Dominant – when an individual has two dominant alleles for a gene Ex : AA Homozygous Recessive – when an individual has two recessive alleles for a gene Ex: aa Heterozygous – when an individual has both a dominant and a recessive allele for a gene ...
genes. Numbers of 6-10 copies per genome have
... The SSU genes and flanking regions in TSSU3-2 and TSSU3-8 were sequenced. Using sequences of other SSU genes, the leader peptide, mature coding regions and introns were located. In Figure 2, the sequence of these two genes is shown and compared to that of a previously sequenced tobacco SSU gene, NtS ...
... The SSU genes and flanking regions in TSSU3-2 and TSSU3-8 were sequenced. Using sequences of other SSU genes, the leader peptide, mature coding regions and introns were located. In Figure 2, the sequence of these two genes is shown and compared to that of a previously sequenced tobacco SSU gene, NtS ...
78KB - NZQA
... chromosomes. Because gametes end up with a random mix instead of a pre-defined "set" from either parent, gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes forme ...
... chromosomes. Because gametes end up with a random mix instead of a pre-defined "set" from either parent, gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes forme ...
complement based renal disease
... over-activation of the AP. Most mutations are point mutations or small deletion/insertions. For most aHUS, the mode of inheritance is autosomal dominant where individuals carry a single copy of a mutation in one of these genes (heterozygous). However, individuals carrying two copies of the same muta ...
... over-activation of the AP. Most mutations are point mutations or small deletion/insertions. For most aHUS, the mode of inheritance is autosomal dominant where individuals carry a single copy of a mutation in one of these genes (heterozygous). However, individuals carrying two copies of the same muta ...
DNA, restriction enzymes
... temperature of 41C. The blot reveals a band at 4.3 kb for the wild-type strain but, for the mutant, no detectable hybridizing band is seen. This mutant is a deletion of (at least) the entire exon. b) In this case, the Southern blot (performed as described above) gives identical 4.3 kb bands for both ...
... temperature of 41C. The blot reveals a band at 4.3 kb for the wild-type strain but, for the mutant, no detectable hybridizing band is seen. This mutant is a deletion of (at least) the entire exon. b) In this case, the Southern blot (performed as described above) gives identical 4.3 kb bands for both ...
To Release or Not to Release: Evaluating Information Leaks
... population of a species. • Single Nucleotide Polymorphism (SNP): The smallest possible polymorphism, which involves two types of nucleotides out of four (A, T, C, G) at a single nucleotide site in the genome. • Haplotype: Haplotype, also referred to as SNP sequence, is the specific combination of al ...
... population of a species. • Single Nucleotide Polymorphism (SNP): The smallest possible polymorphism, which involves two types of nucleotides out of four (A, T, C, G) at a single nucleotide site in the genome. • Haplotype: Haplotype, also referred to as SNP sequence, is the specific combination of al ...
2008 LASKER AWARDS for MEDICAL RESEARCH
... mRNA—through typical Watson-Crick base-pairing—and promote destruction of the mRNA or interfere with its translation into protein. However, no one could find such RNAs. Baulcombe reasoned that the predicted RNAs might have eluded researchers because the molecules were shorter than anyone imagined an ...
... mRNA—through typical Watson-Crick base-pairing—and promote destruction of the mRNA or interfere with its translation into protein. However, no one could find such RNAs. Baulcombe reasoned that the predicted RNAs might have eluded researchers because the molecules were shorter than anyone imagined an ...
Solid Tumour Section Bone: t(3;17)(q21;p13) in aneurysmal bone cyst
... Online updated version : http://AtlasGeneticsOncology.org/Tumors/t0317q21p13BoneCystID5671.html DOI: 10.4267/2042/47307 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematolo ...
... Online updated version : http://AtlasGeneticsOncology.org/Tumors/t0317q21p13BoneCystID5671.html DOI: 10.4267/2042/47307 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematolo ...
Transposable elements
... Cointegration = movement of a transposon from one genome (e.g., plasmid) to another (e.g., chromosome) integrates transposon to both genomes (duplication). ...
... Cointegration = movement of a transposon from one genome (e.g., plasmid) to another (e.g., chromosome) integrates transposon to both genomes (duplication). ...
Analysis of mutations within multiple genes associated
... Research has shown that resistance of other drug treatments are likely due to mutations at penA, mtrR, and penB loci. This study was aimed at discovery of molecular basis for resistance of ceftriaxone ...
... Research has shown that resistance of other drug treatments are likely due to mutations at penA, mtrR, and penB loci. This study was aimed at discovery of molecular basis for resistance of ceftriaxone ...
Recombinant DNA Technology
... name from the earlier technique. It is used to detect cellular RNA rather than DNA. Initially, it was thought that RNA would not bind efficiently to nitrocellulose, and other modified materials were synthesised for use as a membrane. However, it was then shown that when RNA was denatured, that it wo ...
... name from the earlier technique. It is used to detect cellular RNA rather than DNA. Initially, it was thought that RNA would not bind efficiently to nitrocellulose, and other modified materials were synthesised for use as a membrane. However, it was then shown that when RNA was denatured, that it wo ...
Phylogenetic relationships among iguanian lizards using alternative
... 1986). This model was chosen based on preliminary analyses using Modeltest v3.7 (Posada and Crandall, 1998) that chose the TVM + C + I as the optimal model with the Akaike Information Criterion. However, current implementation of RAxML does not allow for specification of the TVM substitution model. P ...
... 1986). This model was chosen based on preliminary analyses using Modeltest v3.7 (Posada and Crandall, 1998) that chose the TVM + C + I as the optimal model with the Akaike Information Criterion. However, current implementation of RAxML does not allow for specification of the TVM substitution model. P ...
BIO 103 Genetics Ch.12
... F2 generation: offspring resulting from the selffertilization of F1 plants F2 plants exhibited both forms of the trait: ¾ plants with the dominant form ¼ plant with the recessive form Mendel discovered the ratio is actually: 1 pure-bred dominant plant 2 hybrid dominant plants 1 pure-bred recessive p ...
... F2 generation: offspring resulting from the selffertilization of F1 plants F2 plants exhibited both forms of the trait: ¾ plants with the dominant form ¼ plant with the recessive form Mendel discovered the ratio is actually: 1 pure-bred dominant plant 2 hybrid dominant plants 1 pure-bred recessive p ...
Mapping the Genetic Architecture of Gene Expression in Human Liver
... associated traits. Because a majority of single nucleotide polymorphisms (SNPs) detected as associated with disease traits from the recent wave of genome-wide association studies (GWASs) do not appear to affect protein sequence, it is likely that these SNPs either regulate gene activity at the trans ...
... associated traits. Because a majority of single nucleotide polymorphisms (SNPs) detected as associated with disease traits from the recent wave of genome-wide association studies (GWASs) do not appear to affect protein sequence, it is likely that these SNPs either regulate gene activity at the trans ...
Whose got Genes?
... Genes are a segment of DNA on a chromosome that controls a particular trait. Genes are located on the chromosomes in the nuclei. Each organims has a fixed number of ...
... Genes are a segment of DNA on a chromosome that controls a particular trait. Genes are located on the chromosomes in the nuclei. Each organims has a fixed number of ...
ppt - Chair of Computational Biology
... interacts with the promoters of active genes, and the NPC-associated protein Mlp1 (myosin-like protein 1) accumulates at the 3′ end of active genes, where it contributes to an RNA surveillance mechanism. Optimal activation can require both localization of the induced gene at the NPC as well as at th ...
... interacts with the promoters of active genes, and the NPC-associated protein Mlp1 (myosin-like protein 1) accumulates at the 3′ end of active genes, where it contributes to an RNA surveillance mechanism. Optimal activation can require both localization of the induced gene at the NPC as well as at th ...
Engineering a Gene Silencing Viral Construct that Targets the
... We are using a combined approach to permanently sterilize cats. This approach employs two complementary methodologies: RNA interference (RNAi) to silence genes involved in the central control of reproduction; and a virus-based gene therapy system intended to deliver RNAi selectively to the hypothala ...
... We are using a combined approach to permanently sterilize cats. This approach employs two complementary methodologies: RNA interference (RNAi) to silence genes involved in the central control of reproduction; and a virus-based gene therapy system intended to deliver RNAi selectively to the hypothala ...
b) Inheritance - iGCSE Science Courses
... 3.15 describe a DNA molecule as two strands coiled to form a double helix, the strands being linked by a series of paired bases: adenine (A) with thymine (T), and cytosine (C) with guanine (G) 3.16 understand that genes exist in alternative forms called alleles which give rise to differences in inhe ...
... 3.15 describe a DNA molecule as two strands coiled to form a double helix, the strands being linked by a series of paired bases: adenine (A) with thymine (T), and cytosine (C) with guanine (G) 3.16 understand that genes exist in alternative forms called alleles which give rise to differences in inhe ...
COMPUTATIONAL BIOLOGY
... from entry X01714, the one that describes its bacterial homologue. The top part of the entry follows the general information keywords order: LOCUS, ACCESSION, DEFINITION and VERSION The KEYWORD line, which is supposed to list readily relevant and searchable terms, is empty for entry U90223. Unfortun ...
... from entry X01714, the one that describes its bacterial homologue. The top part of the entry follows the general information keywords order: LOCUS, ACCESSION, DEFINITION and VERSION The KEYWORD line, which is supposed to list readily relevant and searchable terms, is empty for entry U90223. Unfortun ...
exportin-5 mediates their nuclear export
... The identification of Exp5 as the export factor for premiRNA is an important step towards understanding the regulatory mechanism of miRNA biogenesis. Evidence suggests that miRNA expression might be regulated at the level of RNA maturation. Some miRNAs accumulate as long forms (70 – 100-nt) at early ...
... The identification of Exp5 as the export factor for premiRNA is an important step towards understanding the regulatory mechanism of miRNA biogenesis. Evidence suggests that miRNA expression might be regulated at the level of RNA maturation. Some miRNAs accumulate as long forms (70 – 100-nt) at early ...
Identification of cell types from single-cell
... not effective enough for high-dimensional data with few objects. An alternative similarity measure utilizes the ranking induced by a specified primary similarity. One commonly used secondary similarity is based on the notion of shared nearest neighbor (SNN), which takes into account the effect of su ...
... not effective enough for high-dimensional data with few objects. An alternative similarity measure utilizes the ranking induced by a specified primary similarity. One commonly used secondary similarity is based on the notion of shared nearest neighbor (SNN), which takes into account the effect of su ...
Oncogenes - University of Bath
... identical: tumour development is a complex process, and there are many paths to malignancy. Nevertheless, certain tenets persist: that cancer arises as the result of genetic change; that this leads to loss of control over cellular proliferation, and that usually several genetic errors are required t ...
... identical: tumour development is a complex process, and there are many paths to malignancy. Nevertheless, certain tenets persist: that cancer arises as the result of genetic change; that this leads to loss of control over cellular proliferation, and that usually several genetic errors are required t ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.