Cell
... Percivall Pott found that chimney sweeps show substantially higher rates of skin cancer ...
... Percivall Pott found that chimney sweeps show substantially higher rates of skin cancer ...
New Potential Lung Cancer Biomarkers Identified
... treated and untreated xenograft tumors (FFPE); also MSI analysis of frozen tumors allowed for detection of the precision therapy drug, as well as lipids that were changing in expression as a result of treatment.” A common problem in the treatment of cancer is that the tumors become resistant to the ...
... treated and untreated xenograft tumors (FFPE); also MSI analysis of frozen tumors allowed for detection of the precision therapy drug, as well as lipids that were changing in expression as a result of treatment.” A common problem in the treatment of cancer is that the tumors become resistant to the ...
the spread of cancer
... Without a blood supply to provide the needed nutrients, neoplasms cannot grow more than a few millimeters. Tumors that lack this ability remain in situ, a steady state in which the number of new cells equals the number of dying cells.8,19 But, for unknown reasons, an in situ tumor can suddenly induc ...
... Without a blood supply to provide the needed nutrients, neoplasms cannot grow more than a few millimeters. Tumors that lack this ability remain in situ, a steady state in which the number of new cells equals the number of dying cells.8,19 But, for unknown reasons, an in situ tumor can suddenly induc ...
Identification of Human Lung Cancer Stem Cell Markers
... Lung cancer, the most common cancer in humans, causes more than 1 million deaths worldwide each year. A growing body of evidence suggests that lung cancers contain a subpopulation of cancer cells responsible for the initiation, propagation, and metastasis of lung cancers. These cells are termed canc ...
... Lung cancer, the most common cancer in humans, causes more than 1 million deaths worldwide each year. A growing body of evidence suggests that lung cancers contain a subpopulation of cancer cells responsible for the initiation, propagation, and metastasis of lung cancers. These cells are termed canc ...
Five years of successful stem cell research at HI-STEM
... achieve our present size of over 50 employees. We were able to recruit five highly talented young research group leaders from top international research institutes for HI-STEM, and have obtained important results that we have published in leading international journals. HISTEM has already secured it ...
... achieve our present size of over 50 employees. We were able to recruit five highly talented young research group leaders from top international research institutes for HI-STEM, and have obtained important results that we have published in leading international journals. HISTEM has already secured it ...
Title: What is Cancer?
... There are many different types of cancer depending on which tissue or organ they come from - for example, cancer that begins in the cells of the large bowel is called colon cancer. Normally body cells grow and divide in a controlled way to produce more cells as they are needed to keep the body healt ...
... There are many different types of cancer depending on which tissue or organ they come from - for example, cancer that begins in the cells of the large bowel is called colon cancer. Normally body cells grow and divide in a controlled way to produce more cells as they are needed to keep the body healt ...
“Science will soon create the perfect human
... CREDITS: S. Beauvais, November 2009 J. PAVICH, AICE: General Paper, Boca Raton H.S. ...
... CREDITS: S. Beauvais, November 2009 J. PAVICH, AICE: General Paper, Boca Raton H.S. ...
Techniques for Obtaining Stem Cells: Article 2 Therapeutic Cloning
... donor. It has been used to clone non-human animals, the most famous being the sheep Dolly. Therapeutic cloning has been negatively associated with the idea of human reproductive cloning but the majority of scientists do not support the reproductive uses of this procedure in humans. A somatic cell is ...
... donor. It has been used to clone non-human animals, the most famous being the sheep Dolly. Therapeutic cloning has been negatively associated with the idea of human reproductive cloning but the majority of scientists do not support the reproductive uses of this procedure in humans. A somatic cell is ...
Cancer Stem Cells: Controversial or Just Misunderstood?
... evident and responsible for generating a bulk tumor population (e.g., chronic myelogenous leukemia), then therapies that directly target CSCs may be useful. If tumors do not maintain a hierarchical development structure, then it may be more important to focus on those stemlike properties most releva ...
... evident and responsible for generating a bulk tumor population (e.g., chronic myelogenous leukemia), then therapies that directly target CSCs may be useful. If tumors do not maintain a hierarchical development structure, then it may be more important to focus on those stemlike properties most releva ...
Pancreatic cancer breakthrough: scientists turn cancer cells into
... A new research study has shown that pancreatic cancer cells can be coaxed to revert back toward normal cells by introducing a protein called E47. E47 binds to specific DNA sequences and controls genes involved in growth and differentiation. The research provides hope for a new treatment approach for ...
... A new research study has shown that pancreatic cancer cells can be coaxed to revert back toward normal cells by introducing a protein called E47. E47 binds to specific DNA sequences and controls genes involved in growth and differentiation. The research provides hope for a new treatment approach for ...
View Press Release
... numbers of mature neurons that will subsequently promote cognitive improvement in patients with Alzheimer's disease, stroke or depression. Neuronascent has laboratories in Rockville and Walkersville, Maryland. International Stem Cell Corporation (ISCO) is a biotechnology company focused on developin ...
... numbers of mature neurons that will subsequently promote cognitive improvement in patients with Alzheimer's disease, stroke or depression. Neuronascent has laboratories in Rockville and Walkersville, Maryland. International Stem Cell Corporation (ISCO) is a biotechnology company focused on developin ...
Targeting of the tumor stroma for improved cancer therapy
... of inhibitory signals can be sufficient for obtaining extremely impressive clinical results. Still, however, many cancer patients do not respond to immunotherapy – the reason for that being largely unknown. One likely possibility is that the local T cell response in the tumor gets suppressed by comp ...
... of inhibitory signals can be sufficient for obtaining extremely impressive clinical results. Still, however, many cancer patients do not respond to immunotherapy – the reason for that being largely unknown. One likely possibility is that the local T cell response in the tumor gets suppressed by comp ...
Link
... to self-renew, differentiate, and form metastatic tumours.1 CSCs effectively evade conventional chemotherapy and radiotherapy as these treatments specifically target fast growing cancer cells, and CSCs, due to their stem cell-like properties, divide more slowly.2 After surviving treatment, CSCs are ...
... to self-renew, differentiate, and form metastatic tumours.1 CSCs effectively evade conventional chemotherapy and radiotherapy as these treatments specifically target fast growing cancer cells, and CSCs, due to their stem cell-like properties, divide more slowly.2 After surviving treatment, CSCs are ...
Carcinogenesis – The Development of Cancer
... The cells of the cancer, at least at its beginning, must have been derived from a single cell that went wrong. The cell must have independent ability to divide continuously and out of control. The cell must be able to separate from its neighbouring cells and move to a new location where a new mass o ...
... The cells of the cancer, at least at its beginning, must have been derived from a single cell that went wrong. The cell must have independent ability to divide continuously and out of control. The cell must be able to separate from its neighbouring cells and move to a new location where a new mass o ...
Cancer stem cell
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease.Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. However, animals do not provide a complete model of human disease. In particular, in mice, whose life spans do not exceed two years, tumor relapse is difficult to study.The efficacy of cancer treatments is, in the initial stages of testing, often measured by the ablation fraction of tumor mass (fractional kill). As CSCs form a small proportion of the tumor, this may not necessarily select for drugs that act specifically on the stem cells. The theory suggests that conventional chemotherapies kill differentiated or differentiating cells, which form the bulk of the tumor but do not generate new cells. A population of CSCs, which gave rise to it, could remain untouched and cause relapse.Cancer stem cells were first identified by John Dick in acute myeloid leukemia in the late 1990s. Since the early 2000s they have been an intense focus of cancer research