Common poisoning in childhood
... -when hepatic store of glutathione are depleted to <70% of normal , the NAPQI can combined to the hepatic macromolecules to produce hepatocellular damage. - The acute toxic dose of acetaminophen is >200mg/kg - -single injection of 7.5mg is considered a minimal toxic dose for adolescent and adult. - ...
... -when hepatic store of glutathione are depleted to <70% of normal , the NAPQI can combined to the hepatic macromolecules to produce hepatocellular damage. - The acute toxic dose of acetaminophen is >200mg/kg - -single injection of 7.5mg is considered a minimal toxic dose for adolescent and adult. - ...
The Liver
... • Deamination and transamination of amino acids, followed by conversion of the nonnitrogenous part of those molecules to glucose or lipids. ...
... • Deamination and transamination of amino acids, followed by conversion of the nonnitrogenous part of those molecules to glucose or lipids. ...
Detoxification of substances by the liver
... will then be neutralized by phase 2 of the enzyme system. This pathway converts a toxic chemical into a less harmful chemical and is achieved by oxidation, reduction and hydrolysis reactions. During this process, free radicals are produced and if there are too many it can damage the liver cells. Wit ...
... will then be neutralized by phase 2 of the enzyme system. This pathway converts a toxic chemical into a less harmful chemical and is achieved by oxidation, reduction and hydrolysis reactions. During this process, free radicals are produced and if there are too many it can damage the liver cells. Wit ...
Liver disease
... • In liver disease there are crossovers between purely biliary disease and hepatocellular disease • To interpret these, the physician will look at the entire picture of the hepatocellular disease and biliary tract disease to determine which is the primary abnormality • Acute liver disease • Chronic ...
... • In liver disease there are crossovers between purely biliary disease and hepatocellular disease • To interpret these, the physician will look at the entire picture of the hepatocellular disease and biliary tract disease to determine which is the primary abnormality • Acute liver disease • Chronic ...
Chemical Toxicology Questions
... 11.What is the name of the paracetamol metabolite responsible for liver toxicity? ...
... 11.What is the name of the paracetamol metabolite responsible for liver toxicity? ...
Toxicology learning objectives File
... 3) Altered CNS – benzodiazepines; barbiturates; toxic alcohols; oral hypogylcemics 4) Other: Paracetamol ...
... 3) Altered CNS – benzodiazepines; barbiturates; toxic alcohols; oral hypogylcemics 4) Other: Paracetamol ...