Interpretation of bafilomycin, pH neutralizing or protease inhibitor
... of lysosomal protease inhibitors (such as leupeptin), intralysosomal pH neutralizing agents (such as chloroquine), or drugs that inhibit the vacuolar type H+ -ATPase (v-ATPase) complex necessary for lysosomal acidification (such as bafilomycin A1). These treatments block autophagic degradation at a ...
... of lysosomal protease inhibitors (such as leupeptin), intralysosomal pH neutralizing agents (such as chloroquine), or drugs that inhibit the vacuolar type H+ -ATPase (v-ATPase) complex necessary for lysosomal acidification (such as bafilomycin A1). These treatments block autophagic degradation at a ...
Μάθημα φοιτητών Ιωάννινα - E
... A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase. The phosphate group is attached to the amino acid tyrosine on the protein. Phosp ...
... A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase. The phosphate group is attached to the amino acid tyrosine on the protein. Phosp ...
Targeting protein synthesis in cancer cells (PDF Available)
... mRNA translation into protein. Ribosome recruitment at the mRNA 5’ end is actually controlled by the mRNA 5’ cap binding protein eIF4E (eukaryotic translation initiation factor 4E) whose activity is inhibited by the hypophosphorylated forms of 4E-BPs (eIF4E-binding proteins 1 and 2) [1]. Upon mitoge ...
... mRNA translation into protein. Ribosome recruitment at the mRNA 5’ end is actually controlled by the mRNA 5’ cap binding protein eIF4E (eukaryotic translation initiation factor 4E) whose activity is inhibited by the hypophosphorylated forms of 4E-BPs (eIF4E-binding proteins 1 and 2) [1]. Upon mitoge ...
Gene Targeting by the Vitamin D Response Element Binding Protein
... signaling pathway that regulates cell cycle progression, growth and metabolism homeostasis, protein synthesis, ribosome biogenesis, the actin cytoskeleton and autophagy (4). mTOR is a member of the phosphoinositol kinase-related kinase family whose induction is regulated by phosphorylation by protei ...
... signaling pathway that regulates cell cycle progression, growth and metabolism homeostasis, protein synthesis, ribosome biogenesis, the actin cytoskeleton and autophagy (4). mTOR is a member of the phosphoinositol kinase-related kinase family whose induction is regulated by phosphorylation by protei ...
THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) AS A
... characterization of these compounds suggest they partially inhibit mTOR through modulation of an Akt regulated target TSC2. Taken together, these data suggest that persistent activation of Akt confers sensitivity to mTOR inhibitors. The effect of mTOR inhibition on protein expression is not restrict ...
... characterization of these compounds suggest they partially inhibit mTOR through modulation of an Akt regulated target TSC2. Taken together, these data suggest that persistent activation of Akt confers sensitivity to mTOR inhibitors. The effect of mTOR inhibition on protein expression is not restrict ...
Phospho-MTOR(T1870) Blocking Peptide
... growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 ...
... growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 ...
Dissecting the mechanisms of mTOR activation. Supervisor: Dr. Zita
... Alzheimer's disease is the most common form of dementia in old age. Amyloid Precursor Protein (APP) plays a key role in Alzheimer's disease (AD). Mutations in APP gene cause an early onset or familial form of AD. The aberrant processing of APP by secretases is thought to be a key driver in AD as fam ...
... Alzheimer's disease is the most common form of dementia in old age. Amyloid Precursor Protein (APP) plays a key role in Alzheimer's disease (AD). Mutations in APP gene cause an early onset or familial form of AD. The aberrant processing of APP by secretases is thought to be a key driver in AD as fam ...
P023 Brk and mTOR signalling: potential involvement in Taxol
... kinase mTOR pathway. We examined the protein and activation levels of mTOR pathway components in a Taxol-sensitive (T-47D) and Taxol-resistant (T-47D TaxR) breast cancer cell line by western blotting. We showed that mTOR signalling was up-regulated in the Taxolresistant cell line compared to parenta ...
... kinase mTOR pathway. We examined the protein and activation levels of mTOR pathway components in a Taxol-sensitive (T-47D) and Taxol-resistant (T-47D TaxR) breast cancer cell line by western blotting. We showed that mTOR signalling was up-regulated in the Taxolresistant cell line compared to parenta ...
Role of TMEM127 in the endomembrane system and mTOR
... sorting of proteins. In addition, we found that when TMEM127 is reduced, cells turn on the mTOR pathway, which suggests that under normal circumstances TMEM127 works by restraining mTOR. mTOR is an enzyme that controls many important functions of the cell, including growth, survival, protein product ...
... sorting of proteins. In addition, we found that when TMEM127 is reduced, cells turn on the mTOR pathway, which suggests that under normal circumstances TMEM127 works by restraining mTOR. mTOR is an enzyme that controls many important functions of the cell, including growth, survival, protein product ...