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The hygiene hypothesis revisited
The hygiene hypothesis revisited

... lated. The necessity of interaction with ambient microorganisms the existence of normal interactions of the immune system is interpreted as the necessity of their contact with the immune with self tissues, which are assumed to be part of the primary system, whose insufficient stimulation leads to ch ...
INNATE (NON-SPECIFIC) IMMUNITY
INNATE (NON-SPECIFIC) IMMUNITY

Isotype switching Diversification of Igs after B cells encounter antigens
Isotype switching Diversification of Igs after B cells encounter antigens

... Very common Induce IgG and all other isotypes Much stronger immune response ...
Jess - PBL-J-2015
Jess - PBL-J-2015

... that can damage or destroy microorganisms (e.g. lysozyme in saliva and tears, low pH in the stomach, sticky mucus on many surfaces, and the presence in the gut and genital tract of normal bacterial flora that are able to prevent the growth of pathogenic organisms ...
CD8 T cells
CD8 T cells

... and one CD8β chain. CD8+ T cells recognise peptides presented by MHC Class I molecules, found on all nucleated cells. The CD8 heterodimer binds to a conserved portion (the α3 region) of MHC Class I during T cell/antigen presenting cell interactions (see Figure 1). CD8+ T cells (often called cytotoxi ...
CD8+ T Cells
CD8+ T Cells

... and one CD8β chain. CD8+ T cells recognise peptides presented by MHC Class I molecules, found on all nucleated cells. The CD8 heterodimer binds to a conserved portion (the α3 region) of MHC Class I during T cell/antigen presenting cell interactions (see Figure 1). CD8+ T cells (often called cytotoxi ...
The Immune System
The Immune System

... Allergies are due to another type of immune malfunction. It is an exaggerated response by the immune system to such allergens as pollen, mould or cat dander. Allergic reactions to food or to inhaled allergens (as in asthma) are also possible. An allergic reaction may be immediate or delayed with the ...
Document
Document

Immunity Answers
Immunity Answers

... What is meant by “herd immunity”?  Herd immunity occurs when a large number of people are vaccinated at the same time. This prevents the pathogen from being transmitted within the population because there are no longer any host individuals who act as reservoirs of infection. ...
INNATE (NON-SPECIFIC) IMMUNITY
INNATE (NON-SPECIFIC) IMMUNITY

...  phagocytosis, intracellular and extracellular killing, tissue repair, antigen presentation for specific immune response  characteristic nucleus and CD14 membrane marker. ...
Chapter 22 - Martini
Chapter 22 - Martini

... Antigens & Antigenic Determinants (epitopes) ...
九十九學年度 生技 /生醫系免疫學期中考(II) 姓名: 學號: 周開平副教授
九十九學年度 生技 /生醫系免疫學期中考(II) 姓名: 學號: 周開平副教授

... 4. Single positive cells that have strong binding to the cortical epithelial cells live. 5. Negative selection is for self tolerance. 6. Germinal center cells bear CD3 on their surface. 7. IL12 is produced by activated Th1 cells. 8. The homing of effector T cells to inflammatory sites is dependent u ...
The Immune Response
The Immune Response

... Specific Defenses • Body must distinguish between “self” and “nonself” and inactivate or kill any foreign substance or cell that enters the body • Immune defenses are triggered by antigens typically located on the outer surface of bacteria, viruses or parasites • Responds by increasing the number o ...
Concept check 31 - Plain Local Schools
Concept check 31 - Plain Local Schools

... B cells defend against bacteria and viruses by secreting antibiotics (humoral). T cells directly attack infected cells (cell-mediated immunity) 3. Explain why a second exposure to chicken pox does not usually result in illness. Memory B and T cells rapidly produce large number of plasma cells and cy ...
Document
Document

... - referred to as secondary immunity ...
CELLS& ORGANS OF IMMUNE MECHANISM.
CELLS& ORGANS OF IMMUNE MECHANISM.

... • B –Lymphocytes develop in the bone marrow,gut associated lymphoid tissue,spleen and lymph nodes. • The ratio of T to B cells is approximately 3:1. ...
Elevated potassium levels suppress T cell activation within tumors
Elevated potassium levels suppress T cell activation within tumors

... ability of the adaptive immune system to recognize cancer cells. Ion gradients regulate T cell function but their role in intratumoral immune responses is unexplored. We found that the concentration of K+ was strikingly elevated within tumors while the concentration of the divalent cations Ca 2+ and ...
Lymphatic System
Lymphatic System

... • Involves the production of a specific cell or molecule (antibody) to destroy a specific disease-causing organism or its toxin (antigen). ...
Tissue effector memory T cells Lymphoid central memory T cells
Tissue effector memory T cells Lymphoid central memory T cells

... memory T cells in the whole body. Estimates of the number of T cells in human tissues are 2 × 1010 in the skin,17, 1 × 1010 in the lungs18, 3 × 1010 in the intestines and 20 × 1010 in lymphoid tissues (that is, the spleen, the lymph nodes and the bone marrow). Therefore, peripheral blood T cells (5– ...
Document
Document

... • low resolution (groups of alleles), high resolution (single alleles) • More time-consuming method, however, also highly accurate ...
Name: Date: Period: ___ Immune System Immune System Guided
Name: Date: Period: ___ Immune System Immune System Guided

...  Complement proteins might attract phagocytes to an infected area. Antibodies are proteins made by B cells that cause pathogens to become inactive. Interferons are proteins that prevent viruses from reproducing. People do not get sick every time they become infected because they have immunity.  Pa ...
Activity Overview Continued
Activity Overview Continued

... foreign invaders, see Figure 2. They present markers (antigens) from foreign invaders to the immune system. Natural killer (NK) cells seek and destroy any cells that have been invaded by bacteria or viruses. Macrophages are white blood Figure 2 cells that, moving like amoeba, can leave the Dendritic ...
ABSTRACT WRITING
ABSTRACT WRITING

... pro-inflammatory cytokines, organelle redistribution, and protection from apoptosis. To examine the molecular basis of these and other changes, gene expression profiles of human foreskin fibroblasts infected with Toxoplasma were studied using human cDNA microarrays consisting of ~22,000 known genes ...
دانلود فایل
دانلود فایل

... system is defense against infectious microbes & microbial products & also tumors. ...
Ch_31_Immune_system
Ch_31_Immune_system

... *5 Macrophages and eosinophils called to area increase activity *6 more cytokines released stimulating fibroblasts to produce scar tissue *7 activity stimulates neural response as sense of pain causing organism to respond *8 specific responses initiated (cell mediated immunity) foreign invaders ‘pre ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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