NIH Center for Human Immunology
... (a) assays of immune cells and their products, mainly based on flow cytometry and other emerging multiplexed techniques; (b) highthroughput systems technologies, involving the use of new methods for large-scale examination of the genome, gene expression, epigenetic modulation, as well as the proteom ...
... (a) assays of immune cells and their products, mainly based on flow cytometry and other emerging multiplexed techniques; (b) highthroughput systems technologies, involving the use of new methods for large-scale examination of the genome, gene expression, epigenetic modulation, as well as the proteom ...
Antigen-non-specific regulation centered on CD25+Foxp3+
... The primary aim of the immune system is to clear invading pathogens; however, excessive responses result in self-damage. Activation-induced cell death might be an intracellular mechanism to control excessive immune responses, but this negative feedback may be unable to detect an excessive response t ...
... The primary aim of the immune system is to clear invading pathogens; however, excessive responses result in self-damage. Activation-induced cell death might be an intracellular mechanism to control excessive immune responses, but this negative feedback may be unable to detect an excessive response t ...
15 Blood
... (including organ transplants!) B CELLS: – mature into plasma cells PLASMA CELLS secrete antibodies; the antibodies are what kill the attacking cell. Antibodies attack in two ways: – They attach to bacteria and pop the cell membrane – They attach to encapulated bacteria to help neutrophils phagocyt ...
... (including organ transplants!) B CELLS: – mature into plasma cells PLASMA CELLS secrete antibodies; the antibodies are what kill the attacking cell. Antibodies attack in two ways: – They attach to bacteria and pop the cell membrane – They attach to encapulated bacteria to help neutrophils phagocyt ...
Affecting Cucurbit hormonal status by a ZYMV transient expression
... gibberellin can induce male flowers mainly in cucumber (Perl-Treves and Rajagopalan 2006). The AGII clone of ZYMV encodes a full length genome of the potyvirus ZYMV, developed as an aphid-non-transmitted strain that infects various cucurbit species, causing only mild symptoms (Arazi et al. 2001a). I ...
... gibberellin can induce male flowers mainly in cucumber (Perl-Treves and Rajagopalan 2006). The AGII clone of ZYMV encodes a full length genome of the potyvirus ZYMV, developed as an aphid-non-transmitted strain that infects various cucurbit species, causing only mild symptoms (Arazi et al. 2001a). I ...
Can Immunity to Breast Cancer Eliminate Residual Micrometastases?
... recently published analysis of a dataset of almost 2,000 breast cancers identified three distinct immune-related gene groups that all predicted metastasis-free survival: a T-cell/ natural killer cell cluster, an APC cluster, and a B-cell cluster (7). All of these genes are associated with the adapti ...
... recently published analysis of a dataset of almost 2,000 breast cancers identified three distinct immune-related gene groups that all predicted metastasis-free survival: a T-cell/ natural killer cell cluster, an APC cluster, and a B-cell cluster (7). All of these genes are associated with the adapti ...
NAD+-Consuming Enzymes in the Regulation of Lung Immune
... gene by premature stop codons [30]. Mouse ART2 homologs are coexpressed on the surface of most mature peripheral T lymphocytes and show similar target specificities [31]. Yet ART2.1 is active only in the presence of reducing agent such as dithiothreitol (DTT) or cystein while ART2.2 appears to be co ...
... gene by premature stop codons [30]. Mouse ART2 homologs are coexpressed on the surface of most mature peripheral T lymphocytes and show similar target specificities [31]. Yet ART2.1 is active only in the presence of reducing agent such as dithiothreitol (DTT) or cystein while ART2.2 appears to be co ...
Kuby Immunology 6/e
... endocytosis by antigen-presenting cells and presented to TH cells by MHC Class II ...
... endocytosis by antigen-presenting cells and presented to TH cells by MHC Class II ...
Slide
... • Figure 1: Insect and hybridoma derived A20 Id proteins were analyzed by the cIEF and CE carbohydrate methods. Only insect celldervied Id has a high content of terminal mannose residues Betting DJ et al. Abstract #2343. Presented December 9, 2007, at the 49th ASH Annual Meeting in Atlanta, Georgia. ...
... • Figure 1: Insect and hybridoma derived A20 Id proteins were analyzed by the cIEF and CE carbohydrate methods. Only insect celldervied Id has a high content of terminal mannose residues Betting DJ et al. Abstract #2343. Presented December 9, 2007, at the 49th ASH Annual Meeting in Atlanta, Georgia. ...
Cancer Incidence and Mortality
... The primary tumour is removed by surgery. If it has not metastasised then the surgery may prove curative. • Radiotherapy, irradiation with high energy X-rays (4 to 25 MeV), may be applied subsequent to surgery to help prevent re-growth of the primary tumour. • Surgery plus radiotherapy is a common t ...
... The primary tumour is removed by surgery. If it has not metastasised then the surgery may prove curative. • Radiotherapy, irradiation with high energy X-rays (4 to 25 MeV), may be applied subsequent to surgery to help prevent re-growth of the primary tumour. • Surgery plus radiotherapy is a common t ...
Cell Physiology
... – Includes glycolipids & glycoproteins – Form a glycocalyx on the exoplasmic surface – Many functions • Integrated with other membrane molecules/structures such as sphingolipids ...
... – Includes glycolipids & glycoproteins – Form a glycocalyx on the exoplasmic surface – Many functions • Integrated with other membrane molecules/structures such as sphingolipids ...
PowerPoint
... Rho, Rac and Cdc42 regulate the production of focal adhesions/stress fibers and lamellipodia Cytoplasmic tails of integrins regulate affinity for ligand Engagement of integrins strongly ...
... Rho, Rac and Cdc42 regulate the production of focal adhesions/stress fibers and lamellipodia Cytoplasmic tails of integrins regulate affinity for ligand Engagement of integrins strongly ...
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients , S. Boniface*,
... ABSTRACT: Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ ...
... ABSTRACT: Obliterative bronchiolitis (OB) is the major cause of long-term lung allograft loss resulting from an unclear immune process occurring in the absence of the donor’s immune cells. The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ ...
Immunology
... CELLS OF THE ADAPTIVE IMMUNE SYSTEM 1. Lymphoid cells …T lymphocytes, B lymphocyte, NK cells. 2. The mononuclear phagocyte system cells. 3. Cells involved in the inflammatory phase of immune response (Neutrophils, Basophils)… ...
... CELLS OF THE ADAPTIVE IMMUNE SYSTEM 1. Lymphoid cells …T lymphocytes, B lymphocyte, NK cells. 2. The mononuclear phagocyte system cells. 3. Cells involved in the inflammatory phase of immune response (Neutrophils, Basophils)… ...
Syndecan-2 as an emerging target for migration
... Since ABH blood group antigen was found on the surface of red blood cells in 1900, many tissues of human body have been demonstrated to express ABH blood group antigen and their precursors, including skin. In vivo, human skin tissue expresses ABH antigens only in fully differentiated epidermal kerat ...
... Since ABH blood group antigen was found on the surface of red blood cells in 1900, many tissues of human body have been demonstrated to express ABH blood group antigen and their precursors, including skin. In vivo, human skin tissue expresses ABH antigens only in fully differentiated epidermal kerat ...
Immunocontrol in dogs
... immunosterilant vaccines has arisen because of its importance in fertilization, its unique expression in oocytes, and its strong immunogenicity. If the ZP is masked or structurally altered, fertilization will not occur and one would have an immunocontraceptive vaccine. Thus, much research has focuse ...
... immunosterilant vaccines has arisen because of its importance in fertilization, its unique expression in oocytes, and its strong immunogenicity. If the ZP is masked or structurally altered, fertilization will not occur and one would have an immunocontraceptive vaccine. Thus, much research has focuse ...
Primary antibody deficiency
... mixture of antibodies that help fight infections. Immunoglobulin is made from screened, donated, blood-derived plasma. During manufacture everything except IgG is removed from the plasma. IgG is very good at fighting bacteria and viruses. Immunoglobulin therapy can be given through a vein or through ...
... mixture of antibodies that help fight infections. Immunoglobulin is made from screened, donated, blood-derived plasma. During manufacture everything except IgG is removed from the plasma. IgG is very good at fighting bacteria and viruses. Immunoglobulin therapy can be given through a vein or through ...
Antigens and Antibodies
... What seems to happen when an antibody comes in contact with an antigen? ...
... What seems to happen when an antibody comes in contact with an antigen? ...
Nowrin
... CT- IgG response was elevated in 24 months children than newborns (P< 0.0001) and 6 months infants (P= 0.03). Similarly the IgA and IgG response was seen against the heat labile toxin (LT) of Escherichia coli. Significantly high tetanus toxoid (TT) specific IgG response was seen in newborns than in ...
... CT- IgG response was elevated in 24 months children than newborns (P< 0.0001) and 6 months infants (P= 0.03). Similarly the IgA and IgG response was seen against the heat labile toxin (LT) of Escherichia coli. Significantly high tetanus toxoid (TT) specific IgG response was seen in newborns than in ...
Origin and fate of hematopoietic stem precursor cells in the leech
... anti-human CD14, CD11b and CD11c in sipunculids, a phylum closely related to annelids. The observed cross-reactivity of sipunculid and earthworm leukocytes with anti-human CD markers is a further confirmation that cell recognition and immunodefense system share similar characteristics and effector m ...
... anti-human CD14, CD11b and CD11c in sipunculids, a phylum closely related to annelids. The observed cross-reactivity of sipunculid and earthworm leukocytes with anti-human CD markers is a further confirmation that cell recognition and immunodefense system share similar characteristics and effector m ...
Increased F-FDG uptake within the reticuloendothelial system in
... cancer, the metabolic activity of these organs would be greater than that of the subjects with no active tumor. We have studied two groups of subjects who had undergone 18F-FDG-PET imaging for clinical purposes. The first group consisted of 39 subjects (20 women, 19 men, mean age 64.8±10.2 years) wi ...
... cancer, the metabolic activity of these organs would be greater than that of the subjects with no active tumor. We have studied two groups of subjects who had undergone 18F-FDG-PET imaging for clinical purposes. The first group consisted of 39 subjects (20 women, 19 men, mean age 64.8±10.2 years) wi ...
clinical management of immuno- suppression in sportsmen
... physically debilitating medical condition that results in these men and women being totally compromised in their capacity to perform and compete athletically. Many physiological systems are affected by the process of overtraining and the OTS; but one system in particular, the immune, is highly susce ...
... physically debilitating medical condition that results in these men and women being totally compromised in their capacity to perform and compete athletically. Many physiological systems are affected by the process of overtraining and the OTS; but one system in particular, the immune, is highly susce ...
IMMUNOLOGIC PROPERTIES OF PURIFIED EPIDERMAL
... 12 h of culture, the nonadherent low-density EC were 7-17% la', and after 72 h, 3060% were la' . Immune Responses in Culture. Three T-dependent responses were monitored as specified in the Results: the primary and secondary MLR (6, 7), the primary antibody response to SRBC and TNP-KLH (8, 9), and th ...
... 12 h of culture, the nonadherent low-density EC were 7-17% la', and after 72 h, 3060% were la' . Immune Responses in Culture. Three T-dependent responses were monitored as specified in the Results: the primary and secondary MLR (6, 7), the primary antibody response to SRBC and TNP-KLH (8, 9), and th ...
RAG mediated rearranging of antigen receptors
... lymphocyte-specific template-independent DNA polymerase introduces untemplated nucleotides at the junctions of V, D and J segments thereby TdT increases diversity not found in jaweless vertebrates or below ...
... lymphocyte-specific template-independent DNA polymerase introduces untemplated nucleotides at the junctions of V, D and J segments thereby TdT increases diversity not found in jaweless vertebrates or below ...
Chapter 17
... • TH1 cells produce IFN-g, which activates macrophages, enhances complement, and stimulates antibody production that promotes phagocytosis • TH2 cells activate B cells to produce IgE; activate eosinophils ...
... • TH1 cells produce IFN-g, which activates macrophages, enhances complement, and stimulates antibody production that promotes phagocytosis • TH2 cells activate B cells to produce IgE; activate eosinophils ...
Colloquim II 1. Which of the definitions of "arterial hyperemia" is
... to injury; +b) the acute phase response - the overall reaction of the organism to injury; c) the all manifestations of the acute phase response always have a exceptionally positive value for the body; d) acute phase response is always accompanied by a decrease in resistance of the organism; e) the a ...
... to injury; +b) the acute phase response - the overall reaction of the organism to injury; c) the all manifestations of the acute phase response always have a exceptionally positive value for the body; d) acute phase response is always accompanied by a decrease in resistance of the organism; e) the a ...