Jenny Walldén Studies of immunological risk factors in type 1 diabetes
... environmental factors involved in the pathogenesis of T1D. This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulat ...
... environmental factors involved in the pathogenesis of T1D. This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulat ...
Chemokines as Drug Targets in Type 1 Diabetes
... autoimmunity is molecular mimicry. This hypothesis involves breaking existing self-tolerance due to an inherent structural similarity of pathogen molecules to self-components [20-25]. The concept of molecular mimicry has been successfully integrated into animal models for various human autoimmune di ...
... autoimmunity is molecular mimicry. This hypothesis involves breaking existing self-tolerance due to an inherent structural similarity of pathogen molecules to self-components [20-25]. The concept of molecular mimicry has been successfully integrated into animal models for various human autoimmune di ...
Implications of CTL-Mediated Killing of HIV
... intracellular delay of virion production) become productively infected cells, P, and release new viral particles (Fig. 1, top). Both populations experience cell death, at a rate dI and dP respectively, that can at least partly be due to CTL-mediated killing (see Methods for the mathematical descript ...
... intracellular delay of virion production) become productively infected cells, P, and release new viral particles (Fig. 1, top). Both populations experience cell death, at a rate dI and dP respectively, that can at least partly be due to CTL-mediated killing (see Methods for the mathematical descript ...
immunoregulation (ir)
... Introduction: Inflammatory bowel diseases (IBD) are characterized by a chronic inflammation of the gastrointestinal tract (GIT). Although the causes for IBD remain obscure, there is evidence that IBD results from abnormal immune responses to the gut microbiota in individuals with genetic predisposit ...
... Introduction: Inflammatory bowel diseases (IBD) are characterized by a chronic inflammation of the gastrointestinal tract (GIT). Although the causes for IBD remain obscure, there is evidence that IBD results from abnormal immune responses to the gut microbiota in individuals with genetic predisposit ...
cliff
... The final topic to discuss is the medical relevance of CD14 to human health and disease. Normally, CD14 serves a vital role in the body's first line of defense against infection. However, in the complex rules played out through evolution, certain bacteria attack this defense mechanism by causing mac ...
... The final topic to discuss is the medical relevance of CD14 to human health and disease. Normally, CD14 serves a vital role in the body's first line of defense against infection. However, in the complex rules played out through evolution, certain bacteria attack this defense mechanism by causing mac ...
for T cell activation A
... 5. First and second signals induce expression of CD40 ligand (CD40L) on T cells being activated. CD40 L binds to CD40 on DCs ( this will enhance the activation process by increasing the expression of B-7 on DC----Increase the second signal triggered by CD28 as more and more CD28 on T cells being ac ...
... 5. First and second signals induce expression of CD40 ligand (CD40L) on T cells being activated. CD40 L binds to CD40 on DCs ( this will enhance the activation process by increasing the expression of B-7 on DC----Increase the second signal triggered by CD28 as more and more CD28 on T cells being ac ...
Immunizations What you need to know
... Most reactions are minor and last for 2448 hours Most common reactions involve swelling, redness and pain at the injection site as well as fever ...
... Most reactions are minor and last for 2448 hours Most common reactions involve swelling, redness and pain at the injection site as well as fever ...
GrayetalBBI - University of Aberdeen
... Long chain n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), abundant in oily fish, are beneficial against chronic inflammatory disease, such as cardiovascular disease (Lemaitre et al., 2003) or diabetes mellitus (Nettleton and Katz, 2005), ...
... Long chain n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), abundant in oily fish, are beneficial against chronic inflammatory disease, such as cardiovascular disease (Lemaitre et al., 2003) or diabetes mellitus (Nettleton and Katz, 2005), ...
4 lichenoidз-аллерг eng
... that express cutaneous lymphocyte antigen (CLA; the skin homing receptor) and chemokine receptors such as CCR4. Expression of α1β1 integrin (VLA-1) on psoriatic T cells, which allows their interaction with basement membrane collagen IV, is key for the entrance of these cells into psoriatic epidermis ...
... that express cutaneous lymphocyte antigen (CLA; the skin homing receptor) and chemokine receptors such as CCR4. Expression of α1β1 integrin (VLA-1) on psoriatic T cells, which allows their interaction with basement membrane collagen IV, is key for the entrance of these cells into psoriatic epidermis ...
Modeling the effector - regulatory T cell cross
... (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of autoimmune diseases is significant, how their activity generates this prototypical dynamics is not understood yet. In order to gain insight about the mechanisms that drive these relapsing-r ...
... (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of autoimmune diseases is significant, how their activity generates this prototypical dynamics is not understood yet. In order to gain insight about the mechanisms that drive these relapsing-r ...
Modeling the effector - regulatory T cell cross
... (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of autoimmune diseases is significant, how their activity generates this prototypical dynamics is not understood yet. In order to gain insight about the mechanisms that drive these relapsing-r ...
... (MS). Although current understanding of both cellular and molecular mechanisms involved in the pathogenesis of autoimmune diseases is significant, how their activity generates this prototypical dynamics is not understood yet. In order to gain insight about the mechanisms that drive these relapsing-r ...
Name_________________________________ pd____ pg_____
... and attach to specific “foreign” materials that enter the blood stream. When the viruses responsible for mumps enter the blood, the body recognizes them as foreign and begins synthesizing antibodies that combine only with specific antigens of the virus. Antibody-coated viruses are readily “eaten” by ...
... and attach to specific “foreign” materials that enter the blood stream. When the viruses responsible for mumps enter the blood, the body recognizes them as foreign and begins synthesizing antibodies that combine only with specific antigens of the virus. Antibody-coated viruses are readily “eaten” by ...
Isolation of the intracellular and extracellular polysaccharides of
... EPSs and IPSs from G. neojaponicum were extracted using cultivation broth (B) and the mycelium (M), respectively. This procedure was carried out as previously described by Hsieh et al. [6]. The mycelium was separated from the broth by centrifugation (Beckman Coulter, Germany) at 10,000 rpm for 10 mi ...
... EPSs and IPSs from G. neojaponicum were extracted using cultivation broth (B) and the mycelium (M), respectively. This procedure was carried out as previously described by Hsieh et al. [6]. The mycelium was separated from the broth by centrifugation (Beckman Coulter, Germany) at 10,000 rpm for 10 mi ...
Induced Pluripotent Stem Cells: Therapeutic Applications in
... regard, advanced therapies based on the by-products of gene therapy, cell therapy and nanomedicine/tissue engineering are of great importance for their potential to radically improve treatment of a large number of conditions. The different schools of thought that advocate the emerging concept of adv ...
... regard, advanced therapies based on the by-products of gene therapy, cell therapy and nanomedicine/tissue engineering are of great importance for their potential to radically improve treatment of a large number of conditions. The different schools of thought that advocate the emerging concept of adv ...
Genetics-squared: combining host and pathogen genetics in the analysis of innate immunity and bacterial virulence.
... have successfully applied genetic approaches to identify novel host genes required for innate immune defense. In addition, a variety of creative bacterial genetic schemes have been developed to identify key bacterial genes involved in triggering or evading host immunity. In cases where both the host ...
... have successfully applied genetic approaches to identify novel host genes required for innate immune defense. In addition, a variety of creative bacterial genetic schemes have been developed to identify key bacterial genes involved in triggering or evading host immunity. In cases where both the host ...
Chap 18 AIDS and Immune Disorders
... • Occur more often in the elderly • Are more common in women than in men • May result when an individual begins to make autoantibodies or cytotoxic T cells against normal body components ...
... • Occur more often in the elderly • Are more common in women than in men • May result when an individual begins to make autoantibodies or cytotoxic T cells against normal body components ...
Protective immunity against Toxoplasma gondii induced by DNA
... involved in gliding motility, cell invasion, egress and some other developmental processes, and so have been implicated as important virulence factors. Methods: In the present study, we constructed a DNA vaccine expressing T. gondii CDPK3 (TgCDPK3) and evaluated its protective efficacy against T. go ...
... involved in gliding motility, cell invasion, egress and some other developmental processes, and so have been implicated as important virulence factors. Methods: In the present study, we constructed a DNA vaccine expressing T. gondii CDPK3 (TgCDPK3) and evaluated its protective efficacy against T. go ...
The Molecular Nature of Tumorigenesis Molecular aspects of cancer
... directly repairing DNA damage, and inactivating or intercepting mutagenic molecules [15]. By inactivating these caretaker genes, tumorigenesis is accelerated by genomic instability. One such pathway, the BRCA1 signaling pathway, which is the pathway that is disrupted in a majority of breast cancers, ...
... directly repairing DNA damage, and inactivating or intercepting mutagenic molecules [15]. By inactivating these caretaker genes, tumorigenesis is accelerated by genomic instability. One such pathway, the BRCA1 signaling pathway, which is the pathway that is disrupted in a majority of breast cancers, ...
Gene Section MME (membrane metallo-endopeptidase) Atlas of Genetics and Cytogenetics
... Note: Follicular lymphomas originate from mature Bcells with germinal center stage of differentiation. Majority of follicular lymphomas typically express MME (referred to in this context as CD10) and its expression positively correlates with survival and negatively with the grade of follicular lymph ...
... Note: Follicular lymphomas originate from mature Bcells with germinal center stage of differentiation. Majority of follicular lymphomas typically express MME (referred to in this context as CD10) and its expression positively correlates with survival and negatively with the grade of follicular lymph ...
secondary immunological lysis in ehrlich`s ascites carcinoma
... of immunological lysis. Thus although the new host can sensitise new generations of tumour cells, lysis as the result of such sensitisation (secondary immunological lysis) fails to occur. If primary lysis could be avoided in intraperitoneal transplants it should then be possible to investigate the r ...
... of immunological lysis. Thus although the new host can sensitise new generations of tumour cells, lysis as the result of such sensitisation (secondary immunological lysis) fails to occur. If primary lysis could be avoided in intraperitoneal transplants it should then be possible to investigate the r ...
Session 467 Autoimmunity
... experimental autoimmune uveitis (EAU). Here, we further delineate molecular and cellular factors involved in orchestrating this Mincledependent mechanism. Methods: EAU was induced in C57BL/J mice deficient in Card9 or Mincle (encoded by Clec4e) by immunization with interphotoreceptor retinoid-bindin ...
... experimental autoimmune uveitis (EAU). Here, we further delineate molecular and cellular factors involved in orchestrating this Mincledependent mechanism. Methods: EAU was induced in C57BL/J mice deficient in Card9 or Mincle (encoded by Clec4e) by immunization with interphotoreceptor retinoid-bindin ...
Data-based Reconstruction of Gene Regulatory Networks of Fungal
... of fungal genes and proteins can be extracted for 298 fungal strains by the Web tool FungiFun2 (Priebe et al., 2014). In general, manually curated databases have high quality. However, they cannot be up-to-date as it takes time before new discoveries are included (Baumgartner et al., 2007). Therefor ...
... of fungal genes and proteins can be extracted for 298 fungal strains by the Web tool FungiFun2 (Priebe et al., 2014). In general, manually curated databases have high quality. However, they cannot be up-to-date as it takes time before new discoveries are included (Baumgartner et al., 2007). Therefor ...