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Conflict: Immunity
Conflict: Immunity

... An animal’s most basic defenses against pathogens include physical barriers, like skin or a shell, and chemical barriers like sweat, tears, saliva, mucus, stomach acid, and urine. If pathogens are able to breach any of these barriers, it is vital that the immune system is able to distinguish these f ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

Studying the Effects of Congaplex® and
Studying the Effects of Congaplex® and

... and then exposed to a substance that would provoke an immune response (antigen). The researchers then measured immune activity via the production of cytokines, proteins that regulate the action of the immune system. These chemicals are released by T cells and have a variety of different tasks. Some, ...
The integrated view
The integrated view

... Red pulp: degradation and consumption of exhausted erythrocytes. White pulp: site of immunological monitoring of blood. Red and white pulp are separated by “marginal zone.” PALS (“periarteriolar lymphoid sheaths) surround blood arteries; arteries deliver blood to sinuses of the marginal zone. Ag’s a ...
the immune system phagocytosis antibody function
the immune system phagocytosis antibody function

... 1. Phagocyte detects chemicals released by a foreign intruder (e.g. bacteria) 2. Phagocyte moves up the concentration gradient towards the intruder 3. The phagocyte adheres to the foreign cell and engulfs it in a vacuole by an infolding of the cell membrane. 4. Lysosomes (organelles which are rich i ...
T cell-mediated immunity
T cell-mediated immunity

... Development of immune response to pathogens Host cellular receptors serve as portals of entry for pathogens • mainly viruses (CD4 – HIV; CD21 – EBV) • bacteria (CR3 – Mycobacterium, Bordetella; β1-integrins – Yersinia, E.coli) ...
The Immune System
The Immune System

Helper T
Helper T

... • Blocking germs from getting inside in the first place – Skin – Mucous membranes – Low pH in stomach ...
File - Mr. Shanks` Class
File - Mr. Shanks` Class

... 1a. several types of leukocytes (white blood cells) that attack and eliminate anything they recognize asforeign. b. macrophages will engulf or eat the invading cells ...
Pathogenicity
Pathogenicity

... onto CR3 and CR4 (degradation can be oxygendependent - production of reactive oxygen species via NADPH-complex, or oxygen-independent) ...
Wk5- Intracell Sig
Wk5- Intracell Sig

... release. -activates the Akt cascade that phosphorylates Bad to keep it from binding Bcl-2. Free Bcl-2 inhibits cytochrome c release and inhibits caspase activity. ...
Specific Immunity
Specific Immunity

... Specific Immunity: The immune response comes into play when pathogens make it past the first and second defenses. The Immune Response Makes Cells SPECIFIC for a Particular Pathogen’s Antigen Markers! G. The Immune Response and How It Works 26. This specific immune response attacks specific antigens ...
Immune System
Immune System

... The Inflammatory Response • Releases histamine – (basophils and mast cells) ...
Figure 16.20 Activation of T cells
Figure 16.20 Activation of T cells

Immune Senescence
Immune Senescence

c. Section 1.3 The Immune System
c. Section 1.3 The Immune System

... and signal Helper T cells to find B cells and tell them to produce antibodies. ...
test question answers
test question answers

... 7. Secondary Immune Response: immune response elicited on second or subsequent exposures to a particular antigen. 8. Humoral Immune Response: immunity that involves the activation of B cells and that leads to the production of antibodies, which defend against bacteria and viruses in body fluids. 9. ...
Organs of the Immune System 01/31/06
Organs of the Immune System 01/31/06

... Primary lymphoid organs Secondary lymphoid organs Self antigens ...
Innate Immune Response - Morgan Community College
Innate Immune Response - Morgan Community College

...  Breaks down hydrogen peroxide to produces reactive oxygen ...
White Blood Cells: An Overview of the Body`s Defense Army Human
White Blood Cells: An Overview of the Body`s Defense Army Human

... Basophils. When these are triggered to leave the blood and enter tissues, they become mast cells and release heparin and histamine (among other chemicals) as an inflammatory response to an allergic trigger. Histamine causes dilation of blood vessels to bring more help to the site of a threat, and he ...
abstract
abstract

B cell
B cell

Immune System - Dr. Annette M. Parrott
Immune System - Dr. Annette M. Parrott

... 1. The mammalian immune system includes two types of specific responses: cell mediated and humoral. 2. In the cell-mediated response, cytotoxic T cells, a type of lymphocytic white blood cell, “target” intracellular pathogens when antigens are displayed on the outside of the cells. 3. In the humoral ...
Why we need many “therapeutic targets”
Why we need many “therapeutic targets”

... the central nervous system. Tysabri (or natalizumab) binds to an ICAM and blocks its function, thereby stopping activated immune cells from leaving the bloodstream. A new therapy called fingolimod, or FTY720, works earlier in the process. It binds to the sphingosine-1-phosphate receptor described ab ...
L3 Defence Against Disease
L3 Defence Against Disease

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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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