UNITED STATES SECURITIES AND EXCHANGE COMMISSION
... Affimed is developing its first-in-class NK-cell engager AFM24 to address the critical unmet need to effectively treat epidermal growth factor receptor (EGFR)-expressing solid tumors such as lung, head & neck and colon cancers,. The molecule has been shown to be well differentiated from other EGFR-t ...
... Affimed is developing its first-in-class NK-cell engager AFM24 to address the critical unmet need to effectively treat epidermal growth factor receptor (EGFR)-expressing solid tumors such as lung, head & neck and colon cancers,. The molecule has been shown to be well differentiated from other EGFR-t ...
The Immune System
... • Body cells infected with viruses produce proteins called interferons (IFNs). • Once produced and released from virus-infected cells, IFN diffuses to uninfected neighboring cells and binds to surface receptors, inducing uninfected cells to synthesize antiviral proteins that interfere with or inhibi ...
... • Body cells infected with viruses produce proteins called interferons (IFNs). • Once produced and released from virus-infected cells, IFN diffuses to uninfected neighboring cells and binds to surface receptors, inducing uninfected cells to synthesize antiviral proteins that interfere with or inhibi ...
History of Discovery - Arteriosclerosis, Thrombosis, and Vascular
... large numbers of microorganisms, allowing recognition of a wide array of microorganisms by a limited number of receptors; and (3) they are essential constituents of the microorganisms, thus preventing escape from recognition by the innate immune system through mutation. For example, the outer membra ...
... large numbers of microorganisms, allowing recognition of a wide array of microorganisms by a limited number of receptors; and (3) they are essential constituents of the microorganisms, thus preventing escape from recognition by the innate immune system through mutation. For example, the outer membra ...
Document
... immunized with the LCM virus. You determine the antigen-specific functional activity of these cells with two different assays: in assay 1, the spleen cells are incubated with macrophages that have been briefly exposed to the LCM virus; the production of interleukin 2 (IL-2) is a positive response; i ...
... immunized with the LCM virus. You determine the antigen-specific functional activity of these cells with two different assays: in assay 1, the spleen cells are incubated with macrophages that have been briefly exposed to the LCM virus; the production of interleukin 2 (IL-2) is a positive response; i ...
Nature_and_role_of_inflammation _
... eventually lead to heart disease and several autoimmune diseases, such as lupus. Effectively manipulating neutrophils is vital in disrupting inflammatory diseases.“3 Functions of inflammation 1. Inflammation is the first step in the healing or repair process after some physical or chemical injury or ...
... eventually lead to heart disease and several autoimmune diseases, such as lupus. Effectively manipulating neutrophils is vital in disrupting inflammatory diseases.“3 Functions of inflammation 1. Inflammation is the first step in the healing or repair process after some physical or chemical injury or ...
Cell Nd Organs - GCG-42
... that may function to induce a local inflammatory reaction. In addition, keratinocytes can be induced to express class II MHC molecules and may function as antigen-presenting cells. Scattered among the epithelial-cell matrix of the epidermis are Langerhans cells, a type of dendritic cell, which inter ...
... that may function to induce a local inflammatory reaction. In addition, keratinocytes can be induced to express class II MHC molecules and may function as antigen-presenting cells. Scattered among the epithelial-cell matrix of the epidermis are Langerhans cells, a type of dendritic cell, which inter ...
Type II hypersensitivity
... Type II hypersensitivity: Ab – mediated, Generally cytotoxic – Tissue specific. ...
... Type II hypersensitivity: Ab – mediated, Generally cytotoxic – Tissue specific. ...
Blood
... a. Antigens- structures (often glycoproteins) that extend from the exterior of a cell membrane, which can be used for selfidentification; more importantly, they can be recognized as foreign by another organism. So, for example, if a bacterium enters your body, immune cells can recognize it as foreig ...
... a. Antigens- structures (often glycoproteins) that extend from the exterior of a cell membrane, which can be used for selfidentification; more importantly, they can be recognized as foreign by another organism. So, for example, if a bacterium enters your body, immune cells can recognize it as foreig ...
Final Exam - Creighton Biology
... nnnnnnnn. activation of apoptosis (programmed cell death) of infected cells. oooooooo. activation of components of the complement system. pppppppp. agglutination by sticking together clumps of antigen. qqqqqqqq. neutralization by preventing the pathogen from being able to contact cells. rrrrrrrr. op ...
... nnnnnnnn. activation of apoptosis (programmed cell death) of infected cells. oooooooo. activation of components of the complement system. pppppppp. agglutination by sticking together clumps of antigen. qqqqqqqq. neutralization by preventing the pathogen from being able to contact cells. rrrrrrrr. op ...
Role of intestinal epithelial cells in the innate immune defence
... neonatal piglets [30]. However in these animals the decreased TEER was not associated with an increased bacterial translocation or a change in Claudin-1, occludin and ZO-1 expression [30]. In a model of gut injury, it has been demonstrated that prostaglandins mediated the recovery of barrier functio ...
... neonatal piglets [30]. However in these animals the decreased TEER was not associated with an increased bacterial translocation or a change in Claudin-1, occludin and ZO-1 expression [30]. In a model of gut injury, it has been demonstrated that prostaglandins mediated the recovery of barrier functio ...
IMMUNOLOGY
... An autoantigen is usually a normal protein or complex of proteins (and sometimes DNA or RNA) that is recognized by the immune system of patients suffering from a specific autoimmune disease. These antigens should under normal conditions not be the target of the immune system, but due to mainly genet ...
... An autoantigen is usually a normal protein or complex of proteins (and sometimes DNA or RNA) that is recognized by the immune system of patients suffering from a specific autoimmune disease. These antigens should under normal conditions not be the target of the immune system, but due to mainly genet ...
Microbial
... of the immune system. The detection of PAMPs by PRRs and their subsequent activation results in an innate and acquired inflammatory immune response. One such family of PRRs is the Toll-like receptor (TLR) family. The different TLRs are characterised by their ligand specificity, some detecting extrac ...
... of the immune system. The detection of PAMPs by PRRs and their subsequent activation results in an innate and acquired inflammatory immune response. One such family of PRRs is the Toll-like receptor (TLR) family. The different TLRs are characterised by their ligand specificity, some detecting extrac ...
Depicting the mechanism of action of an ATMP for
... cytokines that characterize the GvHD development stages: TNF-α, IFN-γ, LPS, IL-2, IL-12, IFN-γ+TNFα+IL-2, TNF-α+IL-1 and TNF-α+IL-1+IL-6. ...
... cytokines that characterize the GvHD development stages: TNF-α, IFN-γ, LPS, IL-2, IL-12, IFN-γ+TNFα+IL-2, TNF-α+IL-1 and TNF-α+IL-1+IL-6. ...
Lecture-6-ANTIBODY-STRUCTURE-AND
... LYMPHOCYTE ACTIVATION IS TRIGGERED BY ANTIGEN RECOGNITION Antigen recognition is mediated by structurally related cell surface molecules: membranebound antibodies on B lymphocytes and T cell receptors on T lymphocytes. ...
... LYMPHOCYTE ACTIVATION IS TRIGGERED BY ANTIGEN RECOGNITION Antigen recognition is mediated by structurally related cell surface molecules: membranebound antibodies on B lymphocytes and T cell receptors on T lymphocytes. ...
Practical 3 Structures List_updated 050712
... Descending Limb (Loop of Henle) (P) ______________________________ Thin Descending Limb (Loop of Henle) (P) ___________________________ Nephron Loop (Loop of Henle) (P) ...
... Descending Limb (Loop of Henle) (P) ______________________________ Thin Descending Limb (Loop of Henle) (P) ___________________________ Nephron Loop (Loop of Henle) (P) ...
Press Release
... expressed high-levels of these genes, and that this group was also correlated with prolonged survival. Galon has already previously established Immunoscore® as a scoring system based on the quantification of cytotoxic and memory T cells in the core of the tumor. “We were surprised that assessment of ...
... expressed high-levels of these genes, and that this group was also correlated with prolonged survival. Galon has already previously established Immunoscore® as a scoring system based on the quantification of cytotoxic and memory T cells in the core of the tumor. “We were surprised that assessment of ...
HISTOCOMPATIBILITY ANTIGENS
... DIRECT PRESENTATION • Direct presentation in transplantation (MHC + peptide: MHC is from graft; peptides are from cellular proteins, graft and/or host) • Graft dendritic cell is induced to mature, express costimulatory molecules (B7) and migrate to lymph node by stress of surgery, etc. • DC in lym ...
... DIRECT PRESENTATION • Direct presentation in transplantation (MHC + peptide: MHC is from graft; peptides are from cellular proteins, graft and/or host) • Graft dendritic cell is induced to mature, express costimulatory molecules (B7) and migrate to lymph node by stress of surgery, etc. • DC in lym ...
MALARIAL VACCINES
... IMMUNE RESPONSE TO MALARIAL PARASITE PfMEP1-expressed on infected erythrocytic surface and mediates binding of parasite to receptors(CD36, chondoitin sulfate A(CSA) ...
... IMMUNE RESPONSE TO MALARIAL PARASITE PfMEP1-expressed on infected erythrocytic surface and mediates binding of parasite to receptors(CD36, chondoitin sulfate A(CSA) ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑