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The immune system of sea bass, Dicentrarchus labrax, reared in
The immune system of sea bass, Dicentrarchus labrax, reared in

... Teleost ®sh are the largest group of vertebrates (about 20,000 species), arising around 300 million years ago and sharing similar immune system organisation with other vertebrates [1]. This aspect includes the presence of functional lymphocytes [2±4], MHC [5], TCR [6], and cytokines [7]. In this res ...
Advances in Immunotherapy: Abhijit Guha Award Presentation
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... although multiple laboratories across the country have now confirmed the finding. In fact, if you ask Cytomegalovirus biologists what cells they use to grow their viruses in vitro, it turns out they use glioblastoma cells. So, there appears to be a specific tropism for this particular virus in these ...
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... – T cells survey the body for foreign (microbial) peptides • Different classes of MHC molecules present cytosolic (endogenous) and vesicular (ingested) peptides – Helper T cells and CTLs respond to the microbes that each is best able to combat • T cell receptors only recognize MHC-peptide complexes, ...
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... Following its discovery [6], HHV-8 was soon shown to be present in all epidemiological forms of KS: classic, transplant, African endemic and AIDS [7]. The viral DNA sequences can be detected as latent infection in the spindle and endothelial tumour cells in KS [8], as well as the primary e¡usion lym ...
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... malaria-specific T cells from non-exposed individuals have arisen as a result of crossreactive stimulation by other organisms, as demonstrated by expression of CD45Ro^'^ and by the patterns of cross-reactivity of malaria-specific clones (Fig. l).'^ Where differences have been observed between the T ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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