Immunometabolism governs dendritic cell and macrophage function
... R ecent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or n ...
... R ecent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or n ...
Slide 1
... encoded by EBV expressed in CFS despite the absence of replicative virus These peptides are known to modulate immune function, inducing pro-inflammatory and Type 2 cytokines Lerner’s group found evidence of a subgroup of CFS patients with incomplete viral expression and cardiac motility abnormal ...
... encoded by EBV expressed in CFS despite the absence of replicative virus These peptides are known to modulate immune function, inducing pro-inflammatory and Type 2 cytokines Lerner’s group found evidence of a subgroup of CFS patients with incomplete viral expression and cardiac motility abnormal ...
Immunometabolism governs dendritic cell and macrophage function
... R ecent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or n ...
... R ecent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or n ...
Immune selection in neoplasia: towards a microevolutionary model
... Both TGF-β and IL-10 are understood to play a role in shifting the Th1-Th2 balance toward Th2, thus inhibiting the cell-mediated immunity believed to be responsible for tumour rejection (Maeda and Shiraishi, 1996). Secretion of IL-10 has been observed in renal cell carcinoma, colon carcinoma, melano ...
... Both TGF-β and IL-10 are understood to play a role in shifting the Th1-Th2 balance toward Th2, thus inhibiting the cell-mediated immunity believed to be responsible for tumour rejection (Maeda and Shiraishi, 1996). Secretion of IL-10 has been observed in renal cell carcinoma, colon carcinoma, melano ...
Innate and adaptive immune responses in the lungs
... epithelial cells might also act as immune effector cells in response to harmful exogenous stimuli. Several studies have shown that airway epithelial cells express on their surface adhesion molecules and secrete various immune molecules such as cytokines, chemokines and other factors (6-11). Through ...
... epithelial cells might also act as immune effector cells in response to harmful exogenous stimuli. Several studies have shown that airway epithelial cells express on their surface adhesion molecules and secrete various immune molecules such as cytokines, chemokines and other factors (6-11). Through ...
Can worms defend our hearts? Chronic Opisthorchis felineus
... correlation between serum total cholesterol levels and any type of atherosclerotic lesions in the study groups. 2. AA area in subjects with O. felineus CHI is lower than in uninfected gender- and age-matched controls; 3. O. felineus burden is the independent negative predictor of ...
... correlation between serum total cholesterol levels and any type of atherosclerotic lesions in the study groups. 2. AA area in subjects with O. felineus CHI is lower than in uninfected gender- and age-matched controls; 3. O. felineus burden is the independent negative predictor of ...
CD1d Ligands: The Good, the Bad, and the Ugly
... populations identified by CD1d1 tetramers or dimers loaded with this glycolipid. Approximately one-half of those NKT cells that are ␣-GalCer/CD1d1 tetramer positive are GSL-1/CD1d1 dimer (or tetramer) positive. Furthermore, the demonstration that the clearance of these bacteria from animals that are ...
... populations identified by CD1d1 tetramers or dimers loaded with this glycolipid. Approximately one-half of those NKT cells that are ␣-GalCer/CD1d1 tetramer positive are GSL-1/CD1d1 dimer (or tetramer) positive. Furthermore, the demonstration that the clearance of these bacteria from animals that are ...
Meningeal Mast Cell Show No Sex differences in EAE
... different immune responses. As a result, the cellular mechanisms that drive these different responses are of great interest in learning more about autoimmunity. → In this study, the meninges (mast cell rich tissues that surround the brain and spinal cord) from mice with the induced mouse model of MS ...
... different immune responses. As a result, the cellular mechanisms that drive these different responses are of great interest in learning more about autoimmunity. → In this study, the meninges (mast cell rich tissues that surround the brain and spinal cord) from mice with the induced mouse model of MS ...
Slide 1
... defects in innate immunity. • Key role in containing and preventing the systemic spread of the bacterial infection. • MBL contributes to the pool of genes that together comprise to the “innate immune haplotype”, that ultimately defines the immunological fitness of the host. ...
... defects in innate immunity. • Key role in containing and preventing the systemic spread of the bacterial infection. • MBL contributes to the pool of genes that together comprise to the “innate immune haplotype”, that ultimately defines the immunological fitness of the host. ...
File
... The first known vaccination procedures were performed by the Chinese during the Sung dynasty (A.D. 960-1280) against smallpox. “Variolation” used small amounts of powdered crusts from smallpox pustules which were inhaled or placed in small cuts in the skin. A mild disease was usually produced, follo ...
... The first known vaccination procedures were performed by the Chinese during the Sung dynasty (A.D. 960-1280) against smallpox. “Variolation” used small amounts of powdered crusts from smallpox pustules which were inhaled or placed in small cuts in the skin. A mild disease was usually produced, follo ...
Training load and URTI - ACCEPTED MS Text 01-11
... 2.2 vs 1.0 ± 1.6, respectively: P < 0.05). The HIGH group had ~3-fold higher IL-2, IL-4 and ...
... 2.2 vs 1.0 ± 1.6, respectively: P < 0.05). The HIGH group had ~3-fold higher IL-2, IL-4 and ...
Functional Avidity–Driven Activation
... The frequency of responsive T cells with a TCR specific for a given peptide–MHC complex is another key point for ID. In fact, during a cellular immune response to a pathogen, the CD8+ T cell population undergoes a strong selection for a highly restricted TCR repertoire (11, 12), to limit potential a ...
... The frequency of responsive T cells with a TCR specific for a given peptide–MHC complex is another key point for ID. In fact, during a cellular immune response to a pathogen, the CD8+ T cell population undergoes a strong selection for a highly restricted TCR repertoire (11, 12), to limit potential a ...
INTRODUCTION - HAL
... active phase of the disease is not well understood. It implies, at least, a downregulation of IB gene activity through reduced induction of transcription and increased destabilization of IB mRNA, as well as increased proteasome-mediated IB degradation, as demonstrated by the accumulation of th ...
... active phase of the disease is not well understood. It implies, at least, a downregulation of IB gene activity through reduced induction of transcription and increased destabilization of IB mRNA, as well as increased proteasome-mediated IB degradation, as demonstrated by the accumulation of th ...
Keeping the Salon Clean PowerPoint
... Though there are some treatments for infection, many types of bacteria are becoming resistant, meaning there is now a greater need for pathogen control in cosmetology Local Infection Confined to a particular part of the body Identified by a pus-containing lesion ...
... Though there are some treatments for infection, many types of bacteria are becoming resistant, meaning there is now a greater need for pathogen control in cosmetology Local Infection Confined to a particular part of the body Identified by a pus-containing lesion ...
Skeletal Articulations Synovial Joints
... • Physiological Functions of Skeletal System – Storage of Ca, Phosphorus – Bone marrow produces blood cells, part of body’s immune system *Osteocytes: basic cells in matrix of bone *Osteoblasts: bone-forming cells *Osteoclasts: bone-eroding cells ...
... • Physiological Functions of Skeletal System – Storage of Ca, Phosphorus – Bone marrow produces blood cells, part of body’s immune system *Osteocytes: basic cells in matrix of bone *Osteoblasts: bone-forming cells *Osteoclasts: bone-eroding cells ...
Interferon???dependent inhibition of B cell activation by bone
... killed, and their kidneys were isolated, preserved in 10% formalin, and embedded in paraffin. Histopathologic assessments were performed on 4-m formalin-fixed, paraffinembedded sections that had been stained with periodic acid– Schiff. A total of 50 sequential glomeruli from the superior, middle, a ...
... killed, and their kidneys were isolated, preserved in 10% formalin, and embedded in paraffin. Histopathologic assessments were performed on 4-m formalin-fixed, paraffinembedded sections that had been stained with periodic acid– Schiff. A total of 50 sequential glomeruli from the superior, middle, a ...
Cytokines
... The Complexity of Cytokine-Receptor Signaling and Effects What cytokine is being made? When is it being made? At what concentration? How long will it be around? Is it being modified by other proteins? Activated? Degraded? What other cytokines are being made? Do they affect the first cytokine? Do t ...
... The Complexity of Cytokine-Receptor Signaling and Effects What cytokine is being made? When is it being made? At what concentration? How long will it be around? Is it being modified by other proteins? Activated? Degraded? What other cytokines are being made? Do they affect the first cytokine? Do t ...
Do all creatures possess an acquired immune system of some sort?
... NK, natural killer; NKT, natural killer T; PAMP, pathogen-associated molecular pattern; PRR, pattern recognition receptor; RAG, recombination activating genes; R genes, resistance genes; RM, restriction modification; RNAi, RNA interference; TCR, T-cell receptor; VLR, variable lymphocyte receptor. ...
... NK, natural killer; NKT, natural killer T; PAMP, pathogen-associated molecular pattern; PRR, pattern recognition receptor; RAG, recombination activating genes; R genes, resistance genes; RM, restriction modification; RNAi, RNA interference; TCR, T-cell receptor; VLR, variable lymphocyte receptor. ...
Yogurt Beverage with Wellmune WGP Nutrition Facts
... Yogurt Beverage with Wellmune wgp® Biothera, the immune health company, is pleased to introduce Wellmune wgp®, a natural ingredient that is clinically proven to enhance key immune responses. To demonstrate the ingredient’s pleasant sensory qualities and ease of formulation, Biothera and its U.S. dis ...
... Yogurt Beverage with Wellmune wgp® Biothera, the immune health company, is pleased to introduce Wellmune wgp®, a natural ingredient that is clinically proven to enhance key immune responses. To demonstrate the ingredient’s pleasant sensory qualities and ease of formulation, Biothera and its U.S. dis ...
Haptoglobin, inflammation and disease
... TH 1 cytokines, while those activated by Hp1-1-Hb complex generate TH 2 cytokines with an increased IL-6 and IL-10 cytokine release (Guetta et al., 2007). The balance of the T cell response may be particularly important at extravascular sites, where the local expression of Hp would play a role in re ...
... TH 1 cytokines, while those activated by Hp1-1-Hb complex generate TH 2 cytokines with an increased IL-6 and IL-10 cytokine release (Guetta et al., 2007). The balance of the T cell response may be particularly important at extravascular sites, where the local expression of Hp would play a role in re ...
Epithelial antimicrobial peptides and proteins: their role in
... cell culture studies and results from bronchial xenografts generated from surface epithelial cells, show that the surface epithelium itself may play a major role in the overall synthesis. The expression of antimicrobial polypeptides may either be constitutive, induced or decreased by a variety of st ...
... cell culture studies and results from bronchial xenografts generated from surface epithelial cells, show that the surface epithelium itself may play a major role in the overall synthesis. The expression of antimicrobial polypeptides may either be constitutive, induced or decreased by a variety of st ...
God-given Natural Healing Power Immune cells in your Body!
... Unlike other cells, virus-infected cells and cancer cells have abnormalities such as a decrease in specific protain(MHC Class 1) on the cell surface. NK cells detect the abnormality and recognize virus-infected cells and cancer cells and attack. At this time, perforin is secreted to punture cell mem ...
... Unlike other cells, virus-infected cells and cancer cells have abnormalities such as a decrease in specific protain(MHC Class 1) on the cell surface. NK cells detect the abnormality and recognize virus-infected cells and cancer cells and attack. At this time, perforin is secreted to punture cell mem ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑