CP p53 Fahraeus, Jan 20, 2012
... Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50% of cancer patients. If researchers succeed in re-establishing the presence of p53 in patients, they may hold the key to a promising avenue of research. However, ...
... Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50% of cancer patients. If researchers succeed in re-establishing the presence of p53 in patients, they may hold the key to a promising avenue of research. However, ...
Molecular Structures Shared by Prokaryotes
... they exhibit certain characteristics which are unusual for prokaryotes, and which are also shared by eukaryotes. Such characteristics include a nuclear membrane, budding reproduction, sterol biosynthesis, and condensed nucleoids. These characteristics challenge the long-held concept that the presenc ...
... they exhibit certain characteristics which are unusual for prokaryotes, and which are also shared by eukaryotes. Such characteristics include a nuclear membrane, budding reproduction, sterol biosynthesis, and condensed nucleoids. These characteristics challenge the long-held concept that the presenc ...
doc bio notes
... Cdc20: an accessory molecule that targets APC to securin. Cdh1: an accessory molecule that targets APC to mitotic cyclin (B-type cyclins) and cdc20. When it’s phosphorylated, it’s inactive, it’s phosphorylated for most of the cell cycle. Can be dephosphorylated by cdc14, it activates APC to break do ...
... Cdc20: an accessory molecule that targets APC to securin. Cdh1: an accessory molecule that targets APC to mitotic cyclin (B-type cyclins) and cdc20. When it’s phosphorylated, it’s inactive, it’s phosphorylated for most of the cell cycle. Can be dephosphorylated by cdc14, it activates APC to break do ...
Maximilian J. Telford , 764 (2013); DOI: 10.1126/science.1234378
... The authors attribute their observations to an allosteric effect, in Allosteric coupling. Kim et al. show that oscillation of the major groove width R(L) causes variation of the allosteric couwhich a distortion of the DNA pling between two DNA-binding proteins A and B, both of which widen the major ...
... The authors attribute their observations to an allosteric effect, in Allosteric coupling. Kim et al. show that oscillation of the major groove width R(L) causes variation of the allosteric couwhich a distortion of the DNA pling between two DNA-binding proteins A and B, both of which widen the major ...
Resistance Gene-Dependent Activation of a Calcium
... of phosphorylation activity at 70 kD from 24% (of total phosphorylation activity at 68 and 70 kD) at time zero to 70% at 15 min after IF(Avr9⫹) elicitation, whereas in the control experiment with IF(Avr9⫺), phosphorylation activity remained unaltered at 28% (Figure 2A). Complementary changes were de ...
... of phosphorylation activity at 70 kD from 24% (of total phosphorylation activity at 68 and 70 kD) at time zero to 70% at 15 min after IF(Avr9⫹) elicitation, whereas in the control experiment with IF(Avr9⫺), phosphorylation activity remained unaltered at 28% (Figure 2A). Complementary changes were de ...
Protein Synthesis: Translation
... 3) A transfer RNA with an amino acid is called a charged tRNA. (An enzyme and ATP bind to the correct amino acid to the transfer RNA molecule. At that point it is ready to carry the amino acid to its correct place in the growing polypeptide chain.) ...
... 3) A transfer RNA with an amino acid is called a charged tRNA. (An enzyme and ATP bind to the correct amino acid to the transfer RNA molecule. At that point it is ready to carry the amino acid to its correct place in the growing polypeptide chain.) ...
Synthetic Chloroplasts - BLI-Research-in-Synthetic-Biology
... • The Synechococcus elongatus were engineered with invasin from Yersinia pestis, and Listeriolysin O from Listeria monocytogenes • Invasin: a protein that causes an uptake in bacterial cells • Listeriolysin O: hemolysin that allows bacteria to enter the cytoplasm after the uptake ...
... • The Synechococcus elongatus were engineered with invasin from Yersinia pestis, and Listeriolysin O from Listeria monocytogenes • Invasin: a protein that causes an uptake in bacterial cells • Listeriolysin O: hemolysin that allows bacteria to enter the cytoplasm after the uptake ...
Adding Protein Context to the Human Protein-Protein
... To demonstrate that our automated context association approach allows identification of relevant interactions, we tested if networks of interactions of our inferred MESH-based disease-annotation are enriched in well-known disease proteins. Therefore, we repeatedly generated disease-context networks ...
... To demonstrate that our automated context association approach allows identification of relevant interactions, we tested if networks of interactions of our inferred MESH-based disease-annotation are enriched in well-known disease proteins. Therefore, we repeatedly generated disease-context networks ...
Roles of the mammalian target of rapamycin
... As noted above, mTORC1 is known to control the transcription of rRNA as well as the synthesis of ribosomal proteins [13]. Rapamycin impairs the formation of transcriptioninitiation complexes involved in transcribing the 45S prerRNA genes [15]. The major rRNAs (5.8S, 18S and 28S) are derived from a s ...
... As noted above, mTORC1 is known to control the transcription of rRNA as well as the synthesis of ribosomal proteins [13]. Rapamycin impairs the formation of transcriptioninitiation complexes involved in transcribing the 45S prerRNA genes [15]. The major rRNAs (5.8S, 18S and 28S) are derived from a s ...
brochure - Your Bakery and Snack Solutions
... Nutritious PrOatein® is a natural protein concentrate from oats that can help you meet the fast growing consumer demand for protein-enriched foods. At Tate & Lyle Oat Ingredients in Sweden we extract the protein component of the oat bran using a patented process without the use of solvents – so that ...
... Nutritious PrOatein® is a natural protein concentrate from oats that can help you meet the fast growing consumer demand for protein-enriched foods. At Tate & Lyle Oat Ingredients in Sweden we extract the protein component of the oat bran using a patented process without the use of solvents – so that ...
4.2 How to get other molecules across membranes
... Model of protein shape change in response to change in voltage across a membrane Roderick MacKinnon, M.D., Howard Hughes Medical Institute Investigator, Youxing Jiang, Ph.D. ...
... Model of protein shape change in response to change in voltage across a membrane Roderick MacKinnon, M.D., Howard Hughes Medical Institute Investigator, Youxing Jiang, Ph.D. ...
Back to the Future: Molecular Biology Meets Metabolism
... Benjamin Tu provides compelling evidence that the HAT enzyme component of the Spt-Ada-GCN5 acetyltransferase (SAGA) complex is only activated during a brief window of the yeast metabolic cycle wherein acetylCoA levels exceed the substrate threshold demanded by the relatively high Michaelis constant ...
... Benjamin Tu provides compelling evidence that the HAT enzyme component of the Spt-Ada-GCN5 acetyltransferase (SAGA) complex is only activated during a brief window of the yeast metabolic cycle wherein acetylCoA levels exceed the substrate threshold demanded by the relatively high Michaelis constant ...
Macromolecules
... • More specifically- polypeptides dipeptide Amino acids linked by peptide bonds ...
... • More specifically- polypeptides dipeptide Amino acids linked by peptide bonds ...
Study Questions
... Answer: c Rationale: If competent, she must be allowed to make her own decisions, even if they are not the ideal ones. Telling her family would be a breach of confidentiality. Her neighbors may be in a good position to keep an eye on her as she ages, and they and the family should stay in touch. ...
... Answer: c Rationale: If competent, she must be allowed to make her own decisions, even if they are not the ideal ones. Telling her family would be a breach of confidentiality. Her neighbors may be in a good position to keep an eye on her as she ages, and they and the family should stay in touch. ...
YANG Keqian
... and evaluation of the mutant enzymes, we identified several mutants with improved properties (recognize alternative substrates, with better kinetics). One paper was published (FEMS Microbiology Letters, 2005), another is being prepared for AEM. 4. Functional studies of bacterial biosynthetic and reg ...
... and evaluation of the mutant enzymes, we identified several mutants with improved properties (recognize alternative substrates, with better kinetics). One paper was published (FEMS Microbiology Letters, 2005), another is being prepared for AEM. 4. Functional studies of bacterial biosynthetic and reg ...
Virus partners in phloem Absence of sugar residues on structural
... Absence of sugar residues on structural proteins of poleroviruses: glycosylation not involved in aphid transmission Immunodectection of structural proteins with Ab@complex glycans ...
... Absence of sugar residues on structural proteins of poleroviruses: glycosylation not involved in aphid transmission Immunodectection of structural proteins with Ab@complex glycans ...
Membranes and Cell Transport
... Osmotic pressure - the pressure exerted to prevent the inward flow of water across a semipermeable membrane toward a higher concentration of solutes Consider osmotic pressure to be the pressure that water exerts against a membrane as it tries to move toward the higher concentration of solutes The mo ...
... Osmotic pressure - the pressure exerted to prevent the inward flow of water across a semipermeable membrane toward a higher concentration of solutes Consider osmotic pressure to be the pressure that water exerts against a membrane as it tries to move toward the higher concentration of solutes The mo ...
In vivo chloroplast protein synthesis by the
... labeled in vivo by this technique form a distinct subset of the total proteins synthesized by the cell. Approximately 50 plastid proteins (35 soluble, 15 membrane) were detected after two-dimensional gel electrophoresis and fluorography. Three ctDNA-coded proteins, the large subunit of ribulosebisph ...
... labeled in vivo by this technique form a distinct subset of the total proteins synthesized by the cell. Approximately 50 plastid proteins (35 soluble, 15 membrane) were detected after two-dimensional gel electrophoresis and fluorography. Three ctDNA-coded proteins, the large subunit of ribulosebisph ...
presentation Prof Khwaja
... What can we learn from the identification of specific molecular abnormalities in malignant disease? ...
... What can we learn from the identification of specific molecular abnormalities in malignant disease? ...
No Slide Title
... V-SNARE - in transport vesicle important for targeting T-SNARE - on target, along with ubiquitous SNAP-25 V-SNARE, T-SNARE, SNAP25 form complex - fusion Other proteins involved - NSF (ATPase), SNAP proteins ...
... V-SNARE - in transport vesicle important for targeting T-SNARE - on target, along with ubiquitous SNAP-25 V-SNARE, T-SNARE, SNAP25 form complex - fusion Other proteins involved - NSF (ATPase), SNAP proteins ...
Biological Membranes and Transport
... Functions of membranes Define cell boundaries, compartments Maintain electric and chemical potentials Self-sealing (break and reseal) Selectively permeable to polar solutes (retain charged species within membranes) Actively transport specific molecules Cell surface has transporters, receptors, adhes ...
... Functions of membranes Define cell boundaries, compartments Maintain electric and chemical potentials Self-sealing (break and reseal) Selectively permeable to polar solutes (retain charged species within membranes) Actively transport specific molecules Cell surface has transporters, receptors, adhes ...
Membranes and transport - part 1
... Functions of membranes Define cell boundaries, compartments Maintain electric and chemical potentials Self-sealing (break and reseal) Selectively permeable to polar solutes (retain charged species within membranes) Actively transport specific molecules Cell surface has transporters, receptors, adhes ...
... Functions of membranes Define cell boundaries, compartments Maintain electric and chemical potentials Self-sealing (break and reseal) Selectively permeable to polar solutes (retain charged species within membranes) Actively transport specific molecules Cell surface has transporters, receptors, adhes ...
Materials and Methods - UROP
... concentration of 1 mM, and allowed to grow for another four hours. The cultures were then centrifuged at 6 krpm for 15 minutes and stored at -80 °C. The pellet was resuspended in 40 ml of binding buffer (5 mM imidazole, 500 mM NaCl, 20 mM Tris-HCl (pH7.5)). The bacterial suspension was sonicated and ...
... concentration of 1 mM, and allowed to grow for another four hours. The cultures were then centrifuged at 6 krpm for 15 minutes and stored at -80 °C. The pellet was resuspended in 40 ml of binding buffer (5 mM imidazole, 500 mM NaCl, 20 mM Tris-HCl (pH7.5)). The bacterial suspension was sonicated and ...
Protein phosphorylation
Protein phosphorylation is a post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most commonly phosphorylated are serine, threonine, and tyrosine in eukaryotes, and histidine in prokaryotes, which play important and well-characterized roles in signaling pathways and metabolism. However, many other amino acids can also be phosphorylated, including arginine, lysine, and cysteine. Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin. However, it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered.