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3&4-Antiarrhythmic drugs
3&4-Antiarrhythmic drugs

... Prolong action potential duration and refractory period Additional actions of classes Ia, 2 & 4 vasodilating effects ( α- and βadrenoceptor blocking effects and calcium channel blocking effects ) ...
acute atrial fibrillation treatment in the surgical patient
acute atrial fibrillation treatment in the surgical patient

... to sinus rhythm within 2 hours of treatment compared with only 33% for patients randomized to receive diltiazem (intention to treat, p=0.049). After 12 hours of therapy, the number of patients converting to sinus rhythm increased in both groups (esmolol 85%; diltiazem, 62%), and the rates of convers ...
Randomized Trial Amiodarone for the Prevention of Atrial Fibrillation
Randomized Trial Amiodarone for the Prevention of Atrial Fibrillation

... associated with high daily dosages and long-term therapy14,15 but does not increase mortality in patients with heart failure and ischemic heart disease.16,17 Efforts to reduce the adverse event rate by using low-dose amiodarone (ⱕ400 mg/d after adequate loading) suggest that they still may occur. Sh ...
Canadian Implantable Defibrillator Study (CIDS)
Canadian Implantable Defibrillator Study (CIDS)

... This randomized trial compared ICD therapy with amiodarone therapy in patients who had VF, sustained VT, or unmonitored syncope likely due to VT. The study was designed to detect reliably a relative reduction in risk of death of 33% from an expected 3-year mortality rate of 30% on amiodarone. The ob ...
The Pharmacist`s Role in Advanced Cardiac Life Support
The Pharmacist`s Role in Advanced Cardiac Life Support

... • Coronary and Pulmonary thrombosis are most common causes of cardiac arrest • Insufficient evidence to advocate routine use – 2 large studies showed no benefit with tpa or tenecteplase (increased ICH) – Consider use if suspected AMI or PE ...
Document
Document

... (heart muscle) - if this persists it can lead to myocardial infarction. There are many causes to tachycardia, and one of them is the using of ant- asthmatic drugs like salbutamol and aminophylline which are well defined to cause tachycardia. Aim of study: Use of amiodaron to overcome tachycardia tha ...
Article - Johns Hopkins Medicine
Article - Johns Hopkins Medicine

... voltage for activation more positive), thereby reducing automaticity (ectopic triggers) and prolonging conduction velocity (length of the tachycardia cycle) (12–14). Amiodarone may also reduce automaticity by decreasing the recruitment of voltage-dependent inward current (the “pacemaker current”) du ...
Medical Control
Medical Control

... – One shock followed immediately by CPR (beginning with chest compressions). – Manufacturer’s recommendations for energy settings. – Do not attempt to palpate a pulse or check the rhythm after shock delivery. – After about two minutes of CPR if an organized rhythm is apparent during rhythm check, th ...
Click here for ALPS training slides from ROC
Click here for ALPS training slides from ROC

... Should I start an infusion after achieving ROSC? • No known value of prophylactic antiarrhythmic drug infusions after cardiac arrest • Since no open label amiodarone or lidocaine can be given in the field, no infusions of these drugs should be given by EMS providers (includes no IO administration o ...
Amiodarone Hydrochloride 150 mg/3 mL Name of the
Amiodarone Hydrochloride 150 mg/3 mL Name of the

... (related to prolonged repolarisation) with the possible development of U-waves. However these changes do not reflect toxicity. Amiodarone Hydrochloride 150 mg/3 mL is not contraindicated in patients with latent or manifest heart failure but caution should be exercised as existing heart failure may o ...
Multifocal Atrial Tachycardia in 2 Children
Multifocal Atrial Tachycardia in 2 Children

... recurred with pulmonary infections, and the frequency gradually decreased after improvement of pulmonary infection. He was free of MAT when followed up at clinics. Moreover, this patient had airway anomalies (bilateral vocal cord palsy and laryngomalacia) that may cause frequent pulmonary infections ...
Key Issues in Emergency Management
Key Issues in Emergency Management

... preferred approach in some patients, particularly where this leads to a marked improvement in symptoms,[8] and where recurrences of AF while on antiarrhythmic therapy are not ...
acls pretest answer key - PRO-CPR
acls pretest answer key - PRO-CPR

... it should be to give a post-conversion dosage of Amiodarone. The heart is clearly irritated here – it is a logical assumption that it could need a post-conversion dosage of Amiodarone to reduce that irritation or the irritation could be from the hypoxia created from the currently low blood pressure ...
Physiology of cardiac rate and rhythm
Physiology of cardiac rate and rhythm

...  Major effect acutely is depression of AV node  Acute Rx/prophylaxis  Atrial and ventricular arrhythmias  Oral or IV (central line)  Loading and maintenance doses  T1/2 roughly 54 days  Large volume of distribution  Accumulates  Hepatic metabolism- biliary and intestinal excretion ...
Agents Used in Cardiac Arrhythmias
Agents Used in Cardiac Arrhythmias

... Agents Used in Cardiac Arrhythmias Cardiac arrhythmias are a common problem in clinical practice, occurring in up to 25% of patients treated with digitalis, 50% of anesthetized patients, and over 80% of patients with acute myocardial infarction. Arrhythmias may require treatment because rhythms that ...
Amiodarone-Induced Postrepolarization Refractoriness Suppresses
Amiodarone-Induced Postrepolarization Refractoriness Suppresses

... (Department of Medicine, University Hospital Münster, Münster, Germany), by the Franz-Loogen-Foundation (Düsseldorf, Germany), and by the German Research Council (Deutsche Forschungsgemeinschaft, project SFB 556-Z2). Portions of this work have been presented at the annual meetings of the North Am ...
Rhythm Problems Atrioventricular Septal Defect Alpay Çeliker MD
Rhythm Problems Atrioventricular Septal Defect Alpay Çeliker MD

... Walsh ED, et al. J Am Coll Cardiol, 1997; 29: 1046-1053 ...
Functional Class IIand III Congestive Heart Failure
Functional Class IIand III Congestive Heart Failure

... cardiomyopathies, whereas no benefit was observed in another study where heart failure was mainly due to Ischemic cardiomyopathies [31]. In another study, Amiodarone increased the left ventricular ejection fraction by 42 percent at two years [32], confirming the results of previous studies [33]. The ...
Ventricular tachycardia (broad complex)
Ventricular tachycardia (broad complex)

... Structural heart disease (valves, cardiomyopathy), pulmonary disease, drugs ...
Cardiac arrest- asystole PEA VT
Cardiac arrest- asystole PEA VT

... Adrenaline 10mcg/kg and Amiodarone 5mg/kg reassess rhythm ...
Antiarrhythmic Drugs
Antiarrhythmic Drugs

... i. Digoxin ii. Warfarin b. Extensively metabolized by hepatic CYP450 system i. Given with CYP450 inducer ↓efficacy ii. Given with CYP450 inhibitor ↑toxicity ...
recurrent ventricular tachycardia in a methadone dependent patient
recurrent ventricular tachycardia in a methadone dependent patient

... University of Miami Miller School of Medicine, Miami, FL, USA Background: Methadone is a commonly used drug for opioid dependence and chronic pain. Cardiac side effects, especially QT interval prolongation and ventricular arrhythmias have recently become a concern, even though it rarely causes ventr ...
PEDIATRIC CARDIAC RHYTHM DISTURBANCES
PEDIATRIC CARDIAC RHYTHM DISTURBANCES

... increased cardiac output or oxygen delivery • Common causes include anxiety, fever, pain, blood loss, sepsis, or shock • History is compatible for S. tach ...
Neonatal Cardiac Arrhythmias
Neonatal Cardiac Arrhythmias

... -Usually with atrio-ventricular dissociation and slower atrial than ventricular rate. -Capture beats with no fusion. ...
Atrial Fibrillation
Atrial Fibrillation

... M E M O RIA L H E R M AN N T E X AS M E D IC AL C E N TE R ...
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Amiodarone



Amiodarone is a class III antiarrhythmic agent used for various types of cardiac dysrhythmias, both ventricular and atrial. It was discovered in 1961. Despite relatively common side-effects, it is used in arrhythmias that are otherwise difficult to treat with medication.
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