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Genetic Testing for Marfan Syndrome, Thoracic Aortic Aneurysms
Genetic Testing for Marfan Syndrome, Thoracic Aortic Aneurysms

... MFS is an autosomal-dominant condition, in which there is a high degree of clinical variability of systemic manifestations, ranging from isolated features of MFS to neonatal presentation of severe and rapidly progressive disease in multiple organ systems.2 Despite the clinical variability, the princ ...
apgenetics1206
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bb2013_03 - Territory Stories
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Lecture 3: (Part 1) Natural selection

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Divergent evolution of lifespan associated with mitochondrial DNA

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Extended Life-Span and Stress Resistance in Drosophila

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... Male gamete dispersal is characterized by a log-normal, isotropic dispersal kernel (Greene et al. 2004), with average log-scale distance dg and a log-scale standard deviation of 0.5. To gain computational efficiency, gamete dispersal is simulated in a simplified way compared to offspring dispersal ( ...
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Genetic Regulation of Meristem Maintenance and Organ

... Molecular genetic studies in Arabidopsis thaliana over the last 15 years have produced a wealth of information that has considerably advanced our understanding of plant development at the molecular level. Among these advances, the ABC model of floral organ specification and the negative feedback mod ...
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Appendix I

Gene Pool Recombination in Genetic Algorithms
Gene Pool Recombination in Genetic Algorithms

... Genetic algorithms (GAs) use at least three different components for guiding the search to an optimum — selection, mutation and recombination. Understanding the evolution of genetic populations is still an important problem for biology and for scientific breeding. Mühlenbein and Schlierkamp-Voosen ...
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Monohybrid Crosses - GaryTurnerScience

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Dragon Genetics -- Independent Assortment and Genetic Linkage
Dragon Genetics -- Independent Assortment and Genetic Linkage

... Assume that the wing, fire-breathing and fang genes are so close together on Chromosome 1 that there is no crossing over in this region of the chromosome. ...
Recurrent Pregnancy Loss and Its Relation to Combined Parental
Recurrent Pregnancy Loss and Its Relation to Combined Parental

...  Just 2 % of pregnant women experience two consecutive pregnancy losses and only 0.4 to 1% have three consecutive pregnancy losses. ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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