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03 Beyond Mendel

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... is that in a more or less stable environment, when the total number of individuals is more or less constant, the only way for an individual to increase its proportion (the number of its progeny in further generations) is by producing more viable offspring than its neighbors. This a very strong assum ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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