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8.1 Human Chromosomes and Genes
8.1 Human Chromosomes and Genes

... people worldwide. In addition to differences in skin color genes, differences in exposure to UV light explain most of the variation. As shown in Figure 8.10, exposure to UV light darkens the skin. ...
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Incomplete Dominance and Codominance
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... Before the development of a process that permitted the extraction of insulin from animals, many people who had the recessive allele for diabetes in the homozygous condition died before passing on their genes to offspring. Genetic screening attempts to identify genetic conditions prior to birth or at ...
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Genetics introduction
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... and IB alleles are said to be co-dominant. 22. Define and give examples of pleiotrophy and epistasis. 23. Describe a simple model for polygenic inheritance and explain why most polygenic characters are described in quantitative. 24. Describe how environmental conditions can influence the phenotypic ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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