Practice Problems1
... body color b+b (wild type is grey and dominant). He wants to get homozygous recessive flies to use in test crosses. He mates the two heterozygotes and throws away all but 8 eggs, claiming that he will get one female b b and one male b b from these eggs. (a) What is the probability that he will get e ...
... body color b+b (wild type is grey and dominant). He wants to get homozygous recessive flies to use in test crosses. He mates the two heterozygotes and throws away all but 8 eggs, claiming that he will get one female b b and one male b b from these eggs. (a) What is the probability that he will get e ...
CLASSIFYING CANCER GENES
... collaborative, online building of a data set accomplished by the students and the genome analysis done by the researchers (on a larger scale). Students could post their 3-2-1 analyses as blog posts (on a class blog or individual student blogs). Once posted, the comments feature could be used to faci ...
... collaborative, online building of a data set accomplished by the students and the genome analysis done by the researchers (on a larger scale). Students could post their 3-2-1 analyses as blog posts (on a class blog or individual student blogs). Once posted, the comments feature could be used to faci ...
screening and selection for recombinants
... also involves the insertional inactivation of a gene and uses the production of a blue compound as an indicator (Brown, 1990). The gene is lacZ, which encodes the enzyme ß-galactosidase, and is under the control of the lac promoter. If the host E. coli strain is expressing the lac repressor, express ...
... also involves the insertional inactivation of a gene and uses the production of a blue compound as an indicator (Brown, 1990). The gene is lacZ, which encodes the enzyme ß-galactosidase, and is under the control of the lac promoter. If the host E. coli strain is expressing the lac repressor, express ...
First level Spring (VI) Face-to-face
... The science of genetics and other natural sciences. Mendelian genetics. The inheritance of traits. Cytological basis of inheritance. Chromosomal theory of inheritance. Genetic information. The central dogma of molecular biology. Genome – transcriptome - proteome. DNA repeated sequences. Mechanism of ...
... The science of genetics and other natural sciences. Mendelian genetics. The inheritance of traits. Cytological basis of inheritance. Chromosomal theory of inheritance. Genetic information. The central dogma of molecular biology. Genome – transcriptome - proteome. DNA repeated sequences. Mechanism of ...
Macular conditions – Genes and genetic testing
... Macular conditions – Genes and genetic testing The chance of developing a particular condition often depends on both environmental and genetic factors. For some conditions, it’s mainly environmental. For some, such as juvenile macular dystrophy, it's mainly genetic and for others, such as age-relate ...
... Macular conditions – Genes and genetic testing The chance of developing a particular condition often depends on both environmental and genetic factors. For some conditions, it’s mainly environmental. For some, such as juvenile macular dystrophy, it's mainly genetic and for others, such as age-relate ...
Sequence Alignment Introduction
... In modern taxonomic practice, scientists routinely analyze the DNA from specimens they collect to obtain a “DNA barcode,” a short DNA sequence unique to a particular species, which is used to identify the species it belongs to. For animals and many other eukaryotes, different genes have been used ...
... In modern taxonomic practice, scientists routinely analyze the DNA from specimens they collect to obtain a “DNA barcode,” a short DNA sequence unique to a particular species, which is used to identify the species it belongs to. For animals and many other eukaryotes, different genes have been used ...
BIOLOGY - Learner
... characteristics cluster with others for reasons other than homology. For instance, if the set of characters were weighted toward those involved in carnivory, carnivorous animals may cluster together — not because of homology but because of shared function. This problem would be less likely if using ...
... characteristics cluster with others for reasons other than homology. For instance, if the set of characters were weighted toward those involved in carnivory, carnivorous animals may cluster together — not because of homology but because of shared function. This problem would be less likely if using ...
Proximal promoter
... the distal sequence upstream of the gene that may contain additional regulatory elements, often with a weaker influence than the proximal promoter – Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/orientation independent) – Specific transcripti ...
... the distal sequence upstream of the gene that may contain additional regulatory elements, often with a weaker influence than the proximal promoter – Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/orientation independent) – Specific transcripti ...
Unit B 4-4
... the environment. Their phenotype is either one thing or the other. These traits most easily show how genes are inherited. An example is coat color. Quantitative traits are traits controlled by several pairs of genes. These traits are expressed across a range. These traits can also be altered by en ...
... the environment. Their phenotype is either one thing or the other. These traits most easily show how genes are inherited. An example is coat color. Quantitative traits are traits controlled by several pairs of genes. These traits are expressed across a range. These traits can also be altered by en ...
Chapter 13 Vocabulary Name
... 3. plasmid: small, circular DNA molecule found in bacteria that is separate from the bacterial chromosome (Concept 13.2) 4. restriction enzyme: enzyme that cuts sugar-phosphate bonds in the DNA backbone at specific points within particular nucleotide sequences in DNA (Concept 13.2) 5. genomic librar ...
... 3. plasmid: small, circular DNA molecule found in bacteria that is separate from the bacterial chromosome (Concept 13.2) 4. restriction enzyme: enzyme that cuts sugar-phosphate bonds in the DNA backbone at specific points within particular nucleotide sequences in DNA (Concept 13.2) 5. genomic librar ...
Comparative Genomic Hybridization
... important genes that are being affected, so there will be contiguous regions of the genome with constant copy number, with an abrupt step to different level at the edge of an aberration. • E.g..-If a portion of a chromosome is lost in the cell population we would expect a CH of this genomic DNA with ...
... important genes that are being affected, so there will be contiguous regions of the genome with constant copy number, with an abrupt step to different level at the edge of an aberration. • E.g..-If a portion of a chromosome is lost in the cell population we would expect a CH of this genomic DNA with ...
A stepwise procedure for conditional testing of
... Differential gene expression between B-cell ALL with the BCR/ABL (37 samples) fusion and cytogenetically normal NEG B-cell (42 samples) ALL The BCR/ABL fusion (Dudoit 2006) A number of recent articles have investigated the prognostic relevance of the BCR/ABL fusion in adult ALL of the B-cell lineage ...
... Differential gene expression between B-cell ALL with the BCR/ABL (37 samples) fusion and cytogenetically normal NEG B-cell (42 samples) ALL The BCR/ABL fusion (Dudoit 2006) A number of recent articles have investigated the prognostic relevance of the BCR/ABL fusion in adult ALL of the B-cell lineage ...
Horvitz et al 1979
... The existence of a gene is revealed by the phenotypic effect(s) of a mutation. In general, mutations that have similar phenotypic effects, fail to complement, and are located in virtually identical positions on the genetic map are assumed to be allelic (i.e., to lie in the same gene). However, it is ...
... The existence of a gene is revealed by the phenotypic effect(s) of a mutation. In general, mutations that have similar phenotypic effects, fail to complement, and are located in virtually identical positions on the genetic map are assumed to be allelic (i.e., to lie in the same gene). However, it is ...
Gene Section PEG3 (paternally expressed 3) Atlas of Genetics and Cytogenetics
... breast cancers and other gynecologic cancers (Kohda et al., 2001; Dowdy et al., 2005; Feng et al., 2008). There are several studies revealed murine Peg3 acts as an intermediary between p53 and Bax in a cell death pathway activated by DNA damage in primary mouse cortical neurons, inhibiting Peg3 acti ...
... breast cancers and other gynecologic cancers (Kohda et al., 2001; Dowdy et al., 2005; Feng et al., 2008). There are several studies revealed murine Peg3 acts as an intermediary between p53 and Bax in a cell death pathway activated by DNA damage in primary mouse cortical neurons, inhibiting Peg3 acti ...
Genetic Mutations
... amino acid in the protein after the deletion to be changed. • A mutation in which a single base is added or deleted from DNA is called a frameshift mutation because it shifts the reading of codons by one base. ...
... amino acid in the protein after the deletion to be changed. • A mutation in which a single base is added or deleted from DNA is called a frameshift mutation because it shifts the reading of codons by one base. ...
Sequencing the Human Genome
... The haploid human genome comprises approximately three billion base pairs of DNA that are organized into 23 chromosomes. The order of these nucleotides creates genes, which are discrete units of genetic information that contain the instructions to build and maintain an organism. DNA sequencing is th ...
... The haploid human genome comprises approximately three billion base pairs of DNA that are organized into 23 chromosomes. The order of these nucleotides creates genes, which are discrete units of genetic information that contain the instructions to build and maintain an organism. DNA sequencing is th ...
Gene Regulatory Network Discovery from Time-Series - kedri
... operators used for crossover, mutation and selection are respectively the standard crossover, the binary mutation and the (µ, λ) selection operators. Since there are two series – the plus and the minus series of time-course gene expression observations in our case study, a new fitness function is de ...
... operators used for crossover, mutation and selection are respectively the standard crossover, the binary mutation and the (µ, λ) selection operators. Since there are two series – the plus and the minus series of time-course gene expression observations in our case study, a new fitness function is de ...
A History of Computing
... distantly related proteins, try using the PAM 250 or BLOSUM 45 matrices as well. If comparing closely related proteins, try using the PAM 1 or BLOSUM 80 matrices as well. • Keep in mind that BLAST is a heuristic version of Smith-Waterman, and may miss a significant alignment. The following examples, ...
... distantly related proteins, try using the PAM 250 or BLOSUM 45 matrices as well. If comparing closely related proteins, try using the PAM 1 or BLOSUM 80 matrices as well. • Keep in mind that BLAST is a heuristic version of Smith-Waterman, and may miss a significant alignment. The following examples, ...
Genetic Mutations
... amino acid in the protein after the deletion to be changed. • A mutation in which a single base is added or deleted from DNA is called a frameshift mutation because it shifts the reading of codons by one base. ...
... amino acid in the protein after the deletion to be changed. • A mutation in which a single base is added or deleted from DNA is called a frameshift mutation because it shifts the reading of codons by one base. ...
Exercise
... In how many experiments was mat1a observed up-regulated, in liver? Can you find out more information about these experiments? In which experiment is mat1a up-regulation statistically more significant? ...
... In how many experiments was mat1a observed up-regulated, in liver? Can you find out more information about these experiments? In which experiment is mat1a up-regulation statistically more significant? ...
challenge questions
... proteins. Multiple NRE binding elements may enhance the binding either by simply providing a higher concentration of binding sites or through cooperativity (the binding of protein to one NRE enhances the binding of protein to other NREs). The complex of Nanos (and other proteins) bound to the NREs a ...
... proteins. Multiple NRE binding elements may enhance the binding either by simply providing a higher concentration of binding sites or through cooperativity (the binding of protein to one NRE enhances the binding of protein to other NREs). The complex of Nanos (and other proteins) bound to the NREs a ...
Gene Section IGL@ (Immunoglobulin Lambda) Atlas of Genetics and Cytogenetics
... haplotypes, each IGLC gene being preceded by one IGLJ segment. Fifty-six to 57 genes belong to 11 subgroups, whereas 14 pseudogenes which are too divergent to be assigned to subgroups have been assigned to 3 clans. The most 5' IGLV genes occupy the more centromeric position, whereas the IGLC genes, ...
... haplotypes, each IGLC gene being preceded by one IGLJ segment. Fifty-six to 57 genes belong to 11 subgroups, whereas 14 pseudogenes which are too divergent to be assigned to subgroups have been assigned to 3 clans. The most 5' IGLV genes occupy the more centromeric position, whereas the IGLC genes, ...
Key Concepts -- Lecture 17 (BIOSYSTEMATICS 2) Spring 2009 IB
... timing of origin of reproductive barriers, with different perennial lineages often retaining interfertility long after divergence and different annual lineages often becoming intersterile or losing crossability before much morphological or ecological change has occurred. This difference between annu ...
... timing of origin of reproductive barriers, with different perennial lineages often retaining interfertility long after divergence and different annual lineages often becoming intersterile or losing crossability before much morphological or ecological change has occurred. This difference between annu ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.