Unifactorial or single gene disorders
... FRAXA gene codes for a protein needed for development and function of cerebral neurons The syndrome is caused by unstable mutation: too many CGG repeats on the 5’ untranslated region causes suppression of expression 10-50 copies:normal 50-200 copies :premutation , may cause fragile X tremor/ataxia s ...
... FRAXA gene codes for a protein needed for development and function of cerebral neurons The syndrome is caused by unstable mutation: too many CGG repeats on the 5’ untranslated region causes suppression of expression 10-50 copies:normal 50-200 copies :premutation , may cause fragile X tremor/ataxia s ...
Patents 101 - The Zhao Bioinformatics Laboratory
... EST alignments across the full length of the coding sequence. E (14737 genes) expressed/EST matches: Expression of the gene is supported by Medicago EST sequence that matches the gene call (partially). H (14209 genes) homology/heterologous: the gene call is supported by similarity to Medicago or oth ...
... EST alignments across the full length of the coding sequence. E (14737 genes) expressed/EST matches: Expression of the gene is supported by Medicago EST sequence that matches the gene call (partially). H (14209 genes) homology/heterologous: the gene call is supported by similarity to Medicago or oth ...
Genetic Algorithms
... • They concentrate either on search or on finding a good evaluation function. • They can help to improve good players but they can’t produce good players. • Improvements on a random player don’t worth ...
... • They concentrate either on search or on finding a good evaluation function. • They can help to improve good players but they can’t produce good players. • Improvements on a random player don’t worth ...
A compact new computer program for handling nucleic acid se
... restriction enzyme data. The program contains a table of commercially or otherwise readily available, or seemingly interesting restriction enzyme cleavage sites; to date this includes 57 different restriction enzymes. The name of the appropriate restriction enzyme will be printed above the 5'-termin ...
... restriction enzyme data. The program contains a table of commercially or otherwise readily available, or seemingly interesting restriction enzyme cleavage sites; to date this includes 57 different restriction enzymes. The name of the appropriate restriction enzyme will be printed above the 5'-termin ...
evolution - Janelia Research Campus
... Darwin himself was well aware of the correlation between different characters. Today we see the same phenomenon as the multiple effects of a single gene. Since the gene exists in every cell of the body, it may be expected to affect the organism as a whole, even if its most striking effect is on some ...
... Darwin himself was well aware of the correlation between different characters. Today we see the same phenomenon as the multiple effects of a single gene. Since the gene exists in every cell of the body, it may be expected to affect the organism as a whole, even if its most striking effect is on some ...
Core promoter
... were required for the timed regulation of developmental events. Since then, hundreds of microRNAs have been identified in almost all metazoan genomes, including worms, flies, plants and mammals. MicroRNAs have diverse expression patterns and might regulate various developmental and physiological ...
... were required for the timed regulation of developmental events. Since then, hundreds of microRNAs have been identified in almost all metazoan genomes, including worms, flies, plants and mammals. MicroRNAs have diverse expression patterns and might regulate various developmental and physiological ...
Explain what genetic recombination is, why it is important and ho it
... cDNA library. A cDNA library includes only DNA fragments g that actually code for proteins rather than all DNA fragments. This means that introns and other non non--coding sections of the genome are not included. ...
... cDNA library. A cDNA library includes only DNA fragments g that actually code for proteins rather than all DNA fragments. This means that introns and other non non--coding sections of the genome are not included. ...
Origin of the Science of genetics
... • Genes on the X chromosome are called “sexlinked”, because they expressed more often in males than in females • There are very few genes on the Y chromosome. • Since males only have one X chromosome, all genes on it, whether dominant or recessive, are expressed. ...
... • Genes on the X chromosome are called “sexlinked”, because they expressed more often in males than in females • There are very few genes on the Y chromosome. • Since males only have one X chromosome, all genes on it, whether dominant or recessive, are expressed. ...
In the descendants of the cross between true breeding lines
... were allowed to grow 4 to 8 weeks in the nurseries by which time the hairiness ...
... were allowed to grow 4 to 8 weeks in the nurseries by which time the hairiness ...
parent `B` - University of Washington
... The maximum proportion of recombinant gametes is 50%. The two loci are far enough apart that they will behave as if they are unlinked even though they are on the same chromosome. 1c. Loci A and B each code for a protein involved in adenine biosythesis. If a haploid yeast strain has alleles A and B, ...
... The maximum proportion of recombinant gametes is 50%. The two loci are far enough apart that they will behave as if they are unlinked even though they are on the same chromosome. 1c. Loci A and B each code for a protein involved in adenine biosythesis. If a haploid yeast strain has alleles A and B, ...
Name
... have 23 pairs of chromosomes for a total of 46 that can be divided into two sets: 23 from your mother and 23 from your father. Just as you use both gloves when it’s cold outside, your cells use both sets of chromosomes to function properly. Together, each pair of chromosomes is referred to as a homo ...
... have 23 pairs of chromosomes for a total of 46 that can be divided into two sets: 23 from your mother and 23 from your father. Just as you use both gloves when it’s cold outside, your cells use both sets of chromosomes to function properly. Together, each pair of chromosomes is referred to as a homo ...
Click here for handouts
... from the same parent, instead of one member being inherited from each parent. Often, uniparental disomy does not have clinical consequences. Some exceptions are when it involves chromosomes 6, 7, 11, 14, 15. These offspring are at increased risk for an abnormality tht results from parent-of-origin d ...
... from the same parent, instead of one member being inherited from each parent. Often, uniparental disomy does not have clinical consequences. Some exceptions are when it involves chromosomes 6, 7, 11, 14, 15. These offspring are at increased risk for an abnormality tht results from parent-of-origin d ...
The genetics of mental retardation
... which a translocation disrupted the elastin gene, a candidate locus for SVAS31. Since SVAS occurred in Williams syndrome, researchers hypothesised that there might be deletions affecting both the elastin locus and nearby genes with other functions which, when monosomic, would contribute to other fea ...
... which a translocation disrupted the elastin gene, a candidate locus for SVAS31. Since SVAS occurred in Williams syndrome, researchers hypothesised that there might be deletions affecting both the elastin locus and nearby genes with other functions which, when monosomic, would contribute to other fea ...
In recent year there have been rapid progress made in mapping the
... original test statistic is then computed as the tail area from the distribution of these new resampled test statistics. The major benefit of this method is that it does not assume independence between the tests, however it requires relatively large samples to be effective. Microarray studies frequen ...
... original test statistic is then computed as the tail area from the distribution of these new resampled test statistics. The major benefit of this method is that it does not assume independence between the tests, however it requires relatively large samples to be effective. Microarray studies frequen ...
EXTRACTION OF GENE-DISEASE RELATIONS FROM
... such as M edLine have a vast amount of knowledge. Our aim in this paper is to extract diseases and their relevant genes from M edLine abstracts, which we term relation extraction. There are some existing systems for relation extraction from biomedical literature. ArrowSmith (Swanson 1986) 1 and BITO ...
... such as M edLine have a vast amount of knowledge. Our aim in this paper is to extract diseases and their relevant genes from M edLine abstracts, which we term relation extraction. There are some existing systems for relation extraction from biomedical literature. ArrowSmith (Swanson 1986) 1 and BITO ...
ppt - Chair of Computational Biology
... Typically, unmethylated clusters of CpG pairs are located in tissue-specific genes and in essential housekeeping genes. (House-keeping genes are involved in routine maintenance roles and are expressed in most tissues.) ...
... Typically, unmethylated clusters of CpG pairs are located in tissue-specific genes and in essential housekeeping genes. (House-keeping genes are involved in routine maintenance roles and are expressed in most tissues.) ...
Investigation of the premelanosome protein
... and portions of upstream and downstream introns 6 and 7 (404 bp). Within a total of 1 437 bp re-sequenced fragments, only 2 single nucleotide polymorphisms were identified in intronic regions: one was in intron 4 (g.39510357G>A); the second was in intron 7 (g.39508302G>A). Sequences have been submit ...
... and portions of upstream and downstream introns 6 and 7 (404 bp). Within a total of 1 437 bp re-sequenced fragments, only 2 single nucleotide polymorphisms were identified in intronic regions: one was in intron 4 (g.39510357G>A); the second was in intron 7 (g.39508302G>A). Sequences have been submit ...
Mobile genetic elements in antibiotic resistance
... carrying cells will be eliminated. Plasmids are passed on vertically to the cell's progeny during cell division. However, many resistance plasmids are also capable of mediating their transfer to other organisms, and indeed to organisms of other species, by conjugation. This greatly increases the pot ...
... carrying cells will be eliminated. Plasmids are passed on vertically to the cell's progeny during cell division. However, many resistance plasmids are also capable of mediating their transfer to other organisms, and indeed to organisms of other species, by conjugation. This greatly increases the pot ...
Harvard Medical School - MGH-PGA
... Microarray Data: Gene expression profiles of mouse models of cardiomyopathies Gene expression profiles of normal mouse hearts Gene expression profiles of human tissues from heart failure patients ...
... Microarray Data: Gene expression profiles of mouse models of cardiomyopathies Gene expression profiles of normal mouse hearts Gene expression profiles of human tissues from heart failure patients ...
Allelic Association
... that are correlated with trait variants… We do not measure the trait variants themselves •But, for study design and power, we concern ourselves with frequencies and effect sizes at the trait locus…. This can only lead to underpowered studies and ...
... that are correlated with trait variants… We do not measure the trait variants themselves •But, for study design and power, we concern ourselves with frequencies and effect sizes at the trait locus…. This can only lead to underpowered studies and ...
Investigation 1: Examining RNA-Seq data
... be used to help us identify exons and introns for the gene under study. All RNAs in the cell are collectively known as the 'transcriptome,’ as almost all RNA is produced by transcription from a DNA template. (In some cases, RNA is made from an RNA template.) The transcriptome includes messenger RNAs ...
... be used to help us identify exons and introns for the gene under study. All RNAs in the cell are collectively known as the 'transcriptome,’ as almost all RNA is produced by transcription from a DNA template. (In some cases, RNA is made from an RNA template.) The transcriptome includes messenger RNAs ...
Recombinant DNA
... 12.17 Genomics is the scientific study of whole genomes Genomics is the study of an organism’s complete set of genes and their interactions – Initial studies focused on prokaryotic genomes – Many eukaryotic genomes have since been investigated ...
... 12.17 Genomics is the scientific study of whole genomes Genomics is the study of an organism’s complete set of genes and their interactions – Initial studies focused on prokaryotic genomes – Many eukaryotic genomes have since been investigated ...
video slide - Course
... • However, much evidence is accumulating – That noncoding DNA plays important roles in the cell Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings ...
... • However, much evidence is accumulating – That noncoding DNA plays important roles in the cell Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.