Genetic aspects in sarcoidosis REVIEW M. Luisetti*, A. Beretta*, L. Casali*
... the two regions (28.2 versus 3.7 per 100,000, respectively) [15]. The most informative study in this field was conducted in the Detroit area in southeastern Michigan. In a preliminary investigation the authors evaluated 727 cases which included 91 families containing 210 affected members with 147 re ...
... the two regions (28.2 versus 3.7 per 100,000, respectively) [15]. The most informative study in this field was conducted in the Detroit area in southeastern Michigan. In a preliminary investigation the authors evaluated 727 cases which included 91 families containing 210 affected members with 147 re ...
Genetic Analysis of Variation in Human Meiotic Recombination
... diversity. Given its importance, we would expect the number and location of exchanges to be tightly regulated. However, studies show significant gender and interindividual variation in genome-wide recombination rates. The genetic basis for this variation is poorly understood. In this study, we used ...
... diversity. Given its importance, we would expect the number and location of exchanges to be tightly regulated. However, studies show significant gender and interindividual variation in genome-wide recombination rates. The genetic basis for this variation is poorly understood. In this study, we used ...
Small- and Large-Effect Quantitative Trait Locus
... small-effect QTL. To identify and study small-effect QTL, we used sporulation efficiency in the yeast Saccharomyces cerevisiae as a model complex trait (Gerke et al. 2006). This system offers several advantages for the study of QTL with relatively small-effect sizes. Sporulation efficiency is a highly ...
... small-effect QTL. To identify and study small-effect QTL, we used sporulation efficiency in the yeast Saccharomyces cerevisiae as a model complex trait (Gerke et al. 2006). This system offers several advantages for the study of QTL with relatively small-effect sizes. Sporulation efficiency is a highly ...
article in press
... So, with genotype matrices under the interactive allele requirement, we have two mathematical functions that can operate on the entire set of alleles in an organism’s genotype and will act on two alleles if and only if they are interactive alleles. We should note, though, that this requirement means ...
... So, with genotype matrices under the interactive allele requirement, we have two mathematical functions that can operate on the entire set of alleles in an organism’s genotype and will act on two alleles if and only if they are interactive alleles. We should note, though, that this requirement means ...
Overview
... – genetic underpinnings of multiple phenotypes – genetic basis of genotype by environment interaction Sieberts, Schadt (2007 Mamm Genome); Emilsson et al. (2008 Nature) Chen et al. 2008 Nature); Ayroles et al. MacKay (2009 Nature Genetics) SysGen: Overview ...
... – genetic underpinnings of multiple phenotypes – genetic basis of genotype by environment interaction Sieberts, Schadt (2007 Mamm Genome); Emilsson et al. (2008 Nature) Chen et al. 2008 Nature); Ayroles et al. MacKay (2009 Nature Genetics) SysGen: Overview ...
Designs for QTL detection in livestock and their implications for MAS
... backcross and F2 populations have been developed. This is only realistically feasible when the cross itself can be developed into an economically viable synthetic or when the phenotype(s) under study has very large economic or welfare relevance. A more common approach is to exploit the large paterna ...
... backcross and F2 populations have been developed. This is only realistically feasible when the cross itself can be developed into an economically viable synthetic or when the phenotype(s) under study has very large economic or welfare relevance. A more common approach is to exploit the large paterna ...
Causes that Make a Difference - Philsci
... physical sciences. In physical sciences, investigators often prize causal generalizations that hold over as wide a range of conditions as possible. Indeed, many philosophers of science claim that physical scientists seek causal generalizations which hold over all possible conditions. There is an act ...
... physical sciences. In physical sciences, investigators often prize causal generalizations that hold over as wide a range of conditions as possible. Indeed, many philosophers of science claim that physical scientists seek causal generalizations which hold over all possible conditions. There is an act ...
DEPARTAMENT DE FARMACOLOGIA, DE TERAPÈUTICA I DE TOXICOLOGIA
... MDMA was first synthesized in 1912 by Anton Kollisch in the Merck laboratories as a chemical intermediate in the synthesis of hydrastinine, an astringent and clotting agent (Freudenmann et al., 2006). It was patented two years later but it never became marketed. In 1953, the US Army Chemical Centre ...
... MDMA was first synthesized in 1912 by Anton Kollisch in the Merck laboratories as a chemical intermediate in the synthesis of hydrastinine, an astringent and clotting agent (Freudenmann et al., 2006). It was patented two years later but it never became marketed. In 1953, the US Army Chemical Centre ...
Genetics of Alcohol Metabolism
... effects of alcohol depend on its systemic concentrations, variability in the pharmacokinetics of alcohol can have a significant impact on its pharmacodynamic effects. Following oral ingestion, alcohol is absorbed by passive diffusion, primarily from the small intestine [2, 3]. The rate of absorption ...
... effects of alcohol depend on its systemic concentrations, variability in the pharmacokinetics of alcohol can have a significant impact on its pharmacodynamic effects. Following oral ingestion, alcohol is absorbed by passive diffusion, primarily from the small intestine [2, 3]. The rate of absorption ...
Textbook Animal Breeding and Genetics
... students. The text book started as an initiative of the Dutch Universities for Applied (Agricultural) Sciences. The textbook is made available by the Animal Breeding and Genomics Centre (ABGC) of Wageningen UR (University and Research Centre) . It is written by two animal breeding scientists from Wa ...
... students. The text book started as an initiative of the Dutch Universities for Applied (Agricultural) Sciences. The textbook is made available by the Animal Breeding and Genomics Centre (ABGC) of Wageningen UR (University and Research Centre) . It is written by two animal breeding scientists from Wa ...
Textbook animal breeding Animal breeding and genetics for
... students. The text book started as an initiative of the Dutch Universities for Applied (Agricultural) Sciences. The textbook is made available by the Animal Breeding and Genomics Centre (ABGC) of Wageningen UR (University and Research Centre) . It is written by two animal breeding scientists from Wa ...
... students. The text book started as an initiative of the Dutch Universities for Applied (Agricultural) Sciences. The textbook is made available by the Animal Breeding and Genomics Centre (ABGC) of Wageningen UR (University and Research Centre) . It is written by two animal breeding scientists from Wa ...
NCC Collaborator - New England Genetics Collaborative
... Funds reduced, but what will remain similar: – NGECN and NCC will be even more completely integrated together. Genetic Alliance will continue to lead the NGECN effort within NCC. NGECN will continue to focus on developing tools and resources that link patients to information and services. – NCC will ...
... Funds reduced, but what will remain similar: – NGECN and NCC will be even more completely integrated together. Genetic Alliance will continue to lead the NGECN effort within NCC. NGECN will continue to focus on developing tools and resources that link patients to information and services. – NCC will ...
Genetics of Alcohol Metabolism
... effects of alcohol depend on its systemic concentrations, variability in the pharmacokinetics of alcohol can have a significant impact on its pharmacodynamic effects. Following oral ingestion, alcohol is absorbed by passive diffusion, primarily from the small intestine [2, 3]. The rate of absorption ...
... effects of alcohol depend on its systemic concentrations, variability in the pharmacokinetics of alcohol can have a significant impact on its pharmacodynamic effects. Following oral ingestion, alcohol is absorbed by passive diffusion, primarily from the small intestine [2, 3]. The rate of absorption ...
Dissection of genetic factors modulating fetal growth in
... QTL model, only markers with > 200 informative meioses in the F2 design were included, because it was indicated that the random QTL model may be instable, when information gaps occur in the genotype file. The confidence interval for the QTL investigated by the variance component model was determined ...
... QTL model, only markers with > 200 informative meioses in the F2 design were included, because it was indicated that the random QTL model may be instable, when information gaps occur in the genotype file. The confidence interval for the QTL investigated by the variance component model was determined ...
Pathogenesis of type 1 diabetes: lessons from natural history studies
... T1D affects 1.4 million people in the United States,1 and its incidence has doubled over the past 20 years.2–4 In the United States, the prevalence of T1D in youth under age 20 has increased by 23% from 2001 to 2009.5 While children are the most visibly affected, half of T1D patients are diagnosed a ...
... T1D affects 1.4 million people in the United States,1 and its incidence has doubled over the past 20 years.2–4 In the United States, the prevalence of T1D in youth under age 20 has increased by 23% from 2001 to 2009.5 While children are the most visibly affected, half of T1D patients are diagnosed a ...
Do universal codon-usage patterns minimize the effects of mutation
... value of the message. The second codon position determines about 70% of the total error value, the first codon position another 29%, and the third codon position less than 1%. To highlight possible changes in code-error value along the three compositional axes, which are difficult to see in the simp ...
... value of the message. The second codon position determines about 70% of the total error value, the first codon position another 29%, and the third codon position less than 1%. To highlight possible changes in code-error value along the three compositional axes, which are difficult to see in the simp ...
Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene
... College of Animal Science and Technology, China Agricultural University, Beijing, 100094, P. R. China ABSTRACT : The aim of the experiment was to detect polymorphisms in the keratin-associated protein 8.2 (KAP8.2) gene to determine associations between the genotype and fibre traits in Chinese Inner ...
... College of Animal Science and Technology, China Agricultural University, Beijing, 100094, P. R. China ABSTRACT : The aim of the experiment was to detect polymorphisms in the keratin-associated protein 8.2 (KAP8.2) gene to determine associations between the genotype and fibre traits in Chinese Inner ...
Age-related macular degeneration: a perspective on genetic studies
... Age-related macular degeneration (AMD) is a common macular disease affecting about 30% of adults aged 75 or older who have some signs of maculopathy, and about 6–8% of the individuals in this age group are afflicted with the advanced stages of this disease which causes the most severe visual loss.1 ...
... Age-related macular degeneration (AMD) is a common macular disease affecting about 30% of adults aged 75 or older who have some signs of maculopathy, and about 6–8% of the individuals in this age group are afflicted with the advanced stages of this disease which causes the most severe visual loss.1 ...
review neurochemical markers of alcoholism vulnerability in humans
... to identify individual variations in the trait marker, in the absence of any interference from alcohol. Challenge studies often attempt to identify individual variations of the trait marker after alcohol intake, while some studies use challenge drugs other than alcohol (acting on one or more of the ...
... to identify individual variations in the trait marker, in the absence of any interference from alcohol. Challenge studies often attempt to identify individual variations of the trait marker after alcohol intake, while some studies use challenge drugs other than alcohol (acting on one or more of the ...
Inheritance involved in the pathogenesis of idiopathic scoliosis
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
Candidate gene scan for Single Nucleotide Polymorphisms involved
... This study identified the largest number of genetic variants associated with normal variation ...
... This study identified the largest number of genetic variants associated with normal variation ...
Biology Test- Chapter 11: Introduction to Genetics
... a. two genetically identical cells. b. four genetically different cells. c. four genetically identical cells. d. two genetically different cells. 31. In a 2 factor cross where both parents are heterozygous for both traits (TtYy x TtYy), the expected phenotypic ratio would be: a. 1:1:1:1 c. 3:1 b. 12 ...
... a. two genetically identical cells. b. four genetically different cells. c. four genetically identical cells. d. two genetically different cells. 31. In a 2 factor cross where both parents are heterozygous for both traits (TtYy x TtYy), the expected phenotypic ratio would be: a. 1:1:1:1 c. 3:1 b. 12 ...
Publication - The University of Texas Health Science Center at
... function and regulation of AIF-1 expression has not been characterized thoroughly. AIF-1 is expressed by macrophages and neutrophils, and immunohistochemical analyses of scleroderma biopsies have demonstrated increased AIF-1 expression in the infiltrating cells within lesions [54–56]. A recent study ...
... function and regulation of AIF-1 expression has not been characterized thoroughly. AIF-1 is expressed by macrophages and neutrophils, and immunohistochemical analyses of scleroderma biopsies have demonstrated increased AIF-1 expression in the infiltrating cells within lesions [54–56]. A recent study ...
The genetic consequences of fluctuating inbreeding depression and
... Exploratory analyses showed that the mean selection coefficient of deleterious mutations had little effect on the results presented here, which is consistent with previous theory showing that equilibrium inbreeding depression in a population depends little on the selection coefficient of deleterious ...
... Exploratory analyses showed that the mean selection coefficient of deleterious mutations had little effect on the results presented here, which is consistent with previous theory showing that equilibrium inbreeding depression in a population depends little on the selection coefficient of deleterious ...
HETEROSIS IN THE PERFORMANCE OF MICE
... can provide much information useful in the planning of genetic experiments with larger animals, since mice, like cattle, sheep and swine are lactating mammals in which the direct maternal influence on survival and early development is highly important. Of course, the applicability of results with mi ...
... can provide much information useful in the planning of genetic experiments with larger animals, since mice, like cattle, sheep and swine are lactating mammals in which the direct maternal influence on survival and early development is highly important. Of course, the applicability of results with mi ...