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The genetics of obesity - National Genetics Education Centre
The genetics of obesity - National Genetics Education Centre

... http://www.geneticseducation.nhs.uk/search/it em/29-0029-genetics-and-obesity • PHG Foundation. Genomics of Obesity: The Application of Public Health Genomics to the Prevention and Management of Obesity in the ...
genetics bio 250 module 3
genetics bio 250 module 3

... disorders. You may recall, from Module 2, that Sutton and Boveri‟s Chromosome Theory of Inheritance proposed in 1902; postulates that genes are located on chromosomes. Just previous to this (end of 19th century), biologists had discovered that half of all sperm cells carried a structure they called ...
36 The Roots of Narcissus: Old and New Models of the Evolution of
36 The Roots of Narcissus: Old and New Models of the Evolution of

... ing  a  larger  penis  (Moskowitz  et  al.  2009)  than  nonnarcissists. Although  self­reports  of  a  larger  penis  might  be  explained  by  the  self­enhancing  tendencies of narcissists, other findings are more  difficult to explain as artifacts of reporting. Thus,  some  connection  between  ...
Goings on in Mendel`s Garden
Goings on in Mendel`s Garden

... needs, and science from potentially more productive research directions that might develop a better understanding of the nature of complex traits, and how they evolve. That would lead us to view genes not as peas deeply embedded under every princess, but as temporary combinations of alleles in genom ...
Reflections on the Field of Human Genetics: A Call for Increased
Reflections on the Field of Human Genetics: A Call for Increased

... priori, that tens or hundreds of thousands loci across the genome harbor alleles of very small effect sizes, all marginally contributing to additively increase disease risk. Moreover, many types of models may appear to have additive and nearly independent effects as those effect sizes become small. ...
PDF
PDF

... leads to hormonal sex-differences that have traditionally been considered the major proximal cause for extra-gonadal phenotypic sex-differences. However, diverse studies, including recent work in transgenic mice that uncouple Ychromosome and gonadal status, have revealed direct SCD effects on severa ...
Sex Chromosome Dosage Effects On Gene Expression In
Sex Chromosome Dosage Effects On Gene Expression In

... leads to hormonal sex-differences that have traditionally been considered the major proximal cause for extra-gonadal phenotypic sex-differences. However, diverse studies, including recent work in transgenic mice that uncouple Ychromosome and gonadal status, have revealed direct SCD effects on severa ...
basic features of breeding
basic features of breeding

... could be developed (AABBCCDDEE….) Why then are there no inbred equal in performance to hybrids?? This was considered a until it was recognized that only 1 in 4n individuals in a population would be homozygous for all loci For 10 loci that would be 410 = one individual in a million. ...
3-23_Genetics
3-23_Genetics

... we use to represent alleles? Alleles are different versions of the same gene/trait. We use CAPITAL and lowercase letters to represent them! ...
apbio ch 14 study guide
apbio ch 14 study guide

... Mendel developed a hypothesis to explain these results that consisted of four related ideas. We will explain each idea with the modern understanding of genes and chromosomes. 1. Alternative versions of genes account for variations in inherited characters. o The gene for flower color in pea plants ex ...
Genetic polymorphisms of vein wall remodeling in chronic venous
Genetic polymorphisms of vein wall remodeling in chronic venous

... spectrum of disorders caused by an abnormal venous system. They include chronic venous insufficiency, varicose veins, lipodermatosclerosis, postthrombotic syndrome, and venous ulceration. Some evidence suggests a genetic predisposition to chronic venous disease from gene polymorphisms associated mai ...
The CHARGE Targeted Sequencing Study
The CHARGE Targeted Sequencing Study

... (FHS).6 The CHARGE Targeted Sequencing Study included a cohort random sample and selected case groups from a variety of related cardiometabolic phenotypes, including a sample of ≈200 participants (100 ARIC study, 50 CHS, 50 FHS) from the high extremes of FI (≥8-hour fast) in individuals without diab ...
Implementation of molecular markers for quantitative traits in
Implementation of molecular markers for quantitative traits in

... relatively small number of genes, primarily those affecting traits that are difficult to phenotype. Another good candidate for widespread use of MAS in forward crossing programs is soybean cyst nematode resistance. MAS for this trait seems to be better than conventional selection because the phenoty ...
An Analysis of Gray versus Binary Encoding in Genetic Search 1
An Analysis of Gray versus Binary Encoding in Genetic Search 1

... 2L distinct values. Thus, for L = 3, we have a total of (23 )! = 40,320 different functions, corresponding to as many permutations. For example, L = 3 gives 23 = 8 function evaluations: 1,2, . . . , 8, and for these 8 evaluations, one possible permutation is {F (0) = 1, F (1) = 2, . . . , F (7) = 8} ...
Invitation Letter
Invitation Letter

... Atherosclerosis is an inflammatory disease with multifactorial etiology. In the last years a large body of evidence accumulated supporting this statement. More and more information indicates that inflammatory reactions are present from the very early stages of atherosclerosis till the rupture of a p ...
Alcoholism - University of Colorado-MCDB
Alcoholism - University of Colorado-MCDB

... Alcohol dependence is a complex disorder that combines alcohol abuse – continued drinking despite negative consequences – with physical symptoms of tolerance, withdrawal and uncontrollable craving for alcohol. The heritability of alcohol dependence is estimated to be between 38% and 64%. This means ...
use of genomic tools to discover the cause of
use of genomic tools to discover the cause of

... were identified based on testing 182 additional horses representing 15 breeds, suggesting that this mutation may be the causative for the dilution phenotype. While this gene is expected to function as a proton/amino acid symporter based on its sequence and gene family, this observation for the horse ...
View/Open
View/Open

... occur in discrete or distinct phenotypic classes and exhibit discontinuous variation in a population. Inheritance studies have shown that variation for each qualitative trait in a population is under the genetic control of two or more alleles of a single major gene with high heritability as environ ...
Pedigrees - Newark City Schools
Pedigrees - Newark City Schools

... probability of a child having a disorder in a particular family.  To begin to interpret a pedigree, determine if the disease or condition is autosomal or Xlinked and dominant or recessive. ...
Pedigree Charts
Pedigree Charts

... probability of a child having a disorder in a particular family. ♣ To begin to interpret a pedigree, determine if the disease or condition is autosomal or Xlinked and dominant or recessive. ...
Safety Administration Implementation Regulation on Agricultural
Safety Administration Implementation Regulation on Agricultural

... recipient organism have no unfavorable effect on human health and ecological environment, such as the storage protein gene for improving nutrition values. Type 3 Genetic manipulations which reduce the safety of recipient organisms include: 1.Genetic manipulations which cause the occurrence of known ...
Trans-ethnic meta-analysis of white blood cell phenotypes
Trans-ethnic meta-analysis of white blood cell phenotypes

... White blood cell (WBC) count is a common clinical measure used as a predictor of certain aspects of human health, including immunity and infection status. WBC count is also a complex trait that varies among individuals and ancestry groups. Differences in linkage disequilibrium structure and heteroge ...
Identification of loci affecting teat number by
Identification of loci affecting teat number by

... QTLs have been identified for this trait on almost all pig chromosomes except for SSC13, suggesting that teat number is controlled by multiple genes with generally small effects. We have previously identified 11 genome-wide significant QTLs for teat number by a genome scan on the White Duroc×Erhuali ...
Text (Open Access) - Reading`s CentAUR
Text (Open Access) - Reading`s CentAUR

... electronic supplementary material, figure A1, trajectories with specified values of b and c were found to converge within a few generations whatever the initial genotype frequencies. So figure 1 and electronic supplementary material, figure A1, give a fair representation of the process of selection ...
View PDF
View PDF

... Ossification of the posterior longitudinal ligament (OPLL) is pathological ectopic ossification of this ligament at the cervical and thoracic spine, causing myeloradiculopathy as a result of chronic pressure on the spinal cord and nerve roots [1, 2]. OPLL of the spine was first reported in Japan an ...
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Heritability of IQ

Research on heritability of IQ infers from the similarity of IQ in closely related persons the proportion of variance of IQ among individuals in a study population that is associated with genetic variation within that population. This provides a maximum estimate of genetic versus environmental influence for phenotypic variation in IQ in that population. ""Heritability"", in this sense, ""refers to the genetic contribution to variance within a population and in a specific environment"". There has been significant controversy in the academic community about the heritability of IQ since research on the issue began in the late nineteenth century. Intelligence in the normal range is a polygenic trait. However, certain single gene genetic disorders can severely affect intelligence, with phenylketonuria as an example.Estimates in the academic research of the heritability of IQ have varied from below 0.5 to a high of 0.8 (where 1.0 indicates that monozygotic twins have no variance in IQ and 0 indicates that their IQs are completely uncorrelated). Some studies have found that heritability is lower in families of low socioeconomic status. IQ heritability increases during early childhood, but it is unclear whether it stabilizes thereafter. A 1996 statement by the American Psychological Association gave about 0.45 for children and about .75 during and after adolescence. A 2004 meta-analysis of reports in Current Directions in Psychological Science gave an overall estimate of around 0.85 for 18-year-olds and older. The general figure for heritability of IQ is about 0.5 across multiple studies in varying populations. Recent studies suggest that family environment (i.e., upbringing) has negligible long-lasting effects upon adult IQ.
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