KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
... transfer to primates. The term »Goodpasture’s syndrome« was then used for the triad of lung hemorrhage, renal failure and anti-GBM antibodies. Now some authors prefer the term »Goodpasture’s disease« for glomerulonephritis caused by antibodies directed against the a3-chain of type IV collagen, with ...
... transfer to primates. The term »Goodpasture’s syndrome« was then used for the triad of lung hemorrhage, renal failure and anti-GBM antibodies. Now some authors prefer the term »Goodpasture’s disease« for glomerulonephritis caused by antibodies directed against the a3-chain of type IV collagen, with ...
Inflammatory Myopathies
... Clinical features • Progressive painless weakness – Difficulty lifting above head/combing hair – Difficulty arising from a low chair or toilet – Nasal regurgitation or choking when eating – Hoarseness, change in voice – *Ocular/facial muscle involvement is very ...
... Clinical features • Progressive painless weakness – Difficulty lifting above head/combing hair – Difficulty arising from a low chair or toilet – Nasal regurgitation or choking when eating – Hoarseness, change in voice – *Ocular/facial muscle involvement is very ...
HEENT History - SFrost
... Muscle Tension Headache: Constant band like pressure lasting days to weeks; usually worse at the end of the day; often occipital location Migraine Headache: Throbbing, often unilateral frontal headache; usually visual prodromata, nausea and vomiting precede the attack. Positive family history of mig ...
... Muscle Tension Headache: Constant band like pressure lasting days to weeks; usually worse at the end of the day; often occipital location Migraine Headache: Throbbing, often unilateral frontal headache; usually visual prodromata, nausea and vomiting precede the attack. Positive family history of mig ...
Invest in ME – London, June 1st 2012
... macrophages communicate with the microglia, which in turn affect the neurons. These inflammatory changes are seen in Alzheimer’s disease. Systemic infection in elderly sufferers may be acute or chronic. Worsening symptoms are associated with increased microglia and cytokines in the brain. A longitud ...
... macrophages communicate with the microglia, which in turn affect the neurons. These inflammatory changes are seen in Alzheimer’s disease. Systemic infection in elderly sufferers may be acute or chronic. Worsening symptoms are associated with increased microglia and cytokines in the brain. A longitud ...
Biological therapy
... The ligand of CD20 is unknown, the molecule is involved in the regulation of calcium flux The mechanisms of action are: induction of ADCC reaction, of complement dependent cytotoxicity, and of apoptosis; and saturation of Fc receptors Recently, the drug found its way to treat diseases characterized ...
... The ligand of CD20 is unknown, the molecule is involved in the regulation of calcium flux The mechanisms of action are: induction of ADCC reaction, of complement dependent cytotoxicity, and of apoptosis; and saturation of Fc receptors Recently, the drug found its way to treat diseases characterized ...
an oxidase-positive, gram-negative bacil
... morbidity and mortality, mucosal leishmaniasis (ML) is an important endemic disease and a public health problem in underdeveloped countries. The increase in ecological tourism has resulted in the extension of this problem to developed countries. The current treatment for ML ...
... morbidity and mortality, mucosal leishmaniasis (ML) is an important endemic disease and a public health problem in underdeveloped countries. The increase in ecological tourism has resulted in the extension of this problem to developed countries. The current treatment for ML ...
3-Autoimmune disorders - Light at the End of the
... definitions of the parameters that are being considered as positive signs of a disease. Autoimmune diseases involve a multigenic predisposition. For example, an individual who has an identical twin with SLE has a much higher frequency of developing SLE than a member of the general population (27-54% ...
... definitions of the parameters that are being considered as positive signs of a disease. Autoimmune diseases involve a multigenic predisposition. For example, an individual who has an identical twin with SLE has a much higher frequency of developing SLE than a member of the general population (27-54% ...
Hemolytic Anemia - UCSF | Department of Medicine
... • Coombs’ test: positive only in antibody-mediated (i.e. autoimmune) hemolysis a. Direct = patient’s RBCs plus antisera against IgG and C3 -- will be positive in almost all cases of warm autoimmune hemolysis and most cases of cold agglutinin disease (if test done properly) -- pattern of anti-IgG vs. ...
... • Coombs’ test: positive only in antibody-mediated (i.e. autoimmune) hemolysis a. Direct = patient’s RBCs plus antisera against IgG and C3 -- will be positive in almost all cases of warm autoimmune hemolysis and most cases of cold agglutinin disease (if test done properly) -- pattern of anti-IgG vs. ...
Autoimmune Hepatitis/ Autoimmune Pancreatitis
... Autoantigen Driven cell-mediated Autoantibody Dependent cell- mediated cytotoxicity ...
... Autoantigen Driven cell-mediated Autoantibody Dependent cell- mediated cytotoxicity ...
Infectious Mono
... Perform the Infectious Mononucleosis kit test for the detection of antibodies to obtain control and patient results that match instructor values with 100% accuracy. ...
... Perform the Infectious Mononucleosis kit test for the detection of antibodies to obtain control and patient results that match instructor values with 100% accuracy. ...
Antinuclear Antibodies (ANA)
... “foreign” and dangerous. The antibodies that target “normal” proteins within the nucleus of a cell are called antinuclear antibodies (ANA). ANAs could signal the body to begin attacking itself which can lead to autoimmune diseases, including lupus, scleroderma, Sjögren’s syndrome, polymyositis/ derm ...
... “foreign” and dangerous. The antibodies that target “normal” proteins within the nucleus of a cell are called antinuclear antibodies (ANA). ANAs could signal the body to begin attacking itself which can lead to autoimmune diseases, including lupus, scleroderma, Sjögren’s syndrome, polymyositis/ derm ...
biopresibstandards
... differences between human cells and bacterial cells and so there are many antibiotics that block a process in bacterial cells without causing any harm to human cells. Viruses carry out very few processes themselves. They rely instead on a host cell such as a human cell to carry out the processes f ...
... differences between human cells and bacterial cells and so there are many antibiotics that block a process in bacterial cells without causing any harm to human cells. Viruses carry out very few processes themselves. They rely instead on a host cell such as a human cell to carry out the processes f ...
IMMUNOLOGY SIMPLIFIED Autoimmune diseases
... overlap with other more benign illnesses • One symptom that is uniform throughout—profound fatigue; described as “debilitating” fatigue, “impacts every aspect” of their lives • HAVE A HIGH INDEX OF SUSCPICION if you are a PCP out there!!! ...
... overlap with other more benign illnesses • One symptom that is uniform throughout—profound fatigue; described as “debilitating” fatigue, “impacts every aspect” of their lives • HAVE A HIGH INDEX OF SUSCPICION if you are a PCP out there!!! ...
The biochemistry and genetics of autoimmune disease
... Central tolerance develops in thymus and bone marrow (negative selection to eliminate cells reactive with antigens Present soon after cell expresses antigen receptor Present at high concentration over long periods of time ...
... Central tolerance develops in thymus and bone marrow (negative selection to eliminate cells reactive with antigens Present soon after cell expresses antigen receptor Present at high concentration over long periods of time ...
Antibodies
... • The use of monoclonal antibodies in enabling the targeting of specific substances and cells. Candidates should be able to – evaluate methodology, evidence and data relating to the use of monoclonal antibodies – discuss ethical issues associated with the use of monoclonal antibodies – explain the r ...
... • The use of monoclonal antibodies in enabling the targeting of specific substances and cells. Candidates should be able to – evaluate methodology, evidence and data relating to the use of monoclonal antibodies – discuss ethical issues associated with the use of monoclonal antibodies – explain the r ...
European Respiratory Society Annual Congress 2012
... Pneumology, Hospital Clinic, Barcelona, Spain ; 2 Microbiology, Hospital Clínic, Barcelona, Spain and 3 Infectious Diseases, Hospital Clínic, Barcelona, Spain . Body: Introduction Long-term use of inhaled corticosteroids (ICS) in patients with Chronic Obstructive Pulmonary Disease (COPD) has been as ...
... Pneumology, Hospital Clinic, Barcelona, Spain ; 2 Microbiology, Hospital Clínic, Barcelona, Spain and 3 Infectious Diseases, Hospital Clínic, Barcelona, Spain . Body: Introduction Long-term use of inhaled corticosteroids (ICS) in patients with Chronic Obstructive Pulmonary Disease (COPD) has been as ...
Slide 1
... Indirect immunofluorescence performed with high titer Celiac disease serum placed on monkey esophagus with or without tTG pretreatment Untreated serum revealed a characteristic endomysial immunofluorescence pattern consistent with disease whereas the treated serum pattern nearly completely abolish ...
... Indirect immunofluorescence performed with high titer Celiac disease serum placed on monkey esophagus with or without tTG pretreatment Untreated serum revealed a characteristic endomysial immunofluorescence pattern consistent with disease whereas the treated serum pattern nearly completely abolish ...
Malaria in Pregnancy & Anaemia in Pregnancy
... Tolerance and Autoimmunity The Immune system could go awry and instead of reacting only against foreign antigens, could focus its attack on SELF ANTIGENS ...
... Tolerance and Autoimmunity The Immune system could go awry and instead of reacting only against foreign antigens, could focus its attack on SELF ANTIGENS ...
Vasculitis
... mononeuritis multiplex and eosinophilia on a background of resistant asthma. Pulmonary infiltrates and pleural or pericardial effusions due to serositis may be present. Up to 50% of patients have abdominal symptoms due to mesenteric vasculitis. Either c-ANCA or p-ANCA is present in around 40% of ...
... mononeuritis multiplex and eosinophilia on a background of resistant asthma. Pulmonary infiltrates and pleural or pericardial effusions due to serositis may be present. Up to 50% of patients have abdominal symptoms due to mesenteric vasculitis. Either c-ANCA or p-ANCA is present in around 40% of ...
C.5 Articles
... A commercially available dot immunoassay that employs the lipoarabinomannan antigen was evaluated for the serologic diagnosis of tuberculosis. The test showed a high specificity (100%); however, its sensitivity was low (18.5%). Antibodies to lipoarabinomannan were detected in the sera of 7 of 71 pat ...
... A commercially available dot immunoassay that employs the lipoarabinomannan antigen was evaluated for the serologic diagnosis of tuberculosis. The test showed a high specificity (100%); however, its sensitivity was low (18.5%). Antibodies to lipoarabinomannan were detected in the sera of 7 of 71 pat ...
Experiences from the NEUROSCIENCE
... Despite the wealth of data out there (> 2500 databases on-line), the majority of data is still published in papers But...we write for other humans to consume and information continues to be hard to find ...
... Despite the wealth of data out there (> 2500 databases on-line), the majority of data is still published in papers But...we write for other humans to consume and information continues to be hard to find ...
Alissa Pharma
... ◦ >25 years developing 100+ monoclonal antibodies ◦ Consultant with Roche, Ortho-Diagnostic, Merck ◦ Biotech entrepreneur (founder or co-founder of Clonatec, Novagali, MAT BioPharma, Immune Pharmaceuticals) ◦ Licensing & Strategy Director at Sangstat (acquired by Genzyme) ...
... ◦ >25 years developing 100+ monoclonal antibodies ◦ Consultant with Roche, Ortho-Diagnostic, Merck ◦ Biotech entrepreneur (founder or co-founder of Clonatec, Novagali, MAT BioPharma, Immune Pharmaceuticals) ◦ Licensing & Strategy Director at Sangstat (acquired by Genzyme) ...
Parvovirus B19 Genome in Endomyocardial Biopsy Specimen
... the August 28, 2003, issue of Circulation, Kühl et al4 reported the association of PVB19 genome in endomyocardial biopsies in the clinical setting of acute myocardial infarction. Follow-up of a subgroup of PVB19-positive patients revealed that viral persistence may be associated with progression of ...
... the August 28, 2003, issue of Circulation, Kühl et al4 reported the association of PVB19 genome in endomyocardial biopsies in the clinical setting of acute myocardial infarction. Follow-up of a subgroup of PVB19-positive patients revealed that viral persistence may be associated with progression of ...
Functional β cells detected in long-standing T1DM
... RESEARCH HIGHLIGHTS Nature Reviews Endocrinology 8, 256 (2012); published online 13 March 2012; doi:10.1038/nrendo.2012.32 ...
... RESEARCH HIGHLIGHTS Nature Reviews Endocrinology 8, 256 (2012); published online 13 March 2012; doi:10.1038/nrendo.2012.32 ...