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Mechanisms of cell death
Mechanisms of cell death

... activation is common among caspases. Thus activation shows positive feedback characteristics consistent with a binary on-off regulation. • Ectopic expression of caspases in mammalian cells induces apoptosis. This is the strongest evidence for proteolytic mediation of apoptosis. The key intracellular ...
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Chapter 1: The Biochemical Basis of life

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CHAPTER 3: CELLS

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Helping students understand cell ultrastructure with

... Image viewer is now freely available throughout the university as a plug-in to UniTube (file sharing system, wide range of file types including images, videos and audio files). Once uploaded the UniTube URL can be shared or embed it into Blackboard or any other website. ...
View Full PDF - Biochemical Society Transactions
View Full PDF - Biochemical Society Transactions

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... of mitosis should be known. To avoid confusion in terminology, teachers are encouraged to refer to the two parts of a chromosome as sister chromatids, while they are attached to each other by a centromere in the early stages of mitosis. From anaphase onwards, when sister chromatids have separated to ...
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...  Major cellular receptors for ECM proteins and provide link between internal cytoskeleton of cells (primarily actin microfilament system) and extracellular proteins, such as fibronectin, collagen, and laminin  Consist of an α and β-subunit – 24 different combinations discovered  Integrins involve ...
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... system required for the regulated transport of water and nutrients. They develop from procambial or cambial cells (i.e cells of the secondary meristem surrounding the vascular tissue) or can be induced to form from parenchymal cells by wound stress. Transdifferentiation from parenchymal cells into xy ...
CYTOSKELETON
CYTOSKELETON

... muscle resulting in opening of sodium/potassium channel (sodium rush in, potassium rush out) 5) action potential (nerve signal) spreads through muscle fiber's network of T tubules (invagination of membrane) and depolarizes the inner portion of the muscle fiber ...
ultracentrifugation
ultracentrifugation

CYTOSKELETON
CYTOSKELETON

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The Cell Cycle Control System
The Cell Cycle Control System

... released by certain cells that stimulate other cells to divide • Another example of external signals is density-dependent inhibition, in which crowded cells stop dividing • Most animal cells also exhibit anchorage dependence, in which they must be attached to a substratum in order to ...
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Cytosol



The cytosol or intracellular fluid (ICF) or cytoplasmic matrix is the liquid found inside cells. It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into many compartments.In the eukaryotic cell, the cytosol is within the cell membrane and is part of the cytoplasm, which also comprises the mitochondria, plastids, and other organelles (but not their internal fluids and structures); the cell nucleus is separate. In prokaryotes, most of the chemical reactions of metabolism take place in the cytosol, while a few take place in membranes or in the periplasmic space. In eukaryotes, while many metabolic pathways still occur in the cytosol, others are contained within organelles.The cytosol is a complex mixture of substances dissolved in water. Although water forms the large majority of the cytosol, its structure and properties within cells is not well understood. The concentrations of ions such as sodium and potassium are different in the cytosol than in the extracellular fluid; these differences in ion levels are important in processes such as osmoregulation, cell signaling, and the generation of action potentials in excitable cells such as endocrine, nerve and muscle cells. The cytosol also contains large amounts of macromolecules, which can alter how molecules behave, through macromolecular crowding.Although it was once thought to be a simple solution of molecules, the cytosol has multiple levels of organization. These include concentration gradients of small molecules such as calcium, large complexes of enzymes that act together to carry out metabolic pathways, and protein complexes such as proteasomes and carboxysomes that enclose and separate parts of the cytosol.
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